IRWD

SEC source: 0000950170-24-029910 · ownership.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 310,756

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted on March 8, 2023. The earned PSUs were certified on February 12, 2024, and March 7, 2024, and vested on March 8, 2024.

SEC source: 0000950170-24-028623 · ownership.xml · nonDerivative · entry 1

Duane Jon R · CIK 0001772129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,028

SEC source: 0000950170-24-027917 · ownership.xml · derivative · entry 2

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,438

Underlying: Class A Common Stock · 132,438 shares

Expires 2027-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0000950170-24-027917 · ownership.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,097,650

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 33.33% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-027128 · ownership.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 301,733

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.37 to $9.38, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0000950170-24-015557 · ownership.xml · derivative · entry 3

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,214

Underlying: Class A Common Stock · 27,214 shares

Expires 2027-02-28

F4 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F4 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0000950170-24-015557 · ownership.xml · nonDerivative · entry 2

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 394,911

F3 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-015557 · ownership.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 340,484

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units and performance-based restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.85 to $15.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0000950170-24-015560 · ownership.xml · derivative · entry 3

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,214

Underlying: Class A Common Stock · 27,214 shares

Expires 2027-02-28

F4 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F4 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0000950170-24-015560 · ownership.xml · nonDerivative · entry 2

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 279,223

F3 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-015560 · ownership.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 224,796

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units and performance-based restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.85 to $15.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0000950170-24-015542 · ownership.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 832,774

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units and performance-based restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.85 to $15.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0000950170-24-015548 · ownership.xml · derivative · entry 3

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,656

Underlying: Class A Common Stock · 32,656 shares

Expires 2027-02-28

F5 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F5 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0000950170-24-015548 · ownership.xml · nonDerivative · entry 2

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 273,636

F4 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-015548 · ownership.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,324

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.85 to $15.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F3 · balance_after: The reporting person acquired 796 shares of Class A Common Stock under the issuer's employee stock purchase plan on December 31, 2023.

SEC source: 0000950170-24-015553 · ownership.xml · nonDerivative · entry 2

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 161,477

F3 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-015553 · ownership.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 134,264

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a sell to cover transaction and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.85 to $15.53, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0000950170-24-015545 · ownership.xml · derivative · entry 2

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,656

Underlying: Class A Common Stock · 32,656 shares

Expires 2027-02-28

F2 · derivative.exercise_price: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

F2 · derivative.exercise_date: Each performance-based restricted stock unit (PSU) represents a contingent right to receive shares of the Issuer's Class A Common Stock upon vesting such award. The PSUs vest upon the Issuer's Class A Common Stock achieving a specified price per share.

SEC source: 0000950170-24-015545 · ownership.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 291,049

F1 · kind: The restricted stock unit award, granted as an annual performance award, vests as to 25% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0000950170-24-013817 · ownership.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,737

F1 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the vesting of performance-based restricted stock units and restricted stock units.

SEC source: 0001209191-24-001905 · doc4.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 379,102

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted March 26, 2021. The earned PSUs were certified and vested on January 17, 2024.

SEC source: 0001209191-24-001904 · doc4.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 272,176

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted August 2, 2021. The earned PSUs were certified and vested on January 17, 2024.

SEC source: 0001209191-24-001906 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,009,938

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted March 26, 2021 and June 7, 2021. The earned PSUs were certified and vested on January 17, 2024.

F2 · balance_after: The reporting person acquired 2,037 shares of Class A common stock under the issuer's employee stock purchase plan on June 30, 2023.

SEC source: 0001209191-24-001903 · doc4.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 267,069

F1 · kind: Represents shares earned upon satisfaction of certain performance criteria associated with performance-based restricted stock units (PSUs) granted December 6, 2021. The earned PSUs were certified and vested on January 17, 2024.

SEC source: 0001209191-23-059112 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,277

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-059113 · doc4.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,633

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-058948 · doc4.xml · nonDerivative · entry 1

Kessler Marla L · CIK 0001772124 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,572

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 7, 2023, to satisfy tax obligations in connection with the vesting of 21,571 restricted stock awards on June 19, 2023.

SEC source: 0001209191-23-056446 · doc4.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,374

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · balance_after: The reporting person acquired 1,334 shares of Class A common stock under the issuer's employee stock purchase plan on June 30, 2023.

SEC source: 0001209191-23-056023 · doc4.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 182,069

F1 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001209191-23-049781 · doc4.xml · nonDerivative · entry 1

Emany Sravan Kumar · CIK 0001897662 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 188,730

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.31 to $8.33, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001209191-23-049996 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,930

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-049998 · doc4.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 127,061

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-047842 · doc4.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,172

F1 · kind: The restricted stock unit award, granted as a recognition award, vests as to 50% of the shares of Class A Common Stock on each approximate anniversary of the grant thereof.

SEC source: 0001209191-23-046017 · doc4.xml · nonDerivative · entry 1

John Minardo · CIK 0001875067 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,195

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-23-046018 · doc4.xml · nonDerivative · entry 1

Silver Ronald · CIK 0001873731 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 134,172

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

F2 · balance_after: The reporting person acquired 2,037 shares of Class A Common Stock under the issuer's employee stock purchase plan on June 30, 2023.

SEC source: 0001209191-23-039134 · doc4.xml · nonDerivative · entry 1

Dreyfus Andrew · CIK 0001670893 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,980

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

F2 · balance_after: Since the date of the reporting person's last ownership report, the individual transferred 5,009 shares of Class A common stock to the individual's ex-spouse pursuant to a domestic relations order. The reporting person no longer reports as beneficially owned any securities owned by the individual's ex-spouse.

SEC source: 0001209191-23-039139 · doc4.xml · nonDerivative · entry 1

McHugh Julie · CIK 0001487179 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,294

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039132 · doc4.xml · nonDerivative · entry 1

Currie Mark G · CIK 0001478244 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 544,108

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039143 · doc4.xml · nonDerivative · entry 1

Shepard Jay · CIK 0001587788 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,244

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039142 · doc4.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,963

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039136 · doc4.xml · nonDerivative · entry 1

Kessler Marla L · CIK 0001772124 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,498

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039135 · doc4.xml · nonDerivative · entry 1

Duane Jon R · CIK 0001772129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,108

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-039133 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,132

F1 · kind: The restricted stock, granted pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023, vests in full on the date immediately preceding the date of the annual meeting of stockholders for the next calendar year.

SEC source: 0001209191-23-038340 · doc4.xml · nonDerivative · entry 1

Moukheibir Catherine · CIK 0001772130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,613

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-038339 · doc4.xml · nonDerivative · entry 1

DENNER ALEXANDER J · CIK 0001361754 · Director · 10% owner

Sarissa Capital Management LP · CIK 0001577524 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,782

F1 · kind: Issued pursuant to the Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2023.

SEC source: 0001209191-23-033396 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 758,284

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 12, 2022.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.60 to $10.82, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-031874 · doc4.xml · nonDerivative · entry 1

Shetzline Michael · CIK 0001808509 · CMO,SVP,Head-Res&Drug

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 321,131

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-23-031875 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 784,916

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-23-031873 · doc4.xml · nonDerivative · entry 1

Davis Andrew · CIK 0001932525 · SVP, Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,327

F1 · kind: The sale reported on this Form 4 represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. The sale occurred automatically to satisfy the tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the Reporting Person.

SEC source: 0001209191-23-028453 · doc4.xml · nonDerivative · entry 1

MCCOURT Thomas A · CIK 0001478448 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 820,916

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 12, 2022.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.59 to $10.68, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.