SPIEGELMAN DANIEL K

SEC source: 0001238403-26-000006 · wk-form4_1782763816.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Class A Common Stock · 6,000 shares

Expires 2036-06-26

F1 · derivative.exercise_date: The option vests on the earlier of June 26, 2027, and the date of the 2027 annual general meeting of shareholders, subject to the director's continued service on the board of directors through such vesting.

SEC source: 0001238403-26-000004 · form4-06102026_080629.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2036-06-07

F1 · derivative.exercise_date: The option shall vest and be fully exercisable on the earlier of (i) the date of the issuer's 2027 annual stockholders meeting or (ii) June 8, 2027, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001238403-26-000002 · form4-05262026_040510.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,700

Underlying: Common Stock · 1,700 shares

Expires 2036-05-20

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2027 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 6

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 400 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 5

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400

Underlying: Common Stock · 400 shares

Expires 2033-05-24

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 4

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 88 shares

Expires 2031-05-19

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 3

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88

Underlying: Common Stock · 88 shares

Expires 2031-05-19

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 458 shares

Expires 2030-09-08

F1 · derivative.exercise_price: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000007 · form4-12152025_111257.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 458

Underlying: Common Stock · 458 shares

Expires 2030-09-08

F1 · shares: Effective August 4, 2025, the Issuer effected a reverse stock split (the "Reverse Split") whereby every seventy-five shares of its issued and outstanding Common Stock were automatically combined into one share of Common Stock. In connection with the Reverse Split, each stock option to purchase 75 shares of Common Stock was automatically combined into a stock option to purchase one share of Common Stock and the exercise prices of such options were multiplied by seventy-five.

F3 · price: The transactions reported herein reflect a one-time stock option repricing (the "Option Repricing") effective on December 11, 2025 (the "Repricing Date"). The Option Repricing applies to options with exercise prices of $106.09 per share or greater held by employees and directors of the Issuer who remained in continuous service with the Company as of the Repricing Date.

F4 · price: Pursuant to the Option Repricing, the exercise price of the repriced options has been amended to reduce the exercise price to $104.13 per share, the thirty (30)-day trailing volume-weighted average price of the Common Stock on the Nasdaq Capital Market on the Repricing Date. However, if an optionholder exercises a repriced option before the end of a retention period of one year (which period may be shorter in certain circumstances), such optionholder will be required to pay the original exercise price per share of such repriced option. No other changes were made to the repriced options in connection with the Option Repricing, including with respect to the vesting schedules, expiration dates or number of shares underlying such repriced options.

F2 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001238403-25-000005 · form4-09242025_080900.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2035-09-21

F1 · derivative.exercise_date: The option shall vest as to 1/9 of the total award monthly with the first tranche vesting on October 1, 2025, subject to the reporting person's continued service to the Issuer on the applicable vesting date.

SEC source: 0001415889-25-020270 · form4-07242025_110741.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-07-21

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2026 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001641489-25-000046 · wk-form4_1749760089.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Class A Common Stock · 4,000 shares

Expires 2035-06-10

F1 · derivative.exercise_date: The option vests on the earlier of June 10, 2026, and the date of the 2026 annual general meeting of shareholders, subject to the director's continued service on the board of directors through such vesting.

SEC source: 0000950170-25-080456 · ownership.xml · derivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,351

Underlying: Common Stock · 65,351 shares

Expires 2035-05-29

F2 · derivative.exercise_date: All of the shares subject to the option shall be fully vested and exercisable on the earlier of (i) May 29, 2026, and (ii) immediately prior to the date of the Issuer's 2026 annual meeting of stockholders, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0000950170-25-080456 · ownership.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,634

F1 · shares: Represents a restricted stock unit award of common stock, which will vest in full on the earlier of (i) May 29, 2026, and (ii) immediately prior to the date of the Issuer's 2026 annual meeting of stockholders, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001641489-24-000051 · wk-form4_1719520815.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Class A Common Stock · 6,000 shares

Expires 2034-06-25

F1 · derivative.exercise_date: The options will vest monthly over the three year period following date of grant.

SEC source: 0001238403-24-000002 · wk-form4_1717538237.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,917

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001238403-24-000002 · wk-form4_1717538237.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,705

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001415889-24-014493 · form4-05242024_080517.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-21

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2025 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001238403-23-000002 · wk-form4_1685744119.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,493

F2 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001238403-23-000002 · wk-form4_1685744119.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,131

F1 · kind: Consists of restricted stock units granted pursuant to Myriad Genetics, Inc.'s 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of common stock and vests upon the earlier of (a) the first anniversary of the date of grant and (b) the date of the next annual meeting of stockholders following such grant.

SEC source: 0001209191-23-032663 · doc4.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-05-24

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2024 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001238403-22-000002 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,980

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.01 to $19.57, inclusive. The Reporting Person undertakes to provide to Myriad Genetics, Inc., any security holder of Myriad Genetics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001628280-22-016223 · wf-form4_165429164220216.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,404

F1 · kind: Consists of restricted stock units granted pursuant to Myriad Genetics, Inc.'s 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of common stock and vests upon the earlier of (a) the first anniversary of the Date of Grant and (b) the date of the next annual meeting of stockholders following such grant.

SEC source: 0001209191-22-032503 · doc4.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2023 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001238403-21-000008 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,129

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.41 to $30.65, inclusive. The Reporting Person undertakes to provide to Myriad Genetics, Inc., any security holder of Myriad Genetics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001238403-21-000006 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,268

F1 · kind: Consists of restricted stock units granted pursuant to Myriad Genetics, Inc.'s 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of common stock and vests on the anniversary of the date of grant.

SEC source: 0001238403-21-000004 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,420

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.75 to $29.30, inclusive. The Reporting Person undertakes to provide to Myriad Genetics, Inc., any security holder of Myriad Genetics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001238403-21-000002 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,562

F1 · kind: On May 27, 2021, the Company rescinded Mr. Spiegelman's grant of 15,889 restricted stock units granted on December 4, 2020 and reported on the Form 4 filed with the Securities and Exchange Commission on December 7, 2020.

SEC source: 0001209191-21-035152 · doc4.xml · derivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,667

Underlying: Common Stock · 6,667 shares

Expires 2031-05-19

F1 · derivative.exercise_date: The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2022 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).

SEC source: 0001238403-20-000007 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,451

F1 · kind: Consists of restricted stock units granted pursuant to the Company's 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of the Company's common stock and vests on the anniversary of the date of grant.

SEC source: 0001238403-20-000005 · edgardoc.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,562

F1 · kind: Consists of restricted stock units granted pursuant to the Company's 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of the Company's common stock and vests on the anniversary of the date of grant.

SEC source: 0001567619-19-013093 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,686

F1 · date: Represents shares acquired by the reporting person on April 30, 2019, pursuant to the issuer's Employee Stock Purchase Plan.

SEC source: 0001567619-19-008275 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,510

F1 · date: Trade made pursuant to a 10b5-1 plan executed on February 26, 2019.

SEC source: 0001567619-19-007872 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,983

F1 · date: Trade made pursuant to a 10b5-1 plan executed on February 26, 2019.

SEC source: 0001567619-19-007684 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,083

SEC source: 0001567619-19-007257 · doc1.xml · derivative · entry 3

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,450

Underlying: Common Stock · 23,450 shares

Expires 2029-03-14

F2 · date: Option grant vests 12/48th on March 15, 2020 and 1/48th on the 15th day of each month thereafter.

SEC source: 0001567619-19-007257 · doc1.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,681

F1 · price: Restricted stock units granted on March 15, 2019. Price not applicable.

SEC source: 0001567619-19-007257 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,311

SEC source: 0001567619-19-006240 · doc1.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,538

SEC source: 0001567619-19-006240 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,450

F1 · date: Transaction Date is the date that the Issuer's Board of Directors' Compensation Committee Chair certified that the reporting person earned the Restricted Stock Units (RSUs), which are convertible into shares of the Issuer's Common Stock on a 1:1 basis.

F2 · shares: Represents the total number of RSUs earned pursuant to a calculation set forth in the performance-based RSU awards previously granted under the Issuer's 2017 Equity Incentive Plan based on the level of the Issuer's total adjusted net product revenues for the fiscal year ended December 31, 2018 as set forth in the Issuer's audited financial statements.

F3 · shares: Although earned, the RSUs only vest according to the following schedule: 1/3 vests on each of March 15, 2019, 2020 and 2021, so long as the reporting person remains continuously employed with the Issuer through that date, subject to earlier vesting upon certain events.

SEC source: 0001567619-18-008459 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,245

F1 · date: Represents shares acquired by the reporting person on October 31, 2018, pursuant to the issuer's Employee Stock Purchase Plan.

SEC source: 0001140361-18-030011 · doc1.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,070

F1 · date: Trade made pursuant to a 10b5-1 plan executed on August 15, 2017.

SEC source: 0001140361-18-030011 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,542

F1 · date: Trade made pursuant to a 10b5-1 plan executed on August 15, 2017.

SEC source: 0001140361-18-027605 · doc1.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,070

SEC source: 0001140361-18-027605 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,781

F1 · date: Represents shares acquired by the reporting person on April 30, 2018, pursuant to the issuer's Employee Stock Purchase Plan.

F2 · balance_after: Amount of securities beneficially owned has been adjusted from the reporting person's prior report to: a) add 86 shares reported as acquired in the Form 4 Amendment filed with the S.E.C. on 4/26/2018; and b) subtract 15 shares reported as disposed of in the Form 4 Amendment filed with the S.E.C. on 4/27/2018.

SEC source: 0001140361-18-019613 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,543

F1 · date: Trade made pursuant to a 10b5-1 plan executed on December 11, 2017.

SEC source: 0001140361-18-015081 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,602

SEC source: 0001140361-18-020306 · doc1.xml · nonDerivative · entry 1

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,587

F1 · shares: This amendment is being filed solely to correct an administrative error in the original filing regarding the number of shares reported as forfeited.

SEC source: 0001140361-18-014184 · doc1.xml · derivative · entry 3

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,900

Underlying: Common Stock · 39,900 shares

Expires 2028-03-14

F2 · derivative.exercise_date: Option grant vests 12/48th on March 15, 2019 and 1/48th on the 15th day of each month thereafter.

SEC source: 0001140361-18-014184 · doc1.xml · nonDerivative · entry 2

SPIEGELMAN DANIEL K · CIK 0001238403 · EVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,185

F1 · price: Restricted stock units granted on March 15, 2018. Price not applicable.