Ruddy Marcella K.

SEC source: 0002023849-26-000014 · form4-10022026_081032.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,157

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on September 25, 2025.

SEC source: 0002023849-26-000012 · form4-09082026_040903.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-09-02

F1 · derivative.exercise_date: 1/8th of the shares subject to the option vest on September 3, 2026 with the remaining shares subject to the option vesting in the following 42 equal monthly installments beginning on October 3, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000010 · edgardoc.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,340

Underlying: Common Stock · 17,340 shares

Expires 2036-06-16

F1 · derivative.exercise_date: This option vests in full upon the earlier of June 17, 2027 or the date of the next annual meeting of Sionna Therapeutics, Inc., subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001193125-26-268169 · ownership.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,096

Underlying: Common Stock · 17,096 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares underlying this option shall vest in full upon the earlier of (i) June 9, 2027 and (ii) the date of the next Annual Meeting of Stockholders of the Issuer, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0002023849-26-000008 · form4-05062026_050501.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,682

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0002023849-26-000006 · form4-04032026_080442.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,747

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0002023849-26-000004 · form4-03092026_100315.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,747

F1 · kind: This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 8, 2025.

SEC source: 0002023849-26-000003 · form4-03052026_100303.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,250

Underlying: Common Stock · 24,250 shares

Expires 2036-03-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on April 4, 2026, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000003 · form4-03052026_100303.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,747

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of March 4, 2027, March 4, 2028 and March 4, 2029, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-26-000002 · form4-02102026_090218.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,247

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0002023849-25-000003 · form4-09292025_050903.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,750

Underlying: Common Stock · 9,750 shares

Expires 2035-09-24

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-25-000003 · form4-09292025_050903.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,311

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002036042-25-000031 · edgardoc.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,959

Underlying: Common Stock · 19,959 shares

Expires 2035-06-11

F1 · derivative.exercise_date: This option vests in full upon the earlier of June 12, 2026 or the date of the next annual meeting of Sionna Therapeutics, Inc., subject to the Reporting Person's continued service on such vesting date.

SEC source: 0000950170-25-085382 · ownership.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,096

Underlying: Common Stock · 17,096 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares underlying this option shall vest upon the earlier of (i) June 10, 2026 and (ii) the date of the next Annual Meeting of Stockholders of the Issuer, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0000950170-25-017037 · ownership.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,919

Underlying: Common Stock · 39,919 shares

Expires 2035-02-05

F1 · derivative.exercise_date: The shares underlying this option vest in three equal annual installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001415889-25-003226 · form4-02062025_040203.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,502

Underlying: Common Stock · 32,502 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003226 · form4-02062025_040203.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,941

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0000950170-24-114684 · ownership.xml · derivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,096

Underlying: Common Stock · 17,096 shares

Expires 2034-10-09

F1 · derivative.exercise_date: The shares underlying this option shall vest upon the earlier of (i) October 10, 2025 and (ii) the date of the next Annual Meeting of Stockholders of the Issuer, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 4

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,700

Underlying: Common Stock · 81,700 shares

Expires 2034-06-19

F7 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on June 20, 2025 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 3

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,704

Underlying: Common Stock · 18,704 shares

Expires 2033-11-30

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F6 · price: Received in exchange for a stock option to acquire 35,000 shares of Tectonic common stock pursuant to the Merger Agreement.

F5 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on December 1, 2023, subject to the Reporting Person's continued service to the Issuer on each such vesting date

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,946

Underlying: Common Stock · 43,946 shares

Expires 2031-09-16

F2 · derivative.exercise_price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F2 · price: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

F4 · price: Received in exchange for a stock option to acquire 82,233 shares of Tectonic common stock pursuant to the Merger Agreement.

F3 · derivative.exercise_date: 23,360 of the shares subject to the option are immediately exercisable and the remainder vest in 13 equal monthly installments beginning on July 19, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · derivative.underlying_shares: Upon the closing of the Merger, each outstanding option to purchase shares of Tectonic common stock was assumed by the Issuer and converted into an option to purchase the Issuer's common stock, on the same terms and conditions as were applicable to such Tectonic stock option prior to the Merger, as adjusted for the exchange ratio and the reverse stock split.

SEC source: 0001415889-24-017964 · form4-06242024_080626.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,065

F1 · price: Received in exchange for 60,000 shares of common stock of Tectonic Therapeutic, Inc., a Delaware corporation ("Tectonic"), pursuant to an Agreement and Plan of Merger dated as of January 30, 2024 (the "Merger Agreement") by and among AVROBIO, Inc., a Delaware corporation ("AVROBIO"), Tectonic and Alpine Merger Subsidiary, Inc., a direct, wholly owned subsidiary of AVROBIO (the "Merger Sub"). Under the terms of the Merger Agreement, on June 20, 2024, Merger Sub merged with and into Tectonic (the "Merger"), with Tectonic surviving the Merger as a wholly owned subsidiary of AVROBIO. Upon the closing of the Merger, each share of Tectonic common stock was converted into the right to receive 0.534419990 shares of the Issuer's common stock, after giving effect to a reverse stock split of the Issuer's common stock of 1-for-12. Subsequent to the Merger, the name of the Issuer was changed from AVROBIO, Inc. to Tectonic Therapeutic, Inc.