RNTX

SEC source: 0000899243-22-012856 · doc4a.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 393,000

Underlying: Common Stock · 393,000 shares

Expires 2032-03-29

F1 · date: This amendment is being filed to correct the date of grant and the exercise price for the stock option reported on a Form 4 filed by the reporting person on March 24, 2022. This option became effective on March 30, 2022.

F2 · derivative.exercise_date: The shares underlying the option are scheduled to vest in equal monthly installments through March 30, 2026.

SEC source: 0000899243-22-012144 · doc4.xml · derivative · entry 1

Vukovic Vojo · CIK 0001466794 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2032-03-21

F1 · derivative.exercise_date: This option was granted on March 22, 2022. The shares underlying the option are scheduled to vest in equal monthly installments through March 22, 2026.

SEC source: 0000899243-22-012149 · doc4.xml · derivative · entry 1

Annis Allen · CIK 0001709601 · SVP, Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 313,000

Underlying: Common Stock · 313,000 shares

Expires 2032-03-21

F1 · derivative.exercise_date: This option was granted on March 22, 2022. The shares underlying the option are scheduled to vest in equal monthly installments through March 22, 2026.

SEC source: 0000899243-22-012150 · doc4.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 393,000

Underlying: Common Stock · 393,000 shares

Expires 2032-03-21

F1 · derivative.exercise_date: This option was granted on March 22, 2022. The shares underlying the option are scheduled to vest in equal monthly installments through March 22, 2026.

SEC source: 0000899243-22-012148 · doc4.xml · derivative · entry 1

Aivado Manuel · CIK 0001709603 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,133,000

Underlying: Common Stock · 1,133,000 shares

Expires 2032-03-21

F1 · derivative.exercise_date: This option was granted on March 22, 2022. The shares underlying the option are scheduled to vest in equal monthly installments through March 22, 2026.

SEC source: 0000899243-21-024525 · doc4.xml · derivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024521 · doc4.xml · derivative · entry 1

Annis Allen · CIK 0001709601 · SVP, Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 474,000

Underlying: Common Stock · 474,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest as to 25% of the shares on June 15, 2022 and thereafter in equal monthly installments through June 15, 2025.

SEC source: 0000899243-21-024530 · doc4.xml · derivative · entry 1

Ambros Reinhard J. · CIK 0001709690 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024531 · doc4.xml · derivative · entry 1

Morrison Jodie Pope · CIK 0001618247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024533 · doc4.xml · derivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024524 · doc4.xml · derivative · entry 1

Vukovic Vojo · CIK 0001466794 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest as to 25% of the shares on June 15, 2022 and thereafter in equal monthly installments through June 15, 2025.

SEC source: 0000899243-21-024522 · doc4.xml · derivative · entry 1

Sigal Nolan Howard · CIK 0001323291 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024532 · doc4.xml · derivative · entry 1

Aivado Manuel · CIK 0001709603 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,440,000

Underlying: Common Stock · 2,440,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest as to 25% of the shares on June 15, 2022 and thereafter in equal monthly installments through June 15, 2025.

SEC source: 0000899243-21-024526 · doc4.xml · derivative · entry 1

MCKEE WILLIAM · CIK 0001237262 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,000

Underlying: Common Stock · 96,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 15, 2022 or (ii) the date of the Issuer's 2022 Annual Meeting of Stockholders.

SEC source: 0000899243-21-024528 · doc4.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2031-06-14

F1 · derivative.exercise_date: This option was granted on June 15, 2021. The shares underlying the option are scheduled to vest as to 25% of the shares on June 15, 2022 and thereafter in equal monthly installments through June 15, 2025.

SEC source: 0000899243-21-001163 · doc4.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 16,609,449

F1 · shares: Reflects shares that were purchased from the Issuer on January 8, 2021 in a registered direct offering pursuant to a Securities Purchase Agreement, dated January 6, 2021. The amount in Column 4 includes (a) 863,636 shares purchased by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 863,636 shares purchased by various trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares and (c) 7,272,728 shares purchased by Satter Medical Technology Partners, L.P. ("SMTP") for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (1), except to the extent of his pecuniary interest therein.

F2 · balance_after: The amount in Column 5 includes (a) 1,025,076 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 1,231,044 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by SMTP for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (2), except to the extent of his pecuniary interest therein.

F2 · ownership.nature: The amount in Column 5 includes (a) 1,025,076 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 1,231,044 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by SMTP for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (2), except to the extent of his pecuniary interest therein.

SEC source: 0000899243-20-017544 · doc4.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,000

Underlying: Common Stock · 91,000 shares

Expires 2030-06-22

F1 · derivative.exercise_date: This option was granted on June 23, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from June 23, 2020.

SEC source: 0000899243-20-017085 · doc4.xml · derivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders.

SEC source: 0000899243-20-017079 · doc4.xml · derivative · entry 1

Ambros Reinhard J. · CIK 0001709690 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders

SEC source: 0000899243-20-017083 · doc4.xml · derivative · entry 1

Morrison Jodie Pope · CIK 0001618247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders.

SEC source: 0000899243-20-017080 · doc4.xml · derivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders.

SEC source: 0000899243-20-017086 · doc4.xml · derivative · entry 1

Sigal Nolan Howard · CIK 0001323291 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders.

SEC source: 0000899243-20-017084 · doc4.xml · derivative · entry 1

MCKEE WILLIAM · CIK 0001237262 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2030-06-16

F1 · derivative.exercise_date: This option was granted on June 17, 2020. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 17, 2021 or (ii) the date of the Issuer's 2021 Annual Meeting of Stockholders.

SEC source: 0000899243-20-016859 · doc4.xml · nonDerivative · entry 1

Ambros Reinhard J. · CIK 0001709690 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,800

SEC source: 0000899243-20-015869 · doc4.xml · nonDerivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 445,460

F1 · shares: Reflects 227,272 shares that the were purchased by the Reporting Person directly from the underwriter in an underwritten public offering conducted by the Issuer.

SEC source: 0000899243-20-015868 · doc4.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 7,609,449

F1 · shares: Reflects shares that were purchased directly from the underwriter in an underwritten public offering conducted by the Issuer. The amount in Column 4 includes (a) 350,742 shares purchased by various trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares and (b) 3,349,258 shares purchased by Satter Medical Technology Partners, L.P. ("SMTP") for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (a) and (b) of this footnote (1), except to the extent of his pecuniary interest.

F2 · balance_after: The amount in Column 5 includes (a) 161,440 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 367,408 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by SMTP for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (2), except to the extent of his pecuniary interest therein.

F2 · ownership.nature: The amount in Column 5 includes (a) 161,440 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 367,408 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by SMTP for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (2), except to the extent of his pecuniary interest therein.

SEC source: 0000899243-20-002808 · doc4.xml · derivative · entry 1

Annis Allen · CIK 0001709601 · SVP, Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2030-01-30

F1 · derivative.exercise_date: This option was granted on January 31, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from January 31, 2020.

SEC source: 0000899243-20-002807 · doc4.xml · derivative · entry 1

Vukovic Vojo · CIK 0001466794 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2030-01-30

F1 · derivative.exercise_date: This option was granted on January 31, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from January 31, 2020.

SEC source: 0000899243-20-002804 · doc4.xml · derivative · entry 1

Gregory Kathryn · CIK 0001768530 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 185,000 shares

Expires 2030-01-30

F1 · derivative.exercise_date: This option was granted on January 31, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from January 31, 2020.

SEC source: 0000899243-20-002805 · doc4.xml · derivative · entry 1

Aivado Manuel · CIK 0001709603 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2030-01-30

F1 · derivative.exercise_date: This option was granted on January 31, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from January 31, 2020.

SEC source: 0000899243-20-002802 · doc4.xml · derivative · entry 1

Wanstall Rick · CIK 0001771222 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2030-01-30

F1 · derivative.exercise_date: This option was granted on January 31, 2020. The shares underlying the option are scheduled to vest in equal monthly installments over four years from January 31, 2020.

SEC source: 0000899243-19-027510 · doc4.xml · nonDerivative · entry 2

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,894

SEC source: 0000899243-19-027510 · doc4.xml · nonDerivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,752

SEC source: 0000899243-19-027279 · doc4.xml · nonDerivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,894

SEC source: 0000899243-19-023645 · doc4.xml · nonDerivative · entry 2

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 218,188

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.9360 per share to $0.99 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-023645 · doc4.xml · nonDerivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 193,188

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.8608 per share to $1.05 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-022827 · doc4.xml · nonDerivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,043

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.68 per share to $0.7486 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-022724 · doc4.xml · nonDerivative · entry 2

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,818

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.6805 per share to $0.7204 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-022724 · doc4.xml · nonDerivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,352

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.7155 per share to $0.75 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-022676 · doc4.xml · nonDerivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,352

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.76 per share to $0.77 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-022104 · doc4.xml · nonDerivative · entry 1

Vukovic Vojo · CIK 0001466794 · SVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.5890 per share to $0.5980 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-19-021791 · doc4.xml · nonDerivative · entry 1

Gregory Kathryn · CIK 0001768530 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

SEC source: 0000899243-19-017791 · doc4.xml · derivative · entry 1

Ambros Reinhard J. · CIK 0001709690 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 19, 2020 or (ii) the date of the Issuer's 2020 Annual Meeting of Stockholders.

SEC source: 0000899243-19-017792 · doc4.xml · derivative · entry 1

Morrison Jodie Pope · CIK 0001618247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 19, 2020 or (ii) the date of the Issuer's 2020 Annual Meeting of Stockholders.

SEC source: 0000899243-19-017788 · doc4.xml · derivative · entry 1

Bailey Jeffrey Allen · CIK 0001500210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 19, 2020 or (ii) the date of the Issuer's 2020 Annual Meeting of Stockholders.

SEC source: 0000899243-19-017794 · doc4.xml · derivative · entry 1

MCARTHUR JOHN H · CIK 0001242370 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in full on the earlier of (i) June 19, 2020 or (ii) the date of the Issuer's 2020 Annual Meeting of Stockholders.

SEC source: 0000899243-19-017793 · doc4.xml · derivative · entry 1

Sigal Nolan Howard · CIK 0001323291 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in equal annual installments over three years from April 2, 2019.

SEC source: 0000899243-19-017968 · doc4.xml · derivative · entry 1

VON RICKENBACH JOSEF H · CIK 0001007706 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in equal annual installments over three years from June 19, 2019.

SEC source: 0000899243-19-017965 · doc4.xml · derivative · entry 1

MCKEE WILLIAM · CIK 0001237262 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-18

F1 · derivative.exercise_date: This option was granted on June 19, 2019. The shares underlying the option are scheduled to vest in equal annual installments over three years from June 19, 2019.

SEC source: 0000899243-19-010812 · doc4.xml · derivative · entry 1

Annis Allen · CIK 0001709601 · SVP, Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2029-04-14

F1 · derivative.exercise_date: This option was granted on April 15, 2019. The shares underlying the option are scheduled to vest in equal monthly installments over four years from April 15, 2019.