ATEC

SEC source: 0001179110-19-006134 · edgar.xml · nonDerivative · entry 3

Hunsaker Craig E · CIK 0001509282 · EVP, People/Culture & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 861,112

F4 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2019.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.50 to $4.505, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001179110-19-006131 · edgar.xml · nonDerivative · entry 2

Black Jeffrey G. · CIK 0001449439 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 520,791

F2 · date: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F2 · shares: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006131 · edgar.xml · nonDerivative · entry 1

Black Jeffrey G. · CIK 0001449439 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 452,041

F1 · date: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006133 · edgar.xml · nonDerivative · entry 1

Miles Patrick · CIK 0001289409 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,242,997

F1 · date: On May 13, 2019, issuer granted to the reporting person 1,250,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 1,250,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F2 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 1,250,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F2 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006129 · edgar.xml · nonDerivative · entry 2

Sponsel David · CIK 0001772837 · EVP, Sales

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 431,556

F2 · date: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F2 · shares: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: On May 13, 2019, issuer granted to the reporting person 68,750 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F4 · balance_after: Includes 4,056 shares acquired under the issuer's employee stock purchase plan on May 15, 2019.

SEC source: 0001179110-19-006129 · edgar.xml · nonDerivative · entry 1

Sponsel David · CIK 0001772837 · EVP, Sales

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 358,750

F1 · date: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 275,000 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006134 · edgar.xml · nonDerivative · entry 2

Hunsaker Craig E · CIK 0001509282 · EVP, People/Culture & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 911,112

F2 · date: On May 13, 2019, issuer granted to the reporting person 57,020 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F2 · shares: On May 13, 2019, issuer granted to the reporting person 57,020 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: On May 13, 2019, issuer granted to the reporting person 57,020 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006134 · edgar.xml · nonDerivative · entry 1

Hunsaker Craig E · CIK 0001509282 · EVP, People/Culture & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 854,092

F1 · date: On May 13, 2019, issuer granted to the reporting person 228,078 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 228,078 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 228,078 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006128 · edgar.xml · nonDerivative · entry 2

Snider Brian · CIK 0001702383 · EVP, Strat. Mktg. & Prod. Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 391,102

F2 · date: On May 13, 2019, issuer granted to the reporting person 44,335 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F2 · shares: On May 13, 2019, issuer granted to the reporting person 44,335 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F4 · balance_after: Includes 4520 shares acquired under the issuer's employee stock purchase plan on May 15, 2019.

F2 · balance_after: On May 13, 2019, issuer granted to the reporting person 44,335 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006128 · edgar.xml · nonDerivative · entry 1

Snider Brian · CIK 0001702383 · EVP, Strat. Mktg. & Prod. Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 342,247

F1 · date: On May 13, 2019, issuer granted to the reporting person 177,340 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 177,340 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 177,340 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-006124 · edgar.xml · nonDerivative · entry 2

Howell Kelli Mari · CIK 0001734485 · EVP, Clinical Strategies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 390,368

F2 · date: On May 13, 2019, issuer granted to the reporting person 35,345 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F2 · shares: On May 13, 2019, issuer granted to the reporting person 35,345 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: On May 13, 2019, issuer granted to the reporting person 35,345 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest on the fourth anniversary of grant date; provided, however, that no portion of such restricted stock units shall vest unless the publicly-traded stock price for the issuer's common stock at the close of the market on such fourth anniversary date is equal to or greater than $6.18 per share (representing a 50% increase in the price per share as of the grant date).

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F4 · balance_after: Includes 8,004 shares acquired under the issuer's employee stock purchase plan on May 15, 2019.

SEC source: 0001179110-19-006124 · edgar.xml · nonDerivative · entry 1

Howell Kelli Mari · CIK 0001734485 · EVP, Clinical Strategies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 347,019

F1 · date: On May 13, 2019, issuer granted to the reporting person 141,379 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F1 · shares: On May 13, 2019, issuer granted to the reporting person 141,379 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · shares: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F1 · balance_after: On May 13, 2019, issuer granted to the reporting person 141,379 restricted stock units, subject to stockholder approval of an amendment to issuer's 2016 Equity Incentive Plan to increase the number of shares authorized for issuance under the plan by 4,000,000 shares. The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date; provided, however, that no portion of the restricted stock units shall vest at any time during the first four years following the grant date unless and until the publicly-traded stock price for the issuer's common stock reaches a 30-day average trading price equal to or above $5.36 per share (representing a 30% increase in the price per share as of the grant date). Should the publicly traded stock price for the issuer's common stock reach a 30-day average trading price at or above $5.36 per share, this pricing condition on the vesting of the restricted stock units shall be satisfied, and shall terminate.

F3 · balance_after: Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-19-005448 · edgar.xml · nonDerivative · entry 1

Hunsaker Craig E · CIK 0001509282 · EVP, People/Culture & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 626,014

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12, 2019.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.00 to $4.01, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001179110-19-003808 · edgar.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,433

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.45 to $2.48, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (1) to this Form 4.

SEC source: 0001179110-19-003774 · edgar.xml · nonDerivative · entry 1

Howell Kelli Mari · CIK 0001734485 · EVP, Clinical Strategies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 205,640

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.47 to $2.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (1) to this Form 4.

F2 · balance_after: Includes 6,830 shares acquired under the issuer's employee stock purchase plan on November 15, 2018.

SEC source: 0001179110-19-003773 · edgar.xml · nonDerivative · entry 1

Bakst Evan · CIK 0001733939 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 726,912

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.51 to $2.63, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (1) to this Form 4.

SEC source: 0001179110-19-003606 · edgar.xml · nonDerivative · entry 1

Miles Patrick · CIK 0001289409 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,992,997

F1 · date: Shares withheld by issuer to satisfy tax withholding obligations of reporting person resulting from vesting of shares.

F1 · kind: Shares withheld by issuer to satisfy tax withholding obligations of reporting person resulting from vesting of shares.

F1 · shares: Shares withheld by issuer to satisfy tax withholding obligations of reporting person resulting from vesting of shares.

SEC source: 0001179110-19-002568 · edgar.xml · nonDerivative · entry 3

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tullis Grown Fund, L.P.

Disclosed balance after: 1,128,828

F1 · kind: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-19-002568 · edgar.xml · nonDerivative · entry 2

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tullis Dickerson Capital Focus III, LP

Disclosed balance after: 1,743,803

F1 · kind: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-19-002568 · edgar.xml · nonDerivative · entry 1

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,216

F1 · kind: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On February 22, 2019, the reporting person became entitled to receive the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-20-000413 · edgar.xml · nonDerivative · entry 1

Rydin Jeffrey P · CIK 0001345767 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 393,746

F1 · date: On January 1, 2019, issuer granted to the reporting person 150,000 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on January 2, 2020.

F1 · shares: On January 1, 2019, issuer granted to the reporting person 150,000 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on January 2, 2020.

F1 · balance_after: On January 1, 2019, issuer granted to the reporting person 150,000 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on January 2, 2020.

SEC source: 0001179110-19-001892 · edgar.xml · nonDerivative · entry 3

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tullis Growth Fund, L.P.

Disclosed balance after: 976,765

F1 · kind: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-19-001892 · edgar.xml · nonDerivative · entry 2

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Tullis Dickerson Capital Focus III, LP

Disclosed balance after: 1,407,924

F1 · kind: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-19-001892 · edgar.xml · nonDerivative · entry 1

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,732

F1 · kind: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

F1 · price: On September 24, 2018, the reporting person received the reported shares at a value of $3.2575 per share upon satisfaction of a post-closing performance condition contained in the merger agreement pursuant to which Issuer acquired all of the outstanding capital stock of SafeOp Surgical, Inc.

SEC source: 0001179110-18-010074 · edgar.xml · nonDerivative · entry 2

Blackford Quentin S. · CIK 0001612451 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 484,081

F3 · date: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010074 · edgar.xml · nonDerivative · entry 1

Blackford Quentin S. · CIK 0001612451 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 462,970

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010079 · edgar.xml · derivative · entry 3

Black Jeffrey G. · CIK 0001449439 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,445

Underlying: Common Stock · 148,445 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010079 · edgar.xml · nonDerivative · entry 1

Black Jeffrey G. · CIK 0001449439 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 177,041

F1 · date: On July 30, 2018, issuer granted to the reporting person 102,041 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 102,041 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 102,041 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010083 · edgar.xml · nonDerivative · entry 1

Mowry David H · CIK 0001414301 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,431

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010081 · edgar.xml · derivative · entry 3

Miles Patrick · CIK 0001289409 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 721,193

Underlying: Common Stock · 721,193 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010081 · edgar.xml · nonDerivative · entry 1

Miles Patrick · CIK 0001289409 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,108,330

F1 · date: On July 30, 2018, issuer granted to the reporting person 463,435 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 463,435 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 463,435 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010073 · edgar.xml · nonDerivative · entry 2

WOODS WARD W JR · CIK 0001196931 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,603

F3 · date: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 21,111 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010073 · edgar.xml · nonDerivative · entry 1

WOODS WARD W JR · CIK 0001196931 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,492

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010070 · edgar.xml · nonDerivative · entry 2

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,490

F3 · date: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010070 · edgar.xml · nonDerivative · entry 1

TULLIS JAMES L L · CIK 0001230641 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,056

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010075 · edgar.xml · nonDerivative · entry 2

Rydin Jeffrey P · CIK 0001345767 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 245,660

F3 · date: On July 30, 2018, issuer granted to the reporting person 24,734 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 24,734 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 24,734 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010075 · edgar.xml · nonDerivative · entry 1

Rydin Jeffrey P · CIK 0001345767 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,926

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010085 · edgar.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,433

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010080 · edgar.xml · derivative · entry 3

Rich Terry · CIK 0001544482 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,511

Underlying: Common Stock · 237,511 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010080 · edgar.xml · nonDerivative · entry 1

Rich Terry · CIK 0001544482 · Director · President & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 732,102

F1 · date: On July 30, 2018, issuer granted to the reporting person 163,265 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 163,265 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 163,265 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010078 · edgar.xml · derivative · entry 2

Hunsaker Craig E · CIK 0001509282 · EVP - People/Culture, GC & Sec

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,550

Underlying: Common Stock · 114,550 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010078 · edgar.xml · nonDerivative · entry 1

Hunsaker Craig E · CIK 0001509282 · EVP - People/Culture, GC & Sec

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 676,014

F1 · date: On July 30, 2018, issuer granted to the reporting person 78,741 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 78,741 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 78,741 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010071 · edgar.xml · nonDerivative · entry 2

Bakst Evan · CIK 0001733939 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 706,346

F3 · date: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010071 · edgar.xml · nonDerivative · entry 1

Bakst Evan · CIK 0001733939 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 701,912

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

SEC source: 0001179110-18-010077 · edgar.xml · derivative · entry 2

Snider Brian · CIK 0001702383 · EVP, Strat. Mktg. & Prod. Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,222

Underlying: Common Stock · 74,222 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010077 · edgar.xml · nonDerivative · entry 1

Snider Brian · CIK 0001702383 · EVP, Strat. Mktg. & Prod. Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,907

F1 · date: On July 30, 2018, issuer granted to the reporting person 51,020 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 51,020 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 51,020 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010076 · edgar.xml · derivative · entry 2

Howell Kelli Mari · CIK 0001734485 · EVP, Clinical Strategies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,006

Underlying: Common Stock · 71,006 shares

Expires 2028-07-30

F3 · derivative.exercise_date: The option will vest 25% on the first anniversary of the grant date and thereafter in 36 equal monthly installments; provided, however, that no portion of the option shall be exercisable at any time during the first four years following the grant date unless and until the publicly-traded stock price for the securities underlying the option reaches a 30-day average trading price equal to or above $4.20 per share. Should the publicly-traded stock price for the securities underlying the option reach a 30-day average trading price at or above $4.20 per share, this pricing condition on the exercise of the option shall be satisfied, and shall terminate.

SEC source: 0001179110-18-010076 · edgar.xml · nonDerivative · entry 1

Howell Kelli Mari · CIK 0001734485 · EVP, Clinical Strategies

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,810

F1 · date: On July 30, 2018, issuer granted to the reporting person 48,810 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 48,810 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 48,810 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest in four equal installments on each of the first four anniversaries of the grant date.

SEC source: 0001179110-18-010072 · edgar.xml · nonDerivative · entry 2

Hochberg Jason · CIK 0001392348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,926

F3 · date: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · shares: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F3 · balance_after: On July 30, 2018, issuer granted to the reporting person 4,434 restricted stock units, which vested immediately upon grant. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

SEC source: 0001179110-18-010072 · edgar.xml · nonDerivative · entry 1

Hochberg Jason · CIK 0001392348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,492

F1 · date: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · date: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · shares: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · shares: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.

F1 · balance_after: On July 30, 2018, issuer granted to the reporting person 20,492 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of issuer's common stock.

F2 · balance_after: The restricted stock units vest on the earlier of (i) the 12 month anniversary of the grant date and (ii) the date of issuer's next annual meeting of stockholders.