CTMX

SEC source: 0001610717-24-000246 · form4.xml · derivative · entry 1

Mohindru Mani · CIK 0001664708 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2025 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-24-000243 · form4.xml · derivative · entry 1

Gilbert Halley E · CIK 0001601360 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Common Stock · 38,000 shares

Expires 2034-05-14

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2025 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0001610717-24-000190 · form4.xml · derivative · entry 3

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 109,768 shares

Expires 2025-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option is fully vested and exercisable.

F4 · balance_after: The Reporting Person previously transferred 9,768 shares subject to this stock option to a family member.

SEC source: 0001610717-24-000190 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 634,249

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 197,500 restricted stock units.

SEC source: 0001610717-24-000181 · form4.xml · derivative · entry 1

Su Zhen · CIK 0001991642 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,000

Underlying: Common Stock · 76,000 shares

Expires 2034-03-19

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from March 20, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000176 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,579

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 109,166 restricted stock units.

SEC source: 0001610717-24-000179 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,728

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 52,916 restricted stock units.

SEC source: 0001610717-24-000178 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 524,481

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 197,500 restricted stock units.

SEC source: 0001610717-24-000177 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,686

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 60,310 restricted stock units.

SEC source: 0001610717-24-000175 · form4.xml · nonDerivative · entry 1

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,060

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 64,802 restricted stock units.

SEC source: 0001610717-24-000032 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000032 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,500

Underlying: Common Stock · 122,500 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000032 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,374

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 143,125 RSUs.

SEC source: 0001610717-24-000031 · form4.xml · derivative · entry 3

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000031 · form4.xml · derivative · entry 2

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,500

Underlying: Common Stock · 122,500 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000031 · form4.xml · nonDerivative · entry 1

Chu Yu-Waye · CIK 0001854586 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,250

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 26,250 RSUs.

SEC source: 0001610717-24-000035 · form4.xml · derivative · entry 3

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000035 · form4.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000035 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,996

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 66,875 RSUs.

SEC source: 0001610717-24-000033 · form4.xml · derivative · entry 5

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000033 · form4.xml · derivative · entry 4

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000033 · form4.xml · nonDerivative · entry 1

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,622

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 82,205 RSUs.

SEC source: 0001610717-24-000034 · form4.xml · derivative · entry 3

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000034 · form4.xml · derivative · entry 2

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,000

Underlying: Common Stock · 154,000 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000034 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,657

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 70,466 RSUs.

SEC source: 0001610717-24-000036 · form4.xml · derivative · entry 4

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,000

Underlying: Common Stock · 260,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F5 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F5 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000036 · form4.xml · derivative · entry 3

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 420,000

Underlying: Common Stock · 420,000 shares

Expires 2034-01-17

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000036 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 544,704

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 251,250 RSUs.

SEC source: 0001610717-23-000422 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,124

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000420 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,996

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001610717-23-000423 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 454,704

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 161,250 restricted stock units.

SEC source: 0001610717-23-000421 · form4.xml · nonDerivative · entry 1

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,622

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 52,205 restricted stock units.

SEC source: 0001610717-23-000419 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,657

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 30,466 restricted stock units.

SEC source: 0001610717-23-000408 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F3 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F3 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000408 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 159,201

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000409 · form4.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000409 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 41,875 restricted stock units.

F3 · balance_after: Includes 4,560 shares and 5,654 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on May 31, 2023 and November 30, 2023, respectively.

SEC source: 0001610717-23-000412 · form4.xml · derivative · entry 2

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,875

Underlying: Common Stock · 6,875 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000412 · form4.xml · nonDerivative · entry 1

Ogden Christopher · CIK 0001914523 · SVP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,647

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 30,466 restricted stock units.

F3 · balance_after: Includes 6,000 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on May 31, 2023.

SEC source: 0001610717-23-000411 · form4.xml · derivative · entry 3

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000411 · form4.xml · nonDerivative · entry 1

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 468,255

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 161,250 restricted stock units.

SEC source: 0001610717-23-000410 · form4.xml · derivative · entry 4

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000410 · form4.xml · nonDerivative · entry 1

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,699

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 52,205 restricted stock units.

F3 · balance_after: Includes 1,310 shares and 1,760 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on May 31, 2023 and November 30, 2023, respectively.

SEC source: 0001610717-23-000299 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,951

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000296 · form4.xml · nonDerivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,609

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001610717-23-000298 · form4.xml · nonDerivative · entry 2

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,379

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 52,205 restricted stock units.

SEC source: 0001610717-23-000297 · form4.xml · nonDerivative · entry 2

McCarthy Sean A. · CIK 0001654058 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 430,755

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 161,250 restricted stock units.

SEC source: 0001610717-23-000299 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,070

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The second milestone vesting condition was determined to be satisfied upon which the remaining 50% of the PSUs vested.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000296 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,095

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The second milestone vesting condition was determined to be satisfied upon which the remaining 50% of the PSUs vested.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001610717-23-000298 · form4.xml · nonDerivative · entry 1

Landau Jeffrey B · CIK 0001918615 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,498

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The second milestone vesting condition was determined to be satisfied upon which the remaining 50% of the PSUs vested.

F2 · balance_after: Includes 52,205 restricted stock units.