TECX

SEC source: 0001757533-26-000008 · form4a-03052026_040323.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 127,030

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $21.02 to $21.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: These shares are held by the Reicin-Boiarsky Family Trust (the "Trust"). The Reporting Person's spouse is a co-trustee of the Trust. Accordingly, the Reporting Person may be deemed to have shared voting and dispositive power over the securities held by the Trust. The Reporting Person disclaims beneficial ownership of the shares held by the Trust except to the extent of her pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001791187-26-000003 · form4-02112026_100208.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,044

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $21.24 to $21.82, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0002023175-26-000003 · form4-02122026_040201.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,014

Underlying: Common Stock · 4,500 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Received in exchange for a stock option to acquire 170,679 shares of Tectonic common stock pursuant to that certain merger, as more specifically described in the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017972/xslF345X05/form4-06242024_080616.xml

F1 · derivative.exercise_date: The shares subject to the option vest as to 25% of the shares on March 15, 2022 with the remainder vesting in the following 36 equal monthly installments, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0002023175-26-000003 · form4-02122026_040201.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,814

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001791187-26-000002 · form4-02102026_090247.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,044

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0002023849-26-000002 · form4-02102026_090218.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,247

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0002023175-26-000002 · form4-02102026_090237.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,314

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0002023255-26-000002 · form4-02102026_090217.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,131

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0001757533-26-000004 · form4-02102026_090253.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,047

F1 · shares: This transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the vesting and settlement of the restricted stock units granted on February 4, 2025.

SEC source: 0001757533-26-000002 · form4-01052026_100128.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,957

Underlying: Common Stock · 10,966 shares

Expires 2031-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Received in exchange for a stock option to acquire 63,478 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017952/xslF345X05/form4-06242024_080648.xml

F2 · derivative.exercise_date: The shares subject to the option vested as follows: (i) 4,079 shares on June 30, 2024; (ii) 4,078 shares on July 31, 2024, (iii) 4,078 shares on August 31, 2024, (iv) 4,079 shares on September 30, 2024, (v) 4,078 shares on October 31, 2024, (vi) 1,297 shares on November 30, 2024, (vii) 4,078 shares on January 31, 2025, (viii) 4,078 shares on February 28, 2025 and (iv) 4,078 shares on March 31, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date..

SEC source: 0001757533-26-000002 · form4-01052026_100128.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 239,151

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0002023255-25-000005 · form4-12292025_041201.xml · derivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,065

Underlying: Common Stock · 7,000 shares

Expires 2032-06-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Received in exchange for a stock option to acquire 60,000 shares of common stock pursuant to that certain merger, as more fully described on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on June 24, 2024. https://www.sec.gov/Archives/edgar/data/1681087/000141588924017962/xslF345X05/form4-06242024_080611.xml

F1 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on June 27, 2022, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-25-000005 · form4-12292025_041201.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,879

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001791187-25-000003 · form4-09292025_050905.xml · derivative · entry 2

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,860

Underlying: Common Stock · 9,860 shares

Expires 2035-09-24

F3 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001791187-25-000003 · form4-09292025_050905.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,121

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

F2 · balance_after: Please note that the total number of securities beneficially owned following the reported transaction has been corrected to reflect the correct amount. The amount reported on the Reporting Person's Form 4 filed with the Securities and Exchange Commission on February 7, 2025 should have reflected that the total number of securities beneficially owned following the reported transaction was 22,691 shares instead of 4,617 shares.

SEC source: 0002023175-25-000003 · form4-09292025_050908.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,650

Underlying: Common Stock · 7,650 shares

Expires 2035-09-24

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023175-25-000003 · form4-09292025_050908.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,933

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-25-000003 · form4-09292025_050903.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,750

Underlying: Common Stock · 9,750 shares

Expires 2035-09-24

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023849-25-000003 · form4-09292025_050903.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,311

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-25-000003 · form4-09292025_050907.xml · derivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,260

Underlying: Common Stock · 8,260 shares

Expires 2035-09-24

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0002023255-25-000003 · form4-09292025_050907.xml · nonDerivative · entry 1

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,879

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001757533-25-000004 · form4-09292025_050901.xml · derivative · entry 3

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,710

Underlying: Common Stock · 26,710 shares

Expires 2035-09-24

F3 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on October 25, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001757533-25-000004 · form4-09292025_050901.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,185

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of September 25, 2026, September 25, 2027 and September 25, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-018106 · form4-06242025_080636.xml · nonDerivative · entry 1

REICIN ALISE · CIK 0001757533 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 213,485

F1 · shares: The transaction reported represents the withholding of shares by the Issuer to satisfy the Reporting Person's tax withholding obligations in connection with the non-reportable vesting and settlement of restricted stock units granted on December 4, 2024.

SEC source: 0001415889-25-016672 · form4-06112025_040604.xml · derivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2035-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2026, (ii) the date of the Issuer's 2026 Annual Meeting of stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001415889-25-016674 · form4-06112025_040610.xml · derivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2035-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2026, (ii) the date of the Issuer's 2026 Annual Meeting of stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001415889-25-016673 · form4-06112025_040608.xml · derivative · entry 1

Tipirneni Praveen P. · CIK 0001779978 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2035-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2026, (ii) the date of the Issuer's 2026 Annual Meeting of stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001415889-25-016676 · form4-06112025_040615.xml · derivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2035-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2026, (ii) the date of the Issuer's 2026 Annual Meeting of stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001415889-25-016675 · form4-06112025_040613.xml · derivative · entry 1

Vitorovic Stefan · CIK 0001826967 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,200

Underlying: Common Stock · 10,200 shares

Expires 2035-06-08

F1 · derivative.exercise_date: The option shall vest in full on the earliest of (i) June 9, 2026, (ii) the date of the Issuer's 2026 Annual Meeting of stockholders, or (iii) a "Change in Control" (as defined in the Issuer's 2024 Equity Incentive Plan) of the Issuer, subject in each case, to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 8

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,503,358

F4 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $15.96 to $16.68 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F5 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 4

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,334,846

F4 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $15.96 to $16.68 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 7

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,449,652

F3 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $16.29 to $17.00 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F5 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 3

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,325,368

F3 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $16.29 to $17.00 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 6

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,403,794

F2 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $15.1994 to $15.2452 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F5 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 5

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,398,938

F1 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $13.9869 to $14.9578 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F5 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 2

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,317,276

F2 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $15.1994 to $15.2452 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001415889-25-010588 · form4-04112025_100403.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,316,419

F1 · price: The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $13.9869 to $14.9578 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0000950170-25-051671 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 573,062

F1 · ownership.nature: The reportable securities are owned directly by Polaris Partners IX, L.P. ("PP IX"). Polaris Partners GP IX, L.L.C. ("PP GP IX") is the general partner of PP IX. Each of David Barrett, Brian Chee, Amir Nashat and Amy Schulman are the managing members of PP GP IX (collectively, the "PP IX GP Managing Members"), and the Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX. Each of PP GP IX, the PP IX GP Managing Members and the Reporting Person, in their respective capacities with respect to PP GP IX, may be deemed to have shared voting, investment and dispositive power with respect to the securities held by PP IX, and each disclaims beneficial ownership of these securities, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-25-010499 · form4-04092025_090407.xml · nonDerivative · entry 2

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 1,382,723

F1 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-010499 · form4-04092025_090407.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,313,558

SEC source: 0001415889-25-003350 · form4-02072025_090225.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,617

F1 · kind: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

F1 · shares: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

SEC source: 0001415889-25-003351 · form4-02072025_090214.xml · nonDerivative · entry 2

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By LLC

Disclosed balance after: 970,223

F1 · kind: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

F1 · shares: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

F2 · ownership.nature: These shares are held by TAS Partners LLC ("TAS"). The Reporting Person is the sole managing member of TAS and, as such, has sole voting and dispositive power over the shares held by TAS. The Reporting Person disclaims beneficial ownership of the shares held by TAS except to the extent of his pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-003351 · form4-02072025_090214.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,226,058

F1 · kind: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

F1 · shares: These shares of common stock were purchased in a private placement transaction on February 5, 2025, which was previously announced on the Issuer's Current Report on Form 8-K, filed with the Securities and Exchange Commission on February 3, 2025. These shares were offered and sold in reliance on the exemption afforded by Regulation D of the Securities Act of 1933, as amended.

SEC source: 0001415889-25-003227 · form4-02062025_040206.xml · derivative · entry 2

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,862

Underlying: Common Stock · 32,862 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003227 · form4-02062025_040206.xml · nonDerivative · entry 1

Lochner Daniel · CIK 0001791187 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,074

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003226 · form4-02062025_040203.xml · derivative · entry 2

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,502

Underlying: Common Stock · 32,502 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003226 · form4-02062025_040203.xml · nonDerivative · entry 1

Ruddy Marcella K. · CIK 0002023849 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,941

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003229 · form4-02062025_040210.xml · derivative · entry 2

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,496

Underlying: Common Stock · 25,496 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003229 · form4-02062025_040210.xml · nonDerivative · entry 1

Schwabish Marc · CIK 0002023175 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,723

F1 · shares: These shares are represented by restricted stock units. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The shares shall vest in 3 equal annual installments on each of February 4, 2026, February 4, 2027 and February 4, 2028, subject to the Reporting Person's continued service to the Issuer on each such vesting date.

SEC source: 0001415889-25-003228 · form4-02062025_040208.xml · derivative · entry 2

McNamara Peter · CIK 0002023255 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,530

Underlying: Common Stock · 27,530 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The shares subject to the option vest in 48 equal monthly installments beginning on March 4, 2025, subject to the Reporting Person's continued service to the Issuer on each such vesting date.