XNCR

SEC source: 0001179110-20-004802 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,206,005

F1 · price: This transaction was executed in multiple trades at prices ranging from $31.48 to $32.30. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-20-004078 · edgar.xml · nonDerivative · entry 2

Ronin Capital, LLC · CIK 0001512282 · 10% owner

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,012,430

F2 · price: This transaction was executed in multiple trades at prices ranging from $28.09 to $31.65. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

F3 · balance_after: The reported shares of common stock of Xencor, Inc. are held in a Class C Capital Account of John S. Stafford, III at Ronin Capital, LLC ("Ronin"), a limited liability company owned and managed by Mr. Stafford. Mr. Stafford is the indirect beneficial owner of all of the shares of common stock of Xencor, Inc. held of record by Ronin.

SEC source: 0001179110-20-004078 · edgar.xml · nonDerivative · entry 1

Ronin Capital, LLC · CIK 0001512282 · 10% owner

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,063,200

F1 · price: This transaction was executed in multiple trades at prices ranging from $27.37 to $28.86. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

F3 · balance_after: The reported shares of common stock of Xencor, Inc. are held in a Class C Capital Account of John S. Stafford, III at Ronin Capital, LLC ("Ronin"), a limited liability company owned and managed by Mr. Stafford. Mr. Stafford is the indirect beneficial owner of all of the shares of common stock of Xencor, Inc. held of record by Ronin.

SEC source: 0001209191-20-016053 · doc4.xml · derivative · entry 2

Dahiyat Bassil I · CIK 0001591312 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,628

Underlying: Common Stock · 141,628 shares

Expires 2030-03-01

F4 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of March 2, 2020 (the "Vesting Commencement Date") and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-20-016053 · doc4.xml · nonDerivative · entry 1

Dahiyat Bassil I · CIK 0001591312 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,504

F1 · shares: Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant.

F2 · balance_after: Since the date of the reporting person's last ownership report, he transferred 224,052 shares of the Issuer's common stock to his former spouse pursuant to a domestic relations order.

F3 · balance_after: Includes the following shares acquired by the reporting person pursuant to the Issuer's Employee Stock Purchase Plan: 289 shares acquired in December 2018, 297 shares acquired in June 2019 and 298 shares acquired in December 2019.

SEC source: 0001209191-20-016063 · doc4.xml · derivative · entry 2

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,663

Underlying: Common Stock · 40,663 shares

Expires 2030-03-01

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of March 2, 2020 (the "Vesting Commencement Date") and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-20-016063 · doc4.xml · nonDerivative · entry 1

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,422

F1 · shares: Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant.

SEC source: 0001209191-20-016071 · doc4.xml · derivative · entry 2

Eckert Celia · CIK 0001787397 · VP, General Counsel and Secy

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,884

Underlying: Common Stock · 18,884 shares

Expires 2030-03-01

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of March 2, 2020 (the "Vesting Commencement Date") and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-20-016071 · doc4.xml · nonDerivative · entry 1

Eckert Celia · CIK 0001787397 · VP, General Counsel and Secy

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,147

F1 · shares: Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant.

SEC source: 0001209191-20-016057 · doc4.xml · derivative · entry 2

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,553

Underlying: Common Stock · 54,553 shares

Expires 2030-03-01

F2 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of March 2, 2020 (the "Vesting Commencement Date") and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-20-016057 · doc4.xml · nonDerivative · entry 1

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,953

F1 · shares: Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant.

SEC source: 0001179110-20-000425 · edgar.xml · nonDerivative · entry 3

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,250,776

F3 · price: This transaction was executed in multiple trades at prices ranging from $35.94 to $37.18. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-20-000425 · edgar.xml · nonDerivative · entry 2

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,311,652

F2 · price: This transaction was executed in multiple trades at prices ranging from $35.84 to $36.11. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-20-000425 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,317,699

F1 · price: This transaction was executed in multiple trades at prices ranging from $35.74 to $36.02. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-013159 · edgar.xml · nonDerivative · entry 4

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,376,561

F4 · price: This transaction was executed in multiple trades at prices ranging from $39.93 to $40.13. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-013159 · edgar.xml · nonDerivative · entry 3

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,380,680

F3 · price: This transaction was executed in multiple trades at prices ranging from $39.07 to $39.82. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-013159 · edgar.xml · nonDerivative · entry 2

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,424,400

F2 · price: This transaction was executed in multiple trades at prices ranging from $39.32 to $40.01. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-013159 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,516,077

F1 · price: This transaction was executed in multiple trades at prices ranging from $39.35 to $39.43. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001209191-19-061608 · doc4.xml · derivative · entry 1

ROSA-BJORKESON DAGMAR · CIK 0001643934 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,528

Underlying: Common Stock · 15,528 shares

Expires 2029-12-17

F1 · derivative.exercise_date: 1/3 of the shares subject to the stock option vest and become exercisable on December 18, 2020, and the remaining shares vest in equal monthly installments over the subsequent 24 months.

SEC source: 0001209191-19-061083 · doc4.xml · derivative · entry 2

Yang Allen · CIK 0001797034 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,300

Underlying: Common Stock · 62,300 shares

Expires 2029-12-15

F2 · derivative.exercise_date: 1/4th of the shares vest one year after December 16, 2019 (the "Vesting Commencement Date"); the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date, subject to the optionholder's Continuous Service (as defined in the 2013 Equity Incentive Plan) as of each such date.

SEC source: 0001209191-19-061083 · doc4.xml · nonDerivative · entry 1

Yang Allen · CIK 0001797034 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,900

F1 · shares: Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant.

SEC source: 0001415889-21-001296 · form4a-03032021_080321.xml · derivative · entry 1

Yang Allen · CIK 0001797034 · SR. VICE PRESIDENT & CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,300

Underlying: Common Stock · 62,300 shares

Expires 2029-12-15

F1 · derivative.exercise_price: The initial filing incorrectly listed the exercise price at $37.59 per share due to an administrative error.

F2 · derivative.exercise_date: 1/4th of the shares vest one year after December 16, 2019 (the "Vesting Commencement Date"); the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date, subject to the optionholder's Continuous Service (as defined in the 2013 Equity Incentive Plan) as of each such date.

SEC source: 0001209191-20-007734 · doc4.xml · nonDerivative · entry 1

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,645

F1 · kind: Represents a donation of 500 shares to a charitable trust.

F2 · balance_after: Includes 516 shares acquired by the Reporting Person in December 2019 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001179110-19-012669 · edgar.xml · nonDerivative · entry 3

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,589,500

F3 · price: This transaction was executed in multiple trades at prices ranging from $38.01 to $39.75. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-012669 · edgar.xml · nonDerivative · entry 2

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,627,451

F2 · price: This transaction was executed in multiple trades at prices ranging from $39.27 to $41.45. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-012669 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Trading, LLC

Disclosed balance after: 1,879,676

F1 · price: This transaction was executed in multiple trades at prices ranging from $41.01 to $42.09. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001209191-19-049076 · doc4.xml · derivative · entry 2

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 27,522 shares

Expires 2023-09-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001209191-19-049076 · doc4.xml · nonDerivative · entry 1

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,868

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-047188 · doc4.xml · derivative · entry 3

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,065

Underlying: Common Stock · 20,000 shares

Expires 2024-02-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 21, 2014 (the "Vesting Commencement Date"), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested and exercisable on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-19-047188 · doc4.xml · nonDerivative · entry 2

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,629

F2 · price: The weighted average sale price for the transaction reported was $41.2681, and the range of prices were between $41.06 and $41.55. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001209191-19-047188 · doc4.xml · nonDerivative · entry 1

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,629

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes the following shares acquired by the Reporting Person pursuant to the Issuer's Employee Stock Purchase Plan: 544 shares of Common Stock acquired on December 10, 2018 and 603 shares of Common Stock acquired on June 10, 2019.

SEC source: 0001415889-21-001297 · form4a-03032021_080328.xml · derivative · entry 1

Kuch John J · CIK 0001591306 · SR. VICE PRESIDENT & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,650

Underlying: Common Stock · 20,000 shares

Expires 2024-02-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 21, 2014 (the Vesting Commencement Date), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date.

F2 · balance_after: The initial filing incorrectly listed the number of securities beneficially owned following the transaction as 35,065 due to a typo, this error was carried into a subsequent filing after the date of the initial report.

SEC source: 0001209191-19-046981 · doc4.xml · nonDerivative · entry 1

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,346

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.42 to $41.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F2 · balance_after: Includes the following shares acquired by the Reporting Person pursuant to the Issuer's Employee Stock Purchase Plan: 1,626 shares of Common Stock acquired on December 11, 2018 and 1,622 shares of Common Stock acquired on June 12, 2019.

SEC source: 0001209191-19-039385 · doc4.xml · derivative · entry 1

Hata Yujiro S · CIK 0001649119 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001209191-19-039383 · doc4.xml · derivative · entry 1

GUSTAFSON KURT A · CIK 0001462354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001209191-19-039379 · doc4.xml · derivative · entry 1

GORMAN KEVIN CHARLES · CIK 0001201096 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001209191-19-039381 · doc4.xml · derivative · entry 1

RANIERI RICHARD J · CIK 0001225617 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001209191-19-039380 · doc4.xml · derivative · entry 1

Montgomery Alan Bruce · CIK 0001313936 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001209191-19-039386 · doc4.xml · derivative · entry 1

Feigal Ellen · CIK 0001758108 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,731

Underlying: Common Stock · 12,731 shares

Expires 2029-06-25

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over one year beginning on the one-month anniversary of June 26, 2019, such that the total number of shares will be fully vested on June 26, 2020.

SEC source: 0001179110-19-007384 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,090,000

F1 · price: This transaction was executed in multiple trades at prices ranging from $29.69 to $30.14. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-005598 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,077,359

F1 · balance_after: This transaction was executed in multiple trades at prices ranging from $29.80 to $29.90. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-004286 · edgar.xml · nonDerivative · entry 2

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,062,748

F2 · price: This transaction was executed in multiple trades at prices ranging from $29.70 to $29.90. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-004286 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,059,248

F1 · price: This transaction was executed in multiple trades at prices ranging from $29.95 to $29.99. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-004050 · edgar.xml · nonDerivative · entry 2

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,057,248

F2 · price: This transaction was executed in multiple trades at prices ranging from $29.90 to $29.95. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001179110-19-004050 · edgar.xml · nonDerivative · entry 1

STAFFORD JOHN S III · CIK 0001218981 · 10% owner

Ronin Capital, LLC · CIK 0001512282 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Ronin Capital, LLC

Disclosed balance after: 5,056,148

F1 · price: This transaction was executed in multiple trades at prices ranging from $28.08 to $29.75. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001209191-19-010222 · doc4.xml · derivative · entry 1

Kuch John J · CIK 0001591306 · Sr. Vice President & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,420

Underlying: Common Stock · 50,420 shares

Expires 2029-02-11

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 12, 2019 (the "Vesting Commencement Date"), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested and exercisable on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-19-010217 · doc4.xml · derivative · entry 1

Foster Paul A · CIK 0001591213 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,420

Underlying: Common Stock · 50,420 shares

Expires 2029-02-11

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 12, 2019 (the "Vesting Commencement Date"), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested and exercisable on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-19-010211 · doc4.xml · derivative · entry 1

Desjarlais John R · CIK 0001591313 · Sr. V.P., Research & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,025

Underlying: Common Stock · 63,025 shares

Expires 2029-02-11

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 12, 2019 (the "Vesting Commencement Date"), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested and exercisable on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-19-010194 · doc4.xml · derivative · entry 1

Dahiyat Bassil I · CIK 0001591312 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,655

Underlying: Common Stock · 138,655 shares

Expires 2029-02-11

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on the one year anniversary of February 12, 2019 (the "Vesting Commencement Date"), and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested and exercisable on the four year anniversary of the Vesting Commencement Date.

SEC source: 0001209191-18-057952 · doc4.xml · derivative · entry 1

Feigal Ellen · CIK 0001758108 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,037

Underlying: Common Stock · 15,037 shares

Expires 2028-11-06

F1 · derivative.exercise_date: 1/3 of the shares subject to the stock option vest and become exercisable on November 7, 2019, and the remaining shares vest in equal monthly installments over the subsequent 24 months.