LRMR

SEC source: 0001192482-21-000442 · edgar.xml · derivative · entry 1

LEFF JONATHAN S · CIK 0001215242 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2031-05-12

F1 · shares: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

F2 · derivative.exercise_date: The Option vests on the earlier of (a) May 12, 2022 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

F1 · derivative.underlying_shares: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

F1 · balance_after: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

SEC source: 0001192482-21-000441 · edgar.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2031-05-12

F1 · derivative.exercise_date: The Option vests on the earlier of (a) May 12, 2022 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

SEC source: 0001192482-21-000438 · edgar.xml · derivative · entry 1

Hamilton Thomas Edward · CIK 0001769848 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2031-05-12

F1 · derivative.exercise_date: The Option vests on the earlier of (a) May 12, 2022 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

SEC source: 0001192482-21-000445 · edgar.xml · derivative · entry 1

Truitt Joseph · CIK 0001452429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2031-05-12

F1 · derivative.exercise_date: The Option vests on the earlier of (a) May 12, 2022 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

SEC source: 0001192482-21-000074 · edgar.xml · derivative · entry 1

Celano Michael · CIK 0001377582 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,000

Underlying: Common Stock · 42,000 shares

Expires 2031-01-19

F1 · derivative.exercise_date: The option vests 25% on January 19, 2022, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued employment with the Issuer through the applicable vesting date.

SEC source: 0001192482-21-000075 · edgar.xml · derivative · entry 1

BEN-MAIMON CAROLE · CIK 0001529611 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,700

Underlying: Common Stock · 106,700 shares

Expires 2031-01-19

F1 · derivative.exercise_date: The option vests 25% on January 19, 2022, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued employment with the Issuer through the applicable vesting date.

SEC source: 0001192482-20-000742 · edgar.xml · derivative · entry 1

Truitt Joseph · CIK 0001452429 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000745 · edgar.xml · derivative · entry 1

Celano Michael · CIK 0001377582 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,100

Underlying: Common Stock · 84,100 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The Option vests 25% on July 16, 2021, with the remaining 75% vesting in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000747 · edgar.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000738 · edgar.xml · derivative · entry 1

THOMAS FRANK E · CIK 0001242616 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000740 · edgar.xml · derivative · entry 1

LEFF JONATHAN S · CIK 0001215242 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · shares: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

F2 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

F1 · derivative.underlying_shares: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

F1 · balance_after: The Reporting Person, a partner in Deerfield Management Company, L.P., has no pecuniary interest in the securities reported herein and disclaims beneficial ownership of such securities. The Reporting Person holds the option for the benefit, and at the direction, of Deerfield Management Company, L.P.

SEC source: 0001192482-20-000751 · edgar.xml · derivative · entry 1

Hamilton Thomas Edward · CIK 0001769848 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000749 · edgar.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001192482-20-000736 · edgar.xml · derivative · entry 1

BEN-MAIMON CAROLE · CIK 0001529611 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 411,400

Underlying: Common Stock · 411,400 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The Option vests 25% on July 16, 2021, with the remaining 75% vesting in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0001193805-20-001219 · e619973_4-larimar.xml · derivative · entry 1

Flynn James E · CIK 0001352546 · Director · 10% owner · * Director by Deputization

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · Director · 10% owner · * Director by Deputization

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Through Deerfield Management Company, L.P.

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · shares: Jonathan S. Leff, a partner in Deerfield Management Company, L.P., serves as a director of the Issuer. The option granted to Jonathan S. Leff and reported herein is held for the benefit, and at the direction, of Deerfield Management Company, L.P. ("Deerfield Management")

F2 · derivative.exercise_date: The option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Issuer's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to Jonathan S. Leff 's continued service with the Issuer through each applicable vesting date.

F1 · derivative.underlying_shares: Jonathan S. Leff, a partner in Deerfield Management Company, L.P., serves as a director of the Issuer. The option granted to Jonathan S. Leff and reported herein is held for the benefit, and at the direction, of Deerfield Management Company, L.P. ("Deerfield Management")

F1 · balance_after: Jonathan S. Leff, a partner in Deerfield Management Company, L.P., serves as a director of the Issuer. The option granted to Jonathan S. Leff and reported herein is held for the benefit, and at the direction, of Deerfield Management Company, L.P. ("Deerfield Management")

F1 · ownership.nature: Jonathan S. Leff, a partner in Deerfield Management Company, L.P., serves as a director of the Issuer. The option granted to Jonathan S. Leff and reported herein is held for the benefit, and at the direction, of Deerfield Management Company, L.P. ("Deerfield Management")

F3 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entity listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). James E. Flynn is the sole member of the general partner of Deerfield Management Company, L.P. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise.

SEC source: 0001192482-20-000588 · edgar.xml · nonDerivative · entry 2

Hamilton Thomas Edward · CIK 0001769848 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · FA Life Sciences, Inc.

Disclosed balance after: 292,853

F2 · kind: Pro rata distribution from Holdings to its members, for no consideration.

SEC source: 0001192482-20-000588 · edgar.xml · nonDerivative · entry 1

Hamilton Thomas Edward · CIK 0001769848 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 133,420

F1 · kind: Pro rata distribution from Chondrial Therapeutics Holdings, LLC ("Holdings") to its members, for no consideration. The reporting person is a member of the board of managers of Holdings.

SEC source: 0001192482-20-000587 · edgar.xml · nonDerivative · entry 1

CHONDRIAL THERAPEUTICS HOLDINGS, LLC · CIK 0001776691 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8

F1 · kind: Chondrial Therapeutics Holdings, LLC distributed these shares to its members on a pro rata basis, for no consideration.

SEC source: 0001192482-20-000586 · edgar.xml · nonDerivative · entry 1

BEN-MAIMON CAROLE · CIK 0001529611 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,083

F1 · kind: Pro rata distribution from Chondrial Therapeutics Holdings, LLC ("Holdings") to its members, for no consideration. The reporting person is a member of the board of managers and President and Chief Executive Officer of Holdings.

SEC source: 0001192482-20-000435 · edgar.xml · derivative · entry 1

Celano Michael · CIK 0001377582 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,479

Underlying: Common Stock · 60,479 shares

Expires 2030-05-28

F1 · derivative.exercise_date: The option vests 25% on May 28, 2021, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued employment with the Issuer through the applicable vesting date.

SEC source: 0000899243-19-018485 · doc4.xml · derivative · entry 1

EVERETT WENDY · CIK 0001742622 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018476 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018481 · doc4.xml · derivative · entry 1

PEREZ ROBERT J · CIK 0001263230 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018480 · doc4.xml · derivative · entry 1

THOMAS FRANK E · CIK 0001242616 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018474 · doc4.xml · derivative · entry 1

LAMATTINA JOHN L · CIK 0001216074 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018483 · doc4.xml · derivative · entry 1

McDonough Cameron Geoffrey · CIK 0001579130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-018479 · doc4.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-010033 · doc4.xml · derivative · entry 1

Singhal Priya · CIK 0001769608 · Head of Research & Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 375,000

Underlying: Common Stock · 375,000 shares

Expires 2029-03-03

F1 · derivative.exercise_date: 25% of this option vests on March 4, 2020, and the remainder vests in equal monthly installments thereafter over 36 months. The option has been granted pursuant to an inducement award agreement outside of the company's 2014 Stock Option and Incentive Plan as a material inducement to the reporting person's acceptance of employment with the company in accordance with NASDAQ Listing Rule 5635(c)(4). The option is subject to acceleration upon a change in control.

SEC source: 0000899243-19-002067 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,396

Underlying: Common Stock · 21,396 shares

Expires 2029-01-24

F1 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2019 on a quarterly basis in arrears.

SEC source: 0000899243-19-002064 · doc4.xml · derivative · entry 3

PEREZ ROBERT J · CIK 0001263230 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,717

Underlying: Common Stock · 5,717 shares

Expires 2029-01-24

F3 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2019 on a quarterly basis in arrears.

SEC source: 0000899243-19-002064 · doc4.xml · nonDerivative · entry 1

PEREZ ROBERT J · CIK 0001263230 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,322

F1 · shares: The common stock was acquired in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Restricted Stock Unit Award and the restrictions lapse over a period of one year starting January 1, 2019 on a quarterly basis in arrears. Each restricted stock unit represents a contingent right to receive one share of Zafgen, Inc. common stock.

SEC source: 0000899243-19-002065 · doc4.xml · nonDerivative · entry 1

LAMATTINA JOHN L · CIK 0001216074 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,376

F1 · kind: The common stock was acquired in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Restricted Stock Unit Award and the restrictions lapse over a period of one year starting January 1, 2019 on a quarterly basis in arrears. Each restricted stock unit represents a contingent right to receive one share of Zafgen, Inc. common stock.

SEC source: 0000899243-19-002062 · doc4.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,280

Underlying: Common Stock · 13,280 shares

Expires 2029-01-24

F1 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2019 on a quarterly basis in arrears.

SEC source: 0000899243-19-002061 · doc4.xml · derivative · entry 1

McDonough Cameron Geoffrey · CIK 0001579130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,804

Underlying: Common Stock · 11,804 shares

Expires 2029-01-24

F1 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2019 on a quarterly basis in arrears.

SEC source: 0000899243-19-001928 · doc4.xml · derivative · entry 1

McVeigh Brian · CIK 0001742110 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2029-01-22

F1 · derivative.exercise_date: 25% of this option vests on January 22, 2020, and the remainder vests in equal monthly installments thereafter over 36 months.

SEC source: 0000899243-19-001926 · doc4.xml · derivative · entry 1

KIM DENNIS D · CIK 0001456750 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2029-01-22

F1 · derivative.exercise_date: 25% of this option vests on January 22, 2020, and the remainder vests in equal monthly installments thereafter over 36 months.

SEC source: 0000899243-19-001925 · doc4.xml · derivative · entry 1

Allen Patricia L · CIK 0001348587 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2029-01-22

F1 · derivative.exercise_date: 25% of this option vests on January 22, 2020, and the remainder vests in equal monthly installments thereafter over 36 months.

SEC source: 0000899243-19-001927 · doc4.xml · derivative · entry 1

Hatfield Jeffrey S. · CIK 0001609879 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 525,000

Underlying: Common Stock · 525,000 shares

Expires 2029-01-22

F1 · derivative.exercise_date: 25% of this option vests on January 22, 2020, and the remainder vests in equal monthly installments thereafter over 36 months.

SEC source: 0001104659-18-043521 · a4.xml · nonDerivative · entry 2

Atlas Venture Fund VII L P · CIK 0001346450 · 10% owner

Atlas Venture Associates VII, L.P. · CIK 0001377726 · 10% owner

Atlas Venture Associates VII, Inc. · CIK 0001377725 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11

F2 · kind: On June 29, 2018, Atlas Venture Associates VII LP ("AVA VII LP"), the general partner of Atlas Venture VII distributed, for no consideration, 234,421 shares of the Issuer's Common Stock, pro-rata, to its partners, including its limited partners and its general partner, in accordance with the exemptions afforded by Rule 16a-9 and Rule 16a-13 of the Securities Exchange Act of 1934, as amended. The distribution was effected pursuant to a Rule 10b5-1 plan adopted by AVA VII on December 22, 2017.

F1 · price: On June 29, 2018, Atlas Venture Fund VII LP ("Atlas Venture VII") distributed, for no consideration, 1,126,546 shares of the Issuer's Common Stock, pro-rata, to its partners, including its limited partners and its general partner, in accordance with the exemptions afforded by Rule 16a-9 and Rule 16a-13 of the Securities Exchange Act of 1934, as amended. The distribution was effected pursuant to a Rule 10b5-1 plan adopted by Atlas Venture VII on December 22, 2017.

F4 · ownership.direct: These shares are held directly by AVA VII LP. The general partner of AVA VII LP is AVA VII Inc. AVA VII Inc. disclaims Section 16 beneficial ownership of such shares, except to the extent of a pecuniary interest, if any, therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for the purposes of Section 16 or for any other purpose.

SEC source: 0001104659-18-043521 · a4.xml · nonDerivative · entry 1

Atlas Venture Fund VII L P · CIK 0001346450 · 10% owner

Atlas Venture Associates VII, L.P. · CIK 0001377726 · 10% owner

Atlas Venture Associates VII, Inc. · CIK 0001377725 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,506,184

F1 · kind: On June 29, 2018, Atlas Venture Fund VII LP ("Atlas Venture VII") distributed, for no consideration, 1,126,546 shares of the Issuer's Common Stock, pro-rata, to its partners, including its limited partners and its general partner, in accordance with the exemptions afforded by Rule 16a-9 and Rule 16a-13 of the Securities Exchange Act of 1934, as amended. The distribution was effected pursuant to a Rule 10b5-1 plan adopted by Atlas Venture VII on December 22, 2017.

F1 · price: On June 29, 2018, Atlas Venture Fund VII LP ("Atlas Venture VII") distributed, for no consideration, 1,126,546 shares of the Issuer's Common Stock, pro-rata, to its partners, including its limited partners and its general partner, in accordance with the exemptions afforded by Rule 16a-9 and Rule 16a-13 of the Securities Exchange Act of 1934, as amended. The distribution was effected pursuant to a Rule 10b5-1 plan adopted by Atlas Venture VII on December 22, 2017.

F3 · ownership.direct: These shares are held directly by Atlas Venture VII. The general partner of Atlas Venture VII is AVA VII LP, and the general partner of AVA VII LP is Atlas Venture Associates VII, Inc. ("AVA VII Inc."). AVA VII LP and AVA VII Inc. disclaim Section 16 beneficial ownership of such shares, except to the extent of a pecuniary interest, if any, therein. This report shall not be deemed an admission that the reporting persons are the beneficial owners of such securities for the purposes of Section 16 or for any other purpose.

SEC source: 0000899243-18-018764 · doc4.xml · nonDerivative · entry 1

Hughes Thomas E. · CIK 0001611048 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,247

F1 · kind: The sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

SEC source: 0000899243-18-015555 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015550 · doc4.xml · derivative · entry 1

PEREZ ROBERT J · CIK 0001263230 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015560 · doc4.xml · derivative · entry 1

THOMAS FRANK E · CIK 0001242616 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015554 · doc4.xml · derivative · entry 1

LAMATTINA JOHN L · CIK 0001216074 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015557 · doc4.xml · derivative · entry 2

EVERETT WENDY · CIK 0001742622 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-06-06

F2 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest monthly over a three year period beginning on the grant date subject to the director's continued service on the board of directors, and provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015557 · doc4.xml · derivative · entry 1

EVERETT WENDY · CIK 0001742622 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015551 · doc4.xml · derivative · entry 1

Daniel Thomas O · CIK 0001538894 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-015549 · doc4.xml · derivative · entry 1

McDonough Cameron Geoffrey · CIK 0001579130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-014478 · doc4.xml · derivative · entry 1

McVeigh Brian · CIK 0001742110 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2028-05-29

F1 · derivative.exercise_date: 25% of this option vests on May 29, 2019 and the remainder vests in equal monthly installments thereafter over a 3-year period. The option has been granted pursuant to an inducement award agreement outside of the company's 2014 Stock Option and Incentive Plan as a material inducement to the reporting person's acceptance of employment with the company in accordance with NASDAQ Listing Rule 5635(c)(4). The option is subject to acceleration upon a change in control pursuant to the terms of the reporting person's Severance and Change in Control Agreement dated as of May 29, 2018.