ASTH

SEC source: 0001104659-26-115507 · tm2627437-1_4seq1.xml · nonDerivative · entry 1

Vong John · CIK 0001572846 · SVP - Accounting (PAO)

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,774

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on October 10, 2026.

F2 · balance_after: Includes 3,972 shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 380 shares which will vest on November 30, 2026; and (ii) tranches of 454 shares, 454 shares, 454 shares, 454 shares, and 1,776 shares, each of which will vest in two equal semi-annual installments beginning on November 12, 2026. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 1,552 restricted stock units, which will vest on April 10, 2027; and (ii) 1,887 restricted stock units, which will vest in seven equal semi-annual installments beginning March 15, 2027.

F3 · balance_after: Includes 584 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-114785 · tm2627257-2_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,228,972

F3 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on October 6, 2026.

F4 · balance_after: Includes 17,105 shares of unvested restricted stock, which will vest on March 31, 2027, subject to continuous employment with the Issuer. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 45,261 restricted stock units, which will vest in three equal semi-annual installments beginning on April 2, 2027; (ii) 91,027 restricted stock units, which will vest in five equal semi-annual installments beginning on March 5, 2027; and (iii) 175,924 restricted stock units, which will vest in seven equal semi-annual installments beginning on April 6, 2027.

F5 · balance_after: Includes 2,152 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-114777 · tm2627257-1_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 463,033

F2 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on October 6, 2026.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer and/or its affiliates): (i) 51,667 shares, which will vest in two equal annual installments beginning on March 5, 2027; and (ii) 13,334 shares, which will vest in two equal annual installments beginning on April 1, 2027. Also includes 36,459 restricted stock units, which will vest in seven equal semi-annual installments beginning on April 6, 2027 (subject to continuous employment with the Issuer and/or its affiliates).

SEC source: 0001104659-26-113838 · tm2626980d1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,728

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on October 2, 2026.

F2 · balance_after: Includes 15,202 shares of unvested restricted stock which will vest on May 16, 2027 (subject to continuous employment with the Issuer). Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 11,703 restricted stock units, which will vest in three equal semi-annual installments beginning on April 2, 2027; and (ii) 16,690 restricted stock units, which will vest in five equal semi-annual installments beginning on March 5, 2027.

SEC source: 0001104659-26-108627 · tm2625575-1_4seq1.xml · nonDerivative · entry 1

Vong John · CIK 0001572846 · SVP - Accounting (PAO)

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,330

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on September 15, 2026.

F2 · balance_after: Includes 3,972 shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 380 shares which will vest on November 30, 2026; and (ii) tranches of 454 shares, 454 shares, 454 shares, 454 shares, and 1,776 shares, each of which will vest in two equal semi-annual installments beginning on November 12, 2026. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 3,104 restricted stock units, which will vest in two equal semi-annual installments beginning on October 10, 2026; and (ii) 1,887 restricted stock units, which will vest in seven equal semi-annual installments beginning March 15, 2027.

F3 · balance_after: Includes 584 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-106325 · tm2625066-1_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,238,861

F3 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on September 5, 2026.

F4 · balance_after: Includes 34,207 shares of unvested restricted stock, which will vest in two equal semi-annual installments, beginning September 30, 2026, subject to continuous employment with the Issuer. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 60,347 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; (ii) 91,027 restricted stock units, which will vest in five equal semi-annual installments beginning on March 5, 2027; and (iii) 201,056 restricted stock units, which will vest in eight equal semi-annual installments beginning on October 6, 2026.

F5 · balance_after: Includes 2,152 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-105932 · tm2625011-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,820

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on September 5, 2026.

F2 · balance_after: Includes 15,202 shares of unvested restricted stock which will vest on May 16, 2027 (subject to continuous employment with the Issuer). Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 15,604 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; and (ii) 16,690 restricted stock units, which will vest in five equal semi-annual installments beginning on March 5, 2027.

SEC source: 0001104659-26-104397 · tm2624587-1_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,337

F1 · kind: These shares were repurchased by the Issuer.

F2 · balance_after: Includes 4,991 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-098353 · tm2623303-1_4seq1.xml · derivative · entry 3

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2026-09-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-26-098353 · tm2623303-1_4seq1.xml · nonDerivative · entry 2

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,019

F1 · kind: These shares were repurchased by the Issuer.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-098353 · tm2623303-1_4seq1.xml · nonDerivative · entry 1

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,019

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-094142 · tm2620548-2_4seq1.xml · nonDerivative · entry 1

Sobotka Glenn · CIK 0001855927 · Former Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,246

F1 · shares: Represents the surrender of unvested time-based and performance-based restricted stock that was forfeited in connection with the reporting person's retirement from his positions with the Issuer.

F2 · balance_after: Includes 1,300 shares of restricted stock that will vest on an accelerated basis in connection with the reporting person's retirement from his positions with the Issuer, subject to his execution of a release of claims.

SEC source: 0001104659-26-079333 · tm2619337-1_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,245,292

F3 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with the vesting of certain shares of restricted stock.

F4 · balance_after: Includes 34,207 shares of unvested restricted stock, which will vest in two equal semi-annual installments, beginning September 30, 2026, subject to continuous employment with the Issuer. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 60,347 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; (ii) 109,232 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026; and (iii) 201,056 restricted stock units, which will vest in eight equal semi-annual installments beginning on October 6, 2026.

F5 · balance_after: Includes 1,420 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-073493 · tm2617575-6_4seq1.xml · nonDerivative · entry 1

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,019

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-073488 · tm2617575-5_4seq1.xml · nonDerivative · entry 1

Mazdyasni Matthew · CIK 0001809915 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,288

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-073485 · tm2617575-4_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,837

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,991 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-073484 · tm2617575-3_4seq1.xml · nonDerivative · entry 1

Dong Linda · CIK 0001765204 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,133

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-073475 · tm2617575-2_4seq1.xml · nonDerivative · entry 1

Dai, Weili · CIK 0001134140 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,188

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-073467 · tm2617575-1_4seq1.xml · nonDerivative · entry 1

Chiang John · CIK 0001765302 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,373

F1 · shares: Restricted shares of the Issuer's common stock granted pursuant to the Issuer's 2024 Equity Incentive Plan, which will vest on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

F2 · balance_after: Includes 4,525 shares of restricted stock, which will vest on the earlier of June 10, 2027 or the date of the Issuer's 2027 annual meeting of stockholders.

SEC source: 0001104659-26-063197 · tm2614898-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 159,610

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on May 16, 2026.

F2 · balance_after: Includes 15,202 shares of unvested restricted stock which will vest on May 16, 2027 (subject to continuous employment with the Issuer). Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 15,604 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; and (ii) 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026.

SEC source: 0001104659-26-043808 · tm2611888-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 167,765

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on April 14, 2026.

F2 · balance_after: Includes 30,404 shares of unvested restricted stock, which will vest in two equal annual installments on May 16, 2026 and 2027 (subject to continuous employment with the Issuer). Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 15,604 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; and (ii) 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026.

SEC source: 0001104659-26-040955 · tm2611344-3_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 465,657

F2 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer and/or its affiliates on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on October 6, 2026.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer and/or its affiliates): (i) 51,667 shares, which will vest in two equal annual installments beginning on March 5, 2027; and (ii) 13,334 shares, which will vest in two equal annual installments beginning on April 1, 2027. Also includes 41,667 restricted stock units, which will vest in eight equal semi-annual installments beginning on October 6, 2026 (subject to continuous employment with the Issuer and/or its affiliates).

SEC source: 0001104659-26-040952 · tm2611344-2_4seq1.xml · nonDerivative · entry 1

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739,407

F5 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer and/or its affiliates on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on October 6, 2026.

F6 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer and/or its affiliates): (i) 78,334 shares, which will vest in two equal annual installments beginning on March 5, 2027; and (ii) 66,667 shares, which will vest in two equal annual installments beginning on April 1, 2027. Also includes 100,000 restricted stock units, which will vest in eight equal semi-annual installments beginning on October 6, 2026 (subject to continuous employment with the Issuer and/or its affiliates).

SEC source: 0001104659-26-040951 · tm2611344-1_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,246,385

F3 · shares: Represents a grant of restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Provided the Reporting Person is still employed with the Issuer on the date of vesting, the shares shall vest in eight equal semi-annual installments beginning on October 6, 2026.

F4 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 29,919 shares, which will vest on June 27, 2026; and (ii) 34,207 shares, which will vest in two equal semi-annual installments, beginning September 30, 2026. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 60,347 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; (ii) 109,232 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026; and (iii) 201,056 restricted stock units, which will vest in eight equal semi-annual installments beginning on October 6, 2026.

F5 · balance_after: Includes 1,420 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-039686 · tm2611155-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 171,635

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on April 2, 2026.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; and (ii) 30,404 shares, which will vest in two equal annual installments on May 16, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 15,604 restricted stock units, which will vest in four equal semi-annual installments beginning on October 2, 2026; and (ii) 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026.

SEC source: 0001104659-26-039688 · tm2611155-2_4seq1.xml · nonDerivative · entry 2

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 177,655

F2 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock and restricted stock units that vested on April 1, 2026.

F3 · balance_after: Includes 28,378 shares of restricted stock, which will vest on January 23, 2027 (subject to continuous employment with the Issuer). Also includes 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026 (subject to continuous employment with the Issuer).

F4 · balance_after: Includes 1,405 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-039688 · tm2611155-2_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 235,635

F1 · shares: Shares delivered to the reporting person pursuant to the vesting of performance-based restricted stock units that vested upon achievement of performance goals for the applicable performance period. The reporting person reported an acquisition of 67,238 performance-based restricted stock units on a Form 4 filed November 12, 2024, which represented the number of shares that would be delivered if target performance was achieved during the performance period. Actual performance exceeded the target performance for the performance period, which resulted in an additional grant of 35,300 shares.

SEC source: 0001104659-26-036820 · tm2610061-1_4seq1.xml · nonDerivative · entry 1

Sobotka Glenn · CIK 0001855927 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,039

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on March 26, 2026.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 4,824 shares, which will vest in three equal annual installments beginning on March 26, 2027; and (ii) 8,269 shares, which will vest subject to the achievement of certain performance goals.

SEC source: 0001104659-26-025236 · tm268271-3_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 423,990

F2 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with shares of restricted stock that vested on March 5, 2026.

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 51,667 shares, which will vest in two equal annual installments beginning on March 5, 2027; and (ii) 26,667 shares, which will vest upon achievement of certain pre-established performance goals.

SEC source: 0001104659-26-025234 · tm268271-2_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,335

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on March 5, 2026.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 28,378 shares, which will vest on January 23, 2027; and (ii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026.

F3 · balance_after: Includes 1,405 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-025232 · tm268271-1_4seq1.xml · nonDerivative · entry 1

Basho Chandan · CIK 0001929126 · COO and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 173,727

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain restricted stock units that vested on March 5, 2026.

F2 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 7,214 shares, which will vest on April 14, 2026; and (ii) 30,404 shares, which will vest in two equal annual installments on May 16, 2026 and 2027. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 19,504 restricted stock units, which will vest in five equal semi-annual installments beginning on April 2, 2026; and (ii) 20,027 restricted stock units, which will vest in six equal semi-annual installments beginning on September 5, 2026.

SEC source: 0001104659-26-009940 · tm264894-1_4seq1.xml · derivative · entry 4

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,334 shares

Expires 2026-02-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-26-009940 · tm264894-1_4seq1.xml · nonDerivative · entry 1

Sim Brandon · CIK 0001813532 · CEO and President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,045,329

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 29,919 shares, which will vest on June 27, 2026; and (ii) 51,309 shares, which will vest in three equal semi-annual installments, beginning March 31, 2026. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 75,433 restricted stock units, which will vest in five equal semi-annual installments beginning on April 2, 2026; and (ii) 127,437 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

F4 · balance_after: Includes 1,420 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-007035 · tm264256-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 202,032

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on January 23, 2026.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 28,378 shares, which will vest on January 23, 2027; and (ii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 23,364 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

F3 · balance_after: Includes 1,405 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-26-004091 · tm263273-1_4seq1.xml · derivative · entry 3

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2026-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-26-004091 · tm263273-1_4seq1.xml · nonDerivative · entry 2

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,494

F1 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-26-004091 · tm263273-1_4seq1.xml · nonDerivative · entry 1

Schmidt David · CIK 0001594029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,763

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-26-000806 · tm261927-1_4seq1.xml · nonDerivative · entry 1

Kumar Dinesh M. · CIK 0001850439 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 212,791

F1 · shares: Represents the surrender of shares to offset against tax withholding obligations associated with certain shares of restricted stock that vested on January 1, 2026.

F2 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 56,754 shares, which will vest in two equal annual installments beginning on January 23, 2026; and (ii) grants of 8,158 shares and 3,264 shares, each of which will vest subject to the achievement of certain performance goals. Also includes the following restricted stock units, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 67,238 restricted stock units, which will vest subject to the achievement of certain performance goals; and (ii) 23,364 restricted stock units, which will vest in seven equal semi-annual installments beginning on March 5, 2026.

F3 · balance_after: Includes 1,405 shares acquired under the Issuer's Employee Stock Purchase Plan.

SEC source: 0001104659-25-119985 · tm2533040-1_4seq1.xml · derivative · entry 5

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 29,502 shares

Expires 2025-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-119985 · tm2533040-1_4seq1.xml · nonDerivative · entry 2

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 433,256

F3 · balance_after: Includes the following shares of restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 77,500 shares, which will vest in three equal annual installments beginning on March 5, 2026; and (ii) 26,667 shares, which will vest upon achievement of certain pre-established performance goals.

SEC source: 0001104659-25-119985 · tm2533040-1_4seq1.xml · nonDerivative · entry 1

Lam Thomas S. · CIK 0001664499 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 459,122

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-110503 · tm2530751-1_4seq1.xml · derivative · entry 2

Mazdyasni Matthew · CIK 0001809915 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-110503 · tm2530751-1_4seq1.xml · nonDerivative · entry 1

Mazdyasni Matthew · CIK 0001809915 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,763

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-111328 · tm2531125-1_4seq1.xml · derivative · entry 6

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 29,502 shares

Expires 2025-12-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-111328 · tm2531125-1_4seq1.xml · nonDerivative · entry 1

Sim Kenneth T. · CIK 0001725499 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 639,407

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · balance_after: Includes the following shares of unvested restricted stock, which will vest as follows (in each case subject to continuous employment with the Issuer): (i) 117,501 shares, which will vest in three equal annual installments beginning on March 5, 2026; and (ii) 133,333 shares, which will vest upon achievement of certain pre-established performance goals.

SEC source: 0001104659-25-110504 · tm2530751-2_4seq1.xml · derivative · entry 2

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-110504 · tm2530751-2_4seq1.xml · nonDerivative · entry 1

Kitayama Mitchell W · CIK 0001333154 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,846

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-107189 · tm2530332-1_4seq1.xml · derivative · entry 3

Marsh Linda · CIK 0001765204 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2025-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options were fully vested and exercisable.

SEC source: 0001104659-25-107189 · tm2530332-1_4seq1.xml · nonDerivative · entry 2

Marsh Linda · CIK 0001765204 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,608

F1 · balance_after: Includes 6,449 shares of restricted stock, which will vest on the earlier of June 11, 2026 or the date of the Issuer's 2026 annual meeting of stockholders.

SEC source: 0001104659-25-107189 · tm2530332-1_4seq1.xml · nonDerivative · entry 1

Marsh Linda · CIK 0001765204 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.