QURE

SEC source: 0000904454-23-000392 · edgar.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,273

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000404 · edgar.xml · derivative · entry 3

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,060

Underlying: Ordinary Shares · 17,060 shares

Expires 2033-06-13

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000404 · edgar.xml · nonDerivative · entry 1

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,930

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000394 · edgar.xml · derivative · entry 3

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,060

Underlying: Ordinary Shares · 17,060 shares

Expires 2033-06-13

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000394 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,897

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000386 · edgar.xml · derivative · entry 3

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,060

Underlying: Ordinary Shares · 17,060 shares

Expires 2033-06-13

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000386 · edgar.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,273

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-23-000215 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 468,743

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $21.35 to $21.42. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-23-000223 · edgar.xml · nonDerivative · entry 1

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,135

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $21.33 to $21.36. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-23-000221 · edgar.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,381

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

SEC source: 0000904454-23-000219 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,441

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

SEC source: 0000904454-23-000217 · edgar.xml · nonDerivative · entry 1

Dolmetsch Ricardo · CIK 0001825206 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,245

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of performance-based restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $21.35 to $21.36. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006579 · doc4.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 471,264

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.79 to $21.39. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006591 · doc4.xml · nonDerivative · entry 2

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,966

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $21.02 to $21.16. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006582 · doc4.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,427

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F3 · price: The price reported in Column 4 is a weighted average price. 1,363 of the shares were sold at $20.90 and 6 of the shares were sold at $21.35.

SEC source: 0000899243-23-006569 · doc4.xml · nonDerivative · entry 2

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,197

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006589 · doc4.xml · nonDerivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,998

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.92 to $20.01. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006594 · doc4.xml · nonDerivative · entry 1

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,812

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. 386 of the shares were sold in multiple transactions at prices ranging from $19.66 to $19.97 and 3 of the shares were sold at $20.82. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006573 · doc4.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,699

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.99 to $20.00. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006579 · doc4.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 476,285

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.20 to $20.80. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006579 · doc4.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 477,670

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.20 to $20.17. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006571 · doc4.xml · nonDerivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,071

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.71 to $19.99. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006590 · doc4.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,573

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006591 · doc4.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,178

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006586 · doc4.xml · nonDerivative · entry 2

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,125

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006586 · doc4.xml · nonDerivative · entry 1

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,206

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006582 · doc4.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,796

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.85 to $20.43. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006581 · doc4.xml · nonDerivative · entry 1

Dolmetsch Ricardo · CIK 0001825206 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,082

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. 6,824 of the shares were sold in multiple transactions at prices ranging from $19.21 to $19.81, 63 of the shares were sold at $20.86 and 57 of the shares were sold at $20.87. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006578 · doc4.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,573

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

SEC source: 0000899243-23-006575 · doc4.xml · nonDerivative · entry 1

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,230

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.01 to $20.03. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-006569 · doc4.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,628

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. 530 of the shares were sold in multiple transactions at prices ranging from $19.65 to $19.99 and 7 of the shares were sold at $20.86. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-23-000184 · edgar.xml · derivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 256,500

Underlying: Ordinary Shares · 256,500 shares

Expires 2033-02-23

F2 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000184 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 495,811

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000186 · edgar.xml · derivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,500

Underlying: Ordinary Shares · 64,500 shares

Expires 2033-02-23

F2 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000186 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 146,620

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000182 · edgar.xml · derivative · entry 2

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,600

Underlying: Ordinary Shares · 80,600 shares

Expires 2033-02-23

F2 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000182 · edgar.xml · nonDerivative · entry 1

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,490

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000180 · edgar.xml · derivative · entry 2

Dolmetsch Ricardo · CIK 0001825206 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,600

Underlying: Ordinary Shares · 80,600 shares

Expires 2033-02-23

F2 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-23-000180 · edgar.xml · nonDerivative · entry 1

Dolmetsch Ricardo · CIK 0001825206 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 177,026

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000899243-23-005830 · doc4.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 374,311

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 20, 2023 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000899243-23-005848 · doc4.xml · nonDerivative · entry 1

CALOZ PIERRE · CIK 0001867944 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,790

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 20, 2023 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000899243-23-005846 · doc4.xml · nonDerivative · entry 1

Dolmetsch Ricardo · CIK 0001825206 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,326

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 20, 2023 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000899243-23-005828 · doc4.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,220

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 20, 2023 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000899243-23-005826 · doc4.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,692

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 20, 2023 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000904454-23-000031 · edgar.xml · derivative · entry 3

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Ordinary Shares · 6,000 shares

Expires 2027-01-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-23-000031 · edgar.xml · nonDerivative · entry 2

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,382

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-23-000031 · edgar.xml · nonDerivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,382

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-22-000633 · edgar.xml · derivative · entry 6

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,800 shares

Expires 2023-06-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Stock Option exercise price was EUR 10.10 per share or $10.69, as converted, based on the exchange rate at on December 13, 2022 of EUR 1 to $1.058.

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The Stock Option was granted on June 6, 2013 and vested 25% after one year, with the remainder vesting in weekly installments over a two year period ending on June 10, 2016.

SEC source: 0000904454-22-000633 · edgar.xml · nonDerivative · entry 4

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,382

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-22-000633 · edgar.xml · nonDerivative · entry 3

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,182

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The Stock Option exercise price was EUR 10.10 per share or $10.69, as converted, based on the exchange rate at on December 13, 2022 of EUR 1 to $1.058.