TECX

SEC source: 0002023255-26-000012 · form4-10022026_091039.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,305

F2 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.61 to $23.32, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001757533-26-000016 · form4-10022026_081054.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 309,078

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0002023255-26-000012 · form4-10022026_091039.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,841

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0002023175-26-000009 · form4-10022026_081032.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,903

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0002023849-26-000014 · form4-10022026_081032.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,157

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0001791187-26-000010 · form4-10022026_091013.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,024

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0001791187-26-000008 · form4-09082026_040905.xml · derivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001757533-26-000014 · form4-09082026_040901.xml · derivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,250

Underlying: Common Stock · 69,250 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000012 · form4-09082026_040903.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000011 · form4-09082026_040907.xml · derivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023175-26-000007 · form4-09082026_040909.xml · derivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,750

Underlying: Common Stock · 17,750 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000009 · form4-08262026_040801.xml · derivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,787

Underlying: Common Stock · 43 shares

Expires 2035-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000009 · form4-08262026_040801.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,285

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000009 · form4-08262026_040801.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,328

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000007 · form4-08142026_110840.xml · derivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,830

Underlying: Common Stock · 43 shares

Expires 2035-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000007 · form4-08142026_110840.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,285

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000007 · form4-08142026_110840.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,328

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000006 · form4-07012026_090747.xml · derivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,873

Underlying: Common Stock · 172 shares

Expires 2035-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000006 · form4-07012026_090747.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,285

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000006 · form4-07012026_090747.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,457

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This exercise and subsequent sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0001757533-26-000012 · form4-06232026_090656.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 310,623

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on December 4, 2024.

SEC source: 0001791187-26-000006 · form4-06122026_040619.xml · derivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2034-06-19

F1 · shares: Represents the number of shares earned under a performance-based stock option award based on the Issuer's satisfaction of certain performance criteria. In light of the performance-based conditions of the option award, the option was not reportable under Section 16 until the performance conditions were certified by the Issuer's Board of Directors, which occurred on June 11, 2026. The option reported on this form represents 50% of the total number of shares underlying the performance option subject to the option award. The remaining 50% of the shares will be earned upon the satisfaction of additional performance criteria.

F2 · derivative.exercise_date: The shares underlying the option are fully vested and immediately exercisable as of June 1, 2026.

SEC source: 0001055624-26-000003 · form4-06102026_040607.xml · derivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2027, (ii) the date of the Issuer's 2027 Annual Meeting of Stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001779978-26-000003 · form4-06102026_040605.xml · derivative · entry 1

Tipirneni Praveen P. · CIK 0001779978 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2027, (ii) the date of the Issuer's 2027 Annual Meeting of Stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001238120-26-000010 · form4-06102026_040603.xml · derivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2027, (ii) the date of the Issuer's 2027 Annual Meeting of Stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001826967-26-000003 · form4-06102026_040601.xml · derivative · entry 1

Vitorovic Stefan · CIK 0001826967 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2027, (ii) the date of the Issuer's 2027 Annual Meeting of Stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0002123815-26-000007 · form4-06102026_080616.xml · derivative · entry 1

Chutter Jessica Caroline · CIK 0002123815 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2036-06-07

F1 · derivative.exercise_date: One-third (1/3) of the shares subject to the option shall vest on June 8, 2027, and the balance shall vest in 24 equal monthly installments thereafter, subject in each case to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0002023849-26-000008 · form4-05062026_050501.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,682

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0002023849-26-000006 · form4-04032026_080442.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,747

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0001365343-26-000003 · form4-04032026_080427.xml · derivative · entry 1

Nader Francois · CIK 0001365343 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2036-03-31

F1 · derivative.exercise_date: One Third (1/3) of the shares subject to the option shall vest on April 1, 2027, and the balance shall vest in 24 equal monthly installments thereafter, subject in each case, to the Reporting Person providing continuous service to the Issuer through each applicable vesting date.

SEC source: 0002023849-26-000004 · form4-03092026_100315.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,747

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · derivative · entry 6

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,045

Underlying: Common Stock · 215 shares

Expires 2035-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F4 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · derivative · entry 5

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,959

Underlying: Common Stock · 2,500 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

F3 · price: Received in exchange for a stock option to acquire 71,029 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017962/xslF345X05/form4-06242024_080611.xml

F2 · derivative.exercise_date: 25% of the shares subject to the option vested on June 1, 2022; and the remainder of the shares subject to the option vest in 36 equal monthly installments with the final amount vesting on June 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · nonDerivative · entry 4

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,285

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · nonDerivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,500

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,547

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000005 · form4-03092026_100314.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,332

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These exercises and sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0001791187-26-000005 · form4-03052026_100327.xml · derivative · entry 2

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-03-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001791187-26-000005 · form4-03052026_100327.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,544

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000003 · form4-03052026_100303.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-03-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000003 · form4-03052026_100303.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,747

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023175-26-000005 · form4-03052026_100314.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,750

Underlying: Common Stock · 17,750 shares

Expires 2036-03-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023175-26-000005 · form4-03052026_100314.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,314

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000004 · form4-03052026_100302.xml · derivative · entry 4

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2036-03-03

F3 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000004 · form4-03052026_100302.xml · nonDerivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,832

F1 · kind: These sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0002023255-26-000004 · form4-03052026_100302.xml · nonDerivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,482

F2 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001757533-26-000009 · form4-03052026_100320.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,250

Underlying: Common Stock · 69,250 shares

Expires 2036-03-03

F3 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001757533-26-000009 · form4-03052026_100320.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 311,547

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-26-000004 · form4-03052026_100302.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,482

F1 · kind: These sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2025.

SEC source: 0001757533-26-000005 · form4-02122026_040204.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 237,547

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $21.02 to $21.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.