ALNY

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 8

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,257

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F8 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $275.11 to $276.05. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 7

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,558

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F7 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $273.61 to $274.00. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 6

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,440

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F6 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $272.60 to $273.59. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 5

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,100

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $271.44 to $272.10. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 4

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,531

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F4 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $269.53 to $269.88. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 3

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,776

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $268.28 to $269.16. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 2

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,505

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

F2 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $266.87 to $267.72. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000072 · edgardoc.xml · nonDerivative · entry 1

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,054

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 12, 2024. The 11,250 options exercised and sold by the reporting person were due to expire on June 1, 2025.

SEC source: 0001735276-25-000063 · edgardoc.xml · derivative · entry 3

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F3 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000063 · edgardoc.xml · nonDerivative · entry 1

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 911

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000068 · edgardoc.xml · derivative · entry 3

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F3 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000068 · edgardoc.xml · nonDerivative · entry 1

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 911

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000067 · edgardoc.xml · derivative · entry 3

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F3 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000067 · edgardoc.xml · nonDerivative · entry 1

BONNEY MICHAEL W · CIK 0001219016 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,804

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000066 · edgardoc.xml · derivative · entry 2

BRANDICOURT OLIVIER · CIK 0001508518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000066 · edgardoc.xml · nonDerivative · entry 1

BRANDICOURT OLIVIER · CIK 0001508518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000065 · edgardoc.xml · derivative · entry 2

HAMBURG MARGARET A · CIK 0001266917 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000065 · edgardoc.xml · nonDerivative · entry 1

HAMBURG MARGARET A · CIK 0001266917 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 911

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000064 · edgardoc.xml · derivative · entry 2

KELLOGG PETER N · CIK 0001226287 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000064 · edgardoc.xml · nonDerivative · entry 1

KELLOGG PETER N · CIK 0001226287 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000061 · edgardoc.xml · derivative · entry 2

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000061 · edgardoc.xml · nonDerivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,961

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000062 · edgardoc.xml · derivative · entry 5

Reitan Colleen F · CIK 0001740730 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000062 · edgardoc.xml · nonDerivative · entry 4

Reitan Colleen F · CIK 0001740730 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000060 · edgardoc.xml · derivative · entry 3

Sigal Charles Elliott · CIK 0001661908 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F3 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000060 · edgardoc.xml · nonDerivative · entry 1

Sigal Charles Elliott · CIK 0001661908 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000059 · edgardoc.xml · derivative · entry 2

Bertozzi Carolyn R · CIK 0001698766 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558

Underlying: Common Stock · 1,558 shares

Expires 2035-05-08

F2 · derivative.exercise_date: The stock option vests in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000059 · edgardoc.xml · nonDerivative · entry 1

Bertozzi Carolyn R · CIK 0001698766 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 775

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001735276-25-000047 · edgardoc.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,324

F1 · kind: The reported transaction involves a transfer of securities by bona fide gift for estate planning purposes to the Yvonne Greenstreet 2024 Irrevocable Trust Dtd 10/29/2024, of which the reporting person is neither the trustee nor a beneficiary.

SEC source: 0001735276-25-000062 · edgardoc.xml · nonDerivative · entry 3

Reitan Colleen F · CIK 0001740730 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001735276-25-000040 · edgardoc.xml · derivative · entry 4

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,440 shares

Expires 2025-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on September 5, 2024. The options exercised and sold by the reporting person were due to expire on December 18, 2025.

F3 · derivative.exercise_date: This stock option was fully vested and exercisable as of December 18, 2016.

SEC source: 0001735276-25-000040 · edgardoc.xml · nonDerivative · entry 2

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 136

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on September 5, 2024. The options exercised and sold by the reporting person were due to expire on December 18, 2025.

SEC source: 0001735276-25-000040 · edgardoc.xml · nonDerivative · entry 1

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,576

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on September 5, 2024. The options exercised and sold by the reporting person were due to expire on December 18, 2025.

SEC source: 0001735276-25-000041 · edgardoc.xml · derivative · entry 6

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,445 shares

Expires 2026-12-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

F4 · derivative.exercise_date: This stock option was fully vested and exercisable as of December 20, 2020.

SEC source: 0001735276-25-000041 · edgardoc.xml · nonDerivative · entry 3

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,221

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

SEC source: 0001735276-25-000041 · edgardoc.xml · nonDerivative · entry 2

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

SEC source: 0001735276-25-000041 · edgardoc.xml · nonDerivative · entry 1

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,221

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

SEC source: 0001735276-25-000037 · edgardoc.xml · derivative · entry 2

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,750 shares

Expires 2025-06-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The options exercised and held by the reporting person were due to expire on June 1, 2025.

F2 · derivative.exercise_date: The stock option was fully vested as of June 1, 2016.

SEC source: 0001735276-25-000037 · edgardoc.xml · nonDerivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,186

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The options exercised and held by the reporting person were due to expire on June 1, 2025.

SEC source: 0001735276-25-000034 · edgardoc.xml · nonDerivative · entry 15

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,501

F9 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 10, 2024.

SEC source: 0001735276-25-000034 · edgardoc.xml · nonDerivative · entry 14

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,572

F9 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 10, 2024.

F15 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $241.40 to $241.85. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000034 · edgardoc.xml · nonDerivative · entry 13

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,896

F9 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 10, 2024.

F14 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $240.18 to $241.17. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000034 · edgardoc.xml · nonDerivative · entry 12

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,224

F9 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 10, 2024.

F13 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $238.93 to $239.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000032 · edgardoc.xml · nonDerivative · entry 15

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,542

F10 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

F17 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $242.46 to $242.93. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000032 · edgardoc.xml · nonDerivative · entry 14

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,662

F10 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

F16 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $241.21 to $242.02. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000032 · edgardoc.xml · nonDerivative · entry 13

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,860

F10 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

F15 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $240.18 to $241.17. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000032 · edgardoc.xml · nonDerivative · entry 12

Garg Pushkal · CIK 0001829252 · CMO & EVP Dev & Med Affairs

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,203

F10 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 11, 2024.

F14 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $238.93 to $239.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-25-000035 · edgardoc.xml · derivative · entry 2

Hesslein Robert W. · CIK 0001585018 · EVP, CLO and Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,529

Underlying: Common Stock · 1,529 shares

Expires 2035-03-03

F2 · derivative.exercise_date: The stock option vests as to 25% of the shares on the first anniversary of the grant date and the remaining shares vest in equal installments at the end of each successive three-month period thereafter until the fourth anniversary of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date.

SEC source: 0001735276-25-000035 · edgardoc.xml · nonDerivative · entry 1

Hesslein Robert W. · CIK 0001585018 · EVP, CLO and Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,002

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest over a three-year period, with one third vesting on each of the first, second and third anniversaries of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date.

SEC source: 0001735276-25-000034 · edgardoc.xml · derivative · entry 17

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,819

Underlying: Common Stock · 7,819 shares

Expires 2035-03-03

F17 · derivative.exercise_date: The stock option vests as to 25% of the shares on the first anniversary of the grant date and the remaining shares vest in equal installments at the end of each successive three-month period thereafter until the fourth anniversary of the grant date, subject to the Reporting Persons continuous service with the Issuer as of each such vesting date.