Lim Jonathan E

SEC source: 0001193125-26-271465 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Common Stock · 48,000 shares

Expires 2036-06-14

F1 · derivative.exercise_date: The stock option shall vest in substantially equal monthly installments over the 12 months following June 15, 2026 (or, in the event the next annual meeting of the issuer's stockholders occurs prior to June 15, 2027, any remaining unvested portion of the stock option will vest on the date of such annual meeting), subject to the reporting person's continuing service on the issuer's board of directors through such vesting date.

SEC source: 0001283290-26-000002 · form4-06102026_080618.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001193125-26-030626 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000,000

Underlying: Common Stock · 2,000,000 shares

Expires 2036-01-29

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly on the 29th day of each month (or the last day of February), starting in February 2026, subject to the Reporting Person's continuous service to the issuer on each such vesting date.

SEC source: 0001283290-25-000005 · form4-09242025_080917.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2035-09-21

F1 · derivative.exercise_date: The option shall vest as to 1/9 of the total award monthly with the first tranche vesting on October 1, 2025, subject to the reporting person's continued service to the Issuer on the applicable vesting date.

SEC source: 0000950170-25-089077 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2035-06-22

F1 · derivative.exercise_date: The stock option shall vest in substantially equal monthly installments over the 12 months following June 23, 2025 (or, in the event the next annual meeting of the issuer's stockholders occurs prior to June 23, 2026, any remaining unvested portion of the stock option will vest on the date of such annual meeting), subject to the reporting person's continuing service on the issuer's board of directors through such vesting date.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · derivative · entry 5

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 270,232 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series B Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for- 0.1211056427. The securities have no expiration date.

F3 · price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series B Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for- 0.1211056427. The securities have no expiration date.

F3 · derivative.exercise_date: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series B Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for- 0.1211056427. The securities have no expiration date.

F3 · derivative.expiration_date: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series B Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for- 0.1211056427. The securities have no expiration date.

F2 · ownership.nature: These securities are directly held by City Hill, LLC, of which the reporting person is the managing partner.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · derivative · entry 4

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 37,724 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series A Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for-0.1037236801. The securities have no expiration date.

F1 · price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series A Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for-0.1037236801. The securities have no expiration date.

F1 · derivative.exercise_date: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series A Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for-0.1037236801. The securities have no expiration date.

F1 · derivative.expiration_date: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series A Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for-0.1037236801. The securities have no expiration date.

F2 · ownership.nature: These securities are directly held by City Hill, LLC, of which the reporting person is the managing partner.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · nonDerivative · entry 2

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · City Hill, LLC

Disclosed balance after: 307,956

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series B Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for- 0.1211056427. The securities have no expiration date.

F2 · ownership.nature: These securities are directly held by City Hill, LLC, of which the reporting person is the managing partner.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · City Hill, LLC

Disclosed balance after: 37,724

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Pursuant to the Issuer's Restated Certificate of Incorporation, upon closing of the Issuer's initial public offering of its Common Stock, each share of Series A Convertible Preferred Stock automatically converted into shares of Common Stock at a ratio of 1-for-0.1037236801. The securities have no expiration date.

F2 · ownership.nature: These securities are directly held by City Hill, LLC, of which the reporting person is the managing partner.

SEC source: 0000950170-25-014192 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,500,000

Underlying: Common Stock · 2,500,000 shares

Expires 2035-02-02

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly, with vesting starting on February 1, 2025, subject to the Reporting Person's continuous service to the issuer on each such vesting date.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · derivative · entry 8

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,086

Underlying: Common Stock · 9,086 shares

Expires 2034-12-08

F4 · date: This transaction is an exempt transaction with the Issuer which occurred prior to the Issuer registering a class of equity securities under Section 12 of the Securities Exchange Act of 1934, as amended. It is reported herein as a transaction pursuant to Rule 16a-2(a). All numbers of shares and exercise prices have been adjusted to reflect a 1:9.641 reverse stock split of the Issuer's Common Stock effected on January 24, 2025.

F7 · derivative.exercise_date: The option vested or vests as to 1/36th of the total award monthly, with the first tranche vesting on January 1, 2025, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · derivative · entry 7

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,704 shares

Expires 2033-03-08

F4 · date: This transaction is an exempt transaction with the Issuer which occurred prior to the Issuer registering a class of equity securities under Section 12 of the Securities Exchange Act of 1934, as amended. It is reported herein as a transaction pursuant to Rule 16a-2(a). All numbers of shares and exercise prices have been adjusted to reflect a 1:9.641 reverse stock split of the Issuer's Common Stock effected on January 24, 2025.

F6 · price: This option, which was first granted on March 9, 2023, was canceled and exchanged for a new option having a lower exercise price in connection with an option repricing approved by the Issuer's Board of Directors on December 9, 2024. All terms of the option remained unchanged other than the exercise price.

F5 · derivative.exercise_date: The option vested or vests as to 1/36th of the total award monthly, with the first tranche vesting on April 1, 2023, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0001415889-25-002957 · form4-02042025_090248.xml · derivative · entry 6

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,704

Underlying: Common Stock · 5,704 shares

Expires 2033-03-08

F4 · date: This transaction is an exempt transaction with the Issuer which occurred prior to the Issuer registering a class of equity securities under Section 12 of the Securities Exchange Act of 1934, as amended. It is reported herein as a transaction pursuant to Rule 16a-2(a). All numbers of shares and exercise prices have been adjusted to reflect a 1:9.641 reverse stock split of the Issuer's Common Stock effected on January 24, 2025.

F6 · price: This option, which was first granted on March 9, 2023, was canceled and exchanged for a new option having a lower exercise price in connection with an option repricing approved by the Issuer's Board of Directors on December 9, 2024. All terms of the option remained unchanged other than the exercise price.

F5 · derivative.exercise_date: The option vested or vests as to 1/36th of the total award monthly, with the first tranche vesting on April 1, 2023, and each subsequent tranche vesting on the monthly anniversary thereof, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0000950170-24-075800 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,610

Underlying: Common Stock · 6,610 shares

Expires 2034-06-19

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's 2024 Incentive Award Plan. The stock option vests in 36 substantially equal monthly installments beginning on the first monthly anniversary of June 20, 2024, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001209191-24-005924 · doc4.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 632,759

Underlying: Common Stock · 632,759 shares

Expires 2034-06-19

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly, with vesting starting on June 20, 2024, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0000950170-24-041843 · ownership.xml · derivative · entry 5

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 7,326 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-041843 · ownership.xml · derivative · entry 4

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 5,128 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-041843 · ownership.xml · derivative · entry 3

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 512,820 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-041843 · ownership.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 550,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of the Issuer's preferred stock is convertible into shares of the Issuer's common stock at the holder's election and has no expiration date. The preferred stock automatically converted into common stock upon the closing of the Issuer's initial public offering.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-038705 · ownership.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,219

Underlying: Common Stock · 13,219 shares

Expires 2034-03-26

F1 · derivative.exercise_date: The stock option vests in 36 substantially equal monthly installments beginning on April 27, 2024.

SEC source: 0001209191-24-002968 · doc4.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,500,000

Underlying: Common Stock · 1,500,000 shares

Expires 2034-02-04

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly, with vesting starting on February 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001209191-23-057681 · doc4.xml · nonDerivative · entry 2

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 12,899,360

F1 · balance_after: Includes purchases made on December 5, 2023, and December 6, 2023 that are reported on this Form 4.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-057681 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 12,899,360

F1 · balance_after: Includes purchases made on December 5, 2023, and December 6, 2023 that are reported on this Form 4.

F2 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-052403 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Jonathan E. Lim and Conyee T. lim Family Trust, dated April 28, 2005

Disclosed balance after: 19,456,216

F1 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-23-035590 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 18,396,216

F1 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-23-021458 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 18,296,216

F1 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-23-006482 · doc4.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,500,000

Underlying: Common Stock · 1,500,000 shares

Expires 2033-01-31

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following February 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001209191-23-002802 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 20,256,222

F1 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-22-061352 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 20,196,222

F1 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0000899243-23-005182 · doc5.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman and CEO · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 18,196,216

F1 · kind: Transfer of shares to a trust of which the children of the Reporting Person and his spouse are beneficiaries.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-22-007062 · doc4.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 791,000

Underlying: Common Stock · 791,000 shares

Expires 2032-01-31

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following February 2, 2022, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0000899243-21-029085 · doc4.xml · derivative · entry 6

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 93,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.exercise_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.expiration_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F3 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-029085 · doc4.xml · derivative · entry 5

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 280,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.exercise_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.expiration_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F3 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-029085 · doc4.xml · derivative · entry 4

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 0

Underlying: Common Stock · 5,067,694 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.exercise_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.expiration_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F3 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-029085 · doc4.xml · derivative · entry 3

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 0

Underlying: Common Stock · 5,135,390 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.exercise_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F1 · derivative.expiration_date: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0000899243-21-029085 · doc4.xml · nonDerivative · entry 2

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By City Hill, LLC

Disclosed balance after: 11,899,360

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F3 · ownership.nature: Consists of shares held directly by City Hill, LLC ("City Hill"). Jonathan E. Lim, M.D. serves as the managing partner of City Hill. Dr. Lim exercises voting and dispositive control over the securities held by City Hill and is therefore deemed to be a beneficial owner of securities owned by City Hill. Dr. Lim disclaims beneficial ownership of the reported securities held by City Hill, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-029085 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · See Remarks · 10% owner

Lim Conyee T. · CIK 0001872346 · 10% owner

City Hill, LLC · CIK 0001872305 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005

Disclosed balance after: 20,156,222

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The shares of the Issuer's Series A and Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 1.2-for-1 share, immediately prior to the consummation of the Issuer's initial public offering.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of (i) Jonathan E. Lim, M.D. and (ii) Conyee T. Lim, M.D., who are co-trustees of the Jonathan E. Lim and Conyee T. Lim Family Trust, dated April 28, 2005.

SEC source: 0001209191-18-009148 · doc4.xml · derivative · entry 5

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 120,000 shares

Expires 2027-01-04

F3 · derivative.exercise_date: In connection with the Merger described in footnote (1), this option became fully vested and was automatically canceled and terminated and the holder became entitled to receive an amount in cash, without interest and less the amount of any tax withholding, equal to the product of (1) the number of shares of Common Stock of the Issuer underlying such option multiplied by (2) the excess, if any, of $27.00 over the exercise price per share of such option.

SEC source: 0001209191-18-009148 · doc4.xml · derivative · entry 4

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 100,000 shares

Expires 2015-01-07

F3 · derivative.exercise_date: In connection with the Merger described in footnote (1), this option became fully vested and was automatically canceled and terminated and the holder became entitled to receive an amount in cash, without interest and less the amount of any tax withholding, equal to the product of (1) the number of shares of Common Stock of the Issuer underlying such option multiplied by (2) the excess, if any, of $27.00 over the exercise price per share of such option.

SEC source: 0001209191-18-009148 · doc4.xml · derivative · entry 3

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 400,000 shares

Expires 2023-12-16

F3 · derivative.exercise_date: In connection with the Merger described in footnote (1), this option became fully vested and was automatically canceled and terminated and the holder became entitled to receive an amount in cash, without interest and less the amount of any tax withholding, equal to the product of (1) the number of shares of Common Stock of the Issuer underlying such option multiplied by (2) the excess, if any, of $27.00 over the exercise price per share of such option.

SEC source: 0001209191-18-009148 · doc4.xml · nonDerivative · entry 2

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By City Hill Venture Partners I, LLC

Disclosed balance after: 0

F1 · price: In connection with the acquisition of the Issuer by Roche Holdings, Inc. ("Parent") on February 8, 2018, and pursuant to the terms of the Agreement and Plan of Merger by and among the Issuer, Parent and Abingdon Acquisition Corp. ("Merger Sub") dated December 21, 2017, Merger Sub acquired all of the issued and outstanding shares of Common Stock (the "Shares") for a purchase price of $27.00 per Share (the "Merger").

F2 · ownership.nature: The Reporting Person is the Manager of City Hill Ventures, LLC, which is the Manager of City Hill Ventures Partners I, LLC, and as such the Reporting Person and City Hill Ventures, LLC have the power to vote or dispose of the securities held of record by the Reporting Person and may be deemed to beneficially own those securities. The Reporting Person disclaims beneficial ownership of the securities held of record by the City Hill Venture Partners I, LLC except to the extent of his pecuniary interest therein.

SEC source: 0001209191-18-009148 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · price: In connection with the acquisition of the Issuer by Roche Holdings, Inc. ("Parent") on February 8, 2018, and pursuant to the terms of the Agreement and Plan of Merger by and among the Issuer, Parent and Abingdon Acquisition Corp. ("Merger Sub") dated December 21, 2017, Merger Sub acquired all of the issued and outstanding shares of Common Stock (the "Shares") for a purchase price of $27.00 per Share (the "Merger").

SEC source: 0000899243-17-029701 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO and Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,661

SEC source: 0001209191-17-067162 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,667

F1 · shares: Represents the grant of restricted stock units to the Reporting Person. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units will vest as to 25% of the shares underlying each award on each anniversary of the Grant Date, subject to the Reporting Person's continues service with the Company through the vesting date.

SEC source: 0000899243-17-029643 · doc4a.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,667

F1 · shares: Represents the grant of restricted stock units to the Reporting Person. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units will vest as to 25% of the shares underlying each award on each anniversary of the Grant Date, subject to the Reporting Person's continues service with the Company through the vesting date.

SEC source: 0001209191-17-019996 · doc4.xml · derivative · entry 3

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,945 shares

Expires 2023-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-17-019996 · doc4.xml · nonDerivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-17-002767 · doc4.xml · derivative · entry 1

Lim Jonathan E · CIK 0001283290 · Director · President, CEO & Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2027-01-04

F1 · derivative.exercise_date: The option is exercisable as it vests. 25% of the shares subject to the option vest on January 5, 2018, and 1/48th of the shares subject to the option vest monthly thereafter.