ROWLAND LLOYD A

SEC source: 0001610717-25-000083 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,594

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units ("RSUs").

F2 · balance_after: Includes 30,624 RSUs.

SEC source: 0001610717-24-000434 · form4.xml · derivative · entry 3

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

F1 · kind: Represents vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F5 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

F5 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vested on December 17, 2023 upon achievement of a certain performance-based milestone. In connection with the vesting reported herein, the remaining 50% of the PSUs vested upon achievement of a certain performance-based milestone.

SEC source: 0001610717-24-000434 · form4.xml · nonDerivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,797

F4 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs reported herein.

F3 · balance_after: Includes 52,916 restricted stock units.

SEC source: 0001610717-24-000434 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 134,978

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 6,000 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on May 31, 2024.

F3 · balance_after: Includes 52,916 restricted stock units.

SEC source: 0001610717-24-000179 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,728

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 52,916 restricted stock units.

SEC source: 0001610717-24-000035 · form4.xml · derivative · entry 3

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F4 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F4 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001610717-24-000035 · form4.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-01-17

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 18, 2024 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001610717-24-000035 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,996

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on March 15 of each year, with the first 1/3rd vesting on March 15, 2025, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 66,875 RSUs.

SEC source: 0001610717-23-000420 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,996

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs previously reported on December 19, 2023.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001610717-23-000409 · form4.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 11,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F4 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F4 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. In connection with the vesting reported herein, 50% of the PSUs vested upon achievement of a certain performance-based milestone. The remaining 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001610717-23-000409 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,073

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents partial vesting of a Performance Stock Unit ("PSU") award initially granted on August 10, 2022.

F2 · balance_after: Includes 41,875 restricted stock units.

F3 · balance_after: Includes 4,560 shares and 5,654 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on May 31, 2023 and November 30, 2023, respectively.

SEC source: 0001610717-23-000296 · form4.xml · nonDerivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,609

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of PSUs.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001610717-23-000296 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,095

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The second milestone vesting condition was determined to be satisfied upon which the remaining 50% of the PSUs vested.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001140361-23-012616 · form4.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,095

F1 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of restricted stock units.

F2 · balance_after: Includes 41,875 restricted stock units.

SEC source: 0001567619-23-001928 · doc1.xml · derivative · entry 3

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires not disclosed

F5 · derivative.exercise_price: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F5 · derivative.exercise_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

F5 · derivative.expiration_date: Each Performance-Based Restricted Stock Unit ("PSU") represents a contingent right to receive one (1) share of Common Stock upon vesting. 1/2 of the PSUs vest upon the achievement of each of two clinical milestones, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001567619-23-001928 · doc1.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-02-01

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2023 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001567619-23-001928 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,132

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on Febrary 2 of each year, with the first 1/3rd vesting on February 2, 2024, subject to the Reporting Person continuing as a service provider through each such date.

F2 · balance_after: Includes 47,500 RSUs.

F3 · balance_after: Includes 4,443 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on November 30, 2022.

SEC source: 0001567619-22-015863 · doc1.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2023 and 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2023 and 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2023 and 50% of the PSUs vest upon achievement of a certain performance-based milestone by 12/31/2024.

SEC source: 0001567619-22-015863 · doc1.xml · derivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common Stock · 135,000 shares

Expires 2032-08-09

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from August 10, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-22-014298 · doc1.xml · nonDerivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,689

F3 · kind: The shares were sold solely to satisfy tax or other government withholding obligations in connection with the vesting of shares subject to a PSU of the Issuer.

F2 · balance_after: Includes 22,500 restricted stock units.

SEC source: 0001567619-22-014298 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,291

F1 · kind: Represents Performance Stock Units ("PSUs") initially granted on October 24, 2021 that were subject to a performance-based vesting condition. The first milestone vesting condition was determined to be satisfied upon which 50% of the PSUs vested.

F2 · balance_after: Includes 22,500 restricted stock units.

SEC source: 0001567619-22-002524 · doc1.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common Stock · 135,000 shares

Expires 2032-02-01

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 2, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-22-002524 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,291

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/4th of the RSUs vest annually on March 15 of each year, with the first 1/4th vesting on March 15, 2023, subject to Reporting Person's continued service relationship with the Issuer on each such vesting date.

F2 · balance_after: Includes 22,500 RSUs.

SEC source: 0001567619-21-018719 · doc1.xml · derivative · entry 2

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone within 1 year from grant date and 50% of the PSUs vest upon achievement of a certain performance-based milestone within 2 years from grant date.

F2 · derivative.exercise_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone within 1 year from grant date and 50% of the PSUs vest upon achievement of a certain performance-based milestone within 2 years from grant date.

F2 · derivative.expiration_date: Each Performance Stock Unit ("PSU") represents a contingent right to receive one share of the Issuer's Common Stock upon vesting. 50% of the PSUs vest upon achievement of a certain performance-based milestone within 1 year from grant date and 50% of the PSUs vest upon achievement of a certain performance-based milestone within 2 years from grant date.

SEC source: 0001567619-21-018719 · doc1.xml · derivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-10-23

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from October 24, 2021 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-21-005397 · doc1.xml · derivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2031-02-25

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 26, 2021 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-20-004347 · doc1.xml · derivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2030-02-13

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 1, 2020 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-19-012671 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,791

F1 · kind: 1,812 shares were acquired pursuant to the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001567619-19-006113 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,979

SEC source: 0001567619-19-001864 · doc1.xml · derivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,900

Underlying: Common Stock · 54,900 shares

Expires 2029-01-24

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from January 1, 2019 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service to the Issuer through each such date.

SEC source: 0001567619-18-007414 · doc1.xml · nonDerivative · entry 1

ROWLAND LLOYD A · CIK 0001236395 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 979

F1 · kind: 979 shares were acquired pursuant to the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).