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Nasdaq · USD

RNTX

Rein Therapeutics, Inc.

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7071
SEC CIK
0001420565
Parsed reports
208

Last 12 months

Inside the activity.

6 purchase rows · 0 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202510
Dec 202500
Jan 202600
Feb 202600
Mar 202600
Apr 202610
May 202640
Jun 202600
Jul 202600
Aug 202600
Sep 202600
Oct 202600

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
April 15, 2019 Filed Apr 17, 2019 18:43 UTC
Vukovic VojoSVP, Chief Medical Officer
GrantStock Option (right to buy) · Derivative 100,000 $0.00 Strike: $1.75 $0.00
Disclosure

SEC source: 0000899243-19-010815 · doc4.xml · derivative · entry 1

Vukovic Vojo · CIK 0001466794 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.

Read SEC document
April 15, 2019 Filed Apr 17, 2019 22:45 UTC
Wanstall RickVP, Finance and Operations
GrantStock Option (right to buy) · Derivative 59,000 $0.00 Strike: $1.75 $0.00
Disclosure

SEC source: 0000899243-19-010819 · doc4.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · VP, Finance and Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.

Read SEC document
April 15, 2019 Filed Apr 17, 2019 22:44 UTC
Dougherty DonaldSVP & Chief Financial Officer
GrantStock Option (right to buy) · Derivative 150,000 $0.00 Strike: $1.75 $0.00
Disclosure

SEC source: 0000899243-19-010818 · doc4.xml · derivative · entry 1

Dougherty Donald · CIK 0001709592 · SVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.

Read SEC document
April 15, 2019 Filed Apr 17, 2019 22:41 UTC
Aivado ManuelDirector · President and CEO
GrantStock Option (right to buy) · Derivative 500,000 $0.00 Strike: $1.75 $0.00
Disclosure

SEC source: 0000899243-19-010813 · doc4.xml · derivative · entry 1

Aivado Manuel · CIK 0001709603 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 500,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.

Read SEC document
April 15, 2019 Filed Apr 17, 2019 22:40 UTC
Gregory KathrynSVP, Chief Business Officer
GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $1.75 $0.00
Disclosure

SEC source: 0000899243-19-010811 · doc4.xml · derivative · entry 1

Gregory Kathryn · CIK 0001768530 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.

Read SEC document
April 02, 2019 Filed Apr 4, 2019 00:22 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $1.82 $0.00
Disclosure

SEC source: 0000899243-19-009894 · doc4.xml · derivative · entry 1

Sigal Nolan Howard · CIK 0001323291 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2029-04-01

F1 · derivative.exercise_date: This option was granted on April 2, 2019. The shares underlying the option are scheduled to vest in equal annual installments over three years from April 2, 2019.

Read SEC document
April 01, 2019 Filed Apr 3, 2019 00:23 UTC
NOVARTIS AG10% owner
SaleCommon Stock 20,610 $1.90 $39,159.00
Disclosure

SEC source: 0000925421-19-000143 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,079,394

F2 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $1.81 to $2.02. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F3 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
March 29, 2019 Filed Apr 3, 2019 00:23 UTC
NOVARTIS AG10% owner
SaleCommon Stock 106,540 $1.85 $197,099.00
Disclosure

SEC source: 0000925421-19-000143 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,100,004

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $1.76 to $1.96. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F3 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
March 15, 2019 Filed Mar 15, 2019 21:25 UTC
NOVARTIS AG10% owner
SaleCommon Stock 43,800 $1.92 $84,096.00
Disclosure

SEC source: 0000925421-19-000114 · edgar.xml · nonDerivative · entry 3

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,206,544

F4 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $1.85 to $2.02. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
March 14, 2019 Filed Mar 15, 2019 21:25 UTC
NOVARTIS AG10% owner
SaleCommon Stock 13,800 $1.88 $25,944.00
Disclosure

SEC source: 0000925421-19-000114 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,250,344

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $1.85 to $1.915. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
March 13, 2019 Filed Mar 15, 2019 21:25 UTC
NOVARTIS AG10% owner
SaleCommon Stock 132,738 $2.12 $281,404.56
Disclosure

SEC source: 0000925421-19-000114 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,264,144

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.00 to $2.42. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
February 25, 2019 Filed Feb 25, 2019 22:51 UTC
Gregory KathrynSVP, Chief Business Officer
GrantStock Option (right to buy) · Derivative 100,000 $0.00 Strike: $1.47 $0.00
Disclosure

SEC source: 0000899243-19-004732 · doc4.xml · derivative · entry 1

Gregory Kathryn · CIK 0001768530 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2029-02-24

F1 · derivative.exercise_date: This option was granted on February 25, 2019. The shares underlying the option are scheduled to vest as to 25% of the shares on February 25, 2020 and thereafter in equal monthly installments through February 25, 2023.

Read SEC document
November 05, 2018 Filed Nov 6, 2018 18:18 UTC
Vukovic VojoSVP, Chief Medical Officer
GrantStock Option (right to buy) · Derivative 150,000 $0.00 Strike: $2.16 $0.00
Disclosure

SEC source: 0000899243-18-028339 · doc4.xml · derivative · entry 1

Vukovic Vojo · CIK 0001466794 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2028-11-04

F1 · derivative.exercise_date: This option was granted on November 5, 2018. The shares underlying the option are scheduled to vest as to 25% of the shares on November 5, 2019 and thereafter in equal monthly installments through November 5, 2022.

Read SEC document
September 06, 2018 Filed Sep 7, 2018 21:47 UTC
Aivado ManuelDirector · President and CEO
GrantStock Option (right to buy) · Derivative 232,914 $0.00 Strike: $3.39 $0.00
Disclosure

SEC source: 0000899243-18-024025 · doc4.xml · derivative · entry 1

Aivado Manuel · CIK 0001709603 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 232,914

Underlying: Common Stock · 232,914 shares

Expires 2028-09-05

F1 · derivative.exercise_date: This option was granted on September 6, 2018. The shares underlying the option are scheduled to vest in equal monthly installments over four years from September 6, 2018.

Read SEC document
August 20, 2018 Filed Aug 22, 2018 20:34 UTC
NOVARTIS AG10% owner
SaleCommon Stock 20,388 $2.30 $46,892.40
Disclosure

SEC source: 0000925421-18-000300 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,396,882

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.06 to $2.53. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 17, 2018 Filed Aug 20, 2018 21:12 UTC
NOVARTIS AG10% owner
SaleCommon Stock 8,700 $2.10 $18,270.00
Disclosure

SEC source: 0000925421-18-000294 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,417,270

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.02 to $2.18. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 16, 2018 Filed Aug 20, 2018 21:12 UTC
NOVARTIS AG10% owner
SaleCommon Stock 8,808 $2.10 $18,496.80
Disclosure

SEC source: 0000925421-18-000294 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,425,970

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.02 to $2.20. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 15, 2018 Filed Aug 16, 2018 20:18 UTC
NOVARTIS AG10% owner
SaleCommon Stock 2,635 $2.15 $5,665.25
Disclosure

SEC source: 0000925421-18-000292 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,434,778

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.13 to $2.25. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 14, 2018 Filed Aug 16, 2018 20:18 UTC
NOVARTIS AG10% owner
SaleCommon Stock 3,300 $2.26 $7,458.00
Disclosure

SEC source: 0000925421-18-000292 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,437,413

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.17 to $2.33. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 13, 2018 Filed Aug 14, 2018 21:05 UTC
NOVARTIS AG10% owner
SaleCommon Stock 1,600 $2.36 $3,776.00
Disclosure

SEC source: 0000925421-18-000290 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,440,713

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.32 to $2.40. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 10, 2018 Filed Aug 14, 2018 21:05 UTC
NOVARTIS AG10% owner
SaleCommon Stock 5,615 $2.44 $13,700.60
Disclosure

SEC source: 0000925421-18-000290 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,442,313

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.40 to $2.48. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 10, 2018 Filed Aug 14, 2018 23:38 UTC
LONGENECKER JOHN P PHDPresident and CEO
PurchaseCommon Stock 10,000 $2.45 $24,500.00
Disclosure

SEC source: 0000899243-18-022378 · doc4.xml · nonDerivative · entry 1

LONGENECKER JOHN P PHD · CIK 0001288231 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

F1 · price: The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.40 to $2.48, inclusive. The reporting person undertakes to provide to Aileron Therapeutics, Inc., any security holder of Aileron Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
August 09, 2018 Filed Aug 10, 2018 20:29 UTC
NOVARTIS AG10% owner
SaleCommon Stock 235 $2.48 $582.80
Disclosure

SEC source: 0000925421-18-000284 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,447,928

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.47 to $2.50. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 08, 2018 Filed Aug 10, 2018 20:29 UTC
NOVARTIS AG10% owner
SaleCommon Stock 1,000 $2.78 $2,780.00
Disclosure

SEC source: 0000925421-18-000284 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,448,163

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.77 to $2.81. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 07, 2018 Filed Aug 8, 2018 20:21 UTC
NOVARTIS AG10% owner
SaleCommon Stock 1,739 $2.97 $5,164.83
Disclosure

SEC source: 0000925421-18-000282 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,449,163

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $2.95 to $2.98. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 06, 2018 Filed Aug 8, 2018 20:21 UTC
NOVARTIS AG10% owner
SaleCommon Stock 2,942 $3.02 $8,884.84
Disclosure

SEC source: 0000925421-18-000282 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,450,902

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.00 to $3.03. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 02, 2018 Filed Aug 6, 2018 20:22 UTC
NOVARTIS AG10% owner
SaleCommon Stock 4,702 $3.33 $15,657.66
Disclosure

SEC source: 0000925421-18-000278 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,453,844

F1 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
August 01, 2018 Filed Aug 2, 2018 20:33 UTC
NOVARTIS AG10% owner
SaleCommon Stock 8,181 $3.22 $26,342.82
Disclosure

SEC source: 0000925421-18-000274 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,458,546

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.10 to $3.25. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
July 31, 2018 Filed Aug 2, 2018 20:33 UTC
NOVARTIS AG10% owner
SaleCommon Stock 4,500 $3.07 $13,815.00
Disclosure

SEC source: 0000925421-18-000274 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,466,727

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.08 to $3.14. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

Read SEC document
July 30, 2018 Filed Jul 31, 2018 20:16 UTC
NOVARTIS AG10% owner
SaleCommon Stock 2,000 $3.27 $6,540.00
Disclosure

SEC source: 0000925421-18-000265 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,471,227

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.14 to $3.30. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 27, 2018 Filed Jul 31, 2018 20:16 UTC
NOVARTIS AG10% owner
SaleCommon Stock 6,458 $3.38 $21,828.04
Disclosure

SEC source: 0000925421-18-000265 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,473,227

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.36 to $3.50. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 26, 2018 Filed Jul 27, 2018 20:21 UTC
NOVARTIS AG10% owner
SaleCommon Stock 7,937 $3.63 $28,811.31
Disclosure

SEC source: 0000925421-18-000263 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,479,685

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.52 to $3.81. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 25, 2018 Filed Jul 27, 2018 20:21 UTC
NOVARTIS AG10% owner
SaleCommon Stock 12,460 $3.84 $47,846.40
Disclosure

SEC source: 0000925421-18-000263 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,487,622

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $3.75 to $3.92. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 24, 2018 Filed Jul 25, 2018 20:35 UTC
NOVARTIS AG10% owner
SaleCommon Stock 700 $4.11 $2,877.00
Disclosure

SEC source: 0000925421-18-000261 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,500,082

F3 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $4.04 to $4.22. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 23, 2018 Filed Jul 25, 2018 20:35 UTC
NOVARTIS AG10% owner
SaleCommon Stock 30,600 $4.25 $130,050.00
Disclosure

SEC source: 0000925421-18-000261 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,500,782

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $4.23 to $4.33. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 17, 2018 Filed Jul 18, 2018 20:17 UTC
NOVARTIS AG10% owner
SaleCommon Stock 12,500 $4.71 $58,875.00
Disclosure

SEC source: 0000925421-18-000259 · edgar.xml · nonDerivative · entry 2

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,531,382

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 16, 2018 Filed Jul 18, 2018 20:17 UTC
NOVARTIS AG10% owner
SaleCommon Stock 300 $5.15 $1,545.00
Disclosure

SEC source: 0000925421-18-000259 · edgar.xml · nonDerivative · entry 1

Novartis Bioventures Ltd · CIK 0001297709 · 10% owner

NOVARTIS AG · CIK 0001114448 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,543,882

F1 · price: Reflects sales of common stock executed in multiple transactions at prices ranging from $5.14 to $5.16. The price reported reflects the weighted average sale price. The Reporting Persons hereby undertake to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F2 · ownership.direct: The shares are directly owned by Novartis Bioventures Ltd. Novartis Bioventures Ltd is a wholly-owned indirect subsidiary of Novartis AG, which is an indirect beneficial owner of the reported securities.

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July 06, 2018 Filed Jul 10, 2018 16:26 UTC OtherCommon Stock 1,380,241 $0.00 $0.00
Disclosure

SEC source: 0001012975-18-000906 · edgar.xml · nonDerivative · entry 1

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: On July 6, 2018, Apple Tree Partners II, L.P. distributed 1,380,241 shares of the Issuer's Common Stock on a pro rata basis to its partners for no consideration. Following the distribution, Apple Tree Partners II, L.P. was no longer a holder of record of the Issuer's shares.

F2 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares previously held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison had sole voting and investment power over the shares previously held by Apple Tree Partners II, L.P.

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July 06, 2018 Filed Jul 10, 2018 20:27 UTC OtherCommon Stock 655,797 $0.00 $0.00
Disclosure

SEC source: 0001012975-18-000907 · edgar.xml · nonDerivative · entry 1

Apple Tree Partners II - Annex, L.P. · CIK 0001553255 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: On July 6, 2018, Apple Tree Partners II - Annex, L.P. distributed 655,797 shares of the Issuer's Common Stock on a pro rata basis to its partners for no consideration. Following the distribution, Apple Tree Partners II - Annex, L.P. was no longer a holder of record of the Issuer's shares.

F2 · ownership.direct: Dr. Seth L. Harrison is a principal of the general partner of Apple Tree Partners II - Annex, L.P., and Dr. Harrison disclaims beneficial ownership of the shares previously held by Apple Tree Partners II - Annex, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison had sole voting and investment power over the shares previously held by Apple Tree Partners II - Annex, L.P.

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June 26, 2018 Filed Jun 26, 2018 18:15 UTC SaleCommon Stock 10,528 $5.45 $57,424.98
Disclosure

SEC source: 0001012975-18-000866 · edgar.xml · nonDerivative · entry 3

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,380,241

F4 · price: The transaction was executed in multiple trades at prices ranging from $5.30 to $5.75. The price above reflects the weighted average transaction price. Detailed information regarding the number of shares transacted at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.

F2 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II, L.P.

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June 25, 2018 Filed Jun 26, 2018 18:15 UTC SaleCommon Stock 913 $5.86 $5,353.01
Disclosure

SEC source: 0001012975-18-000866 · edgar.xml · nonDerivative · entry 2

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,390,769

F3 · price: The transaction was executed in multiple trades at prices ranging from $5.75 to $6.00. The price above reflects the weighted average transaction price. Detailed information regarding the number of shares transacted at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.

F2 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II, L.P.

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June 22, 2018 Filed Jun 26, 2018 18:15 UTC SaleCommon Stock 94,816 $5.98 $566,743.68
Disclosure

SEC source: 0001012975-18-000866 · edgar.xml · nonDerivative · entry 1

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,391,682

F1 · price: The transaction was executed in multiple trades at prices ranging from $5.66 to $6.12. The price above reflects the weighted average transaction price. Detailed information regarding the number of shares transacted at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.

F2 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II, L.P.

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June 21, 2018 Filed Jun 21, 2018 21:36 UTC SaleCommon Stock 1,447 $5.30 $7,669.10
Disclosure

SEC source: 0001012975-18-000862 · edgar.xml · nonDerivative · entry 2

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,486,498

F1 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II, L.P.

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June 21, 2018 Filed Jun 25, 2018 18:16 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017967 · doc4.xml · derivative · entry 1

Ambros Reinhard J. · CIK 0001709690 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 21, 2018 Filed Jun 25, 2018 18:13 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017961 · doc4.xml · derivative · entry 1

Winder Caleb Maxfield · CIK 0001709840 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 21, 2018 Filed Jun 25, 2018 18:25 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017977 · doc4.xml · derivative · entry 1

Shanafelt Armen · CIK 0001656151 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 21, 2018 Filed Jun 25, 2018 22:48 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017982 · doc4.xml · derivative · entry 1

Morrison Jodie Pope · CIK 0001618247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 21, 2018 Filed Jun 25, 2018 22:20 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017972 · doc4.xml · derivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 21, 2018 Filed Jun 25, 2018 22:12 UTC GrantStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $6.02 $0.00
Disclosure

SEC source: 0000899243-18-017960 · doc4.xml · derivative · entry 1

MCARTHUR JOHN H · CIK 0001242370 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-20

F1 · derivative.exercise_date: This option was granted on June 21, 2018. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 21, 2019 or (ii) the date of the Issuer's 2019 Annual Meeting of Stockholders.

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June 20, 2018 Filed Jun 21, 2018 21:36 UTC SaleCommon Stock 5,200 $5.30 $27,563.64
Disclosure

SEC source: 0001012975-18-000862 · edgar.xml · nonDerivative · entry 1

APPLE TREE PARTNERS II LP · CIK 0001143789 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,487,945

F1 · ownership.direct: Dr. Seth L. Harrison is the general partner of Apple Tree Ventures II, L.P., the general partner of Apple Tree Partners II, L.P., and Dr. Harrison disclaims beneficial ownership of the shares held by Apple Tree Partners II, L.P., except to the extent of his pecuniary interest therein. Dr. Harrison has sole voting and investment power over the shares held by Apple Tree Partners II, L.P.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.