STE

SEC source: 0001628280-25-044118 · wk-form4_1759524719.xml · nonDerivative · entry 1

Majors Cary L · CIK 0001776271 · SVP and President, Healthcare

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,427

F1 · shares: 303 shares were withheld from the 692 restricted shares that vested on October 1, 2025. These 303 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 692 ordinary shares were awarded to Mr. Majors on October 1, 2021. These vested shares were valued at the NYSE closing market price on October 1, 2025.

F2 · balance_after: As of October 1, 2025, 10,138 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 2,697 on June 1, 2026; 2,140 on June 2, 2026; 2,379 on June 4, 2027 and 2,922 on June 5, 2028.

SEC source: 0001628280-25-044115 · wk-form4_1759524567.xml · derivative · entry 3

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,356

Underlying: Ordinary Shares · 8,356 shares

Expires 2035-10-01

F4 · derivative.exercise_date: This option becomes exercisable as follows: 2,089 on October 1, 2026; 2,089 on October 1, 2027; 2,089 on October 1, 2028 and 2,089 on October 1, 2029.

SEC source: 0001628280-25-044115 · wk-form4_1759524567.xml · nonDerivative · entry 2

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,304

F3 · balance_after: As of October 1, 2025, 5,479 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 340 on June 1, 2026; 225 on June 2, 2026; 651 on June 3, 2026; 306 on June 4, 2026; 783 on October 1, 2026; 651 on June 3, 2027; 306 on June 4, 2027; 783 on October 1, 2027; 651 on June 5, 2028 and 783 on October 1, 2028.

SEC source: 0001628280-25-044115 · wk-form4_1759524567.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,955

F1 · shares: 39 shares were withheld from the 86 restricted shares that vested on October 1, 2025. These 39 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 86 ordinary shares were awarded to Ms. Burton on October 1, 2021. These vested shares were valued at the NYSE closing market price on October 1, 2025.

F2 · balance_after: As of October 1, 2025, 3,130 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 340 on June 1, 2026; 225 on June 2, 2026; 651 on June 3, 2026; 306 on June 4, 2026; 651 on June 3, 2027; 306 on June 4, 2027 and 651 on June 5, 2028.

SEC source: 0001628280-25-044114 · wk-form4_1759524525.xml · nonDerivative · entry 1

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,255

F1 · shares: 130 shares were withheld from the 289 restricted shares that vested on October 1, 2025. These 130 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 289 ordinary shares were awarded to Mr. Carestio on October 1, 2021. These vested shares were valued at the NYSE closing market price on October 1, 2025.

F2 · balance_after: As of October 1, 2025, 33,054 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 4,308 on June 1, 2026; 5,937 on June 3, 2026; 2,369 on June 2, 2026; 4,283 on June 4, 2026; 5,937 on June 3, 2027; 4,283 on June 4, 2027; and 5,937 on June 5, 2028.

SEC source: 0001628280-25-041025 · wk-form4_1755894616.xml · derivative · entry 3

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,204 shares

Expires 2029-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option to purchase 3,204 STERIS plc ordinary shares was awarded on May 31, 2019 and is fully vested.

SEC source: 0001628280-25-041025 · wk-form4_1755894616.xml · nonDerivative · entry 2

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,221

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $249.145 to $249.34 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of August 21, 2025, 1,561 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 86 on October 1, 2025; 241 on June 1, 2026; 141 on June 2, 2026; 217 on June 3, 2026; 221 on June 4, 2026; 217 on June 3, 2027; 221 on June 4, 2027 and 217 on June 5, 2028.

SEC source: 0001628280-25-041025 · wk-form4_1755894616.xml · nonDerivative · entry 1

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,425

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-040522 · wk-form4_1755289866.xml · derivative · entry 3

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,110 shares

Expires 2025-08-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option to purchase 4,110 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 4,110 ordinary shares for $64.05 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option.

SEC source: 0001628280-25-040522 · wk-form4_1755289866.xml · nonDerivative · entry 1

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,664

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · derivative · entry 6

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,110 shares

Expires 2025-08-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: This option to purchase 4,110 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 4,110 ordinary shares for $64.05 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · nonDerivative · entry 2

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,361

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $241.36 to $242.295 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · nonDerivative · entry 1

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,471

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-039969 · wk-form4_1755033953.xml · derivative · entry 6

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,495 shares

Expires 2028-08-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039969 · wk-form4_1755033953.xml · nonDerivative · entry 2

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 705

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $241.38 to $241.705 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001628280-25-039969 · wk-form4_1755033953.xml · nonDerivative · entry 1

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-039965 · wk-form4_1755033639.xml · derivative · entry 3

Burton Karen L · CIK 0001697095 · VP & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 7,900 shares

Expires 2028-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option to purchase 7,900 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 7,900 ordinary shares for $114.22 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option.

SEC source: 0001628280-25-039965 · wk-form4_1755033639.xml · nonDerivative · entry 2

Burton Karen L · CIK 0001697095 · VP & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,994

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $241.33 to $242.32 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of August 12, 2025, 3,216 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 86 on October 1, 2025; 340 on June 1, 2026; 651 on June 3, 2026; 225 on June 2, 2026; 306 on June 4, 2026; 651 on June 3, 2027; 306 on June 4, 2027 and 651 on June 5, 2028.

SEC source: 0001628280-25-039965 · wk-form4_1755033639.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · VP & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,894

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · derivative · entry 5

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,750

Underlying: Ordinary Shares · 506 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F5 · price: These Career Restricted Stock Units were issued to the Reporting Person in lieu of $123,000 in fees.

F4 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F4 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · derivative · entry 4

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,244

Underlying: Ordinary Shares · 772 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F4 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F4 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039974 · wk-form4_1755034076.xml · derivative · entry 3

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,226

Underlying: Ordinary Shares · 2,226 shares

Expires 2035-08-08

F2 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039973 · wk-form4_1755034054.xml · derivative · entry 1

Shapiro Louis · CIK 0001999146 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 975

Underlying: Ordinary Shares · 975 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F2 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F2 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039971 · wk-form4_1755033998.xml · derivative · entry 2

Martin Paul Edward · CIK 0001700415 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,562

Underlying: Ordinary Shares · 487 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039971 · wk-form4_1755033998.xml · derivative · entry 1

Martin Paul Edward · CIK 0001700415 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Ordinary Shares · 1,407 shares

Expires 2035-08-08

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039972 · wk-form4_1755034023.xml · derivative · entry 2

Shah Nirav R · CIK 0001740213 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,503

Underlying: Ordinary Shares · 487 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039972 · wk-form4_1755034023.xml · derivative · entry 1

Shah Nirav R · CIK 0001740213 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Ordinary Shares · 1,407 shares

Expires 2035-08-08

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039970 · wk-form4_1755033975.xml · derivative · entry 1

HOLLAND CHRISTOPHER S · CIK 0001271440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,964

Underlying: Ordinary Shares · 975 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F2 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F2 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039969 · wk-form4_1755033953.xml · derivative · entry 5

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,128

Underlying: Ordinary Shares · 487 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F5 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F5 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039969 · wk-form4_1755033953.xml · derivative · entry 4

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Ordinary Shares · 1,407 shares

Expires 2035-08-08

F3 · derivative.exercise_price: These nonqualified stock options are fully vested and are exercisable immediately.

F3 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039968 · wk-form4_1755033926.xml · derivative · entry 4

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,545

Underlying: Ordinary Shares · 355 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F5 · price: These Career Restricted Stock Units were issued to the Reporting Person in lieu of $86,000 in fees.

F4 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F4 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039968 · wk-form4_1755033926.xml · derivative · entry 3

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,190

Underlying: Ordinary Shares · 487 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F4 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F4 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039968 · wk-form4_1755033926.xml · derivative · entry 2

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,704

Underlying: Ordinary Shares · 297 shares

Expires 2035-08-08

F2 · derivative.exercise_price: These nonqualified stock options were issued to the Reporting Person in lieu of $25,000 in fees.

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039968 · wk-form4_1755033926.xml · derivative · entry 1

Breeden Richard C · CIK 0001300622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Ordinary Shares · 1,407 shares

Expires 2035-08-08

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-039966 · wk-form4_1755033664.xml · derivative · entry 2

Alegria Esther M. · CIK 0001867056 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,896

Underlying: Ordinary Shares · 487 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-25-039966 · wk-form4_1755033664.xml · derivative · entry 1

Alegria Esther M. · CIK 0001867056 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Ordinary Shares · 1,407 shares

Expires 2035-08-08

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-25-031870 · wk-form4_1750192470.xml · nonDerivative · entry 2

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,760

F3 · price: Price reflects a weighted average sale price for multiple transactions ranging from $241.28 to $241.815 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of June 13, 2025, 8,713 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 202 on October 1, 2025; 1,157 on June 1, 2026; 846 on June 2, 2026; 1,252 on June 3, 2026; 1,376 on June 4, 2026; 1,252 on June 3 2027; 1,376 on June 4, 2027 and 1,252 on June 5, 2028.

SEC source: 0001628280-25-031870 · wk-form4_1750192470.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,408

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $240.20 to $241.17 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of June 13, 2025, 8,713 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 202 on October 1, 2025; 1,157 on June 1, 2026; 846 on June 2, 2026; 1,252 on June 3, 2026; 1,376 on June 4, 2026; 1,252 on June 3 2027; 1,376 on June 4, 2027 and 1,252 on June 5, 2028.

SEC source: 0001628280-25-030023 · wk-form4_1749241830.xml · nonDerivative · entry 4

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,385

F2 · balance_after: As of June 4, 2025, 33,343 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 289 on October 1, 2025; 4,308 on June 1, 2026; 5,937 on June 3, 2026; 2,369 on June 2, 2026; 4,283 on June 4, 2026; 5,937 on June 3, 2027; 4,283 on June 4, 2027; and 5,937 on June 5, 2028.

SEC source: 0001628280-25-030023 · wk-form4_1749241830.xml · nonDerivative · entry 3

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,511

F4 · price: Price reflects a weighted average sale price for multiple transactions ranging from $242.39 to $243.07 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of June 4, 2025, 33,343 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 289 on October 1, 2025; 4,308 on June 1, 2026; 5,937 on June 3, 2026; 2,369 on June 2, 2026; 4,283 on June 4, 2026; 5,937 on June 3, 2027; 4,283 on June 4, 2027; and 5,937 on June 5, 2028.

SEC source: 0001628280-25-030023 · wk-form4_1749241830.xml · nonDerivative · entry 2

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,491

F3 · price: Price reflects a weighted average sale price for multiple transactions ranging from $241.33 to $242.31 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · balance_after: As of June 4, 2025, 33,343 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 289 on October 1, 2025; 4,308 on June 1, 2026; 5,937 on June 3, 2026; 2,369 on June 2, 2026; 4,283 on June 4, 2026; 5,937 on June 3, 2027; 4,283 on June 4, 2027; and 5,937 on June 5, 2028.

SEC source: 0001628280-25-030033 · wk-form4_1749242065.xml · nonDerivative · entry 1

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,762

F1 · shares: 194 shares were withheld from the 542 restricted shares that vested on June 4, 2025. These 194 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 542 ordinary shares were awarded to Ms. Madsen on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 4,147 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 144 on October 1, 2025; 578 on June 1, 2026, 352 on June 2, 2026; 666 on June 3, 2026; 542 on June 4, 2026; 666 on June 3, 2027; 542 on June 4, 2027 and 666 on June 5, 2028.

SEC source: 0001628280-25-030027 · wk-form4_1749241883.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,738

F1 · shares: 425 shares were withheld from the 1,376 restricted shares that vested on June 4, 2025. These 425 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 1,376 ordinary shares were awarded to Mr. Zangerle on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 8,713 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 202 on October 1, 2025; 1,157 on June 1, 2026; 846 on June 2, 2026; 1,252 on June 3, 2026; 1,376 on June 4, 2026; 1,252 on June 3 2027; 1,376 on June 4, 2027 and 1,252 on June 5, 2028.

SEC source: 0001628280-25-030035 · wk-form4_1749242097.xml · nonDerivative · entry 1

TOKICH MICHAEL J · CIK 0001235611 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,891

F1 · shares: 341 shares were withheld from the 1,141 restricted shares that vested on June 4, 2025. These 341 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 1,141 ordinary shares were awarded to Mr. Tokich on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 6,506 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 144 on October 1, 2025; 1,293 on June 1, 2026; 564 on June 2, 2026; 741 on June 3, 2026; 1,141 on June 4, 2026; 741 on June 3, 2027; 1,141 on June 4, 2027 and 741 on June 5, 2028.

SEC source: 0001628280-25-030025 · wk-form4_1749241866.xml · nonDerivative · entry 1

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,221

F1 · shares: 66 shares were withheld from the 221 restricted shares that vested on June 4, 2025. These 66 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 221 ordinary shares were awarded to Mr. Tamaro on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 1,561 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 86 on October 1, 2025; 241 on June 1, 2026; 141 on June 2, 2026; 217 on June 3, 2026; 221 on June 4, 2026; 217 on June 3, 2027; 221 on June 4, 2027 and 217 on June 5, 2028.

SEC source: 0001628280-25-030022 · wk-form4_1749241805.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · VP & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,994

F1 · shares: 92 shares were withheld from the 306 restricted shares that vested on June 4, 2025. These 92 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 306 ordinary shares were awarded to Ms. Burton on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 3,216 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 86 on October 1, 2025; 340 on June 1, 2026; 651 on June 3, 2026; 225 on June 2, 2026; 306 on June 4, 2026; 651 on June 3, 2027; 306 on June 4, 2027 and 651 on June 5, 2028.

SEC source: 0001628280-25-030024 · wk-form4_1749241850.xml · nonDerivative · entry 1

Kohler Kenneth E · CIK 0002010979 · SVP & GM, AST

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,776

F1 · shares: 154 shares were withheld from the 513 restricted shares that vested on June 4, 2025. These 154 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 513 ordinary shares were awarded to Mr. Kohler on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 3,514 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 373 on May 31, 2026; 225 on June 2, 2026; 630 on June 3, 2026; 513 on June 4, 2026; 630 on June 3, 2027; 513 on June 4, 2027 and 630 on June 5, 2028.

SEC source: 0001628280-25-030023 · wk-form4_1749241830.xml · nonDerivative · entry 1

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,011

F1 · shares: 1,921 shares were withheld from the 4,283 restricted shares that vested on June 4, 2025. These 1,921 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 4,283 ordinary shares were awarded to Mr. Carestio on June 4, 2024. These vested shares were valued at the NYSE closing market price on June 4, 2025.

F2 · balance_after: As of June 4, 2025, 33,343 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 289 on October 1, 2025; 4,308 on June 1, 2026; 5,937 on June 3, 2026; 2,369 on June 2, 2026; 4,283 on June 4, 2026; 5,937 on June 3, 2027; 4,283 on June 4, 2027; and 5,937 on June 5, 2028.

SEC source: 0001628280-25-029688 · wk-form4_1749155722.xml · derivative · entry 2

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,100

Underlying: Ordinary Shares · 7,100 shares

Expires 2035-06-03

F2 · derivative.exercise_date: This option becomes exercisable as follows: 1,775 on June 3, 2026, 1,775 on June 3, 2027, 1,775 on June 5, 2028 and 1,775 on June 4, 2029.

SEC source: 0001628280-25-029688 · wk-form4_1749155722.xml · nonDerivative · entry 1

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,956

F1 · balance_after: As of June 3, 2025, 4,689 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 542 on June 4, 2025, 144 on October 1, 2025; 578 on June 1, 2026, 352 on June 2, 2026; 666 on June 3, 2026; 542 on June 4, 2026; 666 on June 3, 2027; 542 on June 4, 2027 and 666 on June 5, 2028.