ACRS

SEC source: 0001209191-22-053003 · doc4.xml · nonDerivative · entry 2

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Aisling Capital IV LP

Disclosed balance after: 588,916

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Aisling Capital IV, LP on August 23, 2022.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $16.00 to $16.78, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · ownership.nature: The reportable securities are owned directly by Aisling Capital IV, LP ("Aisling"), and held indirectly by Aisling Capital Partners IV, LP ("Aisling GP"), as general partner of Aisling, Aisling Capital Partners IV LLC ("Aisling Partners"), as general partner of Aisling GP, and each of the individual managing members of Aisling Partners. The individual managing members (collectively, the "Managers") of Aisling Partners are Dr. Andrew Schiff and Steve Elms. Aisling GP, Aisling Partners, and the Managers share voting and dispositive power over the shares directly held by Aisling. Dr. Schiff disclaims beneficial ownership of these securities and this report is not an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-22-053003 · doc4.xml · nonDerivative · entry 1

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Aisling Capital IV LP

Disclosed balance after: 626,755

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Aisling Capital IV, LP on August 23, 2022.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $16.00 to $16.04, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · ownership.nature: The reportable securities are owned directly by Aisling Capital IV, LP ("Aisling"), and held indirectly by Aisling Capital Partners IV, LP ("Aisling GP"), as general partner of Aisling, Aisling Capital Partners IV LLC ("Aisling Partners"), as general partner of Aisling GP, and each of the individual managing members of Aisling Partners. The individual managing members (collectively, the "Managers") of Aisling Partners are Dr. Andrew Schiff and Steve Elms. Aisling GP, Aisling Partners, and the Managers share voting and dispositive power over the shares directly held by Aisling. Dr. Schiff disclaims beneficial ownership of these securities and this report is not an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-22-043928 · doc4.xml · derivative · entry 2

Manion Douglas J. · CIK 0001875875 · Pres and COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,300

Underlying: Common Stock · 62,300 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F3 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on August 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F3 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on August 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-043928 · doc4.xml · derivative · entry 1

Manion Douglas J. · CIK 0001875875 · Pres and COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 217,800

Underlying: Common Stock · 217,800 shares

Expires 2032-07-31

F1 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal annual installments beginning on August 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-040787 · doc4.xml · derivative · entry 2

Cawkwell Gail · CIK 0001761167 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer.

F3 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on July 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

F3 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on July 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-040787 · doc4.xml · derivative · entry 1

Cawkwell Gail · CIK 0001761167 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2032-06-30

F1 · derivative.exercise_date: Exercisable with respect to 25% of the shares subject to the option vesting in four equal annual installments beginning on July 1, 2023, subject to the Reporting Person's continuous service with the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-038451 · doc4.xml · nonDerivative · entry 1

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 16, 2022.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-034617 · doc4.xml · derivative · entry 5

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F6 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F6 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034617 · doc4.xml · nonDerivative · entry 1

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,565

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034585 · doc4.xml · derivative · entry 4

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034585 · doc4.xml · nonDerivative · entry 1

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,565

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034582 · doc4.xml · derivative · entry 4

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034582 · doc4.xml · nonDerivative · entry 1

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,794

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034592 · doc4.xml · derivative · entry 4

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034592 · doc4.xml · nonDerivative · entry 1

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,356

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034601 · doc4.xml · derivative · entry 5

Powell Andrew Kenneth William · CIK 0001304113 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034601 · doc4.xml · nonDerivative · entry 2

Powell Andrew Kenneth William · CIK 0001304113 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034606 · doc4.xml · derivative · entry 4

Reasons Bryan M. · CIK 0001553489 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034606 · doc4.xml · nonDerivative · entry 1

Reasons Bryan M. · CIK 0001553489 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,565

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034596 · doc4.xml · derivative · entry 4

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034596 · doc4.xml · nonDerivative · entry 1

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,247

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034589 · doc4.xml · derivative · entry 4

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,356 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F5 · derivative.exercise_date: The shares underlying these restricted stock units vested on June 3, 2022.

F5 · derivative.expiration_date: The shares underlying these restricted stock units vested on June 3, 2022.

SEC source: 0001209191-22-034589 · doc4.xml · nonDerivative · entry 1

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,197

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-034617 · doc4.xml · derivative · entry 4

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F3 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F5 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F5 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034617 · doc4.xml · derivative · entry 3

SCHIFF ANDREW N · CIK 0001172252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F3 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034585 · doc4.xml · derivative · entry 3

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034585 · doc4.xml · derivative · entry 2

Humphries William D. · CIK 0001674278 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034582 · doc4.xml · derivative · entry 3

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034582 · doc4.xml · derivative · entry 2

GOWEN MAXINE · CIK 0001280044 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034592 · doc4.xml · derivative · entry 3

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034592 · doc4.xml · derivative · entry 2

MILANO VINCENT · CIK 0001187159 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034601 · doc4.xml · derivative · entry 4

Powell Andrew Kenneth William · CIK 0001304113 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034601 · doc4.xml · derivative · entry 3

Powell Andrew Kenneth William · CIK 0001304113 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034606 · doc4.xml · derivative · entry 3

Reasons Bryan M. · CIK 0001553489 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034606 · doc4.xml · derivative · entry 2

Reasons Bryan M. · CIK 0001553489 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034596 · doc4.xml · derivative · entry 3

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034596 · doc4.xml · derivative · entry 2

Molineaux Christopher P. · CIK 0001654773 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034589 · doc4.xml · derivative · entry 3

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,507

Underlying: Common Stock · 4,507 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F4 · derivative.exercise_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

F4 · derivative.expiration_date: The shares underlying these restricted stock units will vest on June 2, 2023, subject to the Reporting Person's continuous service through such date.

SEC source: 0001209191-22-034589 · doc4.xml · derivative · entry 2

Mehra Anand · CIK 0001590102 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

Underlying: Common Stock · 15,750 shares

Expires 2032-06-01

F2 · derivative.exercise_date: This grant was made pursuant to the issuer's seventh amended and restated non-employee director compensation policy.

F3 · derivative.exercise_date: The shares subject to this option will vest in twelve equal monthly installments commencing July 2, 2022, subject to Reporting Person's continuous service through each such date.

SEC source: 0001209191-22-034601 · doc4.xml · nonDerivative · entry 1

Powell Andrew Kenneth William · CIK 0001304113 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,500

SEC source: 0001209191-22-025537 · doc4.xml · nonDerivative · entry 3

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,245,763

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 22, 2022.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.33, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-025537 · doc4.xml · nonDerivative · entry 2

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,265,763

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 22, 2022.

F3 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-025537 · doc4.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,290,763

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 22, 2022.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.77, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-025032 · doc4.xml · nonDerivative · entry 1

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,386

F1 · kind: These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 18, 2022.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.84 to $16.73, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-018516 · doc4.xml · nonDerivative · entry 1

Walker Neal · CIK 0001604457 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,315,763

F1 · kind: Shares sold to satisfy withholding tax obligations upon the delivery of shares of common stock for restricted stock units that vested on March 1, 2022 and March 2, 2022 pursuant to preexisting sell-to-cover elections.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.72 to $16.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-018501 · doc4.xml · nonDerivative · entry 1

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 136,386

F1 · kind: Shares sold to satisfy withholding tax obligations upon the delivery of shares of common stock for restricted stock units that vested on March 1, 2022 and March 2, 2022 pursuant to preexisting sell-to-cover elections.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.22 to $16.00, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-018509 · doc4.xml · nonDerivative · entry 1

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 201,883

F1 · kind: Shares sold to satisfy withholding tax obligations upon the delivery of shares of common stock for restricted stock units that vested on March 1, 2022 and March 2, 2022 pursuant to preexisting sell-to-cover elections.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $15.22 to $16.10, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-22-015829 · doc4.xml · derivative · entry 9

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 12,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F6 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 2, 2021, subject to the Reporting Person's continuous service with the issuer as of the applicable vesting date.

F6 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 2, 2021, subject to the Reporting Person's continuous service with the issuer as of the applicable vesting date.

SEC source: 0001209191-22-015829 · doc4.xml · nonDerivative · entry 3

Monahan Joseph · CIK 0001861790 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,551

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

SEC source: 0001209191-22-015809 · doc4.xml · derivative · entry 8

Ruffo Frank · CIK 0001654450 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,595

Underlying: Common Stock · 8,297 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the issuer.

F6 · derivative.exercise_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 2, 2021, subject to the Reporting Person's continuous service with the issuer as of the applicable vesting date.

F6 · derivative.expiration_date: The shares underlying these restricted stock units vest in four equal annual installments beginning on March 2, 2021, subject to the Reporting Person's continuous service with the issuer as of the applicable vesting date.