KRYS

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,502,579

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F5 · price: The transaction was executed in multiple trades ranging from $218.11 to $219.07. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,505,156

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F4 · price: The transaction was executed in multiple trades ranging from $216.73 to $217.63. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,506,756

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F3 · price: The transaction was executed in multiple trades ranging from $214.99 to $215.80. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000013 · wk-form4_1764978821.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,507,100

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier upon completion of the sale of the maximum number of shares of Common Stock subject to the Rule 10b5-1 trading plan.

F2 · price: The transaction was executed in multiple trades ranging from $213.93 to $214.67. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 11

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,508,056

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 5

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,438,711

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in one trade.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,438,711

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,508,056

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 10

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,509,445

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 9

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,510,345

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F9 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 4

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,440,240

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in one trade.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 3

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,441,040

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,440,240

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,441,040

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F9 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,509,445

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,510,345

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in multiple trades ranging from $150.21 to $151.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,512,529

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F7 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 2

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,443,276

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in one trade.

SEC source: 0001298711-25-000009 · wk-form4_1752705765.xml · nonDerivative · entry 1

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,443,376

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F2 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,443,276

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in one trade.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,443,376

F6 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F7 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000009 · wk-form4_1752705685.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,512,529

F1 · shares: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 12, 2024, and contemplated quarterly sales of 25,000 shares of Common Stock. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F2 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,525,929

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 7

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,526,229

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F3 · price: The transaction was executed in multiple trades ranging from $150.0000 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 3

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,456,711

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 2

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,457,011

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F3 · price: The transaction was executed in multiple trades ranging from $150.0000 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,456,711

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,457,011

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F3 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,525,929

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F4 · price: The transaction was executed in three trades of 100 shares each at $151.350, $151.40, and $151.41, respectively. The price reported above reflects the average sale price.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,526,229

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F3 · price: The transaction was executed in multiple trades ranging from $150.00 to $150.8500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 6

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,532,856

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F7 · price: The transaction was executed in two trades of 100 shares each at $150 and $150.14, respectively. The price reported above reflects the average sale price.

F8 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000007 · wk-form4_1752270332.xml · nonDerivative · entry 1

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,463,511

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F2 · price: The transaction was executed in multiple trades ranging from $150.1200 to $150.1600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,463,511

F6 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, that started on September 12, 2024 and will terminate on September 13, 2025.

F7 · price: The transaction was executed in multiple trades ranging from $150.1200 to $150.1600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F8 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000007 · wk-form4_1752270242.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,532,856

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person that started on September 12, 2024 and will terminate on September 13, 2025 .

F2 · price: The transaction was executed in two trades of 100 shares each at $150 and $150.14, respectively. The price reported above reflects the average sale price.

SEC source: 0001852880-25-000003 · wk-form4_1751321917.xml · derivative · entry 1

Sutherland Everett Rand · CIK 0001852880 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001532023-25-000005 · wk-form4_1751322218.xml · derivative · entry 1

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001711279-25-000057 · wk-form4_1751321689.xml · derivative · entry 1

JANNEY DANIEL · CIK 0001198325 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001836440-25-000003 · wk-form4_1751321359.xml · derivative · entry 1

Mason Christopher · CIK 0001836440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001209059-25-000003 · wk-form4_1751321048.xml · derivative · entry 1

ROSSI DINO A · CIK 0001209059 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001967722-25-000002 · wk-form4_1751320735.xml · derivative · entry 1

Mazzacco Catherine · CIK 0001967722 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: The options were awarded on June 30, 2025 and vest in equal monthly tranches over a one-year period.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 12

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,533,056

F8 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F14 · price: The transaction was executed in multiple trades ranging from $179.29 to $179.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 11

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,534,312

F8 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F13 · price: The transaction was executed in multiple trades ranging from $178.29 to $179.27. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 10

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,541,081

F8 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F12 · price: The transaction was executed in multiple trades ranging from $177.28 to $178.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 9

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,552,012

F8 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F11 · price: The transaction was executed in multiple trades ranging from $176.28 to $177.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,556,956

F8 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F9 · price: The transaction was executed in multiple trades ranging from $175.23 to $176.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 5

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,463,711

F1 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F6 · price: The transaction was executed in multiple trades ranging from $179.33 to $179.70. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 4

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,465,042

F1 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F5 · price: The transaction was executed in multiple trades ranging from $178.31 to $179.26. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 3

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,471,556

F1 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F4 · price: The transaction was executed in multiple trades ranging from $177.30 to $178.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 2

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,482,493

F1 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F3 · price: The transaction was executed in multiple trades ranging from $176.30 to $177.29. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-25-000004 · wk-form4_1741903582.xml · nonDerivative · entry 1

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,487,072

F1 · kind: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F2 · price: The transaction was executed in multiple trades ranging from $175.30 to $176.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.