Barrett Peter

SEC source: 0001193125-26-335078 · ownership.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,653

Underlying: Common Stock · 37,653 shares

Expires 2036-08-02

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable upon the earlier of (i) the one-year anniversary of the grant date or (ii) the date of the Issuer's annual meeting of stockholders following the grant date, subject to the Reporting Person's continued service with the Issuer on such vesting date.

SEC source: 0001193125-26-216724 · ownership.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,293

SEC source: 0001193125-26-216724 · ownership.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,028

F1 · shares: The Reporting Person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 27, 2027, the scheduled date for the issuer's next annual meeting of shareholders, subject to the Reporting Person's continued service through such date or, if earlier, upon the Reporting Person's death, disability or qualifying retirement, or the termination of the Reporting Person's service within 12 months following a change in control.

SEC source: 0000950170-25-061820 · ownership.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,013

SEC source: 0000950170-25-061820 · ownership.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,675

F1 · shares: The Reporting Person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 28, 2026, the scheduled date for the issuer's next annual meeting of shareholders, subject to the Reporting Person's continued service through such date or, if earlier, upon the Reporting Person's death, disability or qualifying retirement, or the termination of the Reporting Person's service within 12 months following a change in control.

SEC source: 0000950170-24-052076 · ownership.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,601

SEC source: 0000950170-24-052076 · ownership.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,383

F1 · shares: The Reporting Person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 22, 2025, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

SEC source: 0000950170-24-001821 · ownership.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,923

Underlying: Common Stock · 24,923 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and committee cash retainers of $81,500 in the aggregate. Such options vest in four equal quarterly installments on the last day of each calendar quarter during 2024 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000950170-23-029787 · ownership.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-22

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject to the non-employee director's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000950170-23-022713 · ownership.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,406

SEC source: 0000950170-23-022713 · ownership.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,451

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 23, 2024, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

SEC source: 0000899243-23-000663 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 156,130

Underlying: Common Stock · 156,130 shares

Expires 2033-01-03

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and committee cash retainers of $81,500 in the aggregate. Such options vest in four equal quarterly installments on the last day of each calendar quarter during 2023 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-22-022180 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject to the non-employee director's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001062993-22-012306 · form4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2032-05-10

F1 · derivative.exercise_date: The options vest on the earlier of (a) May 10, 2023 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

SEC source: 0000899243-22-017245 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,668

SEC source: 0000899243-22-017245 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,924

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 25, 2023, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

SEC source: 0000899243-22-000897 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,334

Underlying: Common Stock · 49,334 shares

Expires 2032-01-03

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and committee cash retainers of $81,500 in the aggregate. Such options vest in four equal quarterly installments on the last day of each calendar quarter during 2022 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-21-030974 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,314

F1 · shares: The transaction represents a gift by the Reporting Person of 5,000 shares of common stock to a donor advised fund.

SEC source: 0000899243-21-023604 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,818

Underlying: Common Stock · 12,818 shares

Expires 2031-06-10

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject to the non-employee director's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001192482-21-000440 · edgar.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,300

Underlying: Common Stock · 8,300 shares

Expires 2031-05-12

F1 · derivative.exercise_date: The Option vests on the earlier of (a) May 12, 2022 or (b) the date of the Company's next annual meeting of stockholders, in each case subject to the Reporting Person's continued service on the Board of Directors of the Company.

SEC source: 0000899243-21-019008 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,314

SEC source: 0000899243-21-019008 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,605

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 26, 2022, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

SEC source: 0001104659-21-001076 · tm211802-1_4seq1.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,498

Underlying: Common Stock · 57,498 shares

Expires 2031-01-04

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and audit committee cash retainers of $85,500 in the aggregate. Such options vest in four equal quarterly installments on the last day of each calendar quarter during 2021 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001192482-20-000747 · edgar.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,600

Underlying: Common Stock · 16,600 shares

Expires 2030-07-16

F1 · derivative.exercise_date: The Option was granted on July 16, 2020 subject to stockholder approval, which was obtained at the Company's special meeting of stockholders on September 29, 2020. The vesting commencement date for the option is July 16, 2020, and the option vests in equal monthly installments over 36 months, subject to the Reporting Person's continued service with the Issuer through each applicable vesting date.

SEC source: 0000899243-20-020582 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,541

Underlying: Common Stock · 1,541 shares

Expires 2030-07-24

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's 2015 Equity Incentive Award Plan in lieu of the non-employee director nominating and governance committee chair cash retainer of $8,000. Such options vest in four equal quarterly installments provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-20-015644 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2030-06-04

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject to the non-employee director's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-20-014541 · doc4.xml · derivative · entry 3

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,750 shares

Expires 2021-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option became exercisable in three equal annual installments beginning on April 29, 2015, which was the first anniversary of the date on which the option was granted.

SEC source: 0000899243-20-014541 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,001

F1 · price: The price reported represents a weighted average sale price of shares sold in multiple transactions at prices ranging from $100.10 to $100.22. The Reporting Person hereby undertakes, upon request of the Staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-20-014541 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,552

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-012813 · doc4.xml · nonDerivative · entry 3

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,803

SEC source: 0000899243-20-012813 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,722

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 27, 2021, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

F2 · price: Restricted stock units were awarded in lieu of the reporting person's first 2020 quarterly cash retainer payment, with the number of restricted stock units determined by dividing the amount of the cash retainer payment by the Black-Scholes value of a restricted stock unit on the date the grant was made.

SEC source: 0000899243-20-012813 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,424

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 27, 2021, the scheduled date for the issuer's next annual meeting of shareholders, subject to the reporting person's continued service through such date or, if earlier, upon the reporting person's death, disability or qualifying retirement, or the termination of the reporting person's service within 12 months following a change in control.

SEC source: 0000899243-20-020581 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,656

Underlying: Common Stock · 48,656 shares

Expires 2030-01-02

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and audit committee cash retainers of $77,500 in the aggregate. Such options vest in four equal quarterly installments on the last day of each calendar quarter during 2020 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-19-027110 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,502

F1 · shares: The transaction represents a gift by the Reporting Person of 955 shares of common stock to a donor advised fund.

SEC source: 0000899243-19-018476 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,000

Underlying: Common Stock · 27,000 shares

Expires 2029-06-26

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 26, 2020 or the date of the 2020 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-19-015996 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-05

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject in each case to each non-employee director's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-19-011612 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,457

SEC source: 0000899243-19-011612 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,414

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on April 30, 2020, which is the first anniversary of the date on which the grant was made.

SEC source: 0000899243-19-003704 · doc4.xml · derivative · entry 3

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,601 shares

Expires 2020-04-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option became exercisable in three equal annual installments beginning on April 30, 2014, which was the first anniversary of the date on which the option was granted.

SEC source: 0000899243-19-003704 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,629

F1 · price: The price reported represents a weighted average sale price of shares sold in multiple transactions at prices ranging from $93.61 to $93.64. The Reporting Person hereby undertakes, upon request of the Staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0000899243-19-003704 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,630

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-19-002067 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,396

Underlying: Common Stock · 21,396 shares

Expires 2029-01-24

F1 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2019 on a quarterly basis in arrears.

SEC source: 0000899243-19-010393 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,380

Underlying: Common Stock · 17,380 shares

Expires 2029-01-02

F1 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and committee cash retainers of $76,250 in the aggregate. Such options vest in four quarterly installments on the last day of each calendar quarter during 2019 provided the Reporting Person continues to provide services to the Issuer.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, LLC. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-18-016592 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-06-13

F1 · derivative.exercise_date: The option vests and becomes exercisable in full on the earlier of (A) the first anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Corporation's stockholders after the date of grant, subject in each case to the reporting person's continued service as a director of the Corporation.

F2 · ownership.direct: The reporting person is a member of Atlas Venture Associates IX, LLC ("AVA IX LLC") and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the equity grants to Atlas Venture Advisors, L.P. As such, the reporting person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-18-015555 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2028-06-06

F1 · derivative.exercise_date: These options were issued under the nonemployee director compensation policy and will vest in full upon the earlier of June 6, 2019 or the date of the 2019 annual meeting of stockholders, subject to the director's continued service on the board of directors, provided that, all shares shall become fully vested upon a change in control of the Company.

SEC source: 0000899243-18-011498 · doc4.xml · nonDerivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,629

SEC source: 0000899243-18-011498 · doc4.xml · nonDerivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,243

F1 · shares: The reporting person was granted restricted stock units, with each unit representing a contingent right to receive one share of the issuer's common stock. The grant of restricted stock units will fully vest on May 3, 2019, which is the first anniversary of the date on which the grant was made.

SEC source: 0000899243-18-000594 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,627

Underlying: Common Stock · 17,627 shares

Expires 2028-01-03

F1 · derivative.exercise_date: The stock option was issued in lieu of cash fees under the Non-Employee Director Compensation Policy pursuant to a Non-Qualified Stock Option Agreement and shall vest over a period of one year starting January 1, 2018 on a quarterly basis in arrears.

SEC source: 0000899243-18-000274 · doc4.xml · derivative · entry 2

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,570

Underlying: Common Stock · 11,570 shares

Expires 2028-01-02

F2 · derivative.exercise_date: The options were issued to the Reporting Person pursuant to the Issuer's Amended and Restated Non-Employee Director Compensation Program and 2015 Equity Incentive Award Plan in lieu of the non-employee director board and committee cash retainers of $76,250 in the aggregate. Such options vest in four quarterly installments on the last day of each calendar quarter during 2018 provided the Reporting Person continues to provide services to the Issuer.

SEC source: 0000899243-18-000274 · doc4.xml · derivative · entry 1

Barrett Peter · CIK 0001291895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,143

Underlying: Common Stock · 17,143 shares

Expires 2027-12-29

F1 · derivative.exercise_date: The options vest and become exercisable in substantially equal installments on each of the first three anniversaries of August 28, 2017 subject to the Reporting Person continuing to provide services to the Issuer through each such vesting date.