ALNY

SEC source: 0001178670-26-000068 · form4.xml · nonDerivative · entry 1

SUPRAN BRYAN · CIK 0001511797 · EVP, CLO and Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,807

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

SEC source: 0001178670-26-000065 · form4.xml · nonDerivative · entry 1

Greenstreet Yvonne · CIK 0001446125 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,802

F1 · kind: On February 23, 2016, the People, Culture, and Compensation Committee of the issuer approved the issuance of shares of Company common stock having an aggregate value of USD $50,000 to each employee who completes 10 consecutive years of employment. The shares issued and reported here on Form 4, net of the minimum statutory tax liability, were issued to the reporting person in recognition of 10 years of continuous employment on September 19, 2026.

SEC source: 0001178670-26-000048 · form4.xml · derivative · entry 8

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,830 shares

Expires 2026-06-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

F7 · derivative.exercise_date: This stock option was fully vested and exercisable as of June 3, 2017.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 6

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,582

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 5

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,599

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $300.45 to $301.15. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 4

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,094

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

F4 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $299.36 to $300.19. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 3

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,316

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $298.33 to $299.33. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 2

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,491

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

F2 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $297.31 to $297.99. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000048 · form4.xml · nonDerivative · entry 1

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on November 12, 2025. The options exercised by the reporting person were due to expire on June 3, 2026.

SEC source: 0001178670-26-000047 · form4.xml · derivative · entry 1

Cravatt Benjamin · CIK 0001819573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,393

Underlying: Common Stock · 4,393 shares

Expires 2036-06-01

F1 · derivative.exercise_date: The stock option will vest as to one third of the shares on each of the first, second and third anniversaries of the date of grant.

SEC source: 0001178670-26-000039 · form4.xml · derivative · entry 3

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F3 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000039 · form4.xml · nonDerivative · entry 1

PYOTT DAVID E I · CIK 0001051578 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,582

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000042 · form4.xml · derivative · entry 3

Sigal Charles Elliott · CIK 0001661908 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F3 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000042 · form4.xml · nonDerivative · entry 1

Sigal Charles Elliott · CIK 0001661908 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,446

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000041 · form4.xml · derivative · entry 2

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,802

Underlying: Common Stock · 1,802 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000041 · form4.xml · nonDerivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,049

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000040 · form4.xml · derivative · entry 2

Reitan Colleen F · CIK 0001740730 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000040 · form4.xml · nonDerivative · entry 1

Reitan Colleen F · CIK 0001740730 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,446

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000038 · form4.xml · derivative · entry 2

KELLOGG PETER N · CIK 0001226287 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000038 · form4.xml · nonDerivative · entry 1

KELLOGG PETER N · CIK 0001226287 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,446

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000037 · form4.xml · derivative · entry 2

HAMBURG MARGARET A · CIK 0001266917 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000037 · form4.xml · nonDerivative · entry 1

HAMBURG MARGARET A · CIK 0001266917 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,582

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000036 · form4.xml · derivative · entry 2

BRANDICOURT OLIVIER · CIK 0001508518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000036 · form4.xml · nonDerivative · entry 1

BRANDICOURT OLIVIER · CIK 0001508518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,446

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000035 · form4.xml · derivative · entry 3

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F3 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000035 · form4.xml · nonDerivative · entry 1

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,582

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000034 · form4.xml · derivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,441

Underlying: Common Stock · 1,441 shares

Expires 2036-05-20

F2 · derivative.exercise_date: The stock option will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000034 · form4.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 671

F1 · shares: These shares are represented by restricted stock units (RSUs) granted under the Second Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. The RSUs will vest in full upon the earlier of the first anniversary of the grant date and the date of any earlier retirement or resignation of the Reporting Person, provided such date of retirement or resignation occurs no more than 90 days prior to the first anniversary of the grant date.

SEC source: 0001178670-26-000017 · form4.xml · derivative · entry 2

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,250 shares

Expires 2026-06-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The options exercised and held by the reporting person were due to expire on June 3, 2026.

SEC source: 0001178670-26-000017 · form4.xml · nonDerivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,211

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The options exercised and held by the reporting person were due to expire on June 3, 2026.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 14

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,443

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on December 16, 2025.

F15 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $333.39 to $334.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 13

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,642

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on December 16, 2025.

F14 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $331.77 to $332.14. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 12

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,935

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on December 16, 2025.

F13 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $330.21 to $330.86. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 11

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,764

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on December 16, 2025.

F12 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $329.22 to $330.18. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 10

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,673

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on December 16, 2025.

F11 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $320.10 to $320.32. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 9

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,729

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 8

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,737

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F9 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $323.39 to $324.01. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 7

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,818

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F8 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $322.31 to $323.13. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 6

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,063

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F7 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $321.26 to $322.20. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 5

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,287

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F6 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $320.21 to $321.11. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 4

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,434

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F5 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $319.19 to $320.10. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 3

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,520

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F4 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $318.09 to $318.83. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 2

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,729

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F3 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $317.07 to $318.05. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001178670-26-000014 · form4.xml · nonDerivative · entry 1

McLaughlin Melissa · CIK 0002127187 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,088

F1 · kind: Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units.

F2 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $316.04 to $317.03. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000063 · edgardoc.xml · nonDerivative · entry 12

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,693

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F14 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $325.67 to $326.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000063 · edgardoc.xml · nonDerivative · entry 11

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,193

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F13 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $324.26 to $325.20. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000063 · edgardoc.xml · nonDerivative · entry 10

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,703

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F12 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $323.09 to $324.08. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000063 · edgardoc.xml · nonDerivative · entry 9

Garg Pushkal · CIK 0001829252 · EVP Chief R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,443

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025.

F11 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $322.03 to $322.96. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000059 · edgardoc.xml · nonDerivative · entry 12

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,569

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on August 14, 2025.

F14 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $326.01 to $326.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001735276-26-000059 · edgardoc.xml · nonDerivative · entry 11

Fitzgerald Kevin Joseph · CIK 0001886431 · CSO & EVP, Head of Research

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,722

F10 · kind: This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on August 14, 2025.

F13 · price: The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $324.36 to $325.01. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.