JAZZ

SEC source: 0001765581-22-000084 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,086

F2 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

SEC source: 0001765581-22-000082 · edgardoc.xml · nonDerivative · entry 2

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,891

F2 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

SEC source: 0001765581-22-000079 · edgardoc.xml · nonDerivative · entry 1

Carr Patricia · CIK 0001784606 · SVP, Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,076

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

SEC source: 0001765581-22-000096 · edgardoc.xml · derivative · entry 5

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 8,000 shares

Expires 2023-05-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option was granted pursuant to the Issuer's 2007 Non-Employee Directors Stock Option Plan. Subject to the Reporting Person's continuous service and certain additional conditions, this option vested over three years from the Vesting Commencement Date, with 1/3 that vested on the first anniversary of the Vesting Commencement Date and the remainder vested in 24 equal monthly installments thereafter.

SEC source: 0001765581-22-000096 · edgardoc.xml · nonDerivative · entry 3

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,960

F2 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000096 · edgardoc.xml · nonDerivative · entry 2

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,399

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $155.80.00 to $156.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001765581-22-000096 · edgardoc.xml · nonDerivative · entry 1

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,399

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000088 · edgardoc.xml · nonDerivative · entry 1

McSharry Heather Ann · CIK 0001576068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,726

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000102 · edgardoc.xml · nonDerivative · entry 1

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,699

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000100 · edgardoc.xml · nonDerivative · entry 1

Sohn Catherine A. · CIK 0001555132 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,123

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000098 · edgardoc.xml · nonDerivative · entry 1

Smith Mark Douglas · CIK 0001756253 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,980

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000094 · edgardoc.xml · nonDerivative · entry 1

ORiordan Anne · CIK 0001767870 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,806

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000092 · edgardoc.xml · nonDerivative · entry 1

O'Keefe Kenneth W · CIK 0001397661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,168

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000090 · edgardoc.xml · nonDerivative · entry 1

Mulligan Seamus · CIK 0001536639 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,160,300

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000086 · edgardoc.xml · nonDerivative · entry 1

Gray Peter · CIK 0001576096 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,413

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000084 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,175

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000082 · edgardoc.xml · nonDerivative · entry 1

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,980

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001765581-22-000077 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP and Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,279

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001765581-22-000075 · edgardoc.xml · derivative · entry 3

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,094

Underlying: Ordinary Shares · 531 shares

Expires 2030-05-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: These options were granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of March 2, 2020, 1/4th vested on the first anniversary of the vesting commencement date and the remainder vests in 36 equal monthly installments thereafter.

SEC source: 0001765581-22-000075 · edgardoc.xml · nonDerivative · entry 2

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,309

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000075 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,840

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000073 · edgardoc.xml · derivative · entry 8

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,605

Underlying: Ordinary Shares · 68 shares

Expires 2023-03-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F7 · derivative.exercise_date: This non-qualified stock option is part of an option granted on March 5, 2013. The ordinary shares subject to this option vested over 4 years from the grant date with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter and were fully vested as of March 5, 2017.

SEC source: 0001765581-22-000073 · edgardoc.xml · derivative · entry 7

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 9,632 shares

Expires 2022-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F6 · derivative.exercise_date: This Non-qualified stock option is part of an option granted on August 9, 2012. The ordinary shares subject to this option vested over 4 years from the grant date with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter and were fully vested as of August 9, 2016.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 6

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,311

F5 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 5

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 355,311

F1 · kind: Shares sold to pay option price and to satisfy tax obligations arising from the exercise of stock options.

F4 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $155.015 to $155.66. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 4

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,411

F1 · kind: Shares sold to pay option price and to satisfy tax obligations arising from the exercise of stock options.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $154.01 to $154.95. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 3

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 359,012

F1 · kind: Shares sold to pay option price and to satisfy tax obligations arising from the exercise of stock options.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $153.01 to $153.935. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 2

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 361,612

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000073 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 361,544

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000071 · edgardoc.xml · derivative · entry 3

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,625

Underlying: Ordinary Shares · 532 shares

Expires 2030-05-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: These options were granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of March 2, 2020, 1/4th vested on the first anniversary of the vesting commencement date and the remainder vests in 36 equal monthly installments thereafter.

SEC source: 0001765581-22-000071 · edgardoc.xml · nonDerivative · entry 2

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,309

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000071 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,841

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000067 · edgardoc.xml · derivative · entry 6

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,632

Underlying: Ordinary Shares · 9,700 shares

Expires 2022-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · derivative.exercise_date: This Non-qualified stock option is part of an option granted on August 9, 2012. The ordinary shares subject to this option vested over 4 years from the grant date with 1/4th vesting on the first anniversary of the grant date and the remainder vesting in 36 equal monthly installments thereafter and were fully vested as of August 9, 2016.

SEC source: 0001765581-22-000067 · edgardoc.xml · nonDerivative · entry 5

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 351,912

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000067 · edgardoc.xml · nonDerivative · entry 4

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 353,412

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000067 · edgardoc.xml · nonDerivative · entry 3

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,412

F2 · kind: Shares sold to pay option price and to satisfy tax obligations arising from the exercise of stock options.

F4 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $157.05 to $157.36. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000067 · edgardoc.xml · nonDerivative · entry 2

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 354,848

F2 · kind: Shares sold to pay option price and to satisfy tax obligations arising from the exercise of stock options.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $156.05 to $157.03. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000067 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director · Chairman & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 360,687

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000069 · edgardoc.xml · derivative · entry 4

Tovey Christopher J. · CIK 0001754163 · EVP, COO & Managing Director E

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,031

Underlying: Ordinary Shares · 4,032 shares

Expires 2031-02-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: Option to acquire Jazz Ordinary Shares received upon conversion of options to acquire shares of GW Pharmaceuticals PLC ("GW") pursuant to the GW Transaction Agreement among Jazz Pharmaceuticals UK Holdings Limited, Jazz Pharmaceuticals Public Limited Company and GW dated February 3, 2021 (the "Merger"). The effective date of the Merger was May 5, 2021. Fifty percent of the award will vest and be available for exercise on February 22, 2022 and fifty percent will vest and be available for exercise on February 22, 2023 in accordance with the terms of the Merger.

SEC source: 0001765581-22-000069 · edgardoc.xml · nonDerivative · entry 3

Tovey Christopher J. · CIK 0001754163 · EVP, COO & Managing Director E

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,663

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000069 · edgardoc.xml · nonDerivative · entry 2

Tovey Christopher J. · CIK 0001754163 · EVP, COO & Managing Director E

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,840

SEC source: 0001765581-22-000069 · edgardoc.xml · nonDerivative · entry 1

Tovey Christopher J. · CIK 0001754163 · EVP, COO & Managing Director E

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,872

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000065 · edgardoc.xml · derivative · entry 3

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,157

Underlying: Ordinary Shares · 8,508 shares

Expires 2030-05-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: These options were granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of March 2, 2020, 1/4th vested on the first anniversary of the vesting commencement date and the remainder vests in 36 equal monthly installments thereafter.

SEC source: 0001765581-22-000065 · edgardoc.xml · nonDerivative · entry 2

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,309

SEC source: 0001765581-22-000065 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,817

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001765581-22-000063 · edgardoc.xml · derivative · entry 4

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,665

Underlying: Ordinary Shares · 5,835 shares

Expires 2030-05-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of March 2, 2020, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in 36 equal monthly installments thereafter.

SEC source: 0001765581-22-000063 · edgardoc.xml · nonDerivative · entry 3

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,309

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000063 · edgardoc.xml · nonDerivative · entry 2

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,961

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000063 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · SVP, Head of Europe & Internat

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,796

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001765581-22-000057 · edgardoc.xml · nonDerivative · entry 7

Sablich Kim · CIK 0001758790 · EVP & GM, North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,754

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $152.595 to $152.60, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.