SENS

SEC source: 0001209191-19-041152 · doc4.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,451

F1 · shares: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $11,875.00 divided by $1.94, the closing price of Issuer's common stock on the NYSE American on July 1, 2019.

SEC source: 0001209191-19-034000 · doc4.xml · derivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-033984 · doc4.xml · derivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-033986 · doc4.xml · derivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-034083 · doc4.xml · derivative · entry 1

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-033993 · doc4.xml · derivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-033985 · doc4.xml · derivative · entry 1

Klein Peter Justin · CIK 0001608710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-033998 · doc4.xml · derivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,930

Underlying: Common Stock · 86,930 shares

Expires 2029-05-29

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the Issuer's common stock on the NYSE American on the date of grant, May 30, 2019.

F2 · shares: This grant was made as compensation for the reporting person's service on the Issuer's board of directors. Under the Issuer's non-employee director compensation policy, each non-employee director who continues to serve as a member of the Issuer's board of directors is eligible to receive an annual stock option grant following each annual meeting of the Issuer's stockholders with a Black Scholes option value of $106,500.

F3 · derivative.exercise_date: The shares underlying the option will vest in full on the earlier of the one year anniversary of the date of grant or the next annual stockholders meeting, subject to the reporting person's continuous service (as defined in the Issuer's 2015 Equity Incentive Plan, as amended) through such vesting date.

SEC source: 0001209191-19-023241 · doc4.xml · derivative · entry 4

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 173,113

Underlying: Common Stock · 13,923 shares

Expires 2025-07-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On April 2, 2019, the Reporting Person completed this option exercise for cash. The Reporting Person did not sell any securities.

F3 · derivative.exercise_date: Shares vest monthly over four years beginning on July 24, 2015.

SEC source: 0001209191-19-023241 · doc4.xml · derivative · entry 3

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,710

Underlying: Common Stock · 8,979 shares

Expires 2024-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On April 2, 2019, the Reporting Person completed this option exercise for cash. The Reporting Person did not sell any securities.

F2 · derivative.exercise_date: Fully vested.

SEC source: 0001209191-19-023241 · doc4.xml · nonDerivative · entry 2

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 336,512

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On April 2, 2019, the Reporting Person completed this option exercise for cash. The Reporting Person did not sell any securities.

SEC source: 0001209191-19-023241 · doc4.xml · nonDerivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 322,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On April 2, 2019, the Reporting Person completed this option exercise for cash. The Reporting Person did not sell any securities.

SEC source: 0001209191-19-023227 · doc4.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,214

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $13,375.00 divided by $2.31, the closing price of Issuer's common stock on the NYSE American on April 1, 2019.

SEC source: 0001209191-19-023214 · doc4.xml · nonDerivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 736,963

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $21,906.25 divided by $2.31, the closing price of Issuer's common stock on the NYSE American on April 1, 2019.

SEC source: 0001209191-19-023222 · doc4.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,444

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $15,687.50 divided by $2.31, the closing price of Issuer's common stock on the NYSE American on April 1, 2019.

SEC source: 0001209191-19-023243 · doc4.xml · nonDerivative · entry 1

Klein Peter Justin · CIK 0001608710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,319

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $6,687.45 divided by $2.31, the closing price of Issuer's common stock on the NYSE American on April 1, 2019.

SEC source: 0001209191-19-023218 · doc4.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,330

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,500.00 divided by $2.31, the closing price of Issuer's common stock on the NYSE American on April 1, 2019.

SEC source: 0001209191-19-017409 · doc4.xml · derivative · entry 1

Kaufman Francine · CIK 0001769791 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 550,000

Underlying: Common Stock · 550,000 shares

Expires 2029-03-03

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the issuer's common stock on the NYSE American on the date of grant, March 4, 2019.

F2 · derivative.exercise_date: One-fourth of the shares vest on March 4, 2020, with the remaining shares vesting in 36 equal installments at the end of the calendar month for each month after March 4, 2020, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-004816 · doc4.xml · derivative · entry 1

Panlilio Mirasol · CIK 0001667551 · VP Global Sales and Marketing

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2029-01-16

F1 · derivative.exercise_date: Shares vest monthly over four years subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-004813 · doc4.xml · derivative · entry 1

Goodnow Timothy T · CIK 0001667588 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800,000

Underlying: Common Stock · 800,000 shares

Expires 2029-01-16

F1 · derivative.exercise_date: Shares vest monthly over four years subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-004818 · doc4.xml · derivative · entry 1

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 535,000

Underlying: Common Stock · 535,000 shares

Expires 2029-01-16

F1 · derivative.exercise_date: Shares vest monthly over four years subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-004807 · doc4.xml · derivative · entry 1

Gill Michael J. · CIK 0001703973 · Vice President of U.S. Sales

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2029-01-16

F1 · derivative.exercise_date: Shares vest monthly over four years subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-003056 · doc4.xml · derivative · entry 1

ISAACSON JON D · CIK 0001764122 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 550,000

Underlying: Common Stock · 550,000 shares

Expires 2029-01-07

F1 · derivative.exercise_price: The exercise price is equal to the closing price of the issuer's common stock on the NYSE American on the date of grant, January 7, 2019.

F2 · derivative.exercise_date: One-fourth of the shares vest on January 7, 2020, with the remaining shares vest in 36 equal installments at the end of the calendar month for each month after January 7, 2020, subject to the reporting person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-19-001949 · doc4.xml · nonDerivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 727,480

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $15,656.25 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-19-001927 · doc4.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,049

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $7,218.75 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-19-001935 · doc4.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,424

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125.00 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-19-001985 · doc4.xml · nonDerivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 512,720

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $9,750 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-19-001989 · doc4.xml · nonDerivative · entry 1

Klein Peter Justin · CIK 0001608710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,424

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-19-001939 · doc4.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,919

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $11,250.00 divided by $2.69, the closing price of Issuer's common stock on the NYSE American on January 2, 2019.

SEC source: 0001209191-18-053825 · doc4.xml · nonDerivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 721,660

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $15,656.25 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018, the last trading day of the prior quarter.

SEC source: 0001209191-18-053820 · doc4.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,366

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $7,218.75 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018, the last trading day of the prior quarter.

SEC source: 0001209191-18-053822 · doc4.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,917

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125.00 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018, the last trading day of the prior quarter.

SEC source: 0001209191-18-053850 · doc4.xml · nonDerivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 509,096

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $9,750 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018.

SEC source: 0001209191-18-053853 · doc4.xml · nonDerivative · entry 1

Klein Peter Justin · CIK 0001608710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,917

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018.

SEC source: 0001209191-18-053823 · doc4.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,737

F1 · price: This common stock was issued to the reporting person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $11,250.00 divided by $4.54, the closing price of Issuer's common stock on the NYSE American on October 1, 2018, the last trading day of the prior quarter.

SEC source: 0001209191-18-041694 · doc4.xml · nonDerivative · entry 1

DeFalco Stephen P · CIK 0001666964 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 718,212

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $15,656.25 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-041688 · doc4.xml · nonDerivative · entry 1

Prince Douglas S · CIK 0001666995 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 132,776

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $7,218.75 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-041704 · doc4.xml · nonDerivative · entry 1

Fiorentino Edward · CIK 0001666972 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,247

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-041703 · doc4.xml · nonDerivative · entry 1

BARRETT M JAMES · CIK 0001219855 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 506,949

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $9,750 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-041699 · doc4.xml · nonDerivative · entry 1

Klein Peter Justin · CIK 0001608710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,247

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $12,125 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-041697 · doc4.xml · nonDerivative · entry 1

Steven Edelman · CIK 0001683354 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,260

F1 · price: This common stock was issued to the Reporting Person pursuant to the Issuer's non-employee director compensation policy in lieu of quarterly retainer fees. The number of shares of common stock is equal to $9,750 divided by $4.43, the closing price of Issuer's common stock on the NYSE American on July 2, 2018.

SEC source: 0001209191-18-039058 · doc4.xml · derivative · entry 3

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 255,599

Underlying: Common Stock · 40,000 shares

Expires 2024-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the record holder of the securities on December 7, 2016.

F3 · derivative.exercise_date: Shares are fully vested and exercisable.

SEC source: 0001209191-18-039058 · doc4.xml · nonDerivative · entry 2

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the record holder of the securities on December 7, 2016.

F2 · price: This transaction was executed in multiple trades at prices ranging from $4.50 to $4.55, inclusive. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.

SEC source: 0001209191-18-039058 · doc4.xml · nonDerivative · entry 1

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the record holder of the securities on December 7, 2016.

SEC source: 0001209191-21-039013 · doc4.xml · derivative · entry 3

JAIN Mukul · CIK 0001667593 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,599

Underlying: Common Stock · 25,000 shares

Expires 2024-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the record holder of the securities on March 15, 2021.

F3 · derivative.exercise_date: Shares are fully vested and exercisable.

SEC source: 0001209191-18-038148 · doc4.xml · nonDerivative · entry 6

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 95,221

F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 19, 2018.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.98 to $4.16, inclusive. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 6 to this Form 4.

F4 · ownership.nature: The reported securities are directly owned by Delphi Bioinvestments VIII, L.P. ("DBI VIII"). Delphi Management Partners VIII, L.L.C. ("DMP VIII"), the general partner of DBI VIII, may be deemed to have sole dispositive and voting power over the securities directly owned by DBI VIII. James J. Bochnowski, David L. Douglass, Deepika R. Pakianathan and Douglas A. Roeder are the managing members of DMP VIII and may be deemed to share voting and dispositive power over the securities held by DBI VIII. Such persons and entities disclaim the existence of a "group" and disclaim beneficial ownership of the securities held by DBI VIII, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-038148 · doc4.xml · nonDerivative · entry 5

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 9,751,725

F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 19, 2018.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.98 to $4.16, inclusive. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 6 to this Form 4.

F3 · ownership.nature: The reported securities are directly owned by Delphi Ventures VIII, L.P. ("DV VIII"). Delphi Management Partners VIII, L.L.C. ("DMP VIII"), the general partner of DV VIII, may be deemed to have sole dispositive and voting power over the securities directly owned by DV VIII. James J. Bochnowski, David L. Douglass, Deepika R. Pakianathan and Douglas A. Roeder are the managing members of DMP VIII and may be deemed to share voting and dispositive power over the securities held by DV VIII. Such persons and entities disclaim the existence of a "group" and disclaim beneficial ownership of the securities held by DV VIII, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-038148 · doc4.xml · nonDerivative · entry 4

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 101,131

F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 19, 2018.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.87 to $4.08, inclusive. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 5 to this Form 4.

F4 · ownership.nature: The reported securities are directly owned by Delphi Bioinvestments VIII, L.P. ("DBI VIII"). Delphi Management Partners VIII, L.L.C. ("DMP VIII"), the general partner of DBI VIII, may be deemed to have sole dispositive and voting power over the securities directly owned by DBI VIII. James J. Bochnowski, David L. Douglass, Deepika R. Pakianathan and Douglas A. Roeder are the managing members of DMP VIII and may be deemed to share voting and dispositive power over the securities held by DBI VIII. Such persons and entities disclaim the existence of a "group" and disclaim beneficial ownership of the securities held by DBI VIII, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-038148 · doc4.xml · nonDerivative · entry 3

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 10,357,080

F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 19, 2018.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.87 to $4.08, inclusive. The Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 5 to this Form 4.

F3 · ownership.nature: The reported securities are directly owned by Delphi Ventures VIII, L.P. ("DV VIII"). Delphi Management Partners VIII, L.L.C. ("DMP VIII"), the general partner of DV VIII, may be deemed to have sole dispositive and voting power over the securities directly owned by DV VIII. James J. Bochnowski, David L. Douglass, Deepika R. Pakianathan and Douglas A. Roeder are the managing members of DMP VIII and may be deemed to share voting and dispositive power over the securities held by DV VIII. Such persons and entities disclaim the existence of a "group" and disclaim beneficial ownership of the securities held by DV VIII, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-18-038148 · doc4.xml · nonDerivative · entry 2

ROEDER DOUGLAS A · CIK 0001270735 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 102,632

F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 19, 2018.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.85 to $4.11, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 2 to this Form 4.

F4 · ownership.nature: The reported securities are directly owned by Delphi Bioinvestments VIII, L.P. ("DBI VIII"). Delphi Management Partners VIII, L.L.C. ("DMP VIII"), the general partner of DBI VIII, may be deemed to have sole dispositive and voting power over the securities directly owned by DBI VIII. James J. Bochnowski, David L. Douglass, Deepika R. Pakianathan and Douglas A. Roeder are the managing members of DMP VIII and may be deemed to share voting and dispositive power over the securities held by DBI VIII. Such persons and entities disclaim the existence of a "group" and disclaim beneficial ownership of the securities held by DBI VIII, except to the extent of any pecuniary interest therein.