NERV

SEC source: 0001209191-18-063195 · doc4.xml · nonDerivative · entry 1

Race Geoff · CIK 0001610382 · EVP, CFO & CBO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 204,369

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-18-063187 · doc4.xml · derivative · entry 4

Luthringer Remy · CIK 0001610384 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 18,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: Represents shares issuable upon the vesting of RSUs awarded to the Reporting Person on December 14, 2016. The RSUs vest in 4 equal annual installments beginning on December 14, 2017 and will be fully vested on December 14, 2020, in all cases so long as there has been no break in the Reporting Person's continuous service through such date.

F3 · derivative.expiration_date: Represents shares issuable upon the vesting of RSUs awarded to the Reporting Person on December 14, 2016. The RSUs vest in 4 equal annual installments beginning on December 14, 2017 and will be fully vested on December 14, 2020, in all cases so long as there has been no break in the Reporting Person's continuous service through such date.

SEC source: 0001209191-18-063187 · doc4.xml · nonDerivative · entry 1

Luthringer Remy · CIK 0001610384 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,306

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-18-063183 · doc4.xml · derivative · entry 3

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 8,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: Represents shares issuable upon the vesting of RSUs awarded to the Reporting Person on December 14, 2016. The RSUs vest in 4 equal annual installments beginning on December 14, 2017 and will be fully vested on December 14, 2020, in all cases so long as there has been no break in the Reporting Person's continuous service through such date.

F3 · derivative.expiration_date: Represents shares issuable upon the vesting of RSUs awarded to the Reporting Person on December 14, 2016. The RSUs vest in 4 equal annual installments beginning on December 14, 2017 and will be fully vested on December 14, 2020, in all cases so long as there has been no break in the Reporting Person's continuous service through such date.

SEC source: 0001209191-18-063183 · doc4.xml · nonDerivative · entry 1

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,927

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-18-062464 · doc4.xml · nonDerivative · entry 1

Russell Richard E. · CIK 0001724897 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,883

F1 · kind: Shares sold to satisfy withholding tax obligations upon the vesting of restricted stock grants.

SEC source: 0001209191-18-062261 · doc4.xml · nonDerivative · entry 2

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,611

SEC source: 0001209191-18-062467 · doc4.xml · derivative · entry 1

Smith Devin Whittemore · CIK 0001747818 · SVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062459 · doc4.xml · derivative · entry 1

Davidson Michael · CIK 0001691467 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062458 · doc4.xml · derivative · entry 1

Ahlholm Frederick W · CIK 0001405279 · SVP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062465 · doc4.xml · derivative · entry 1

Saoud Jay · CIK 0001716202 · SVP and Head of R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062464 · doc4.xml · derivative · entry 2

Russell Richard E. · CIK 0001724897 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 260,000

Underlying: Common Stock · 260,000 shares

Expires 2028-12-10

F2 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062463 · doc4.xml · derivative · entry 1

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062462 · doc4.xml · derivative · entry 1

Race Geoff · CIK 0001610382 · EVP, CFO & CBO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062461 · doc4.xml · derivative · entry 1

Luthringer Remy · CIK 0001610384 · Director · CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 410,000

Underlying: Common Stock · 410,000 shares

Expires 2028-12-10

F1 · derivative.exercise_date: This option vests 25% on December 11, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-062261 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,611

SEC source: 0001209191-18-059709 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,611

SEC source: 0001209191-18-054978 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,611

SEC source: 0000899243-18-025985 · doc4.xml · nonDerivative · entry 1

Index Venture Associates III Ltd · CIK 0001503683 · 10% owner

Index Venture Associates IV Ltd · CIK 0001447962 · 10% owner

Index Venture Associates V Ltd · CIK 0001611751 · 10% owner

Yucca (Jersey) SLP · CIK 0001591294 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,609,189

F1 · shares: Represents 2,677 shares sold by Index Ventures III (Jersey), L.P. ("Index III Jersey"), 5,438 shares sold by Index Ventures III (Delaware), L.P. ("Index III Delaware"), 97 shares sold by Index Ventures III Parallel Entrepreneur Fund (Jersey) L.P. ("Index III Parallel" and, together with Index III Jersey and Index III Delaware, the "Index III Funds"), 3,718 shares sold by Index Ventures IV (Jersey) L.P. ("Index IV Jersey"), 353 shares sold by Index Ventures IV Parallel Entrepreneur Fund (Jersey) L.P. ("Index IV Parallel" and, together with Index IV Jersey, the "Index IV Funds"), 2,941 shares sold by Index Ventures V (Jersey), L.P. ("Index V Jersey"), 24 shares sold by Index Ventures V Parallel Entrepreneur Fund (Jersey), L.P. ("Index V Parallel" and, together with Index V Jersey, the "Index V Funds") and 196 shares sold by Yucca (Jersey) SLP ("Yucca Jersey").

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.00 to $12.80. The reporting persons undertake to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: Represents 798,930 shares held directly by Index III Jersey, 1,622,941 shares held directly by Index III Delaware, 28,911 shares held directly by Index III Parallel, 1,109,799 shares held directly by Index IV Jersey, 105,342 shares held directly by Index IV Parallel, 877,639 shares held directly by Index V Jersey, 7,112 shares held directly by Index V Parallel and 58,515 shares held directly by Yucca Jersey.

F4 · ownership.nature: Index Venture Associates III Ltd. ("Index III GP") is the general partner of the Index III Funds, Index Venture Associates IV Ltd. ("Index IV GP") is the general partner of the Index IV Funds and Index Venture Associates V Ltd. ("Index V GP") is the general partner of the Index V Funds. Yucca (Jersey) SLP is the Administrator of the Index Co-Investment Scheme acting through Intertrust Employee Benefit Services Limited. Each of Index III GP, Index IV GP and Index V GP disclaims Section 16 beneficial ownership of the securities held by the Index III Funds, Index IV Funds and Index V Funds, respectively, and the shares held by Yucca Jersey, except to the extent of its respective pecuniary interest therein, if any, and this report shall not be deemed an admission that Index III GP, Index IV GP or Index V GP is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001209191-18-053871 · doc4.xml · derivative · entry 6

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,524

Underlying: Common Stock · 10,000 shares

Expires 2025-04-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option vested 25% on April 14, 2016 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-053871 · doc4.xml · derivative · entry 5

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,400

Underlying: Common Stock · 15,000 shares

Expires 2025-12-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option vested 25% on December 4, 2016 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-053871 · doc4.xml · nonDerivative · entry 4

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,177

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2016.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.60 to $12.69, inclusive.

SEC source: 0001209191-18-053871 · doc4.xml · nonDerivative · entry 3

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,877

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.60 to $12.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0001209191-18-053871 · doc4.xml · nonDerivative · entry 2

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,177

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-18-053871 · doc4.xml · nonDerivative · entry 1

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,177

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-025642 · doc4.xml · nonDerivative · entry 2

Index Venture Associates III Ltd · CIK 0001503683 · 10% owner

Index Venture Associates IV Ltd · CIK 0001447962 · 10% owner

Index Venture Associates V Ltd · CIK 0001611751 · 10% owner

Yucca (Jersey) SLP · CIK 0001591294 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,624,633

F5 · shares: Represents 5,996 shares sold by Index III Jersey, 12,179 shares sold by Index III Delaware, 217 shares sold by Index III Parallel, 8,328 shares sold by Index IV Jersey, 791 shares sold by Index IV Parallel, 6,586 shares sold by Index V Jersey, 53 shares sold by Index V Parallel and 439 shares sold by Yucca Jersey.

F6 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.45 to $12.75. The reporting persons undertake to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F7 · balance_after: Represents 801,607 shares held directly by Index III Jersey, 1,628,379 shares held directly by Index III Delaware, 29,008 shares held directly by Index III Parallel, 1,113,517 shares held directly by Index IV Jersey, 105,695 shares held directly by Index IV Parallel, 880,580 shares held directly by Index V Jersey, 7,136 shares sold by Index V Parallel and 58,711 shares held directly by Yucca Jersey.

F4 · ownership.nature: Index Venture Associates III Ltd. ("Index III GP") is the general partner of the Index III Funds, Index Venture Associates IV Ltd. ("Index IV GP") is the general partner of the Index IV Funds and Index Venture Associates V Ltd. ("Index V GP") is the general partner of the Index V Funds. Yucca (Jersey) SLP is the Administrator of the Index Co-Investment Scheme acting through Intertrust Employee Benefit Services Limited. Each of Index III GP, Index IV GP and Index V GP disclaims Section 16 beneficial ownership of the securities held by the Index III Funds, Index IV Funds and Index V Funds, respectively, and the shares held by Yucca Jersey, except to the extent of its respective pecuniary interest therein, if any, and this report shall not be deemed an admission that Index III GP, Index IV GP or Index V GP is the beneficial owner of such securities for Section 16 or any other purpose

SEC source: 0000899243-18-025642 · doc4.xml · nonDerivative · entry 1

Index Venture Associates III Ltd · CIK 0001503683 · 10% owner

Index Venture Associates IV Ltd · CIK 0001447962 · 10% owner

Index Venture Associates V Ltd · CIK 0001611751 · 10% owner

Yucca (Jersey) SLP · CIK 0001591294 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,659,222

F1 · shares: Represents 5,492 shares sold by Index Ventures III (Jersey), L.P. ("Index III Jersey"), 11,156 shares sold by Index Ventures III (Delaware), L.P. ("Index III Delaware"), 199 shares sold by Index Ventures III Parallel Entrepreneur Fund (Jersey) L.P. ("Index III Parallel" and, together with Index III Jersey and Index III Delaware, the "Index III Funds"), 7,629 shares sold by Index Ventures IV (Jersey) L.P. ("Index IV Jersey"), 724 shares sold by Index Ventures IV Parallel Entrepreneur Fund (Jersey) L.P. ("Index IV Parallel" and, together with Index IV Jersey, the "Index IV Funds"), 6,033 shares sold by Index Ventures V (Jersey), L.P. ("Index V Jersey"), 49 shares sold by Index Ventures V Parallel Entrepreneur Fund (Jersey), L.P. ("Index V Parallel" and, together with Index V Jersey, the "Index V Funds") and 402 shares sold by Yucca (Jersey) SLP ("Yucca Jersey").

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.375 to $12.95. The reporting persons undertake to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: Represents 807,603 shares held directly by Index III Jersey, 1,640,558 shares held directly by Index III Delaware, 29,225 shares held directly by Index III Parallel, 1,121,845 shares held directly by Index IV Jersey, 106,486 shares held directly by Index IV Parallel, 887,166 shares held directly by Index V Jersey, 7,189 shares sold by Index V Parallel and 59,150 shares held directly by Yucca Jersey.

F4 · ownership.nature: Index Venture Associates III Ltd. ("Index III GP") is the general partner of the Index III Funds, Index Venture Associates IV Ltd. ("Index IV GP") is the general partner of the Index IV Funds and Index Venture Associates V Ltd. ("Index V GP") is the general partner of the Index V Funds. Yucca (Jersey) SLP is the Administrator of the Index Co-Investment Scheme acting through Intertrust Employee Benefit Services Limited. Each of Index III GP, Index IV GP and Index V GP disclaims Section 16 beneficial ownership of the securities held by the Index III Funds, Index IV Funds and Index V Funds, respectively, and the shares held by Yucca Jersey, except to the extent of its respective pecuniary interest therein, if any, and this report shall not be deemed an admission that Index III GP, Index IV GP or Index V GP is the beneficial owner of such securities for Section 16 or any other purpose

SEC source: 0001209191-18-051657 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,011

SEC source: 0001209191-18-051204 · doc4.xml · nonDerivative · entry 2

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,211

SEC source: 0001209191-18-051204 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,011

SEC source: 0001209191-18-050573 · doc4.xml · nonDerivative · entry 2

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,011

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.50 to $9.95, inclusive.

SEC source: 0001209191-18-050573 · doc4.xml · nonDerivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.75 to $10.00, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1) and (2) to this Form 4.

SEC source: 0001209191-18-048366 · doc4.xml · derivative · entry 3

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,400

Underlying: Common Stock · 25,000 shares

Expires 2025-12-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option vested 25% on December 14, 2016 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-048366 · doc4.xml · nonDerivative · entry 2

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,177

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2016.

SEC source: 0001209191-18-048366 · doc4.xml · nonDerivative · entry 1

Reilly Joseph H. · CIK 0001610499 · SVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,177

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-18-045007 · doc4.xml · derivative · entry 1

Smith Devin Whittemore · CIK 0001747818 · SVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2028-08-01

F1 · derivative.exercise_date: This option vests as to 25% of the shares on July 23, 2019 and then in quarterly installments over 3 years thereafter.

SEC source: 0001209191-18-045008 · doc4.xml · derivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-08-01

F1 · derivative.exercise_date: This option shall vest quarterly over one year commencing on August 1, 2018.

SEC source: 0001209191-18-042871 · doc4.xml · derivative · entry 1

HILLEMAN JERYL L · CIK 0001216628 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-07-16

F1 · derivative.exercise_date: The shares subject to this option vest in equal monthly installments commencing on the one-month anniversary of July 16, 2018, subject to the continued service of the Reporting Person as a non-employee director on each vesting date.

SEC source: 0001209191-18-036991 · doc4.xml · derivative · entry 1

VAN HEEK G JAN · CIK 0001021040 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: The shares subject to this option vest in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 7, 2018 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-036986 · doc4.xml · derivative · entry 1

Laghrissi-Thode Fouzia · CIK 0001642015 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: The shares subject to this option vest in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 7, 2018 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-036979 · doc4.xml · derivative · entry 1

Kupfer David · CIK 0001642053 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: The shares subject to this option vest in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 7, 2018 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-036966 · doc4.xml · derivative · entry 1

DOYLE WILLIAM F · CIK 0001194459 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: The shares subject to this option vest in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 7, 2018 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-036972 · doc4.xml · derivative · entry 1

HASLER HANS PETER · CIK 0001226286 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: The shares subject to this option vest in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 7, 2018 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 10

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2020-01-31

F5 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 1, 2017 and provides for vesting in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 1, 2017 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

F5 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 1, 2017 and provides for vesting in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 1, 2017 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 9

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires 2027-05-31

F5 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 1, 2017 and provides for vesting in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 1, 2017 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

F5 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 1, 2017 and provides for vesting in four equal quarterly installments at a rate of 1/4 of the total number of shares every three months, with the first 1/4 vesting on the date that is three months following June 1, 2017 and an additional 1/4 every three months thereafter, subject in each case to the continued service of the Reporting Person as a non-employee director as of such vesting date.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 8

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2020-01-31

F4 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 16, 2016 and is fully vested.

F4 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 16, 2016 and is fully vested.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 7

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires 2026-06-15

F4 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 16, 2016 and is fully vested.

F4 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 16, 2016 and is fully vested.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 6

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2020-01-31

F3 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on February 2, 2015 and is fully vested.

F3 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on February 2, 2015 and is fully vested.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 5

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2025-02-01

F3 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on February 2, 2015 and is fully vested.

F3 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on February 2, 2015 and is fully vested.

SEC source: 0001209191-18-007242 · doc4.xml · derivative · entry 4

Beer Marc D · CIK 0001314575 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 127,513

Underlying: Common Stock · 127,513 shares

Expires 2020-01-31

F2 · kind: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 30, 2014 and is fully vested.

F2 · derivative.exercise_date: The two reported transactions involved an amendment of an outstanding option, resulting in the deemed cancellation of the "old" option and the grant of a replacement option. The option was originally granted on June 30, 2014 and is fully vested.