SYRE

SEC source: 0001209191-21-039228 · doc4.xml · derivative · entry 1

Lawton Alison Frances · CIK 0001542650 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2021, or on the date of the next annual meeting of stockholders, if earlier, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001638599-21-000540 · doc4_7255.xml · derivative · entry 1

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director

667, L.P. · CIK 0001551139 · Director

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director

Baker Brothers Life Sciences LP · CIK 0001363364 · Director

BAKER FELIX · CIK 0001087940 · Director

BAKER JULIAN · CIK 0001087939 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-07

F1 · derivative.exercise_date: 40,000 non-qualified stock options ("Stock Options") exercisable solely into common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") were granted under the Issuer's 2016 Equity Incentive Plan to Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), in her capacity as a director of the Issuer. The Stock Options have a strike price of $6.80 per share, and vest in 12 equal monthly installments beginning on July 8, 2021, or on the date of the next annual meeting of stockholders, if earlier, subject to Sara Brownstein's continued service on the Board of Directors of the Issuer (the "Board").

F1 · ownership.nature: 40,000 non-qualified stock options ("Stock Options") exercisable solely into common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") were granted under the Issuer's 2016 Equity Incentive Plan to Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), in her capacity as a director of the Issuer. The Stock Options have a strike price of $6.80 per share, and vest in 12 equal monthly installments beginning on July 8, 2021, or on the date of the next annual meeting of stockholders, if earlier, subject to Sara Brownstein's continued service on the Board of Directors of the Issuer (the "Board").

F2 · ownership.nature: Sara Brownstein serves on the Board as a representative of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds").

F3 · ownership.nature: Pursuant to the policies of the Adviser, Sara Brownstein does not have any right to any of the Issuer's securities issued as part of her service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the Stock Options. Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interests in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Stock Options (i.e. no direct pecuniary interest).

F4 · ownership.nature: The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds.

F5 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

SEC source: 0001638599-21-000272 · doc4_7114.xml · derivative · entry 1

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director

667, L.P. · CIK 0001551139 · Director

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director

Baker Brothers Life Sciences LP · CIK 0001363364 · Director

BAKER FELIX · CIK 0001087940 · Director

BAKER JULIAN · CIK 0001087939 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 47,200

Underlying: Common Stock · 47,200 shares

Expires 2031-02-22

F1 · derivative.exercise_date: 47,200 non-qualified stock options ("Stock Options") exercisable solely into common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") were granted under the Issuer's 2016 Equity Incentive Plan to Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), in her capacity as a director of the Issuer. The Stock Options have a strike price of $7.11 per share, and vest in 36 equal monthly installments beginning on March 23, 2021, subject to Sara Brownstein's continued service on the Board of Directors of the Issuer (the "Board").

F1 · ownership.nature: 47,200 non-qualified stock options ("Stock Options") exercisable solely into common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") were granted under the Issuer's 2016 Equity Incentive Plan to Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), in her capacity as a director of the Issuer. The Stock Options have a strike price of $7.11 per share, and vest in 36 equal monthly installments beginning on March 23, 2021, subject to Sara Brownstein's continued service on the Board of Directors of the Issuer (the "Board").

F2 · ownership.nature: Sara Brownstein serves on the Board as a representative of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds").

F3 · ownership.nature: Pursuant to the policies of the Adviser, Sara Brownstein does not have any right to any of the Issuer's securities issued as part of her service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the Stock Options. Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interests in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Stock Options (i.e. no direct pecuniary interest).

F4 · ownership.nature: The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. The Adviser GP is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds.

F5 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

SEC source: 0001209191-21-012424 · doc4.xml · derivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,000

Underlying: Common Stock · 330,000 shares

Expires 2031-02-16

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 17, 2021, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-21-012429 · doc4.xml · derivative · entry 1

Weber Steven · CIK 0001844594 · VP, Controller&Princ Acctg Off

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2031-02-16

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 17, 2021, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-21-012427 · doc4.xml · derivative · entry 1

Sloan Leslie · CIK 0001719455 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Stock · 160,000 shares

Expires 2031-02-16

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 17, 2021, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-21-012423 · doc4.xml · derivative · entry 1

Hanley Jr. Michael Conick · CIK 0001791413 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common Stock · 135,000 shares

Expires 2031-02-16

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 17, 2021, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-20-064066 · doc4.xml · derivative · entry 1

Lawton Alison Frances · CIK 0001542650 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,200

Underlying: Common Stock · 47,200 shares

Expires 2030-12-14

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 36 equal monthly installments beginning on January 15, 2021 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035528 · doc4.xml · derivative · entry 1

Shanafelt Armen · CIK 0001656151 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035517 · doc4.xml · derivative · entry 1

Magovcevic Ivana · CIK 0001279281 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035515 · doc4.xml · derivative · entry 1

LAWLIS V BRYAN · CIK 0001247681 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035510 · doc4.xml · derivative · entry 1

Cox Russell J. · CIK 0001512984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035519 · doc4.xml · derivative · entry 1

Mahatme Sandesh · CIK 0001511034 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-035506 · doc4.xml · derivative · entry 1

Bruhn Suzanne Louise · CIK 0001517790 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,100

Underlying: Common Stock · 28,100 shares

Expires 2030-06-07

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 8, 2020 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001209191-20-026662 · doc4.xml · nonDerivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 538,469

F1 · balance_after: Includes 788 shares acquired by the Reporting Person on August 15, 2019 and 773 shares acquired by the Reporting Person on February 15, 2020 pursuant to the Issuer's employee stock purchase plan.

SEC source: 0001567619-20-004316 · doc1.xml · derivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 301,000

Underlying: Common Stock · 301,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 14, 2020, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001567619-20-004319 · doc1.xml · derivative · entry 1

York Charles N II · CIK 0001655962 · Chief Financial Officer and VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126,000

Underlying: Common Stock · 126,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 14, 2020, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001567619-20-004318 · doc1.xml · derivative · entry 1

Sloan Leslie · CIK 0001719455 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 14, 2020, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001567619-20-004317 · doc1.xml · derivative · entry 1

Rao Madduri Ravin · CIK 0001792006 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 14, 2020, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001567619-20-004315 · doc1.xml · derivative · entry 1

Hanley Jr. Michael Conick · CIK 0001791413 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 14, 2020, until such time as the option is 100% vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001567619-19-020399 · doc1.xml · derivative · entry 1

Rao Madduri Ravin · CIK 0001792006 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2029-10-31

F1 · derivative.exercise_date: The options will vest as to 1/4th of the total shares on November 1, 2020, and then 1/48th of the shares monthly thereafter, such that the option is fully vested on November 1, 2023, subject to the Reporting Person's provision of service to the issuer on each vesting date.

SEC source: 0001567619-19-019922 · doc1.xml · derivative · entry 1

Hanley Jr. Michael Conick · CIK 0001791413 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2029-10-20

F1 · derivative.exercise_date: The options will vest as to 1/4th of the total shares on October 21, 2020, and then 1/48th of the shares monthly thereafter, such that the option is fully vested on October 21, 2023, subject to the Reporting Person's provision of service to the issuer on each vesting date.

SEC source: 0001567619-19-019297 · doc1.xml · derivative · entry 4

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,914

Underlying: Common Stock · 17,603 shares

Expires 2028-02-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests and becomes exerciseable in 48 equal monthly installments beginning on March 20, 2018, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-019297 · doc1.xml · derivative · entry 3

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 662 shares

Expires 2026-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option vested and became exerciseable as to 1/36th of the shares subject to the option on April 3, 2016, and thereafter vests as to 1/36th of the shares each month in equal installments, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-019297 · doc1.xml · nonDerivative · entry 2

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 371,908

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-19-019297 · doc1.xml · nonDerivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,305

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-19-013411 · doc1.xml · nonDerivative · entry 3

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 353,643

F3 · price: Represents the weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.18 to $6.2825 per share.

SEC source: 0001567619-19-013411 · doc1.xml · nonDerivative · entry 2

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,361

F2 · price: Represents the weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.14 to $6.23 per share.

SEC source: 0001567619-19-013411 · doc1.xml · nonDerivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 333,955

F1 · price: Represents the weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.07 to $6.20 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1), (2) and (3) to this Form 4.

SEC source: 0001567619-19-013073 · doc1.xml · derivative · entry 1

Shanafelt Armen · CIK 0001656151 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-013071 · doc1.xml · derivative · entry 1

Magovcevic Ivana · CIK 0001279281 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-013074 · doc1.xml · derivative · entry 1

LAWLIS V BRYAN · CIK 0001247681 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-013069 · doc1.xml · derivative · entry 1

Bruhn Suzanne Louise · CIK 0001517790 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-013072 · doc1.xml · derivative · entry 1

Mahatme Sandesh · CIK 0001511034 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-013070 · doc1.xml · derivative · entry 1

Cox Russell J. · CIK 0001512984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,400

Underlying: Common Stock · 12,400 shares

Expires 2029-06-06

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 7, 2019 until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-011852 · doc1.xml · nonDerivative · entry 3

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 321,738

F3 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.69 to $7.05 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-011852 · doc1.xml · nonDerivative · entry 2

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 317,929

F2 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.53 to $7.00 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-011852 · doc1.xml · nonDerivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 304,135

F1 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.39 to $6.73 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-011561 · doc1.xml · nonDerivative · entry 4

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 295,146

F4 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.51 to $6.85 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-011561 · doc1.xml · nonDerivative · entry 3

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 288,928

F3 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.75 to $6.93 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-011561 · doc1.xml · nonDerivative · entry 2

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 283,408

F2 · price: Represents a weighted average purchase price per share. These shares were purchased in multiple transactions at prices ranging from $6.65 to $6.87 per share. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001567619-19-006485 · doc1.xml · derivative · entry 1

Sloan Leslie · CIK 0001719455 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2029-03-05

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on April 6, 2019, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-005837 · doc1.xml · derivative · entry 1

Wooldridge James · CIK 0001710641 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,200

Underlying: Common Stock · 50,200 shares

Expires 2029-02-27

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 28, 2019, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-005836 · doc1.xml · derivative · entry 1

Schuchart Aaron · CIK 0001709258 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2029-02-27

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 28, 2019, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-005835 · doc1.xml · derivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,000

Underlying: Common Stock · 280,000 shares

Expires 2029-02-27

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 28, 2019, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-005839 · doc1.xml · derivative · entry 1

York Charles N II · CIK 0001655962 · Chief Financial Officer and VP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,600

Underlying: Common Stock · 87,600 shares

Expires 2029-02-27

F1 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 28, 2019, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-011561 · doc1.xml · nonDerivative · entry 1

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 277,152

F1 · shares: These shares were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001567619-19-002796 · doc1.xml · derivative · entry 4

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,517

Underlying: Common Stock · 7,433 shares

Expires 2028-02-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests and becomes exercisable in 48 equal monthly installments beginning on March 20, 2018, until such time as the option is 100% vested, subject to the continuing employment of the Reporting Person on each vesting date.

SEC source: 0001567619-19-002796 · doc1.xml · derivative · entry 3

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 662

Underlying: Common Stock · 1,323 shares

Expires 2026-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option vested and became exercisable as to 1/36th of the shares subject to the option on April 3, 2016, and thereafter vests as to 1/36th of the shares each month in equal installments, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001567619-19-002796 · doc1.xml · nonDerivative · entry 2

Quinn Anthony G. · CIK 0001532219 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 276,433

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.