STE

SEC source: 0001628280-26-064926 · wk-form4_1791231027.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,956

F1 · shares: 228 shares were withheld from the 783 restricted shares that vested on October 1, 2026. These 228 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 783 ordinary shares were awarded to Ms. Burton on October 1, 2025. These vested shares were valued at the NYSE closing market price on October 1, 2026.

F2 · balance_after: As of October 2, 2026, 8,499 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,775 on June 2, 2027; 651 on June 3, 2027; 306 on June 4, 2027; 783 on October 1, 2027; 1,775 on June 2, 2028; 651 on June 5, 2028; 783 on October 1, 2028 and 1,775 on June 4, 2029.

SEC source: 0001628280-26-056270 · wk-form4_1786566834.xml · derivative · entry 5

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,058 shares

Expires 2027-08-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option to purchase 4,058 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 4,058 ordinary shares for $86.23 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option.

SEC source: 0001628280-26-056270 · wk-form4_1786566834.xml · nonDerivative · entry 2

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,305

F1 · price: Price reflects a weighted average sale price for multiple transactions ranging from $235.73 to $235.89 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

SEC source: 0001628280-26-056270 · wk-form4_1786566834.xml · nonDerivative · entry 1

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,363

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-056270 · wk-form4_1786566834.xml · derivative · entry 4

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,979

Underlying: Ordinary Shares · 1,229 shares

Expires not disclosed

F3 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F4 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F4 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056270 · wk-form4_1786566834.xml · derivative · entry 3

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,099

Underlying: Ordinary Shares · 1,099 shares

Expires 2036-08-10

F2 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-26-056267 · wk-form4_1786566810.xml · derivative · entry 1

Shapiro Louis · CIK 0001999146 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Ordinary Shares · 1,025 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F2 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F2 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056265 · wk-form4_1786566784.xml · derivative · entry 2

Shah Nirav R · CIK 0001740213 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,015

Underlying: Ordinary Shares · 512 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056265 · wk-form4_1786566784.xml · derivative · entry 1

Shah Nirav R · CIK 0001740213 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,506

Underlying: Ordinary Shares · 1,506 shares

Expires 2036-08-10

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-26-056264 · wk-form4_1786566762.xml · derivative · entry 2

Martin Paul Edward · CIK 0001700415 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,074

Underlying: Ordinary Shares · 512 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056264 · wk-form4_1786566762.xml · derivative · entry 1

Martin Paul Edward · CIK 0001700415 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,506

Underlying: Ordinary Shares · 1,506 shares

Expires 2036-08-10

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-26-056262 · wk-form4_1786566741.xml · derivative · entry 1

HOLLAND CHRISTOPHER S · CIK 0001271440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,989

Underlying: Ordinary Shares · 1,025 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F2 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F2 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056261 · wk-form4_1786566720.xml · derivative · entry 2

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,640

Underlying: Ordinary Shares · 512 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056261 · wk-form4_1786566720.xml · derivative · entry 1

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,506

Underlying: Ordinary Shares · 1,506 shares

Expires 2036-08-10

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-26-056259 · wk-form4_1786566692.xml · derivative · entry 1

Boulud Pierre · CIK 0002134653 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,392

Underlying: Ordinary Shares · 1,025 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F2 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F2 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056257 · wk-form4_1786566666.xml · derivative · entry 2

Alegria Esther M. · CIK 0001867056 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,408

Underlying: Ordinary Shares · 512 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Career Restricted Stock Unit represents the right to receive one STERIS ordinary share six months after the cessation of the Director's Board service.

F3 · derivative.exercise_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

F3 · derivative.expiration_date: These Career Restricted Stock Units are fully vested immediately. They will be settled in STERIS ordinary shares six months after the cessation of the Director's Board service.

SEC source: 0001628280-26-056257 · wk-form4_1786566666.xml · derivative · entry 1

Alegria Esther M. · CIK 0001867056 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,506

Underlying: Ordinary Shares · 1,506 shares

Expires 2036-08-10

F1 · derivative.exercise_date: These nonqualified stock options are fully vested and are exercisable immediately.

SEC source: 0001628280-26-046946 · wk-form4_1783024268.xml · derivative · entry 3

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,781 shares

Expires 2026-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option to purchase 3,781 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 3,781 ordinary shares for $71.40 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option.

SEC source: 0001628280-26-046946 · wk-form4_1783024268.xml · nonDerivative · entry 2

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,305

F1 · shares: Net - Cashless Stock Option Exercise - Options to purchase 1,837 shares were surrendered to the Company for payment of the option price. Options surrendered were valued based on the Company stock closing market price on the NYSE on the day on which the Net - Cashless Stock Option Exercise occurred.

F1 · price: Net - Cashless Stock Option Exercise - Options to purchase 1,837 shares were surrendered to the Company for payment of the option price. Options surrendered were valued based on the Company stock closing market price on the NYSE on the day on which the Net - Cashless Stock Option Exercise occurred.

SEC source: 0001628280-26-046946 · wk-form4_1783024268.xml · nonDerivative · entry 1

Sohi Mohsen · CIK 0001293588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,142

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-26-043561 · wk-form4_1781641870.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,259

F1 · balance_after: As of June 15, 2026, 8,239 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,453 on June 2, 2027; 1,252 on June 3, 2027; 1,376 on June 4, 2027; 1,453 on June 2, 2028; 1,252 on June 5, 2028 and 1,453 on June 4, 2029.

SEC source: 0001628280-26-041629 · wk-form4_1780950690.xml · nonDerivative · entry 3

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,647

F2 · balance_after: As of June 8, 2026, 39,893 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 7,912 on June 2, 2027; 5,937 on June 3, 2027; 4,283 on June 4, 2027; 7,912 on June 2, 2028; 5,937 on June 5, 2028 and 7,912 on June 4, 2029.

SEC source: 0001628280-26-041637 · wk-form4_1780950754.xml · nonDerivative · entry 1

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,257

F1 · shares: 195 shares were withheld from the 542 restricted shares that vested on June 4, 2026. These 195 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 4,190 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 772 on June 2, 2027; 666 on June 3, 2027; 542 on June 4, 2027; 772 on June 2, 2028; 666 on June 5, 2028 and 772 on June 4, 2029.

SEC source: 0001628280-26-041634 · wk-form4_1780950711.xml · nonDerivative · entry 1

Fraser Mary Clare · CIK 0001818882 · SVP & Chief HRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,716

F1 · shares: 600 shares were withheld from the 1,360 restricted shares that vested on June 4, 2026. These 600 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 5,359 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,003 on June 2, 2027; 835 on June 3, 2027; 680 on June 4, 2027; 1,003 on June 2, 2028; 835 on June 5, 2028 and 1,003 on June 4, 2029.

SEC source: 0001628280-26-041640 · wk-form4_1780950796.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,678

F1 · shares: 401 shares were withheld from the 1,376 restricted shares that vested on June 4, 2026. These 401 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 8,239 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,453 on June 2, 2027; 1,252 on June 3, 2027; 1,376 on June 4, 2027; 1,453 on June 2, 2028; 1,252 on June 5, 2028 and 1,453 on June 4, 2029.

SEC source: 0001628280-26-041639 · wk-form4_1780950776.xml · nonDerivative · entry 1

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,194

F1 · shares: 65 shares were withheld from the 221 restricted shares that vested on June 4, 2026. These 65 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 1,405 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 250 on June 2, 2027; 217 on June 3, 2027; 221 on June 4, 2027; 250 on June 2, 2028; 217 on June 5, 2028 and 250 on June 4, 2029.

SEC source: 0001628280-26-041636 · wk-form4_1780950733.xml · nonDerivative · entry 1

Kohler Kenneth E · CIK 0002010979 · SVP & GM, AST

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,332

F1 · shares: 150 shares were withheld from the 513 restricted shares that vested on June 4, 2026. These 150 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 3,972 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 733 on June 2, 2027; 630 on June 3, 2027; 513 on June 4, 2027; 733 on June 2, 2028; 630 on June 5, 2028 and 733 on June 4, 2029.

SEC source: 0001628280-26-041629 · wk-form4_1780950690.xml · nonDerivative · entry 2

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,021

SEC source: 0001628280-26-041629 · wk-form4_1780950690.xml · nonDerivative · entry 1

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,075

F1 · shares: 1,889 shares were withheld from the 4,283 restricted shares that vested on June 4, 2026. These 1,889 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

SEC source: 0001628280-26-041625 · wk-form4_1780950669.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,184

F1 · shares: 90 shares were withheld from the 306 restricted shares that vested on June 4, 2026. These 90 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 4, 2026.

F2 · balance_after: As of June 8, 2026, 9,282 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 783 on October 1, 2026; 1,775 on June 2, 2027; 651 on June 3, 2027; 306 on June 4, 2027; 783 on October 1, 2027; 1,775 on June 2, 2028; 651 on June 5, 2028 and 783 on October 1, 2028 and 1,775 on June 4, 2029.

SEC source: 0001628280-26-041282 · wk-form4_1780691550.xml · nonDerivative · entry 1

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,452

F1 · shares: 239 shares were withheld from the 666 restricted shares that vested on June 3, 2026. These 239 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 4,732 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 542 on June 4, 2026; 772 on June 2, 2027; 666 on June 3, 2027; 542 on June 4, 2027; 772 on June 2, 2028; 666 on June 5, 2028 and 772 on June 4, 2029.

SEC source: 0001628280-26-041278 · wk-form4_1780691509.xml · nonDerivative · entry 1

Fraser Mary Clare · CIK 0001818882 · SVP & Chief HRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,316

F1 · shares: 311 shares were withheld from the 835 restricted shares that vested on June 3, 2026. These 311 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 6,719 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,360 on June 4, 2026; 1,003 on June 2, 2027; 835 on June 3, 2027; 680 on June 4, 2027; 1,003 on June 2, 2028; 835 on June 5, 2028 and 1,003 on June 4, 2029.

SEC source: 0001628280-26-041284 · wk-form4_1780691595.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,079

F1 · shares: 365 shares were withheld from the 1,252 restricted shares that vested on June 3, 2026. These 365 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 9,615 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,376 on June 4, 2026; 1,453 on June 2, 2027; 1,252 on June 3, 2027; 1,376 on June 4, 2027; 1,453 on June 2, 2028; 1,252 on June 5, 2028 and 1,453 on June 4, 2029.

SEC source: 0001628280-26-041283 · wk-form4_1780691571.xml · nonDerivative · entry 1

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,259

F1 · shares: 64 shares were withheld from the 217 restricted shares that vested on June 3, 2026. These 64 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 1,626 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 221 on June 4, 2026; 250 on June 2, 2027; 217 on June 3, 2027; 221 on June 4, 2027; 250 on June 2, 2028; 217 on June 5, 2028 and 250 on June 4, 2029.

SEC source: 0001628280-26-041279 · wk-form4_1780691528.xml · nonDerivative · entry 1

Kohler Kenneth E · CIK 0002010979 · SVP & GM, AST

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,482

F1 · shares: 184 shares were withheld from the 630 restricted shares that vested on June 3, 2026. These 184 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 4,485 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 513 on June 4, 2026; 733 on June 2, 2027; 630 on June 3, 2027; 513 on June 4, 2027; 733 on June 2, 2028; 630 on June 5, 2028 and 733 on June 4, 2029.

SEC source: 0001628280-26-041275 · wk-form4_1780691485.xml · nonDerivative · entry 1

Carestio Daniel A · CIK 0001651806 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,964

F1 · shares: 2,619 shares were withheld from the 5,937 restricted shares that vested on June 3, 2026. These 2,619 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 44,176 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 4,283 on June 4, 2026; 7,912 on June 2, 2027; 5,937 on June 3, 2027; 4,283 on June 4, 2027; 7,912 on June 2, 2028; 5,937 on June 5, 2028 and 7,912 on June 4, 2029.

SEC source: 0001628280-26-041274 · wk-form4_1780691463.xml · nonDerivative · entry 1

Burton Karen L · CIK 0001697095 · Sr. Vice Pres., CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,274

F1 · shares: 190 shares were withheld from the 651 restricted shares that vested on June 3, 2026. These 190 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 3, 2026.

F2 · balance_after: As of June 3, 2026, 9,588 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 306 on June 4, 2026; 783 on October 1, 2026; 1,775 on June 2, 2027; 651 on June 3, 2027; 306 on June 4, 2027; 783 on October 1, 2027; 1,775 on June 2, 2028; 651 on June 5, 2028 and 783 on October 1, 2028 and 1,775 on June 4, 2029.

SEC source: 0001628280-26-040841 · wk-form4_1780605212.xml · derivative · entry 3

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,080

Underlying: Ordinary Shares · 8,080 shares

Expires 2036-06-02

F3 · derivative.exercise_date: This option becomes exercisable as follows: 2,020 on June 2, 2027, 2,020 on June 2, 2028, 2,020 on June 4, 2029 and 2,020 on June 3, 2030.

SEC source: 0001628280-26-040841 · wk-form4_1780605212.xml · nonDerivative · entry 2

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,691

F2 · shares: 127 shares were withheld from the 352 restricted shares that vested on June 2, 2026. These 127 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 2, 2026.

F1 · balance_after: As of June 2, 2026, 5,398 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 666 on June 3, 2026; 542 on June 4, 2026; 772 on June 2, 2027; 666 on June 3, 2027; 542 on June 4, 2027; 772 on June 2, 2028; 666 on June 5, 2028 and 772 on June 4, 2029.

SEC source: 0001628280-26-040841 · wk-form4_1780605212.xml · nonDerivative · entry 1

Madsen Julia · CIK 0001819129 · Sr. VP and GM, Life Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,818

F1 · balance_after: As of June 2, 2026, 5,398 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 666 on June 3, 2026; 542 on June 4, 2026; 772 on June 2, 2027; 666 on June 3, 2027; 542 on June 4, 2027; 772 on June 2, 2028; 666 on June 5, 2028 and 772 on June 4, 2029.

SEC source: 0001628280-26-040838 · wk-form4_1780605169.xml · derivative · entry 3

Fraser Mary Clare · CIK 0001818882 · SVP & Chief HRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,492

Underlying: Ordinary Shares · 10,492 shares

Expires 2036-06-02

F3 · derivative.exercise_date: This option becomes exercisable as follows: 2,623 on June 2, 2027, 2,623 on June 2, 2028, 2,623 on June 4, 2029 and 2,623 on June 3, 2030.

SEC source: 0001628280-26-040838 · wk-form4_1780605169.xml · nonDerivative · entry 2

Fraser Mary Clare · CIK 0001818882 · SVP & Chief HRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,627

F2 · shares: 591 shares were withheld from the 2,028 restricted shares that vested on June 2, 2026. These 591 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 2, 2026.

F1 · balance_after: As of June 2, 2026, 7,554 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 835 on June 3, 2026; 1,360 on June 4, 2026; 1,003 on June 2, 2027; 835 on June 3, 2027; 680 on June 4, 2027; 1,003 on June 2, 2028; 835 on June 5, 2028 and 1,003 on June 4, 2029.

SEC source: 0001628280-26-040838 · wk-form4_1780605169.xml · nonDerivative · entry 1

Fraser Mary Clare · CIK 0001818882 · SVP & Chief HRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,218

F1 · balance_after: As of June 2, 2026, 7,554 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 835 on June 3, 2026; 1,360 on June 4, 2026; 1,003 on June 2, 2027; 835 on June 3, 2027; 680 on June 4, 2027; 1,003 on June 2, 2028; 835 on June 5, 2028 and 1,003 on June 4, 2029.

SEC source: 0001628280-26-040848 · wk-form4_1780605304.xml · derivative · entry 3

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,200

Underlying: Ordinary Shares · 15,200 shares

Expires 2036-06-02

F3 · derivative.exercise_date: This option becomes exercisable as follows: 3,800 on June 2, 2027, 3,800 on June 2, 2028, 3,800 on June 4, 2029 and 3,800 on June 3, 2030.

SEC source: 0001628280-26-040848 · wk-form4_1780605304.xml · nonDerivative · entry 2

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,444

F2 · shares: 247 shares were withheld from the 846 restricted shares that vested on June 2, 2026. These 247 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 2, 2026.

F1 · balance_after: As of June 2, 2026, 10,867 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows:1,252 on June 3, 2026; 1,376 on June 4, 2026; 1,453 on June 2, 2027; 1,252 on June 3, 2027; 1,376 on June 4, 2027; 1,453 on June 2, 2028; 1,252 on June 5, 2028 and 1,453 on June 4, 2029.

SEC source: 0001628280-26-040848 · wk-form4_1780605304.xml · nonDerivative · entry 1

Zangerle John Adam · CIK 0001578804 · Sr. VP, Gen Counsel, and Sec.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,691

F1 · balance_after: As of June 2, 2026, 10,867 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows:1,252 on June 3, 2026; 1,376 on June 4, 2026; 1,453 on June 2, 2027; 1,252 on June 3, 2027; 1,376 on June 4, 2027; 1,453 on June 2, 2028; 1,252 on June 5, 2028 and 1,453 on June 4, 2029.

SEC source: 0001628280-26-040846 · wk-form4_1780605280.xml · derivative · entry 3

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,620

Underlying: Ordinary Shares · 2,620 shares

Expires 2036-06-02

F3 · derivative.exercise_date: This option becomes exercisable as follows: 655 on June 2, 2027, 655 on June 2, 2028, 655 on June 4, 2029 and 655 on June 3, 2030.

SEC source: 0001628280-26-040846 · wk-form4_1780605280.xml · nonDerivative · entry 2

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,323

F2 · shares: 41 shares were withheld from the 141 restricted shares that vested on June 2, 2026. These 41 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These vested shares were valued at the NYSE closing market price on June 2, 2026.

F1 · balance_after: As of June 2, 2026, 1,843 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 217 on June 3, 2026; 221 on June 4, 2026; 250 on June 2, 2027; 217 on June 3, 2027; 221 on June 4, 2027; 250 on June 2, 2028; 217 on June 5, 2028 and 250 on June 4, 2029.

SEC source: 0001628280-26-040846 · wk-form4_1780605280.xml · nonDerivative · entry 1

Tamaro Renato · CIK 0001713987 · V.P. & Corporate Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,364

F1 · balance_after: As of June 2, 2026, 1,843 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 217 on June 3, 2026; 221 on June 4, 2026; 250 on June 2, 2027; 217 on June 3, 2027; 221 on June 4, 2027; 250 on June 2, 2028; 217 on June 5, 2028 and 250 on June 4, 2029.

SEC source: 0001628280-26-040845 · wk-form4_1780605257.xml · derivative · entry 4

McGowan Lindsey · CIK 0002102487 · VP, Chf. Comp. & Quality Offc.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,036

Underlying: Ordinary Shares · 4,036 shares

Expires 2036-06-02

F4 · derivative.exercise_date: This option becomes exercisable as follows: 1,009 on June 2, 2027, 1,009 on June 2, 2028, 1,009 on June 4, 2029 and 1,009 on June 3, 2030.