MAZE

SEC source: 0002050167-26-000019 · form4-07312026_080715.xml · derivative · entry 4

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,643

Underlying: Common Stock · 7,500 shares

Expires 2031-04-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F4 · derivative.exercise_date: The option is fully vested. Pursuant to the terms of the reporting person's award agreement with the Issuer, the award became fully vested on March 17, 2025.

SEC source: 0002050167-26-000019 · form4-07312026_080715.xml · nonDerivative · entry 3

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,250

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.81 to $27.96 per share, inclusive.

SEC source: 0002050167-26-000019 · form4-07312026_080715.xml · nonDerivative · entry 2

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,650

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.81 to $27.79 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0002050167-26-000019 · form4-07312026_080715.xml · nonDerivative · entry 1

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,750

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0002050172-26-000025 · form4-07022026_080753.xml · derivative · entry 4

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 192,945

Underlying: Common Stock · 14,609 shares

Expires 2032-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F4 · derivative.exercise_date: The option vested as to 1/4th of the total award on October 3, 2023, and thereafter vested or vests as to 1/48th of the total award on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0002050172-26-000025 · form4-07022026_080753.xml · nonDerivative · entry 3

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.24 to $30.42 per share, inclusive.

SEC source: 0002050172-26-000025 · form4-07022026_080753.xml · nonDerivative · entry 2

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,200

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.24 to $30.23 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0002050172-26-000025 · form4-07022026_080753.xml · nonDerivative · entry 1

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,609

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0001676170-26-000014 · form4-07022026_080737.xml · nonDerivative · entry 3

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 287,171

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F6 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.385 to $30.49 per share, inclusive.

F5 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000014 · form4-07022026_080737.xml · nonDerivative · entry 2

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 288,768

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.375 to $30.37 per share, inclusive.

F5 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000014 · form4-07022026_080737.xml · nonDerivative · entry 1

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · The Coloma 2021 Irrevocable Trust

Disclosed balance after: 23,337

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.455 to $30.38 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnotes 4 and 6 of this Form 4.

F3 · ownership.nature: These securities are directly held by The Coloma 2021 Irrevocable Trust (the "Irrevocable Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0002050167-26-000016 · form4-07012026_080715.xml · derivative · entry 3

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,143

Underlying: Common Stock · 7,500 shares

Expires 2031-04-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · derivative.exercise_date: The option is fully vested. Pursuant to the terms of the reporting person's award agreement with the Issuer, the award became fully vested on March 17, 2025.

SEC source: 0002050167-26-000016 · form4-07012026_080715.xml · nonDerivative · entry 2

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,250

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0002050167-26-000016 · form4-07012026_080715.xml · nonDerivative · entry 1

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,750

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · balance_after: The reported total includes 1,442 shares of the Issuer's Common Stock acquired by the reporting person in one or more transactions with the Issuer pursuant to its Employee Stock Purchase Plan, which transactions are exempt pursuant to Rules 16a3(f)(1)(i)(B) and 16b3(c).

SEC source: 0001676170-26-000012 · form4-06242026_080649.xml · nonDerivative · entry 3

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 319,079

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.185 per share, inclusive.

F3 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000012 · form4-06242026_080649.xml · nonDerivative · entry 2

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · The Coloma 2021 Irrevocable Trust

Disclosed balance after: 25,930

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F4 · ownership.nature: These securities are directly held by The Coloma 2021 Irrevocable Trust (the "Irrevocable Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000012 · form4-06242026_080649.xml · nonDerivative · entry 1

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 342,944

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.025 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 5 of this Form 4.

F3 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001804999-26-000002 · form4-06102026_080643.xml · derivative · entry 1

Andrews Nancy C · CIK 0001804999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001283290-26-000002 · form4-06102026_080618.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001238403-26-000004 · form4-06102026_080629.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001192591-26-000004 · form4-06102026_080626.xml · derivative · entry 1

HOMCY CHARLES J · CIK 0001192591 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001214133-26-000002 · form4-06102026_080600.xml · derivative · entry 1

SCHELLER RICHARD H · CIK 0001214133 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001596492-26-000007 · form4-06102026_080650.xml · derivative · entry 1

Hoppenot Herve · CIK 0001596492 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0002050172-26-000023 · form4-06032026_090633.xml · derivative · entry 4

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 207,554

Underlying: Common Stock · 14,853 shares

Expires 2032-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F4 · derivative.exercise_date: The option vested as to 1/4th of the total award on October 3, 2023, and thereafter vested or vests as to 1/48th of the total award on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0002050172-26-000023 · form4-06032026_090633.xml · nonDerivative · entry 3

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.16 to $26.53 per share, inclusive.

SEC source: 0002050172-26-000023 · form4-06032026_090633.xml · nonDerivative · entry 2

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,600

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.16 to $26.10 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0002050172-26-000023 · form4-06032026_090633.xml · nonDerivative · entry 1

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,853

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0001676170-26-000009 · form4-06032026_090612.xml · nonDerivative · entry 2

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · The Coloma 2021 Irrevocable Trust

Disclosed balance after: 27,970

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.50 per share, inclusive.

F5 · ownership.nature: These securities are directly held by The Coloma 2021 Irrevocable Trust (the "Irrevocable Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000009 · form4-06032026_090612.xml · nonDerivative · entry 1

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 344,897

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.545 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 4 of this Form 4.

F3 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0002050167-26-000013 · form4-06022026_080603.xml · derivative · entry 3

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,643

Underlying: Common Stock · 7,500 shares

Expires 2031-04-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · derivative.exercise_date: The option is fully vested. Pursuant to the terms of the reporting person's award agreement with the Issuer, the award became fully vested on March 17, 2025.

SEC source: 0002050167-26-000013 · form4-06022026_080603.xml · nonDerivative · entry 2

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,808

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.03 to $26.64 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002050167-26-000013 · form4-06022026_080603.xml · nonDerivative · entry 1

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0001676170-26-000007 · form4-05272026_080518.xml · nonDerivative · entry 3

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 350,987

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.09 per share, inclusive.

F3 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000007 · form4-05272026_080518.xml · nonDerivative · entry 2

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · The Coloma 2021 Irrevocable Trust

Disclosed balance after: 28,523

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F4 · ownership.nature: These securities are directly held by The Coloma 2021 Irrevocable Trust (the "Irrevocable Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000007 · form4-05272026_080518.xml · nonDerivative · entry 1

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 376,569

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.00 to $26.105 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 5 of this Form 4.

F3 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000004 · form4-05182026_090526.xml · nonDerivative · entry 2

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · The Coloma 2021 Irrevocable Trust

Disclosed balance after: 31,001

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F3 · ownership.nature: These securities are directly held by The Coloma 2021 Irrevocable Trust (the "Irrevocable Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0001676170-26-000004 · form4-05182026_090526.xml · nonDerivative · entry 1

Coloma Jason V · CIK 0001676170 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Indirect · Coloma Family Trust

Disclosed balance after: 381,073

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

F2 · ownership.nature: These securities are directly held by the Coloma Family Trust (the "Family Trust"), for which the reporting person and his spouse serve as co-trustees.

SEC source: 0002050172-26-000021 · form4-05182026_090546.xml · derivative · entry 3

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 222,407

Underlying: Common Stock · 15,000 shares

Expires 2032-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · derivative.exercise_date: The option vested as to 1/4th of the total award on October 3, 2023, and thereafter vested or vests as to 1/48th of the total award on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0002050172-26-000021 · form4-05182026_090546.xml · nonDerivative · entry 2

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.77 to $26.44 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002050172-26-000021 · form4-05182026_090546.xml · nonDerivative · entry 1

Bernstein Harold · CIK 0002050172 · President, R&D & CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0002050167-26-000010 · form4-05062026_080545.xml · derivative · entry 4

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,725

Underlying: Common Stock · 5,985 shares

Expires 2033-03-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vested or vests as to 1/48th of the total award monthly, with the first tranche vested on April 1, 2023, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0002050167-26-000010 · form4-05062026_080545.xml · derivative · entry 3

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,204

Underlying: Common Stock · 8,320 shares

Expires 2032-03-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The option is fully vested. Pursuant to the terms of the reporting person's award agreement with the Issuer, the award became fully vested on February 1, 2026.

SEC source: 0002050167-26-000010 · form4-05062026_080545.xml · nonDerivative · entry 2

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,808

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0002050167-26-000010 · form4-05062026_080545.xml · nonDerivative · entry 1

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,823

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001192591-26-000002 · form4-05062026_080559.xml · nonDerivative · entry 1

HOMCY CHARLES J · CIK 0001192591 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,113

F1 · kind: The reported transaction represents a gift, for no consideration, which is exempt pursuant to Rule 16b-5.

F2 · balance_after: The total reflected in Column 5 of Table I includes shares which were previously held directly by the Charles J. Homcy Revocable Trust UA 11/4/1998.

SEC source: 0002050167-26-000008 · form4-05012026_080517.xml · derivative · entry 3

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,143

Underlying: Common Stock · 7,500 shares

Expires 2031-04-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · derivative.exercise_date: The option is fully vested. Pursuant to the terms of the reporting person's award agreement with the Issuer, the award became fully vested on March 17, 2025.

SEC source: 0002050167-26-000008 · form4-05012026_080517.xml · nonDerivative · entry 2

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,503

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.08 to $25.77 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002050167-26-000008 · form4-05012026_080517.xml · nonDerivative · entry 1

Dandekar Atul · CIK 0002050167 · CSBO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,003

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

SEC source: 0002050422-26-000012 · form4-04022026_080443.xml · derivative · entry 4

Bachrodt Amy · CIK 0002050422 · SVP, Finance

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,833

Underlying: Common Stock · 2,500 shares

Expires 2034-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F4 · derivative.exercise_date: The option vested or vests as to 1/48th of the total award monthly, with the first tranche vested on January 1, 2025, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0002050422-26-000012 · form4-04022026_080443.xml · nonDerivative · entry 3

Bachrodt Amy · CIK 0002050422 · SVP, Finance

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,965

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 29, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.05 to $30.50 per share, inclusive.