GCMG

SEC source: 0001628280-22-000083 · wf-form4_164124525978946.xml · nonDerivative · entry 1

Blanton Angela · CIK 0001831814 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,902

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-22-000085 · wf-form4_164124532615393.xml · nonDerivative · entry 1

MASTERS BLYTHE · CIK 0001648686 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,378

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-22-000080 · wf-form4_164124519856357.xml · nonDerivative · entry 1

SCOTT SAMUEL C III · CIK 0001202862 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,902

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-21-019470 · wf-form4_163311989140117.xml · nonDerivative · entry 1

Blanton Angela · CIK 0001831814 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,140

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-21-019469 · wf-form4_163311979077531.xml · nonDerivative · entry 1

MASTERS BLYTHE · CIK 0001648686 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,425

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-21-019468 · wf-form4_163311972023484.xml · nonDerivative · entry 1

SCOTT SAMUEL C III · CIK 0001202862 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,140

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001707785-21-000002 · wf-form4_162923149885491.xml · nonDerivative · entry 1

Idehen Francis Osarume · CIK 0001707785 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,566.33

F1 · shares: Represents shares of Class A Common Stock that have been withheld by the Issuer to satisfy tax withholding obligations of the Reporting Person in connection with the net settlement of vested restricted stock units ("RSUs"). The shares withheld represent a reduction of shares issued to the Reporting Person upon settlement of vested RSUs and do not constitute any open-market sale.

SEC source: 0001684847-21-000002 · wf-form4_162923157902176.xml · nonDerivative · entry 1

SULLIVAN KATHLEEN PATRICIA · CIK 0001684847 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,638.67

F1 · shares: Represents shares of Class A Common Stock that have been withheld by the Issuer to satisfy tax withholding obligations of the Reporting Person in connection with the net settlement of vested restricted stock units ("RSUs"). The shares withheld represent a reduction of shares issued to the Reporting Person upon settlement of vested RSUs and do not constitute any open-market sale.

SEC source: 0001680611-21-000002 · wf-form4_162923142521925.xml · nonDerivative · entry 1

Pollock Frederick · CIK 0001680611 · Chief Investment Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,250

F1 · shares: Represents shares of Class A Common Stock that have been withheld by the Issuer to satisfy tax withholding obligations of the Reporting Person in connection with the net settlement of vested restricted stock units ("RSUs"). The shares withheld represent a reduction of shares issued to the Reporting Person upon settlement of vested RSUs and do not constitute any open-market sale.

SEC source: 0001628280-21-017178 · wf-form4_162923134282846.xml · nonDerivative · entry 1

Bentley Pamela L · CIK 0001610089 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,580.67

F1 · shares: Represents shares of Class A Common Stock that have been withheld by the Issuer to satisfy tax withholding obligations of the Reporting Person in connection with the net settlement of vested restricted stock units ("RSUs"). The shares withheld represent a reduction of shares issued to the Reporting Person upon settlement of vested RSUs and do not constitute any open-market sale.

SEC source: 0001628280-21-013362 · wf-form4_162517124057931.xml · nonDerivative · entry 1

Blanton Angela · CIK 0001831814 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,799

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-21-013358 · wf-form4_162517091973137.xml · nonDerivative · entry 1

MASTERS BLYTHE · CIK 0001648686 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,999

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0001628280-21-013357 · wf-form4_162517078749382.xml · nonDerivative · entry 1

SCOTT SAMUEL C III · CIK 0001202862 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,799

F1 · kind: This award of Class A Common Stock of the Issuer was granted pursuant to the Issuer's 2020 Incentive Award Plan, in lieu of quarterly cash compensation at the election of the Reporting Person, and is fully vested as of the date of grant.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 21

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,942,786

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 20

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,922,807

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 19

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,919,989

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 18

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,913,427

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 17

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,911,385

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 16

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,886,385

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 15

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,849,833

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 14

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,824,833

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 13

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,774,833

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 12

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,759,833

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 11

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,745,279

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 10

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,737,384

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 9

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,734,799

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 8

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,693,684

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 7

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,668,684

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 6

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,643,684

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 5

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,693,684

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 4

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,697,105

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 3

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,722,105

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 2

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,737,105

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003498 · ownership.xml · nonDerivative · entry 1

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,762,105

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 30

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,765,553

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 29

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,715,553

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 28

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,716,442

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 27

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,741,442

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 26

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,776,348

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 25

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,784,338

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 24

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,834,338

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 23

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,879,046

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 22

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,879,946

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 21

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,929,946

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 20

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,964,946

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 19

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,979,946

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 18

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,018,346

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 17

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,058,412

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 16

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,058,514

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.

SEC source: 0000902664-21-003497 · ownership.xml · nonDerivative · entry 15

ADAGE CAPITAL PARTNERS GP, L.L.C. · CIK 0001165408 · 10% owner

Adage Capital Partners, L.P. · CIK 0001163846 · 10% owner

Adage Capital Advisors, L.L.C. · CIK 0001403403 · 10% owner

Atchinson Robert · CIK 0001403404 · 10% owner

Gross Phillip · CIK 0001403413 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,093,514

F1 · ownership.nature: The securities to which this filing relates are held directly by Adage Capital Partners, L.P., a Delaware limited partnership (the "Fund"). Adage Capital Partners GP, L.L.C., a Delaware limited liability company ("ACPGP"), serves as the general partner of the Fund and as such has discretion over the portfolio securities beneficially owned by the Fund. Adage Capital Advisors, L.L.C., a Delaware limited liability company ("ACA"), is the managing member of ACPGP and directs ACPGP's operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities and Exchange Act of 1934, as amended, except as to such extent of such reporting person's pecuniary interest in the securities.