ASTH

SEC source: 0001104659-25-097117 · tm2527993-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 174,967

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on October 2, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; and (ii) 30,404 shares, which will vest in two equal annual installments on May 16, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 19,504 restricted stock units, which will vest in five equal semi-annual installments beginning on April 2, 2026; and (ii) 23,364 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

SEC source: 0001104659-25-090016 · tm2526044-1_4seq1.xml · derivative · entry 4

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 8,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-090016 · tm2526044-1_4seq1.xml · nonDerivative · entry 3

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,846

F1 · kind: These shares were repurchased by the Issuer.

F3 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-090016 · tm2526044-1_4seq1.xml · nonDerivative · entry 2

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,060

F1 · kind: These shares were repurchased by the Issuer.

SEC source: 0001104659-25-090016 · tm2526044-1_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,060

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-088648 · tm2525521-2_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 176,946

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on September 5, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; and (ii) 30,404 shares, which will vest in two equal annual installments on May 16, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 23,404 restricted stock units, which will vest in six equal semi-annual installments beginning on October 2, 2025; and (ii) 23,364 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

SEC source: 0001104659-25-088645 · tm2525521-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,893

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on September 5, 2025.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 13,464 shares, which will vest on January 1, 2026; and (iii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 23,364 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

F3 · balance_after: Includes 1,405 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-087027 · tm2525111-1_4seq1.xml · derivative · entry 3

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-087027 · tm2525111-1_4seq1.xml · nonDerivative · entry 2

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,763

F1 · kind: These shares were repurchased by the Issuer.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-087027 · tm2525111-1_4seq1.xml · nonDerivative · entry 1

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,763

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-078866 · tm2523581-1_4seq1.xml · derivative · entry 3

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-078866 · tm2523581-1_4seq1.xml · nonDerivative · entry 2

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,848

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-078866 · tm2523581-1_4seq1.xml · nonDerivative · entry 1

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,132

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-065430 · tm2519743-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 218,811

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 13,464 shares, which will vest on January 1, 2026; and (iii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

F3 · balance_after: Includes 629 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-059378 · tm2517874-6_4seq1.xml · nonDerivative · entry 1

Mazdyasni Matthew · CIK 0001809915 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,763

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-059377 · tm2517874-5_4seq1.xml · nonDerivative · entry 1

Marsh Linda · CIK 0001765204 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,641

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-059372 · tm2517874-3_4seq1.xml · nonDerivative · entry 1

Dai, Weili · CIK 0001134140 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,663

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-059375 · tm2517874-4_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,060

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-059369 · tm2517874-2_4seq1.xml · nonDerivative · entry 1

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,132

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-059361 · tm2517874-1_4seq1.xml · nonDerivative · entry 1

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,763

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 11, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

F2 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-057334 · tm2517312-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,642

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 26,927 shares, which will vest in two equal semi-annual installments beginning on July 1, 2025; and (iii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

F3 · balance_after: Includes 629 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-050542 · tm2515547-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,640

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on May 16, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; and (ii) 30,404 shares, which will vest in two equal annual installments on May 16, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 23,404 restricted stock units, which will vest in six equal semi-annual installments beginning on October 2, 2025; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-042820 · tm2513707-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 227,298

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 23,663 shares, which will vest in two equal semi-annual installments beginning on July 1, 2025; and (iii) grants of 8,158 shares, 6,527 shares, and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

F3 · balance_after: Includes 629 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-035506 · tm2512412-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 188,675

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on April 14, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; (ii) 4,561 shares, which will vest on May 16, 2025; and (iii) 45,606 shares, which will vest in three equal annual installments on May 16, 2025, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 23,404 restricted stock units, which will vest in six equal semi-annual installments beginning on October 2, 2025; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-031753 · tm2511480-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,358

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on April 2, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 14,427 shares, which will vest in two equal annual installments on April 14, 2025 and 2026; (ii) 4,561 shares, which will vest on May 16, 2025; and (iii) 45,606 shares, which will vest in three equal annual installments on May 16, 2025, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 23,404 restricted stock units, which will vest in six equal semi-annual installments beginning on October 2, 2025; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-028974 · tm2510573-2_4seq1.xml · nonDerivative · entry 2

Sobotka Glenn · CIK 0001855927 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,701

F2 · shares: Restricted a grant of performance-based restricted stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares will vest subject to the achievement of applicable performance goals and applicable time-based conditions.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 6,432 shares, which will vest in four equal annual installments beginning on March 26, 2026; and (ii) 8,269 shares, which will vest subject to the achievement of certain performance goals.

SEC source: 0001104659-25-028974 · tm2510573-2_4seq1.xml · nonDerivative · entry 1

Sobotka Glenn · CIK 0001855927 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,432

F1 · shares: Represents a grant of restricted stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares will vest in four equal annual installments beginning on March 26, 2026.

SEC source: 0001104659-25-021881 · tm258649-4_4seq1.xml · nonDerivative · entry 2

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,023,219

F4 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F5 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 59,837 shares, which will vest in two equal annual installments on June 27, 2025 and 2026; and (ii) 85,513 shares, which will vest in five equal semi-annual installments, beginning March 31, 2025. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 105,605 restricted stock units, which will vest in seven equal semi-annual installments beginning on April 2, 2025; and (ii) 145,642 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

F6 · balance_after: Includes 644 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-021881 · tm258649-4_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,129,014

F3 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-021867 · tm258649-3_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,752

F1 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on September 5, 2025.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 14,427 shares, which will vest in two equal annual installments on April 14, 2025 and 2026; (ii) 4,561 shares, which will vest on May 16, 2025; and (iii) 45,606 shares, which will vest in three equal annual installments on May 16, 2025, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 27,303 restricted stock units, which will vest in seven equal semi-annual installments beginning on April 2, 2025; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-021864 · tm258649-2_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 429,620

F2 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 77,500 shares, which will vest in three equal annual installments beginning on March 5, 2026; and (ii) 26,667 shares, which will vest upon achievement of certain pre-established performance goals.

SEC source: 0001104659-25-021863 · tm258649-1_4seq1.xml · nonDerivative · entry 2

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,126

F2 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 22,021 shares, which will vest in two equal semi-annual installments beginning on July 1, 2025; and (iii) grants of 8,158 shares, 6,527 shares, and 6,527 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 26,701 restricted stock units, which will vest in eight equal semi-annual installments beginning on September 5, 2025.

F4 · balance_after: Includes 629 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-021863 · tm258649-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,992

F1 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on September 5, 2025.

SEC source: 0001104659-25-014916 · tm253769-3_4seq1.xml · nonDerivative · entry 2

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Indirect · By Kenneth T & Simone S Sim Family Trust

Disclosed balance after: 546,349

F6 · kind: Represents the receipt of shares of the Issuer's common stock pursuant to the pro rata distribution for no consideration by APC, of which the Reporting Person is a stockholder.

F4 · ownership.nature: These securities are held by the Kenneth T & Simone S Sim Family Trust U/A dated 11/07/2013. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001104659-25-014916 · tm253769-3_4seq1.xml · nonDerivative · entry 1

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Indirect · By Allied Physicians of California, a Professional Medical Corporation

Disclosed balance after: 6,132,802

F5 · kind: APC distributed these shares of the Issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F5 · shares: APC distributed these shares of the Issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F1 · ownership.nature: These securities are beneficially owned by Allied Physicians of California, a Professional Medical Corporation ("APC"), of which the Reporting Person is the Chairman and a director and stockholder. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001104659-25-014915 · tm253769-2_4seq1.xml · nonDerivative · entry 1

ALLIED PHYSICIANS OF CALIFORNIA, A PROFESSIONAL MEDICAL Corp · CIK 0001725602 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,132,802

F2 · kind: APC distributed these shares of the issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F2 · shares: APC distributed these shares of the issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F1 · ownership.direct: Allied Physicians of California, a Professional Medical Corporation ("APC"), is a consolidated affiliate of the issuer of which Dr. Kenneth Sim, the issuer's Executive Chairman of the Board of Directors, is Chairman and a director and stockholder, and Dr. Thomas Lam, the issuer's Vice Chairman of the Board of Directors, is the Chief Executive Officer and Chief Financial Officer and a director and stockholder. Each of Dr. Sim and Dr. Lam disclaims beneficial ownership of the securities held by APC except to the extent of his pecuniary interest therein. Each of Dr. Sim and Dr. Lam holds, directly and/or indirectly, additional securities of the issuer.

SEC source: 0001104659-25-014912 · tm253769-1_4seq1.xml · nonDerivative · entry 2

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Thomas and Jeanette Lam 2002 Family Trust

Disclosed balance after: 1,133,706

F3 · kind: Represents the receipt of shares of the Issuer's common stock pursuant to the pro rata distribution for no consideration by APC, of which the Reporting Person is a stockholder.

SEC source: 0001104659-25-014912 · tm253769-1_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Allied Physicians of California, a Professional Medical Corporation

Disclosed balance after: 6,132,802

F2 · kind: APC distributed these shares of the Issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F2 · shares: APC distributed these shares of the Issuer's common stock to its stockholders, pursuant to a pro rata distribution for no consideration. Includes 17,839 shares in the aggregate held for the benefit of disqualified shareholders of APC.

F1 · ownership.nature: These securities are beneficially owned by Allied Physicians of California, a Professional Medical Corporation ("APC"), of which the Reporting Person is the Chief Executive Officer and Chief Financial Officer and a director and stockholder. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001104659-25-006326 · tm253769-5_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 209,291

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes 115,493 shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; (ii) 6,527 shares, which will vest in two equal semi-annual installments beginning on July 1, 2025; and (iii) grants of 16,316, 16,316, 13,053 and 6,527 shares, each of which will vest subject to the achievement of certain performance goals. Also includes 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals.

F3 · balance_after: Includes 629 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-005342 · tm253769-4_4seq1.xml · nonDerivative · entry 1

ALLIED PHYSICIANS OF CALIFORNIA, A PROFESSIONAL MEDICAL Corp · CIK 0001725602 · 10% owner

Lam Thomas S. · CIK 0001664499 · Director

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,832,698

F2 · kind: On January 17, 2025, the issuer entered into a stock repurchase agreement with APC, pursuant to which the issuer agreed to repurchase 300,000 shares of the issuer's common stock from APC. The agreement closed, and the issuer completed the stock repurchase, on the same day. The issuer's Board of Directors and the Audit Committee of the Board of Directors approved the repurchase.

F1 · ownership.direct: Allied Physicians of California, a Professional Medical Corporation ("APC"), is a consolidated affiliate of the issuer of which Dr. Kenneth Sim, the issuer's Executive Chairman of the Board of Directors, is Chairman and a director and stockholder, and Dr. Thomas Lam, the issuer's Vice Chairman of the Board of Directors, is the Chief Executive Officer and Chief Financial Officer and a director and stockholder. Each of Dr. Sim and Dr. Lam disclaims beneficial ownership of the securities held by APC except to the extent of his pecuniary interest therein. Each of Dr. Sim and Dr. Lam holds, directly and/or indirectly, additional securities of the issuer.

SEC source: 0001104659-25-000798 · tm251879-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 215,872

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes 143,869 shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 85,130 shares, which will vest in three equal annual installments beginning on January 23, 2025; (ii) 6,527 shares, which will vest in two equal semi-annual installments beginning on July 1, 2025; and (iii) grants of 16,316, 16,316, 13,053 and 6,527 shares, each of which will vest subject to the achievement of certain performance goals. Also includes 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals.

SEC source: 0001104659-24-128048 · tm2430921-1_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,611

F1 · kind: These shares were repurchased by the Issuer.

F2 · balance_after: Includes 3,564 shares of restricted stock, which will vest on the earlier of August 13, 2025 or the date of the Issuer's 2025 annual meeting of stockholders.

SEC source: 0001104659-24-125079 · tm2430064-1_4seq1.xml · nonDerivative · entry 1

Vong John · CIK 0001572846 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,520

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F2 · balance_after: Includes 11,622 shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 1,887 shares, of which 942 shares will vest on July 11, 2025 and 945 shares will vest on July 11, 2026; (ii) tranches of 380 shares and 380 shares, each of which will vest in two equal annual installments beginning on November 30, 2025; and (iii) tranches of 1,134 shares, 1,134 shares, 1,134 shares, 1,134 shares, and 4,439 shares, each of which will vest in five equal semi-annual installments beginning on May 12, 2025.

F3 · balance_after: Includes 76 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-24-123088 · tm2429553-1_4seq1.xml · derivative · entry 3

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,409 shares

Expires 2024-11-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-24-123088 · tm2429553-1_4seq1.xml · nonDerivative · entry 2

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,711

F2 · balance_after: Includes 6,750 shares of restricted stock, which will vest on December 9, 2024, and 3,564 shares of restricted stock, which will vest on the earlier of August 13, 2025 or the date of the Issuer's 2025 annual meeting of stockholders.

SEC source: 0001104659-24-123088 · tm2429553-1_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,201

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-24-121026 · tm2428618-2_4seq1.xml · derivative · entry 3

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,515 shares

Expires 2024-11-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-24-121026 · tm2428618-2_4seq1.xml · nonDerivative · entry 2

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,683

F2 · balance_after: Includes 4,750 shares of restricted stock, which will vest on December 9, 2024, and 3,564 shares of restricted stock, which will vest on the earlier of August 13, 2025 or the date of the Issuer's 2025 annual meeting of stockholders.

SEC source: 0001104659-24-121026 · tm2428618-2_4seq1.xml · nonDerivative · entry 1

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,364

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-24-121024 · tm2428618-1_4seq1.xml · derivative · entry 6

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 28,046 shares

Expires 2024-12-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: These stock options were fully vested and exercisable.