INSM

SEC source: 0001628280-24-023613 · wk-form4_1715805527.xml · derivative · entry 3

Wise John Drayton · CIK 0001930805 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,160

Underlying: Common Stock · 71,160 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023613 · wk-form4_1715805527.xml · nonDerivative · entry 1

Wise John Drayton · CIK 0001930805 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,347

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023608 · wk-form4_1715805452.xml · derivative · entry 3

Smith Michael Alexander · CIK 0001870278 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,230

Underlying: Common Stock · 65,230 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023608 · wk-form4_1715805452.xml · nonDerivative · entry 1

Smith Michael Alexander · CIK 0001870278 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,672

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023605 · wk-form4_1715805404.xml · derivative · entry 3

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,230

Underlying: Common Stock · 65,230 shares

Expires 2034-05-13

F6 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023605 · wk-form4_1715805404.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,268

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

F3 · balance_after: Due to a clerical error related to the reporting of shares previously withheld by the Company to satisfy tax obligations upon the vesting of RSUs, this number was previously overstated by 24 shares. This value reflects the adjustment, decreasing the amount beneficially owned by 24 shares.

SEC source: 0001628280-24-023600 · wk-form4_1715805282.xml · derivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 209,320

Underlying: Common Stock · 209,320 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023600 · wk-form4_1715805282.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 406,323

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023598 · wk-form4_1715805215.xml · derivative · entry 3

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,160

Underlying: Common Stock · 71,160 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023598 · wk-form4_1715805215.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,416

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023591 · wk-form4_1715805145.xml · derivative · entry 3

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,160

Underlying: Common Stock · 71,160 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023591 · wk-form4_1715805145.xml · nonDerivative · entry 1

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,569

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023589 · wk-form4_1715805079.xml · derivative · entry 3

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,160

Underlying: Common Stock · 71,160 shares

Expires 2034-05-13

F5 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001628280-24-023589 · wk-form4_1715805079.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 163,077

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% percent on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023570 · wk-form4_1715804518.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 308,177

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023569 · wk-form4_1715804469.xml · nonDerivative · entry 1

SCHAFER CAROL · CIK 0001272181 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,259

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023568 · wk-form4_1715804396.xml · nonDerivative · entry 1

MCGIRR DAVID W J · CIK 0001219023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,915

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023566 · wk-form4_1715804356.xml · nonDerivative · entry 1

LEE LEO · CIK 0001740789 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,619

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023562 · wk-form4_1715804277.xml · nonDerivative · entry 1

Desjardins Clarissa · CIK 0001793390 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,949

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023560 · wk-form4_1715804216.xml · nonDerivative · entry 1

Brennan David R · CIK 0001609305 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,875

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023557 · wk-form4_1715804131.xml · nonDerivative · entry 1

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,671

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-023555 · wk-form4_1715804068.xml · nonDerivative · entry 1

ALTOMARI ALFRED · CIK 0001285644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,495

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock. The RSUs have a one year cliff vesting period, provided that the director (a) remains a member of the Board of Directors of the issuer on such vesting date, and (b) attends at least 75% of the meetings of the Board of Directors which take place between the grant date and the first anniversary of the grant date.

F2 · price: Each RSU was granted on May 13, 2024 for no consideration.

SEC source: 0001628280-24-007970 · wk-form4_1709240860.xml · derivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By ARTICLE 4 UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A 11/1/2020

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2024-06-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

SEC source: 0001628280-24-007970 · wk-form4_1709240860.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · By ARTICLE 4 UNDER WILLIAM LEWIS FAMILY LEGACY TRUST U/A11/1/2020

Disclosed balance after: 50,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001628280-24-007961 · wk-form4_1709240705.xml · nonDerivative · entry 4

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Melvin Sharoky C/F Nolan M. Wink UTMA/FL

Disclosed balance after: 4,699

F3 · ownership.nature: The Reporting Person is the custodian of Melvin Sharoky C/F Nolan M. Wink UTMA/FL.

SEC source: 0001628280-24-007961 · wk-form4_1709240705.xml · nonDerivative · entry 3

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Melvin Sharoky C/F Tulia L. Sharoky UTMA/FL

Disclosed balance after: 3,000

F2 · ownership.nature: The Reporting Person is the custodian of Melvin Sharoky C/F Tulia Wink UTMA/FL.

SEC source: 0001628280-24-007961 · wk-form4_1709240705.xml · nonDerivative · entry 2

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Melvin Sharoky C/F Sophie C. Wink UTMA/FL

Disclosed balance after: 4,283

F1 · ownership.nature: The Reporting Person is the custodian of Melvin Sharoky C/F Sophie C. Wink UTMA/FL.

SEC source: 0001628280-24-007961 · wk-form4_1709240705.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 295,015

SEC source: 0001628280-24-001253 · wk-form4_1705093570.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,898

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001252 · wk-form4_1705093523.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 148,559

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001162 · wk-form4_1705007317.xml · nonDerivative · entry 2

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,565

F3 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001158 · wk-form4_1705007154.xml · nonDerivative · entry 2

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 153,810

F3 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 363,651

F4 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F5 · price: This is the weighted average sales price representing 9,887 shares sold at prices ranging from $28.62 to $28.84 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001166 · wk-form4_1705007582.xml · nonDerivative · entry 1

Wise John Drayton · CIK 0001930805 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,829

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F2 · price: This is the weighted average sales price representing 1,861 shares sold at prices ranging from $28.76 to $28.82 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001165 · wk-form4_1705007495.xml · nonDerivative · entry 1

Smith Michael Alexander · CIK 0001870278 · General Counsel, Senior VP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,364

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F2 · price: This is the weighted average sales price representing 2,373 shares sold at prices ranging from $28.75 to $28.79 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001164 · wk-form4_1705007402.xml · derivative · entry 4

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 503 shares

Expires 2024-01-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: Stock options granted under the Company's 2013 Incentive Plan. The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001628280-24-001164 · wk-form4_1705007402.xml · nonDerivative · entry 3

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,984

F2 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F3 · price: This is the weighted average sales price representing 3,165 shares sold at prices ranging from $28.72 to $28.74 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001164 · wk-form4_1705007402.xml · nonDerivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,149

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001164 · wk-form4_1705007402.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,652

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001162 · wk-form4_1705007317.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,810

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F2 · price: This is the weighted average sales price representing 4,715 shares sold at prices ranging from $28.88 to $29.10 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001160 · wk-form4_1705007232.xml · nonDerivative · entry 1

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,051

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F2 · price: This is the weighted average sales price representing 4,497 shares sold at prices ranging from $29.11 to $29.21 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001158 · wk-form4_1705007154.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 157,346

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

F2 · price: This is the weighted average sales price representing 3,837 shares sold at prices ranging from $29.19 to $29.28 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · derivative · entry 8

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 45,120 shares

Expires 2024-01-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: Stock options granted under the Company's 2013 Incentive Plan. The options became exercisable based on the following vesting schedule: twenty five percent (25%) vested on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vested on each sixth month anniversary date thereafter through the fourth anniversary date of the date of grant. All options are currently exercisable and were scheduled to expire on January 10, 2024.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 373,538

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 20,169 shares sold at prices ranging from $29.88 to $29.93 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 393,707

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 373,538

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 24,951 shares sold at prices ranging from $28.71 to $29.68 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001628280-24-001036 · wk-form4_1704921303.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 398,489

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001628280-24-000698 · wk-form4_1704494003.xml · nonDerivative · entry 4

Wise John Drayton · CIK 0001930805 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,690

F6 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

SEC source: 0001628280-24-000697 · wk-form4_1704493968.xml · nonDerivative · entry 2

Smith Michael Alexander · CIK 0001870278 · General Counsel, Senior VP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,737

F4 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

SEC source: 0001628280-24-000696 · wk-form4_1704493919.xml · nonDerivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,149

F4 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of Restricted Stock Units and to cover related broker fees.