SENS

SEC source: 0001270735-26-000004 · form4-03162026_020341.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,731

SEC source: 0001666972-26-000002 · form4-01052026_050103.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,363

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,121.82 divided by $5.89, the closing price of Issuer's common stock on the the Nasdaq Global Select Market on January 2, 2026.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001666995-26-000002 · form4-01052026_050107.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,743

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $8,122.31 divided by $5.89, the closing price of Issuer's common stock on the Nasdaq Global Select Market on January 2, 2026.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001270735-26-000002 · form4-01052026_050105.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,231

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,746.06 divided by $5.89, the closing price of Issuer's common stock on the Nasdaq Global Select Market on January 2, 2026.

SEC source: 0001683354-26-000002 · form4-01052026_050101.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,893

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,869.65 divided by $5.89, the closing price of Issuer's common stock on the Nasdaq Global Select Market on January 2, 2026.

SEC source: 0001944539-25-000006 · form4-11182025_071110.xml · nonDerivative · entry 1

Sullivan Frederick T. · CIK 0001944539 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,626

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001667588-25-000006 · form4-11182025_071102.xml · nonDerivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 634,018

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001667593-25-000004 · form4-11182025_071106.xml · nonDerivative · entry 1

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 259,979

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001552047-25-000003 · form4-11182025_071104.xml · nonDerivative · entry 1

Horton Kenneth L · CIK 0001552047 · GC & Corp. Development Advisor

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,434

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001769791-25-000004 · form4-11182025_071108.xml · nonDerivative · entry 1

Kaufman Francine · CIK 0001769791 · Director · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 123,948

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001683354-25-000006 · form4-11132025_091149.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,708

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.48 to $6.58 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001944539-25-000004 · form4-11102025_071108.xml · nonDerivative · entry 1

Sullivan Frederick T. · CIK 0001944539 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,028

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.8401 to $5.885 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001667588-25-000004 · form4-11102025_071101.xml · nonDerivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 661,085

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.80 to $5.90 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F2 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001270735-25-000006 · form4-11102025_071110.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,727

F1 · balance_after: Effective October 17, 2025, the Issuer effected a 1-for-20 reverse stock split of the Issuer's common stock. The number of securities reported herein have been adjusted to reflect the reverse stock split.

SEC source: 0001666972-25-000004 · form4-10032025_041018.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,379,301

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,124.60 divided by $0.413, the closing price of Issuer's common stock on the NYSE American on October 1, 2025.

SEC source: 0001666995-25-000004 · form4-10032025_041022.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,107,280

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $8,124.95 divided by $0.413, the closing price of Issuer's common stock on the NYSE American on October 1, 2025.

SEC source: 0001270735-25-000004 · form4-10032025_041020.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,694,540

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,749.88 divided by $0.413, the closing price of Issuer's common stock on the NYSE American on October 1, 2025.

SEC source: 0001683354-25-000004 · form4-10032025_041016.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,294,175

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,874.86 divided by $0.413, the closing price of Issuer's common stock on the NYSE American on October 1, 2025.

SEC source: 0001415889-25-019313 · form4-07032025_040723.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,345,101

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,124.82 divided by $0.476, the closing price of Issuer's common stock on the NYSE American on July 1, 2025.

SEC source: 0001415889-25-019315 · form4-07032025_040727.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,087,607

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $8,124.84 divided by $0.476, the closing price of Issuer's common stock on the NYSE American on July 1, 2025.

SEC source: 0001415889-25-019314 · form4-07032025_040725.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,658,826

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $14,749.81 divided by $0.476, the closing price of Issuer's common stock on the NYSE American on July 1, 2025.

SEC source: 0001415889-25-019312 · form4-07032025_040721.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,263,001

F1 · kind: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,874.85 divided by $0.476, the closing price of Issuer's common stock on the NYSE American on July 1, 2025.

SEC source: 0001415889-25-017602 · form4-06172025_060613.xml · nonDerivative · entry 1

Sullivan Frederick T. · CIK 0001944539 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,032,251

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-017598 · form4-06172025_060601.xml · nonDerivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,877,501

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-017600 · form4-06172025_060608.xml · nonDerivative · entry 1

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,405,926

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-017599 · form4-06172025_060604.xml · nonDerivative · entry 1

Horton Kenneth L · CIK 0001552047 · GC & Corp. Development Advisor

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,008,622

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-017601 · form4-06172025_060610.xml · nonDerivative · entry 1

Kaufman Francine · CIK 0001769791 · Director · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,571,057

F1 · kind: Represents shares withheld to satisfy withholding tax obligations upon the vesting of restricted stock units.

SEC source: 0001415889-25-014711 · form4-05282025_040503.xml · derivative · entry 2

Sullivan Frederick T. · CIK 0001944539 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 978,342

Underlying: Common Stock · 978,342 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001415889-25-014711 · form4-05282025_040503.xml · nonDerivative · entry 1

Sullivan Frederick T. · CIK 0001944539 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,059,514

F1 · shares: Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2025 and the remaining seven installments vesting in six month increments commencing on November 15, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014720 · form4-05282025_080524.xml · derivative · entry 2

Larkin Sharon · CIK 0001898172 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014720 · form4-05282025_080524.xml · nonDerivative · entry 1

Larkin Sharon · CIK 0001898172 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 640,206

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014712 · form4-05282025_040505.xml · derivative · entry 2

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,397,632

Underlying: Common Stock · 1,397,632 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001415889-25-014712 · form4-05282025_040505.xml · nonDerivative · entry 1

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,464,687

F1 · shares: Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2025 and the remaining seven installments vesting in six month increments commencing on November 15, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014710 · form4-05282025_040501.xml · derivative · entry 2

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,858,157

Underlying: Common Stock · 2,858,157 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001415889-25-014710 · form4-05282025_040501.xml · nonDerivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,957,147

F1 · shares: Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2025 and the remaining seven installments vesting in six month increments commencing on November 15, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014715 · form4-05282025_040511.xml · derivative · entry 2

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014715 · form4-05282025_040511.xml · nonDerivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,023,347

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014717 · form4-05282025_040515.xml · derivative · entry 2

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014717 · form4-05282025_040515.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,315,427

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014722 · form4-05282025_080544.xml · derivative · entry 2

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014722 · form4-05282025_080544.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,070,538

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014716 · form4-05282025_040513.xml · derivative · entry 2

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014716 · form4-05282025_040513.xml · nonDerivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,627,839

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014713 · form4-05282025_040507.xml · derivative · entry 2

Horton Kenneth L · CIK 0001552047 · GC & Corp. Development Advisor

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 712,792

Underlying: Common Stock · 712,792 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001415889-25-014713 · form4-05282025_040507.xml · nonDerivative · entry 1

Horton Kenneth L · CIK 0001552047 · GC & Corp. Development Advisor

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,044,406

F1 · shares: Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2025 and the remaining seven installments vesting in six month increments commencing on November 15, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014718 · form4-05282025_080524.xml · derivative · entry 2

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,234

Underlying: Common Stock · 157,234 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Represents a stock option grant pursuant to the Policy. The options vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0001415889-25-014718 · form4-05282025_080524.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,235,953

F1 · shares: Represents a restricted stock unit ("RSU") grant pursuant to the Issuer's non-employee director compensation policy (the "Policy"). The RSUs vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the Reporting Person's continuous service through such vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014714 · form4-05282025_040509.xml · derivative · entry 2

Kaufman Francine · CIK 0001769791 · Director · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 642,911

Underlying: Common Stock · 642,911 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001415889-25-014714 · form4-05282025_040509.xml · nonDerivative · entry 1

Kaufman Francine · CIK 0001769791 · Director · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,599,910

F1 · shares: Represents a restricted stock unit ("RSU") grant. The RSUs vest in eight equal installments with the first installment vesting on June 15, 2025 and the remaining seven installments vesting in six month increments commencing on November 15, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-014860 · form4-05292025_040502.xml · derivative · entry 2

HANSEN BRIAN B · CIK 0001542377 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,187,987

Underlying: Common Stock · 1,187,987 shares

Expires 2035-05-22

F3 · derivative.exercise_date: The options vest in 48 equal monthly installments commencing on June 23, 2025, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.