IRWD

SEC source: 0001193125-26-394323 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 327,549

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0001193125-26-312410 · ownership.xml · nonDerivative · entry 1

Silber Jeffrey · CIK 0002050938 · SVP, CMO, Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,036

F1 · kind: The restricted stock unit award, granted as a new hire award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-299749 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · PFO & PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 313,680

F1 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.50 to $4.57, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-274275 · ownership.xml · nonDerivative · entry 2

McHugh Julie · CIK 0001487179 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 250,749

F2 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.66 to $3.78, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-274275 · ownership.xml · nonDerivative · entry 1

McHugh Julie · CIK 0001487179 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 272,320

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274288 · ownership.xml · nonDerivative · entry 1

Currie Mark G · CIK 0001478244 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 676,900

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274301 · ownership.xml · nonDerivative · entry 1

Shepard Jay · CIK 0001587788 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,036

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274292 · ownership.xml · nonDerivative · entry 1

Kessler Marla L · CIK 0001772124 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 229,364

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274283 · ownership.xml · nonDerivative · entry 1

Duane Jon R · CIK 0001772129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,820

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274279 · ownership.xml · nonDerivative · entry 2

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 323,855

F2 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274256 · ownership.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,425

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001193125-26-274279 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,374

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0001193125-26-234397 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · PFO & PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 441,570

F1 · kind: The restricted stock unit award vests as to 50% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-111581 · ownership.xml · nonDerivative · entry 3

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 9,188,635

F2 · ownership.nature: Consists of shares that are held by Sarissa Capital Management LP ("Sarissa Capital") or by the funds and other investment vehicles (the "Sarissa Funds") for which Sarissa Capital serves as investment advisor. Dr. Denner is the Chief Investment Officer of Sarissa Capital and the managing member, general partner or other control party of the Sarissa Funds. By virtue of the foregoing, Dr. Denner may be deemed to indirectly beneficially own the shares that these funds directly beneficially own. Each of SarissaCapital, the Sarissa Funds and Dr. Denner disclaims beneficial ownership of these shares except, in each case, to the extent of their pecuniary interest therein.

SEC source: 0001193125-26-111581 · ownership.xml · nonDerivative · entry 2

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 9,194,435

F2 · ownership.nature: Consists of shares that are held by Sarissa Capital Management LP ("Sarissa Capital") or by the funds and other investment vehicles (the "Sarissa Funds") for which Sarissa Capital serves as investment advisor. Dr. Denner is the Chief Investment Officer of Sarissa Capital and the managing member, general partner or other control party of the Sarissa Funds. By virtue of the foregoing, Dr. Denner may be deemed to indirectly beneficially own the shares that these funds directly beneficially own. Each of SarissaCapital, the Sarissa Funds and Dr. Denner disclaims beneficial ownership of these shares except, in each case, to the extent of their pecuniary interest therein.

SEC source: 0001193125-26-111581 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 256,309

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0001193125-26-104111 · ownership.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · SVP, CMO, Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 658,037

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-104107 · ownership.xml · nonDerivative · entry 1

Martini Gregory S. · CIK 0002053936 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 297,213

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-104108 · ownership.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,498

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-104099 · ownership.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,898,838

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 33.33% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-104112 · ownership.xml · nonDerivative · entry 1

Gaskins Tammi L · CIK 0002061679 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,350

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-104110 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 416,570

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001193125-26-071503 · ownership.xml · nonDerivative · entry 2

Shetzline Michael · CIK 0001808509 · SVP, CMO, Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 521,425

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071515 · ownership.xml · nonDerivative · entry 2

Martini Gregory S. · CIK 0002053936 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,601

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071509 · ownership.xml · nonDerivative · entry 2

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,886

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071496 · ownership.xml · nonDerivative · entry 2

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,489,002

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071500 · ownership.xml · nonDerivative · entry 2

Gaskins Tammi L · CIK 0002061679 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 213,738

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071495 · ownership.xml · nonDerivative · entry 2

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 252,636

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.60 to $3.73, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071503 · ownership.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · SVP, CMO, Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 538,437

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071515 · ownership.xml · nonDerivative · entry 1

Martini Gregory S. · CIK 0002053936 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,058

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071509 · ownership.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 382,939

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071496 · ownership.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,592,528

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F3 · balance_after: The reporting person acquired 4 shares of Class A Common Stock under the issuer's employee stock purchase plan on December 31, 2025.

SEC source: 0001193125-26-071500 · ownership.xml · nonDerivative · entry 1

Gaskins Tammi L · CIK 0002061679 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 224,977

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-071495 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 265,257

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the reporting person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.70 to $4.05, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001193125-26-006290 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 276,809

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · balance_after: The reporting person acquired 35,416 shares of Class A Common Stock under the issuer's employee stock purchase plan on December 31, 2025.

SEC source: 0001193125-25-322690 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,858

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0001193125-25-288086 · ownership.xml · nonDerivative · entry 1

Gaskins Tammi L · CIK 0002061679 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,264

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001193125-25-206547 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 247,680

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0000950170-25-108010 · ownership.xml · nonDerivative · entry 1

Martini Gregory S. · CIK 0002053936 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 182,545

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0000950170-25-108013 · ownership.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,378

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0000950170-25-108011 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 276,809

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0000950170-25-108016 · ownership.xml · nonDerivative · entry 1

Gaskins Tammi L · CIK 0002061679 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 241,280

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0000950170-25-087350 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,962

F1 · kind: Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024.

SEC source: 0000950170-25-085437 · ownership.xml · nonDerivative · entry 1

Dreyfus Andrew · CIK 0001670893 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,313

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

F2 · balance_after: Since the date of the reporting person's last ownership report, the individual transferred 4,917 shares of Class A common stock to the individual's ex-spouse pursuant to a domestic relations order. The reporting person no longer reports as beneficially owned any securities owned by the individual's ex-spouse.

SEC source: 0000950170-25-085438 · ownership.xml · nonDerivative · entry 1

McHugh Julie · CIK 0001487179 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,839

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0000950170-25-085440 · ownership.xml · nonDerivative · entry 1

Currie Mark G · CIK 0001478244 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 613,419

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0000950170-25-085452 · ownership.xml · nonDerivative · entry 1

Kessler Marla L · CIK 0001772124 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,883

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0000950170-25-085446 · ownership.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,944

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0000950170-25-085448 · ownership.xml · nonDerivative · entry 1

Shepard Jay · CIK 0001587788 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 171,555

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0000950170-25-085378 · ownership.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 211,769

F1 · kind: The restricted stock, granted pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.