BELVIN MARCIA

SEC source: 0001610717-26-000123 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,760

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 135,833 RSUs.

SEC source: 0001610717-26-000041 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2036-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2026 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-26-000041 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 332,252

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2027, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 218,958 RSUs.

SEC source: 0001610717-25-000354 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,150

Underlying: Common Stock · 18,150 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/3 of the PSUs vest upon the achievement of each of three clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000354 · form4.xml · derivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Common Stock · 36,300 shares

Expires 2035-09-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from September 26, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000235 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 272,252

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 158,958 restricted stock units.

SEC source: 0001610717-25-000235 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 37,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F4 · derivative.exercise_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

F4 · derivative.expiration_date: Each PSU represented a contingent right to receive one (1) share of common stock upon vesting.

SEC source: 0001610717-25-000235 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 286,136

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction represents the vesting of performance stock units ("PSUs") initially granted on February 2, 2023.

F2 · balance_after: Includes 158,958 restricted stock units.

SEC source: 0001610717-25-000082 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,636

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 158,958 RSUs.

SEC source: 0001610717-25-000019 · form4.xml · derivative · entry 4

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Stock · 115,000 shares

Expires 2035-02-03

F5 · derivative.exercise_date: 1/24th of the shares subject to the option vest on each monthly anniversary measured from the Vesting Commencement Date, such that 100% of the shares subject to the option will be fully vested and exercisable on the second anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000019 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2035-02-03

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 4, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000019 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 263,148

F2 · shares: Constitute RSUs for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 50% of the RSUs vest annually on March 15 of each year, with the first 50% vesting on March 15, 2026, subject to the Reporting Person continuing as a service provider through each such date.

F3 · balance_after: Includes 196,666 RSUs.

SEC source: 0001610717-25-000019 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,648

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2026, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-25-000020 · form4.xml · derivative · entry 4

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Stock · 115,000 shares

Expires 2035-02-03

F6 · derivative.exercise_date: 1/24th of the shares subject to the option vest on each monthly anniversary measured from the Vesting Commencement Date, such that 100% of the shares subject to the option will be fully vested and exercisable on the second anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-25-000020 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2035-02-03

F1 · shares: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

F5 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 4, 2025 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

F1 · derivative.underlying_shares: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

F1 · balance_after: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

SEC source: 0001610717-25-000020 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 268,148

F3 · shares: Constitute RSUs for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 50% of the RSUs vest annually on March 15 of each year, with the first 50% vesting on March 15, 2026, subject to the Reporting Person continuing as a service provider through each such date.

F1 · balance_after: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

F4 · balance_after: Includes 201,666 RSUs.

SEC source: 0001610717-25-000020 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,648

F1 · shares: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

F2 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2026, subject to the Reporting Person continuing as a service provider through each such date.

F1 · balance_after: The Form 4 filed by the Reporting Person on February 6, 2025 incorrectly reflected the number of securities acquired in Box 4 of Table I and Box 5 of Table II and consequently the amount beneficially owned reflected in Box 5 of Table I and Box 9 of Table II. The number of securities acquired and the amount beneficially owned following reported transactions has been adjusted in this Form 4/A to correct the aforementioned errors. Except as otherwise noted in this footnote, all other information disclosed in the Reporting Person's original Form 4 was accurately reported.

SEC source: 0001610717-24-000435 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

F1 · kind: Represents vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

SEC source: 0001610717-24-000435 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,648

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs reported herein.

F2 · balance_after: Includes 109,166 restricted stock units.

SEC source: 0001610717-24-000435 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 179,829

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 109,166 restricted stock units.

SEC source: 0001610717-24-000176 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,579

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 109,166 restricted stock units.

SEC source: 0001610717-24-000032 · form4.xml · derivative · entry 3

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000032 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,500

Underlying: Common Stock · 122,500 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000032 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,374

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 143,125 RSUs.

SEC source: 0001610717-23-000422 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,124

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000408 · form4.xml · derivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F3 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F3 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000408 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 159,201

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000299 · form4.xml · nonDerivative · entry 2

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,951

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001610717-23-000299 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,070

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The second milestone vesting condition was determined to be satisfied upon which the remaining 50% of the PSUs vested.

F2 · balance_after: Includes 116,875 restricted stock units.

SEC source: 0001140361-23-014592 · form4.xml · nonDerivative · entry 1

BELVIN MARCIA · CIK 0001970752 · SVP, Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,820

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/4th of the RSUs vest annually on March 15 of each year, with the first 1/4th vesting on March 15, 2024, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 116,875 RSUs.