IRWD

SEC source: 0001209191-23-021524 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 842,064

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.58 to $10.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-019597 · doc4.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,027

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-019596 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,423

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-017889 · doc4.xml · derivative · entry 2

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,935

Underlying: Class A Common Stock · 34,935 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017889 · doc4.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 331,455

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017883 · doc4.xml · derivative · entry 2

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,751

Underlying: Class A Common Stock · 32,751 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017883 · doc4.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 199,240

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017886 · doc4.xml · derivative · entry 2

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,834

Underlying: Class A Common Stock · 21,834 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017886 · doc4.xml · nonDerivative · entry 1

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 376,316

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017882 · doc4.xml · derivative · entry 2

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,297

Underlying: Class A Common Stock · 120,297 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017882 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 888,193

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 33.33% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017892 · doc4.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,111

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017878 · doc4.xml · derivative · entry 2

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,118

Underlying: Class A Common Stock · 37,118 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017878 · doc4.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,658

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-017873 · doc4.xml · derivative · entry 2

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,118

Underlying: Class A Common Stock · 37,118 shares

Expires 2026-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0001209191-23-017873 · doc4.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,632

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-016696 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 647,598

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.16 to $11.33, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014280 · doc4.xml · nonDerivative · entry 4

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 261,586

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020 and April 24, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014280 · doc4.xml · nonDerivative · entry 3

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264,002

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014277 · doc4.xml · nonDerivative · entry 2

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 133,738

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014285 · doc4.xml · nonDerivative · entry 4

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332,648

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014285 · doc4.xml · nonDerivative · entry 3

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 336,090

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014283 · doc4.xml · nonDerivative · entry 4

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 681,354

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014283 · doc4.xml · nonDerivative · entry 3

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 685,942

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014286 · doc4.xml · nonDerivative · entry 2

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,491

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014276 · doc4.xml · nonDerivative · entry 2

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 151,396

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.26 to $11.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014280 · doc4.xml · nonDerivative · entry 2

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 271,440

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020 and April 24, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014280 · doc4.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 273,762

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014277 · doc4.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,153

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014285 · doc4.xml · nonDerivative · entry 2

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 350,077

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014285 · doc4.xml · nonDerivative · entry 1

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 353,385

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014283 · doc4.xml · nonDerivative · entry 2

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 712,581

F3 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of performance-based restricted stock units granted on February 27, 2020. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014283 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 716,990

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014286 · doc4.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,540

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-014276 · doc4.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 153,218

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.29 to $11.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F3 · balance_after: The reporting person acquired 756 shares of Class A Common Stock under the issuer's employee stock purchase plan on December 31, 2022.

SEC source: 0001209191-23-003999 · doc4.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,908

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted February 27, 2020 and April 24, 2020. The earned PSUs were certified and vested on January 17, 2023.

SEC source: 0001209191-23-003991 · doc4.xml · nonDerivative · entry 1

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 366,823

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted February 27, 2020. The earned PSUs were certified and vested on January 17, 2023.

SEC source: 0001209191-23-003990 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 742,585

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted February 27, 2020. The earned PSUs were certified and vested on January 17, 2023.

SEC source: 0001209191-23-002543 · doc4.xml · derivative · entry 3

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Class A Common Stock · 110,962 shares

Expires 2023-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The options, vested as to 1.25% on each monthly anniversary of the vesting commencement date for the first 36 months, and as to 4.5833% of the award on each monthly anniversary thereafter, are presently exercisable in full.

SEC source: 0001209191-23-002543 · doc4.xml · nonDerivative · entry 2

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 712,440

F1 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.01 to $12.29, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-002543 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 823,402

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-061864 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,985

F1 · kind: Issued pursuant to the Director Compensation Policy, effective May 2019.

SEC source: 0001209191-22-061644 · doc4.xml · nonDerivative · entry 1

Rickard Jason · CIK 0001808505 · SVP, Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,736

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.38 to $12.41,inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-22-058611 · doc4.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,422

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-22-058612 · doc4.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,469

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-22-058607 · doc4.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 154,213

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · balance_after: The reporting person acquired 1,032 shares of Class A Common Stock under the issuer's employee stock purchase plan on June 30, 2022.

SEC source: 0001209191-22-052718 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 712,440

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.25 to $10.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-22-050483 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,741

F1 · kind: Issued pursuant to the Director Compensation Policy, effective May 2019.

SEC source: 0001209191-22-048716 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 731,339

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.59 to $10.72, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-22-046220 · doc4.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,435

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.