SGMOQ

SEC source: 0001209191-23-032910 · doc4.xml · nonDerivative · entry 1

McClung David Mark · CIK 0001811505 · EVP, Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 222,849

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on May 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on May 25, 2023 of $1.33/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 3,643 shares resulting from the May 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 38,982 shares will vest in successive equal quarterly installments through February 25, 2025, (b) 33,340 shares subject to the Reporting Person's June 25, 2020 RSU grant that will vest in one final installment on June 25, 2023, (c) 13,336 shares subject to Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024 and (d) 56,250 shares subject to Reporting Person's February 24, 2023 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-032907 · doc4.xml · nonDerivative · entry 1

Fontenot Jason D. · CIK 0001851761 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,329

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on May 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on May 25, 2023 of $1.33/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 3,199 shares resulting from the May 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 29,597 shares will vest in successive equal quarterly installments through February 25, 2025, (b) 7,344 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024 and (c) 42,750 shares subject to Reporting Person's February 24, 2023 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-032906 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,052

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on May 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on May 25, 2023 of $1.33/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 2,515 shares resulting from the May 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 26,907 shares will vest in successive equal quarterly installments through February 25, 2025, (b) 5,000 shares subject to the Reporting Person's June 11, 2022 RSU grant that will vest in two remaining installments of 2,500 shares on each of June 11, 2023 and 2024, (c) 4,584 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024 and (d) 53,438 shares subject to Reporting Person's February 24, 2023 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter.

F3 · balance_after: The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-032903 · doc4.xml · nonDerivative · entry 1

Macrae Sandy · CIK 0001675687 · Director · President, CEO and Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 613,298

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on May 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on May 25, 2023 of $1.33/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 10,589 shares resulting from the May 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 147,000 shares will vest in successive equal quarterly installments through February 25, 2025, (b) 46,134 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024 and (c) 157,300 shares subject to Reporting Person's February 24, 2023 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-025721 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,612

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on April 24, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on April 24, 2023 of $1.65/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 7,525 shares resulting from the April 24, 2023 final vesting installment of the Reporting Person's April 24, 2020 RSU grant, (b) 5,000 shares subject to the Reporting Person's August 13, 2021 RSU grant that will vest in two remaining installments of 2,500 shares on each of August 13, 2023 and 2024, (c) 4,584 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024, (continued in footnote 3)

F3 · balance_after: (d) 30,750 shares subject to Reporting Person's February 25, 2022 RSU grant that will vest in 8 successive equal quarterly installments after February 25, 2023 and (e) 42,750 shares subject to the Reporting Person's February 25, 2023 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-021427 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,380

F1 · shares: Represents shares of common stock underlying the portion of a restricted stock unit ("RSU") grant that vested on March 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on March 24, 2023 of $1.66/share, pursuant to the terms of the Issuer's Amended and Restated Equity Incentive Plan (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 655 shares resulting from the March 25, 2023 final vesting installment of the Reporting Person's March 25, 2020 RSU grant, (b) 4,584 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in one final installment on February 25, 2024, (c) 30,750 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest in 8 successive equal quarterly installments after February 25, 2023, and (e) 5,000 shares subject to the Reporting Person's June 11, 2022 RSU grant that will vest in two remaining installments of 2,500 shares on each of June 11, 2023 and 2024. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016393 · doc4.xml · nonDerivative · entry 2

Dubois-Stringfellow Nathalie · CIK 0001947007 · SVP-Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,558

F2 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F3 · balance_after: Includes: (a) 5,998 shares resulting from the February 25, 2023 final vesting installment of the Reporting Person's February 25, 2020 RSU grant, (b) 5,233 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 8,001 shares subject to such RSU grant that will vest in one final installment on February 25, 2024 and (c) 7,377 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 33,825 shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016399 · doc4.xml · nonDerivative · entry 2

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,589

F3 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes 1 share acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

F4 · balance_after: Includes: (a) 2,999 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 4,584 shares subject to such RSU grant that will vest in one final installment on February 25, 2024, (b) 6,706 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 30,750 shares will vest in 8 successive equal quarterly installments thereafter, (continued in footnote 5)

F5 · balance_after: (c) 11,502 shares subject to the Reporting Person's April 24, 2020 RSU grant that will vest in one final installment on April 24, 2023 and (d) 5,000 shares subject to the Reporting Person's August 13, 2021 RSU grant that will vest in two remaining installments of 2,500 shares on each of August 13, 2023 and 2024. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016397 · doc4.xml · nonDerivative · entry 2

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 173,217

F3 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes 690 shares acquired on May 31, 2022 and 716 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

F4 · balance_after: Includes: (a) 11,997 shares resulting from the February 25, 2023 final vesting installment of the Reporting Person's February 25, 2020 RSU grant, (b) 8,722 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 13,336 shares subject to such RSU grant that will vest in one final installment on February 25, 2024 and (c) 8,832 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 40,500 shares will vest in 8 successive equal quarterly installments. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016395 · doc4.xml · nonDerivative · entry 2

McClung David Mark · CIK 0001811505 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 224,774

F3 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes 2,453 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

F4 · balance_after: Includes: (a) 8,722 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 13,336 shares subject to such RSU grant that will vest in one final installment on February 25, 2024, (b) 9,715 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 44,550 shares will vest in 8 successive equal quarterly installments thereafter and (c) 33,430 shares subject to the Reporting Person's June 25, 2020 RSU grant that will vest in one final installment on June 25, 2023. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016391 · doc4.xml · nonDerivative · entry 2

Fontenot Jason D. · CIK 0001851761 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,358

F2 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F3 · balance_after: Includes: (a) 6,306 shares resulting from the February 25, 2023 final vesting installment of the Reporting Person's February 25, 2020 RSU grant, (b) 5,548 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 7,344 shares subject to such RSU grant that will vest in one final installment on February 25, 2024, and (c) 8,530 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 33,825 shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016390 · doc4.xml · nonDerivative · entry 2

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 133,725

F3 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes 722 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

F4 · balance_after: Includes: (a) 3,599 shares resulting from the February 25, 2023 final vesting installment of the Reporting Person's February 25, 2020 RSU grant, (b) 2,999 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 4,584 shares subject to such RSU grant that will vest in one final installment on February 25, 2024, (c) 6,706 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 30,750 shares will vest in 8 successive equal quarterly installments thereafter, (continued in footnote 5)

F5 · balance_after: (d) 1,000 shares subject to the Reporting Person's March 25, 2020 RSU grant that will vest in one final installment on March 25, 2023 and (e) 5,000 shares subject to the Reporting Person's June 11, 2022 RSU grant that will vest in two remaining installments of 2,500 shares on each of June 11, 2023 and 2024. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016387 · doc4.xml · nonDerivative · entry 2

Macrae Sandy · CIK 0001675687 · Director · President, CEO and Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 623,709

F2 · shares: Represents shares underlying the portions of RSU grants that vested on February 25, 2023, which were surrendered by the Reporting Person solely for mandatory tax withholding purposes using the Issuer's closing stock price on February 24, 2023 of $2.66/share, pursuant to the terms of the 2018 EIP. This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F3 · balance_after: Includes: (a) 36,806 shares resulting from the February 25, 2023 final vesting installment of the Reporting Person's February 25, 2020 RSU grant, (b) 30,172 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2021 RSU grant and 46,134 shares subject to such RSU grant that will vest in one final installment on February 25, 2024 and (c) 36,636 shares resulting from the February 25, 2023 vesting installment of the Reporting Person's February 25, 2022 RSU grant, and the remaining 168,000 shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016393 · doc4.xml · derivative · entry 3

Dubois-Stringfellow Nathalie · CIK 0001947007 · SVP-Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 249,375

Underlying: Common Stock · 249,375 shares

Expires 2033-02-23

F4 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016393 · doc4.xml · nonDerivative · entry 1

Dubois-Stringfellow Nathalie · CIK 0001947007 · SVP-Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,392

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016399 · doc4.xml · derivative · entry 3

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 199,500

Underlying: Common Stock · 199,500 shares

Expires 2033-02-23

F6 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016399 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,717

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

F2 · balance_after: Includes 1 share acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-23-016397 · doc4.xml · derivative · entry 3

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2033-02-23

F5 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016397 · doc4.xml · nonDerivative · entry 1

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 188,835

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

F2 · balance_after: Includes 690 shares acquired on May 31, 2022 and 716 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-23-016395 · doc4.xml · derivative · entry 3

McClung David Mark · CIK 0001811505 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 262,500

Underlying: Common Stock · 262,500 shares

Expires 2033-02-23

F5 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016395 · doc4.xml · nonDerivative · entry 1

McClung David Mark · CIK 0001811505 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 234,519

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

F2 · balance_after: Includes 2,453 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-23-016391 · doc4.xml · derivative · entry 3

Fontenot Jason D. · CIK 0001851761 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 199,500

Underlying: Common Stock · 199,500 shares

Expires 2033-02-23

F4 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016391 · doc4.xml · nonDerivative · entry 1

Fontenot Jason D. · CIK 0001851761 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,917

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016390 · doc4.xml · derivative · entry 3

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 249,375

Underlying: Common Stock · 249,375 shares

Expires 2033-02-23

F6 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016390 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,755

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

F2 · balance_after: Includes 722 shares acquired on November 30, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-23-016387 · doc4.xml · derivative · entry 3

Macrae Sandy · CIK 0001675687 · Director · President, CEO and Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 734,050

Underlying: Common Stock · 734,050 shares

Expires 2033-02-23

F4 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-23-016387 · doc4.xml · nonDerivative · entry 1

Macrae Sandy · CIK 0001675687 · Director · President, CEO and Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 678,476

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit ("RSU") grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-061949 · doc4.xml · derivative · entry 2

Beers Courtney · CIK 0001955191 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-12-14

F2 · derivative.exercise_date: The option is immediately exercisable in full, but any unvested shares that are purchased under the option are subject to certain repurchase rights by the Issuer upon cessation of the Reporting Person's Continuous Service (as defined in the 2018 EIP). The shares subject to the option will vest in 36 successive equal monthly installments following the grant date, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-061949 · doc4.xml · nonDerivative · entry 1

Beers Courtney · CIK 0001955191 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,750

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit grant that will vest in three equal annual installments measured from the grant date, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")), through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-061951 · doc4.xml · derivative · entry 2

Horn Margaret A · CIK 0001294192 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-12-14

F2 · derivative.exercise_date: The option is immediately exercisable in full, but any unvested shares that are purchased under the option are subject to certain repurchase rights by the Issuer upon cessation of the Reporting Person's Continuous Service (as defined in the 2018 EIP). The shares subject to the option will vest in 36 successive equal monthly installments following the grant date, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-061951 · doc4.xml · nonDerivative · entry 1

Horn Margaret A · CIK 0001294192 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,750

F1 · shares: Represents shares of common stock issuable upon settlement of a restricted stock unit grant that will vest in three equal annual installments measured from the grant date, subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")), through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0000899243-22-030136 · doc4.xml · nonDerivative · entry 2

BIOGEN INC. · CIK 0000875045 · 10% owner

Biogen MA Inc. · CIK 0001810387 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Biogen MA Inc.

Disclosed balance after: 23,652,466

F3 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.1235 to $5.49, inclusive. The reporting person undertakes to provide to Sangamo Therapeutics, Inc., any security holder of Sangamo Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F2 · ownership.nature: Shares are owned indirectly by Biogen Inc. and directly by its wholly-owned subsidiary Biogen MA Inc.

SEC source: 0000899243-22-030136 · doc4.xml · nonDerivative · entry 1

BIOGEN INC. · CIK 0000875045 · 10% owner

Biogen MA Inc. · CIK 0001810387 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Biogen MA Inc.

Disclosed balance after: 23,752,466

F1 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.205 to $5.475, inclusive. The reporting person undertakes to provide to Sangamo Therapeutics, Inc., any security holder of Sangamo Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F2 · ownership.nature: Shares are owned indirectly by Biogen Inc. and directly by its wholly-owned subsidiary Biogen MA Inc.

SEC source: 0001209191-22-046022 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,966

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on August 13, 2022 which were surrendered by the Reporting Person to the Issuer solely for mandatory tax withholding purposes using the Issuer's closing stock price on August 12, 2022 of $6.33/share pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 1,636 shares resulting from the August 13, 2022 annual vesting installment of the Reporting Person's August 13, 2021 RSU grant and 5,000 shares subject to such RSU grant that will vest in two remaining annual installments of 2,500 shares on each of August 13, 2023 and 2024, (b) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (c) 11,502 shares subject to the Reporting Person's April 24, 2020 RSU grant that will vest in one final annual installment on April 24, 2023, and (See footnote 3)

F3 · balance_after: (d) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F4 · balance_after: Includes 3,121 shares acquired on May 31, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-22-039649 · doc4.xml · nonDerivative · entry 1

McClung David Mark · CIK 0001811505 · EVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,816

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on June 25, 2022 which were surrendered by the Reporting Person to the Issuer solely for mandatory tax withholding purposes using the Issuer's closing stock price on June 24, 2022 of $4.31/share pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 21,805 shares resulting from the June 25, 2022 vesting of the Reporting Person's June 25, 2020 RSU grant and 33,340 shares subject to such RSU grant that will vest in one final annual installment on June 25, 2023, (b) 26,668 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 13,332 shares and 13,336 shares on February 25, 2023 and 2024, respectively, and (c) 59,400 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F3 · balance_after: Includes 2,357 shares acquired on May 31, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-22-036702 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,617

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on June 11, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on June 10, 2022 of $3.76/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 1,658 shares resulting from the June 11, 2022 annual vesting installment of the Reporting Person's June 11, 2021 RSU grant and 5,000 shares subject to such grant that will vest in two remaining annual installments of 2,500 shares on each of June 11, 2023 and 2024, (b) 5,501 shares subject to the Reporting Person's February 25, 2020 RSU grant that will vest in one final annual installment on February 25, 2023, (c) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (continued in footnote 3)

F3 · balance_after: (d) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, and (e) 1,000 shares subject to the Reporting Person's March 25, 2020 RSU grant that will vest in one final annual installment on March 25, 2023. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F4 · balance_after: Includes 687 shares acquired on May 31, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-23-007355 · doc4a.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,595

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on June 11, 2022 which were surrendered by the Reporting Person to the Issuer solely for mandatory tax withholding purposes using the Issuer's closing stock price on June 10, 2022 of $3.76/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP"). This required tax withholding transaction is deemed to constitute a disposition of these shares to the Issuer for reporting purposes and does not represent a discretionary trade by the Reporting Person in the open market or otherwise.

F2 · balance_after: Includes: (a) 1,658 shares resulting from the June 11, 2022 annual vesting installment of the Reporting Person's June 11, 2021 RSU grant and 5,000 shares subject to such grant that will vest in two remaining annual installments of 2,500 shares on each of June 11, 2023 and 2024, (b) 5,501 shares subject to the Reporting Person's February 25, 2020 RSU grant that will vest in one final annual installment on February 25, 2023, (c) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (continued in footnote 3)

F3 · balance_after: (d) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, and (e) 1,000 shares subject to the Reporting Person's March 25, 2020 RSU grant that will vest in one final annual installment on March 25, 2023. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F4 · balance_after: Includes 687 shares acquired on May 31, 2022 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-22-034538 · doc4.xml · nonDerivative · entry 1

Markels John · CIK 0001803424 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,484

F1 · balance_after: Includes (a) 1,667 shares subject to the Reporting Person's February 11, 2020 restricted stock unit ("RSU") grant that will vest in one final annual installment on February 11, 2023 and (b) 12,500 shares subject to the Reporting Person's February 25, 2022 RSU grant that will fully vest in one installment on February 25, 2023. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP")) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-034036 · doc4.xml · nonDerivative · entry 1

PARKER H STEWART · CIK 0001217456 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,700

SEC source: 0001209191-22-026801 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,709

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on April 29, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on April 29, 2022 of $4.15/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 265 shares resulting from the April 29, 2022 final annual vesting installment of the Reporting Person's April 29, 2022 RSU grant, (b) 7,500 shares subject to the Reporting Person's August 13, 2021 RSU grant that will vest in three annual installments of 2,500 shares on each of August 13, 2022, 2023 and 2024, (c) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (d) 11,502 shares subject to the Reporting Person's April 24, 2020 RSU grant that will vest in one final annual installment on April 24, 2023, and (See footnote 3)

F3 · balance_after: (e) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-025811 · doc4.xml · nonDerivative · entry 1

Fontenot Jason D. · CIK 0001851761 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,167

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on April 25, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on April 25, 2022 of $4.83/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 2,508 shares resulting from the April 25, 2022 final annual vesting installment of the Reporting Person's April 25, 2019 RSU grant, (b) 8,335 shares subject to the Reporting Person's February 25, 2020 RSU grant that will vest in one final annual installment on February 25, 2023, (c) 14,667 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 7,333 shares and 7,334 shares on February 25, 2023 and 2024, respectively, and (continued in footnote 3)

F3 · balance_after: (d) 45,100 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-025809 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,772

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on April 25, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on April 25, 2022 of $4.83/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 1,255 shares resulting from the April 25, 2022 final annual vesting installment of the Reporting Person's April 25, 2019 RSU grant, (b) 7,500 shares subject to the Reporting Person's June 11, 2021 RSU grant that will vest in three annual installments of 2,500 shares on each of June 11, 2022, 2023 and 2024, (c) 5,501 shares subject to the Reporting Person's February 25, 2020 RSU grant that will vest in one final annual installment on February 25, 2023, (d) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (continued in footnote 3)

F3 · balance_after: (e) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, and (f) 1,000 shares subject to the Reporting Person's March 25, 2020 RSU grant that will vest in one final annual installment on March 25, 2023. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-025671 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,849

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on April 24, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on April 22, 2022 of $4.70/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 7,523 shares resulting from the April 24, 2022 vesting of the Reporting Person's April 24, 2020 RSU grant and 11,502 shares subject to such RSU grant that will vest in one final annual installment on April 24, 2023, (b) 405 shares subject to the Reporting Person's November 10, 2020 RSU grant that will vest in one final installment on April 29, 2022, (c) 7,500 shares subject to the Reporting Person's August 13, 2021 RSU grant that will vest in three annual installments of 2,500 shares on each of August 13, 2022, 2023 and 2024, (d) 9,167 shares subject to the Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, and (See footnote 3)

F3 · balance_after: (e) 41,000 shares subject to the Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-021495 · doc4.xml · nonDerivative · entry 1

Duraibabu Prathyusha · CIK 0001779092 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,434

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on March 25, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on March 25, 2022 of $5.75/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 655 shares resulting from the March 25, 2022 vesting of Reporting Person's March 25, 2020 RSU grant and 1,000 shares subject to such RSU grant that will vest in one final annual installment on March 25, 2023, (b) 1,917 shares subject to Reporting Person's April 25, 2019 RSU grant that will vest in one final annual installment on April 25, 2022, (c) 7,500 shares subject to Reporting Person's June 11, 2021 RSU grant that will vest in three annual installments of 2,500 shares on each of June 11, 2022, 2023 and 2024, (d) 5,501 shares subject to Reporting Person's February 25, 2020 RSU grant that will vest in one final annual installment on February 25, 2023, (continued in footnote 3)

F3 · balance_after: (e) 9,167 shares subject to Reporting Person's February 25, 2021 RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, and (f) 41,000 shares subject to Reporting Person's February 25, 2022 RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter. The vesting of all such grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-014179 · doc4.xml · derivative · entry 3

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,700

Underlying: Common Stock · 110,700 shares

Expires 2032-02-24

F6 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-014179 · doc4.xml · nonDerivative · entry 2

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,825

F5 · shares: Represents shares of common stock issuable upon settlement of an RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-014179 · doc4.xml · nonDerivative · entry 1

Willoughby Scott B. · CIK 0001877368 · SVP, Gen. Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,825

F1 · shares: Represents shares underlying the portion of a restricted stock unit ("RSU") grant that vested on February 25, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on February 25, 2022 of $5.90/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 3,017 shares resulting from the February 25, 2022 vesting of the Reporting Person's February 25, 2021 RSU grant and 9,167 shares subject to such RSU grant that will vest in two remaining annual installments of 4,583 shares and 4,584 shares on February 25, 2023 and 2024, respectively, (b) 23,001 shares subject to the Reporting Person's April 24, 2020 RSU grant that will vest in two remaining annual installments of 11,499 shares and 11,502 shares on April 24, 2022 and 2023, respectively, (c) 405 shares subject to the Reporting Person's November 10, 2020 RSU grant that will vest in one final installment on April 29, 2022 and (d) 7,500 shares subject to the Reporting Person's August 13, 2021 RSU grant that will vest in three annual installments of 2,500 shares on each of August 13, 2022, 2023 and 2024. See footnote 3.

F3 · balance_after: The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F4 · balance_after: Includes 936 shares acquired on November 30, 2021 under the Issuer's 2020 Employee Stock Purchase Plan.

SEC source: 0001209191-22-014173 · doc4.xml · derivative · entry 3

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,800

Underlying: Common Stock · 145,800 shares

Expires 2032-02-24

F5 · derivative.exercise_date: One-quarter (1/4) of the shares subject to the option will vest and become exercisable on the first anniversary of the grant date, and the remainder of the shares will vest and become exercisable in 24 successive equal monthly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-014173 · doc4.xml · nonDerivative · entry 2

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,429

F4 · shares: Represents shares of common stock issuable upon settlement of an RSU grant that will vest as to one-quarter (1/4) of the shares on the first anniversary of the grant date, and the remainder of the shares will vest in 8 successive equal quarterly installments thereafter, subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

SEC source: 0001209191-22-014173 · doc4.xml · nonDerivative · entry 1

Ramelmeier Rolf Andrew · CIK 0001789340 · EVP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,429

F1 · shares: Represents shares underlying the portions of restricted stock unit ("RSU") grants that vested on February 25, 2022 which were surrendered by the Reporting Person to the Issuer for tax withholding using the Issuer's closing stock price on February 25, 2022 of $5.90/share, pursuant to the terms of the Issuer's Amended and Restated 2018 Equity Incentive Plan, as amended (the "2018 EIP").

F2 · balance_after: Includes: (a) 2,727 shares resulting from the February 25, 2022 final vesting installment of the Reporting Person's February 25, 2019 RSU grant, (b) 11,993 shares resulting from the February 25, 2022 vesting of the Reporting Person's February 25, 2020 RSU grant and 18,337 shares subject to such RSU grant that will vest in one final annual installment on February 25, 2023, and (c) 8,722 shares resulting from the February 25, 2022 vesting of the Reporting Person's February 25, 2021 RSU grant and 26,668 shares subject to such RSU grant that will vest in two remaining annual installments of 13,332 shares and 13,336 shares on February 25, 2023 and 2024, respectively. The vesting of all such RSU grants is subject to the Reporting Person's Continuous Service (as defined in the 2018 EIP) through each such date and subject to acceleration as provided in the 2018 EIP.

F3 · balance_after: Includes 2,000 shares acquired on April 30, 2021 and 346 shares acquired on October 29, 2021 under the Issuer's 2010 Employee Stock Purchase Plan and 272 shares acquired on May 8, 2021 under the Issuer's 2020 Employee Stock Purchase Plan.