TECX

SEC source: 0001415889-25-003228 · form4-02062025_040208.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,329

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003225 · form4-02062025_040201.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 101,953

Underlying: Common Stock · 101,953 shares

Expires 2035-02-03

F3 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003225 · form4-02062025_040201.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 214,344

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-002262 · form4-01292025_040101.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,514

Underlying: Common Stock · 2,700 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Received in exchange for a stock option to acquire 170,679 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017972/xslF345X05/form4-06242024_080616.xml

F1 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on March 15, 2022 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-25-002262 · form4-01292025_040101.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,700

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-028948 · form4-12112024_091246.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,214

Underlying: Common Stock · 2,000 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Received in exchange for a stock option to acquire 170,679 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017972/xslF345X05/form4-06242024_080616.xml

F1 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on March 15, 2022 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-24-028948 · form4-12112024_091246.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-028516 · form4-12062024_101244.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Common Stock · 6,000 shares

Expires 2034-12-03

F4 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-24-028516 · form4-12062024_101244.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,297

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 4 equal annual installments with the first installment vesting on June 20, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · balance_after: 4,079 of these shares are subject to vesting and a repurchase right in favor of the Issuer. Such repurchase right will lapse on December 31, 2024 so long as the Reporting Person continues to provide service to the Issuer on such vesting date.

SEC source: 0001415889-24-028404 · form4-12052024_091203.xml · derivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,459

Underlying: Common Stock · 34,459 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Received in exchange for a stock option to acquire 71,029 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017962/xslF345X05/form4-06242024_080611.xml.

F1 · derivative.exercise_date: 25% of the shares subject to the option vested on June 1, 2022; and the remainder of the shares subject to the option vest in 36 equal monthly installments with the final amount vesting on June 1, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-24-028404 · form4-12052024_091203.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,188

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-24-025603 · form4-10242024_091007.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,096,764

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 7

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,796,764

F7 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $30.80 to $30.90 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 6

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,794,364

F6 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $29.75 to $30.63 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 5

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,790,294

F5 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $28.69 to $29.68 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 4

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,771,295

F4 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $27.68 to $28.66 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 3

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 186,134

F3 · kind: Represents the acquisition of the shares from TAS, as more specifically described in Footnote (1) herein.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 2

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,746,764

F3 · kind: Represents the acquisition of the shares from TAS, as more specifically described in Footnote (1) herein.

SEC source: 0001415889-24-024003 · form4-09262024_100948.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 310,223

F1 · kind: Represents a distribution in kind, for no additional consideration, by TAS Partners, LLC ("TAS") to the Reporting Person and his spouse.

F2 · ownership.nature: These shares are held by TAS. The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-017958 · form4-06242024_080618.xml · derivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,000

Underlying: Common Stock · 118,000 shares

Expires 2034-06-19

F1 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date and to certain change of control acceleration provisions.

SEC source: 0001415889-24-017984 · form4-06242024_080610.xml · derivative · entry 3

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,760

Underlying: Common Stock · 11,760 shares

Expires 2034-06-19

F4 · derivative.exercise_date: 1/3rd of the shares subject to the option will vest on June 20, 2025, and the balance will vest in equal monthly installments thereafter over the next 24 months, subject in each case to the continuous service of the Reporting Person to the Issuer through the applicable vesting date.

SEC source: 0001415889-24-017984 · form4-06242024_080610.xml · nonDerivative · entry 2

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,551,116

F2 · price: Received in exchange for 2,902,429 shares of common stock of Tectonic on the same terms and conditions as set forth in footnote (1) herein.

F3 · ownership.nature: These shares are held by TAS Partners, LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-017984 · form4-06242024_080610.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,692,005

F1 · price: Received in exchange for 5,037,245 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001415889-24-017975 · form4-06242024_080618.xml · derivative · entry 4

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,760

Underlying: Common Stock · 11,760 shares

Expires 2034-06-19

F7 · derivative.exercise_date: 1/3rd of the shares subject to the option will vest on June 20, 2025, and the balance will vest in equal monthly installments thereafter over the next 24 months, subject in each case to the continuous service of the Reporting Person to the Issuer through the applicable vesting date.

SEC source: 0001415889-24-017975 · form4-06242024_080618.xml · nonDerivative · entry 3

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 64,652

F5 · price: Received in exchange for 120,976 shares of common stock of Tectonic on the same terms and conditions as set forth in footnote (1) herein.

F6 · ownership.nature: The reportable securities are owned directly by Polaris Founders Capital II, LP. ("PFC II"). Polaris Founders Capital Management Co. I, L.L.C. ("PFCM II") is the general partner of PFC II. Each of the Reporting Person, a member of the Issuer's board of directors, and Jonathan Flint are the managing members of PFCM II (the "PFCM II Managing Members"). Each of PFCM II and the PFCM II Managing Members, in their respective capacities with respect to PFCM II, may be deemed to have shared voting, investment and dispositive power with respect to the securities held by PFC II, and each disclaims beneficial ownership of these securities, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-24-017975 · form4-06242024_080618.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 20,262

F3 · price: Received in exchange for 37,914 shares of common stock of Tectonic on the same terms and conditions as set forth in footnote (1) herein.

F4 · ownership.nature: The reportable securities are owned directly by Polaris Founders Capital I, LP. ("PFC I"). Polaris Founders Capital Management Co. I, L.L.C. ("PFCM I") is the general partner of PFC I. Each of the Reporting Person, a member of the Issuer's board of directors, and Jonathan Flint are the managing members of PFCM I (the "PFCM I Managing Members"). Each of PFCM I and the PFCM I Managing Members, in their respective capacities with respect to PFCM I, may be deemed to have shared voting, investment and dispositive power with respect to the securities held by PFC I, and each disclaims beneficial ownership of these securities, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-24-017975 · form4-06242024_080618.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 1,073,062

F1 · price: Received in exchange for 2,007,902 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Partners IX, L.P. ("PP IX"). Polaris Partners GP IX, L.L.C. ("PP GP IX") is the general partner of PP IX. Each of David Barrett, Brian Chee, Amir Nashat and Amy Schulman are the managing members of PP GP IX (collectively, the "PP IX GP Managing Members"), and the Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX. Each of PP GP IX, the PP IX GP Managing Members and the Reporting Person, in their respective capacities with respect to PP GP IX, may be deemed to have shared voting, investment and dispositive power with respect to the securities held by PP IX, and each disclaims beneficial ownership of these securities, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 4

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,700

Underlying: Common Stock · 81,700 shares

Expires 2034-06-19

F7 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 3

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,704

Underlying: Common Stock · 18,704 shares

Expires 2033-11-30

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F6 · price: Received in exchange for a stock option to acquire 35,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F5 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on December 1, 2023, subject to the Reporting Person's continued service to the Issuer on each such vesting date

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,946

Underlying: Common Stock · 43,946 shares

Expires 2031-09-16

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F4 · price: Received in exchange for a stock option to acquire 82,233 shares of Tectonic common stock pursuant to the Merger Agreement.

F3 · derivative.exercise_date: 23,360 of the shares subject to the option are immediately exercisable and the remainder vest in 13 equal monthly installments beginning on July 19, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,065

F1 · price: Received in exchange for 60,000 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001415889-24-017972 · form4-06242024_080616.xml · derivative · entry 3

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,600

Underlying: Common Stock · 61,600 shares

Expires 2034-06-19

F6 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-24-017972 · form4-06242024_080616.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,016

Underlying: Common Stock · 8,016 shares

Expires 2033-11-30

F1 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F1 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F1 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F5 · price: Received in exchange for a stock option to acquire 15,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F4 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on December 1, 2023, subject to the Reporting Person's continued service to the Issuer on each such vesting date

F1 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017972 · form4-06242024_080616.xml · derivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,214

Underlying: Common Stock · 91,214 shares

Expires 2031-06-27

F1 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F1 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F1 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F3 · price: Received in exchange for a stock option to acquire 170,679 shares of Tectonic common stock pursuant to the Merger Agreement.

F2 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on March 15, 2022 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

F1 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017962 · form4-06242024_080611.xml · derivative · entry 5

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 77,000

Underlying: Common Stock · 77,000 shares

Expires 2034-06-19

F9 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-24-017962 · form4-06242024_080611.xml · derivative · entry 4

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,704

Underlying: Common Stock · 18,704 shares

Expires 2033-11-30

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F8 · price: Received in exchange for a stock option to acquire 35,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F7 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on December 1, 2023, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017962 · form4-06242024_080611.xml · derivative · entry 3

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,065

Underlying: Common Stock · 32,065 shares

Expires 2032-06-26

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F6 · price: Received in exchange for a stock option to acquire 60,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F5 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on June 27, 2022, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017962 · form4-06242024_080611.xml · derivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,959

Underlying: Common Stock · 37,959 shares

Expires 2031-06-27

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F4 · price: Received in exchange for a stock option to acquire 71,029 shares of Tectonic common stock pursuant to the Merger Agreement.

F3 · derivative.exercise_date: 25,796 of the shares subject to the option are immediately exercisable. The remainder of the shares subject to the option vest in 12 equal monthly installments beginning on July 1, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017962 · form4-06242024_080611.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,688

F1 · price: Received in exchange for 20,000 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001415889-24-017992 · form4-06242024_080630.xml · derivative · entry 3

Tipirneni Praveen P. · CIK 0001779978 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,760

Underlying: Common Stock · 11,760 shares

Expires 2034-06-19

F5 · derivative.exercise_date: 1/3rd of the shares subject to the option will vest on June 20, 2025, and the balance will vest in equal monthly installments thereafter over the next 24 months, subject in each case to the continuous service of the Reporting Person to the Issuer through the applicable vesting date.

SEC source: 0001415889-24-017992 · form4-06242024_080630.xml · derivative · entry 2

Tipirneni Praveen P. · CIK 0001779978 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,166

Underlying: Common Stock · 12,166 shares

Expires 2031-06-27

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F4 · price: Received in exchange for a stock option to acquire 22,765 shares of Tectonic common stock pursuant to the Merger Agreement.

F3 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on February 12, 2021 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017992 · form4-06242024_080630.xml · nonDerivative · entry 1

Tipirneni Praveen P. · CIK 0001779978 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,037

F1 · price: Received in exchange for 5,682 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001415889-24-017998 · form4-06242024_080629.xml · derivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,760

Underlying: Common Stock · 11,760 shares

Expires 2034-06-19

F1 · derivative.exercise_date: 1/3rd of the shares subject to the option will vest on June 20, 2025, and the balance will vest in equal monthly installments thereafter over the next 24 months, subject in each case to the continuous service of the Reporting Person to the Issuer through the applicable vesting date.

SEC source: 0001415889-24-017995 · form4-06242024_080632.xml · derivative · entry 3

Vitorovic Stefan · CIK 0001826967 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,760

Underlying: Common Stock · 11,760 shares

Expires 2034-06-19

F5 · derivative.exercise_date: 1/3rd of the shares subject to the option will vest on June 20, 2025, and the balance will vest in equal monthly installments thereafter over the next 24 months, subject in each case to the continuous service of the Reporting Person to the Issuer through the applicable vesting date.

SEC source: 0001415889-24-017995 · form4-06242024_080632.xml · nonDerivative · entry 2

Vitorovic Stefan · CIK 0001826967 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 27,774

F3 · price: Received in exchange for 51,969 shares of common stock held by Vida Ventures II-A, LLC ("VIDA II-A") of Tectonic pursuant to the same terms and conditions as described in footnote (1) herein.

F4 · ownership.nature: The Reporting Person, through his position as a member of the investment committee of VV Manager, the manager of VIDA II-A, may be deemed to have voting and dispositive power over the shares held by VIDA II-A. The Reporting Person disclaims beneficial ownership of the shares held by VIDA II-A, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-017995 · form4-06242024_080632.xml · nonDerivative · entry 1

Vitorovic Stefan · CIK 0001826967 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,000,900

F1 · price: Received in exchange for 1,872,873 shares of common stock held by Vida Ventures II, LLC ("VIDA II") of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

F2 · ownership.nature: The Reporting Person, through his position as a member of the investment committee of VV Manager II, LLC ("VV Manager"), the manager of VIDA II, may be deemed to have voting and dispositive power over the shares held by VIDA II. The Reporting Person disclaims beneficial ownership of the shares held by VIDA II, except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-24-017954 · form4-06242024_080632.xml · derivative · entry 3

Cortis Christian · CIK 0001744495 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,704

Underlying: Common Stock · 18,704 shares

Expires 2033-11-30

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F6 · price: Received in exchange for a stock option to acquire 35,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F5 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on December 1, 2023, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017954 · form4-06242024_080632.xml · derivative · entry 2

Cortis Christian · CIK 0001744495 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,061

Underlying: Common Stock · 56,061 shares

Expires 2031-06-27

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F4 · price: Received in exchange for a stock option to acquire 104,901 shares of Tectonic common stock pursuant to the Merger Agreement.

F3 · derivative.exercise_date: 22,508 shares subject to the option are fully vested. The remaining shares subject to the option vest in 10 equal monthly installments beginning on June 30, 2024, such that the option will be fully vested on March 31, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017954 · form4-06242024_080632.xml · nonDerivative · entry 1

Cortis Christian · CIK 0001744495 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,368

F1 · price: Received in exchange for 236,458 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.

SEC source: 0001415889-24-017952 · form4-06242024_080648.xml · derivative · entry 5

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 289,600

Underlying: Common Stock · 289,600 shares

Expires 2034-06-19

F10 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.