TECX

SEC source: 0001415889-24-017952 · form4-06242024_080648.xml · derivative · entry 4

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,380

Underlying: Common Stock · 23,380 shares

Expires 2033-11-30

F5 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F5 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F5 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F9 · price: Received in exchange for a stock option to acquire 43,750 shares of Tectonic common stock pursuant to the Merger Agreement.

F8 · derivative.exercise_date: The shares subject to the option vest in 42 equal monthly installments beginning on July 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F5 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017952 · form4-06242024_080648.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,923

Underlying: Common Stock · 33,923 shares

Expires 2031-06-27

F5 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F5 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F5 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F7 · price: Received in exchange for a stock option to acquire 63,478 shares of Tectonic common stock pursuant to the Merger Agreement.

F6 · derivative.exercise_date: The shares subject to the option vest as follows: (i) 4,079 shares on June 30, 2024; (ii) 4,078 shares on July 31, 2024, (iii) 4,078 shares on August 31, 2024, (iv) 4,079 shares on September 30, 2024, (v) 4,078 shares on October 31, 2024, (vi) 1,297 shares on November 30, 2024, (vii) 4,078 shares on January 31, 2025, (viii) 4,078 shares on February 28, 2025 and (iv) 4,078 shares on March 31, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F5 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017952 · form4-06242024_080648.xml · nonDerivative · entry 2

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 124,530

F3 · price: Received in exchange for 233,019 shares of common stock of Tectonic on the same terms and conditions as set forth in footnote (2) herein.

F4 · ownership.nature: These shares are held by the Reicin-Boiarsky Family Trust (the "Trust"). The Reporting Person's spouse is a co-trustee of the Trust. Accordingly, the Reporting Person may be deemed to have shared voting and dispositive power over the securities held by the Trust. The Reporting Person disclaims beneficial ownership of the shares held by the Trust except to the extent of her pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-017952 · form4-06242024_080648.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 166,580

F1 · shares: Certain of these shares are subject to vesting and a repurchase right in favor of the Issuer, as follows: (i) 2,256 shares on July 10, 2024, (ii) 2,256 shares on August 10, 2024, (iii) 2,781 shares on November 30, 2024, and (iv) 4,079 shares on December 31, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · price: Received in exchange for 311,703 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

F1 · balance_after: Certain of these shares are subject to vesting and a repurchase right in favor of the Issuer, as follows: (i) 2,256 shares on July 10, 2024, (ii) 2,256 shares on August 10, 2024, (iii) 2,781 shares on November 30, 2024, and (iv) 4,079 shares on December 31, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001373604-24-000039 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · Former 10% owner of AVROBIO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,333

F3 · price: Received in exchange for 400,000 shares of common stock of AVROBIO, Inc., pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of AVROBIO common stock reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001373604-24-000039 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · Former 10% owner of AVROBIO

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P,

Disclosed balance after: 400,355

F1 · price: Received in exchange for 4,768,262 shares of common stock of AVROBIO, Inc., pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of AVROBIO common stock reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

F2 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000022 · form4.xml · nonDerivative · entry 3

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 4,768,262

F3 · price: Purchased in multiple transactions with a weighted average price of $1.30. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000022 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 4,471,380

F2 · price: Purchased in multiple transactions with an weighted average price of $1.26. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000022 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 4,255,327

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001127602-24-003481 · form4.xml · nonDerivative · entry 2

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,872

F1 · balance_after: On June 10, 2021, the filer was granted 36,344 RSUs. 50% of the shares vested on the second anniversary of the grant date and the remaining 50% vest on the third anniversary of the grant date. This balance includes 18,172 unvested shares.

SEC source: 0001127602-24-003478 · form4.xml · nonDerivative · entry 2

Ridha Essra · CIK 0001888732 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,881

SEC source: 0001127602-24-003477 · form4.xml · nonDerivative · entry 2

Ostrowski Erik · CIK 0001762507 · Interim CEO, President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,285

SEC source: 0001127602-24-003476 · form4.xml · nonDerivative · entry 2

Avruch Steven · CIK 0001762236 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,022

SEC source: 0001127602-24-003481 · form4.xml · derivative · entry 3

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,999

Underlying: Common Stock · 37,334 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-24-003481 · form4.xml · nonDerivative · entry 1

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,104

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-003478 · form4.xml · derivative · entry 3

Ridha Essra · CIK 0001888732 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,499

Underlying: Common Stock · 32,834 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-24-003478 · form4.xml · nonDerivative · entry 1

Ridha Essra · CIK 0001888732 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,834

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-003477 · form4.xml · derivative · entry 3

Ostrowski Erik · CIK 0001762507 · Interim CEO, President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,249

Underlying: Common Stock · 40,084 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-24-003477 · form4.xml · nonDerivative · entry 1

Ostrowski Erik · CIK 0001762507 · Interim CEO, President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,384

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-003476 · form4.xml · derivative · entry 3

Avruch Steven · CIK 0001762236 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,499

Underlying: Common Stock · 32,834 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-24-003476 · form4.xml · nonDerivative · entry 1

Avruch Steven · CIK 0001762236 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,834

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-23-019705 · form4.xml · derivative · entry 1

Ostrowski Erik · CIK 0001762507 · Interim CEO, President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2027-07-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date.

SEC source: 0001127602-23-018660 · form4.xml · nonDerivative · entry 2

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,770

F1 · security: Consists of 36,344 RSUs granted on June 10, 2021. 50% of the shares vest on the second anniversary of the grant date and the remaining 50% vest on the third anniversary of the grant date.

F2 · kind: Withholding of shares to cover a tax liability due to the vesting of 18,172 RSUs granted on June 10, 2021.

SEC source: 0001127602-23-018660 · form4.xml · nonDerivative · entry 1

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,881

F1 · security: Consists of 36,344 RSUs granted on June 10, 2021. 50% of the shares vest on the second anniversary of the grant date and the remaining 50% vest on the third anniversary of the grant date.

F2 · kind: Withholding of shares to cover a tax liability due to the vesting of 18,172 RSUs granted on June 10, 2021.

SEC source: 0001127602-23-018296 · form4.xml · derivative · entry 1

PAIGE CHRISTOPHER · CIK 0001742209 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-018287 · form4.xml · derivative · entry 1

Vickers Philip J. · CIK 0001635046 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-018283 · form4.xml · derivative · entry 1

Booth Bruce · CIK 0001451612 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

F2 · ownership.direct: This option was granted to the Reporting Person, a director of the Issuer. The proceeds of any sale of shares of common stock issued to the Reporting Person upon exercise of this option will be transferred to Atlas Venture Life Science Advisors, LLC and as such, the Reporting Person disclaims ownership of such securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001127602-23-018290 · form4.xml · derivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-018280 · form4.xml · derivative · entry 1

CLARK IAN T · CIK 0001336504 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-018286 · form4.xml · derivative · entry 1

Farfel Gail M · CIK 0001614780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-018282 · form4.xml · derivative · entry 1

Jenkins Annalisa · CIK 0001639481 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,643

Underlying: Common Stock · 17,643 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 6, 2024 or the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.

SEC source: 0001127602-23-004510 · form4.xml · derivative · entry 1

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,333

Underlying: Common Stock · 149,333 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-004515 · form4.xml · derivative · entry 1

Petersen Deanna M · CIK 0001493139 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,667

Underlying: Common Stock · 86,667 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-004511 · form4.xml · derivative · entry 1

Ostrowski Erik · CIK 0001762507 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,333

Underlying: Common Stock · 160,333 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-004512 · form4.xml · derivative · entry 1

Ridha Essra · CIK 0001888732 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,333

Underlying: Common Stock · 131,333 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-004508 · form4.xml · derivative · entry 1

Avruch Steven · CIK 0001762236 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 131,333

Underlying: Common Stock · 131,333 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-004509 · form4.xml · derivative · entry 1

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,667

Underlying: Common Stock · 300,667 shares

Expires 2027-02-01

F1 · derivative.exercise_date: The shares subject to the RSU shall vest over 4 years, with 25% vesting annually on each anniversary of the Vesting Commencement Date of February 1, 2023.

SEC source: 0001127602-23-002332 · form4.xml · derivative · entry 6

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 45,999 shares

Expires 2027-06-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 25% of the shares vested on June 13, 2018, and the remaining 75% vested in equal monthly installments thereafter over a three-year period.

SEC source: 0001127602-23-002332 · form4.xml · nonDerivative · entry 3

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 188,012

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-23-002332 · form4.xml · nonDerivative · entry 2

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Geoff R. MacKay Irrevocable Trust

Disclosed balance after: 445,123

F1 · shares: This transaction was a bona fide gift of common stock to The Geoff R. MacKay Irrevocable Trust. The reporting person disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0001127602-23-002332 · form4.xml · nonDerivative · entry 1

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,013

F1 · shares: This transaction was a bona fide gift of common stock to The Geoff R. MacKay Irrevocable Trust. The reporting person disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0001127602-22-028329 · form4.xml · derivative · entry 5

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 142,013 shares

Expires 2026-04-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25% of the shares vested on July 1, 2017, and the remaining 75% vested in equal quarterly installments thereafter over a three-year period.

SEC source: 0001127602-22-028329 · form4.xml · nonDerivative · entry 1

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 387,136

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-22-027231 · form4.xml · derivative · entry 1

Golipour Azadeh · CIK 0001932510 · Chief Technology Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,000

Underlying: Common Stock · 165,000 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-027236 · form4.xml · derivative · entry 1

Petersen Deanna M · CIK 0001493139 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,500

Underlying: Common Stock · 111,500 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-027239 · form4.xml · derivative · entry 1

Ridha Essra · CIK 0001888732 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 183,000

Underlying: Common Stock · 183,000 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-027235 · form4.xml · derivative · entry 1

MACKAY GEOFFREY · CIK 0001741849 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 388,000

Underlying: Common Stock · 388,000 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-027233 · form4.xml · derivative · entry 1

Ostrowski Erik · CIK 0001762507 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 221,000

Underlying: Common Stock · 221,000 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-027230 · form4.xml · derivative · entry 1

Avruch Steven · CIK 0001762236 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,500

Underlying: Common Stock · 169,500 shares

Expires 2032-12-07

F1 · derivative.exercise_date: 50% of the shares shall vest and become exercisable on the first anniversary of the grant date, and the remaining 50% shall vest in equal monthly installments thereafter over a one-year period.

SEC source: 0001127602-22-017247 · form4.xml · derivative · entry 2

PAIGE CHRISTOPHER · CIK 0001742209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,478

Underlying: Common Stock · 17,478 shares

Expires 2032-06-07

F1 · derivative.exercise_date: The option shall vest in full upon the earlier of June 8, 2023 or the date of the Issuer's 2023 Annual Meeting of Stockholders, subject to the reporting person's continued service as a director through such vesting date.