INSM

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 12

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,348

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 11

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F6 · price: This is the weighted average sales price representing 11,317 shares sold at prices ranging from $31.75 to $32.00 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 10

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,665

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 9

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F5 · price: This is the weighted average sales price representing 1,000 shares sold at prices ranging from $32.60 to $32.64 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 8

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,348

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 7

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F4 · price: This is the weighted average sales price representing 14,351 shares sold at prices ranging from $32.47 to $32.53 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 6

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 108,699

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 5

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F3 · price: This is the weighted average sales price representing 10,649 shares sold at prices ranging from $32.23 to $32.46 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 4

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,997

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 3

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F2 · price: This is the weighted average sales price representing 12,683 shares sold at prices ranging from $32.02 to $32.58 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 2

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,031

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-105778 · a4.xml · nonDerivative · entry 3

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 236,890

F2 · price: This is the weighted average sales price representing 9,900 shares sold at prices ranging from $30.89 to $31.14 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-105778 · a4.xml · nonDerivative · entry 2

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Baby Gator LLC

Disclosed balance after: 9,900

F1 · price: This is the weighted average sales price representing 10,000 shares sold at prices ranging from $29.94 to $30.86 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

F3 · ownership.nature: The Reporting Person is a managing member of Baby Gator LLC.

SEC source: 0001104659-20-105778 · a4.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Baby Gator LLC

Disclosed balance after: 19,900

F3 · ownership.nature: The Reporting Person is a managing member of Baby Gator LLC.

SEC source: 0001104659-20-094674 · a4.xml · derivative · entry 10

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Underlying: Common Stock · 4,000 shares

Expires 2023-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: On May 23, 2013, the reporting person was granted an option to purchase 25,000 shares of common stock. The option vests in two installments based upon the Issuer's satisfaction of two separate performance metrics. The first installment vested on February 26, 2015. The performance metric applicable to the second installment, the first written approval of a New Drug Application or Marketing Authorization Application from the Food and Drug Administration of European Medicines Agency, respectively, was met on September 28, 2018, resulting in the vesting of the second installment.

SEC source: 0001104659-20-094674 · a4.xml · derivative · entry 9

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 465 shares

Expires 2023-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 7

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,227

F4 · price: This is the weighted average sales price representing 4,000 shares sold at prices ranging from $28.71 to $28.95 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 6

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,227

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 5

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,227

F3 · price: This is the weighted average sales price representing 465 shares sold at prices ranging from $28.75 to $28.79 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 4

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,692

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-094674 · a4.xml · derivative · entry 8

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 465

Underlying: Common Stock · 3,761 shares

Expires 2023-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 3

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,227

F2 · price: This is the weighted average sales price representing 3,761 shares sold at prices ranging from $30.00 to $30.45 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,988

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-093991 · a4.xml · derivative · entry 4

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,744

Underlying: Common Stock · 52,046 shares

Expires 2029-01-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: twenty five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001104659-20-093991 · a4.xml · nonDerivative · entry 3

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,213

F2 · price: This is the weighted average sales price representing 52,046 shares sold at prices ranging from $30.12 to $30.49 per share. The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001104659-20-093991 · a4.xml · nonDerivative · entry 2

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,259

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-093991 · a4.xml · nonDerivative · entry 1

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,253

F1 · security: Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error.

SEC source: 0001104659-20-094674 · a4.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,227

F1 · security: Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error.

SEC source: 0001104659-20-121948 · a4.xml · nonDerivative · entry 1

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,348

F1 · shares: Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error.

SEC source: 0001104659-20-122622 · a4.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair&Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 129,787

F1 · shares: Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error.

SEC source: 0001104659-21-001605 · tm211774d4_4seq1.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,031

F1 · shares: Represents the withholding of shares of common stock to satisfy tax withholding obligations in connection with the vesting of restricted stock units. This transaction was not reported previously due to a clerical error.

SEC source: 0001104659-20-061859 · a4.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 246,790

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061858 · a4.xml · nonDerivative · entry 1

SCHAFER CAROL · CIK 0001272181 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,702

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061856 · a4.xml · nonDerivative · entry 1

LEE LEO · CIK 0001740789 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,062

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061857 · a4.xml · nonDerivative · entry 1

MCGIRR DAVID W J · CIK 0001219023 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,358

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061855 · a4.xml · nonDerivative · entry 1

ENGELSEN STEINAR J · CIK 0001218860 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 296,299

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061854 · a4.xml · nonDerivative · entry 1

Desjardins Clarissa · CIK 0001793390 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,392

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061853 · a4.xml · nonDerivative · entry 1

ALTOMARI ALFRED · CIK 0001285644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,938

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061852 · a4.xml · derivative · entry 1

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,890

Underlying: Common Stock · 34,890 shares

Expires 2030-05-12

F1 · derivative.exercise_date: The option becomes exercisable based on the following vesting schedule: twenty-five percent (25%) vests on the first anniversary of the date of grant and twelve and one-half percent (12.5%) vests on each six-month anniversary date thereafter through the fourth anniversary of the date of grant, subject to Ms. Bonstein's continued employment with the Company on each vesting date.

SEC source: 0001104659-20-061851 · a4.xml · nonDerivative · entry 1

Brennan David R · CIK 0001609305 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,318

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-061850 · a4.xml · nonDerivative · entry 1

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,114

F1 · shares: Represents Restricted Stock Units, each representing a contingent right to receive one share of Common Stock. The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of the vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 12, 2020 for no consideration.

SEC source: 0001104659-20-042576 · a4.xml · nonDerivative · entry 1

SCHAFER CAROL · CIK 0001272181 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,605

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on April 1, 2020, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-20-000034 · edgar.xml · derivative · entry 1

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,640

Underlying: Common Stock · 91,640 shares

Expires 2030-02-03

F1 · derivative.exercise_date: In connection with the appointment of Ms. Bonstein as the Company's Chief Financial Officer, the Company granted Ms. Bonstein an option to purchase a total of 91,640 shares of the Company's common stock. The option becomes exercisable based on the following vesting schedule: twenty-five percent (25%) vest on the first anniversary of the date of grant and twelve and one-half percent (12.5%) vest on each six month anniversary date thereafter through the fourth anniversary of the date of grant, subject to Ms. Bonstein's continued employment with the Company on each vesting date.

SEC source: 0001127430-20-000023 · edgar.xml · derivative · entry 3

GOLL JOHN · CIK 0001779466 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,260

Underlying: Common Stock · 28,260 shares

Expires 2030-01-03

F5 · derivative.exercise_date: Stock options granted under the Company's 2019 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-20-000023 · edgar.xml · nonDerivative · entry 2

GOLL JOHN · CIK 0001779466 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,166

F4 · price: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.

SEC source: 0001127430-20-000023 · edgar.xml · nonDerivative · entry 1

GOLL JOHN · CIK 0001779466 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,374

F1 · shares: Restricted stock units granted pursuant to the Company's 2019 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant for four years.

F2 · price: Each Restricted Stock Unit was granted on January 3, 2020, for no consideration, and represents a contingent right to receive one share of Common Stock.

F3 · balance_after: Includes 2,751 shares acquired through the Company's 2018 Employee Stock Purchase Plan.

SEC source: 0001127430-20-000027 · edgar.xml · derivative · entry 2

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,520

Underlying: Common Stock · 56,520 shares

Expires 2030-01-03

F4 · derivative.exercise_date: Stock options granted under the Company's 2019 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-20-000027 · edgar.xml · nonDerivative · entry 1

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,207

F1 · shares: Restricted stock units granted pursuant to the Company's 2019 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant for four years.

F2 · price: Each Restricted Stock Unit was received as a grant on January 3, 2020, for no consideration, and represents a contingent right to receive one share of Common Stock.

F3 · balance_after: Includes 2,746 shares acquired through the Company's 2018 Employee Stock Purchase Plan.

SEC source: 0001127430-20-000025 · edgar.xml · derivative · entry 3

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,300

Underlying: Common Stock · 141,300 shares

Expires 2030-01-03

F5 · derivative.exercise_date: Stock options granted under the Company's 2019 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-20-000025 · edgar.xml · nonDerivative · entry 2

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,867

F4 · price: Shares withheld by the Company to satisfy tax withholding requirements on vesting of time-based restricted stock units.