ABUS

SEC source: 0001447028-24-000078 · wk-form4_1723838854.xml · nonDerivative · entry 2

MANCHESTER KEITH S · CIK 0001244828 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,069

F1 · kind: Cashless exercise and hold transaction in director stock options due to expire on November 13, 2024, ten years after such options were granted, including the sale of 8,846 of the underlying shares to pay the exercise price. None of the net 46,069 shares were sold.

SEC source: 0001447028-24-000078 · wk-form4_1723838854.xml · nonDerivative · entry 1

MANCHESTER KEITH S · CIK 0001244828 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Cashless exercise and hold transaction in director stock options due to expire on November 13, 2024, ten years after such options were granted, including the sale of 8,846 of the underlying shares to pay the exercise price. None of the net 46,069 shares were sold.

SEC source: 0001447028-24-000055 · wk-form4_1716581649.xml · derivative · entry 1

HENRIQUES RICHARD C JR · CIK 0001181178 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000053 · wk-form4_1716581555.xml · derivative · entry 1

Meyers James R · CIK 0001387521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000059 · wk-form4_1716581859.xml · derivative · entry 1

BURGESS DANIEL D · CIK 0001239650 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000057 · wk-form4_1716581747.xml · derivative · entry 1

MANCHESTER KEITH S · CIK 0001244828 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000051 · wk-form4_1716581426.xml · derivative · entry 1

Rewolinski Melissa · CIK 0001780206 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000049 · wk-form4_1716581215.xml · derivative · entry 1

Torti Frank · CIK 0001647805 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Shares · 67,000 shares

Expires 2034-05-23

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-24-000028 · wk-form4_1707180890.xml · nonDerivative · entry 2

Sims Karen · CIK 0001984652 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,542

F2 · kind: Represents the non-discretionary sale of common shares pursuant to the Reporting Person's 10b5-1 Plan, adopted on March 9, 2023, to satisfy the Reporting Person's tax obligations with respect to the vesting of a previous grant of restricted stock units.

SEC source: 0001447028-24-000027 · wk-form4_1707180869.xml · nonDerivative · entry 2

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 181,907

F2 · kind: Represents the non-discretionary sale of common shares pursuant to the Reporting Person's 10b5-1 Plan, adopted on March 6, 2023, to satisfy the Reporting Person's tax obligations with respect to the vesting of a previous grant of restricted stock units.

SEC source: 0001447028-24-000026 · wk-form4_1707180851.xml · nonDerivative · entry 2

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,485,121

F2 · kind: Represents the non-discretionary sale of common shares pursuant to the Reporting Person's 10b5-1 Plan, adopted on March 5, 2023, to satisfy the Reporting Person's tax obligations with respect to the vesting of a previous grant of restricted stock units.

SEC source: 0001447028-24-000025 · wk-form4_1707180834.xml · nonDerivative · entry 2

McElhaugh Michael J. · CIK 0001635326 · Director · Interim President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,504,793

F2 · kind: Represents the non-discretionary sale of common shares pursuant to the Reporting Person's 10b5-1 Plan, adopted on March 3, 2023, to satisfy the Reporting Person's tax obligations with respect to the vesting of a previous grant of restricted stock units.

SEC source: 0001447028-24-000028 · wk-form4_1707180890.xml · derivative · entry 3

Sims Karen · CIK 0001984652 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 403,900

Underlying: Common Shares · 403,900 shares

Expires 2034-02-01

F3 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F4 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-24-000028 · wk-form4_1707180890.xml · nonDerivative · entry 1

Sims Karen · CIK 0001984652 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 129,900

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-24-000029 · wk-form4_1707180904.xml · derivative · entry 2

Naftzger J. Christopher · CIK 0001496194 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 380,500

Underlying: Common Shares · 380,500 shares

Expires 2034-02-01

F2 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F3 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-24-000029 · wk-form4_1707180904.xml · nonDerivative · entry 1

Naftzger J. Christopher · CIK 0001496194 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,100

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-24-000027 · wk-form4_1707180869.xml · derivative · entry 3

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Shares · 450,000 shares

Expires 2034-02-01

F3 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F4 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-24-000027 · wk-form4_1707180869.xml · nonDerivative · entry 1

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 191,500

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-24-000026 · wk-form4_1707180851.xml · derivative · entry 4

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 437,800

Underlying: Common Shares · 437,800 shares

Expires 2034-02-01

F4 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F5 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-24-000026 · wk-form4_1707180851.xml · nonDerivative · entry 1

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,495,103

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-24-000025 · wk-form4_1707180834.xml · derivative · entry 3

McElhaugh Michael J. · CIK 0001635326 · Director · Interim President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 495,100

Underlying: Common Shares · 495,100 shares

Expires 2034-02-01

F3 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on the date of the grant.

F4 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-24-000025 · wk-form4_1707180834.xml · nonDerivative · entry 1

McElhaugh Michael J. · CIK 0001635326 · Director · Interim President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,514,957

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-23-000076 · wk-form4_1689279213.xml · derivative · entry 1

Rewolinski Melissa · CIK 0001780206 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Shares · 110,000 shares

Expires 2033-07-12

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on July 12, 2023, the date of the grant.

F2 · derivative.exercise_date: The option will vest and become exercisable in three equal annual installments beginning one year from the grant date.

SEC source: 0001447028-23-000070 · wk-form4_1689195036.xml · derivative · entry 1

Sims Karen · CIK 0001984652 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,640

Underlying: Common Shares · 153,640 shares

Expires 2033-07-10

F1 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000066 · wk-form4_1689192740.xml · derivative · entry 1

Naftzger J. Christopher · CIK 0001496194 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Shares · 500,000 shares

Expires 2033-07-10

F1 · derivative.exercise_price: Reflects the closing price of the Issuer's common shares on the Nasdaq Stock Market on July 10, 2023, the date of the grant.

F2 · derivative.exercise_date: This option shall vest over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000048 · wk-form4_1685132843.xml · derivative · entry 1

HENRIQUES RICHARD C JR · CIK 0001181178 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Shares · 55,000 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 24, 2023, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-23-000046 · wk-form4_1685132533.xml · derivative · entry 1

BURGESS DANIEL D · CIK 0001239650 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Shares · 55,000 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 24, 2023, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-23-000044 · wk-form4_1685132251.xml · derivative · entry 1

MANCHESTER KEITH S · CIK 0001244828 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Shares · 55,000 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 24, 2023, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-23-000042 · wk-form4_1685131883.xml · derivative · entry 1

Torti Frank · CIK 0001647805 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Shares · 55,000 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 24, 2023, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-23-000040 · wk-form4_1685131561.xml · derivative · entry 1

Meyers James R · CIK 0001387521 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Shares · 55,000 shares

Expires 2033-05-24

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 24, 2023, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-23-000007 · wf-form4_167545859079631.xml · derivative · entry 2

Howard Elizabeth · CIK 0001669530 · EVP, GC, Compliance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 278,700

Underlying: Common Shares · 278,700 shares

Expires 2033-02-01

F3 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000007 · wf-form4_167545859079631.xml · nonDerivative · entry 1

Howard Elizabeth · CIK 0001669530 · EVP, GC, Compliance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,024

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

F2 · balance_after: Includes 16,324 common shares acquired pursuant to the Arbutus Biopharma Corporation 2020 Employee Stock Purchase Plan.

SEC source: 0001447028-23-000011 · wf-form4_167545871089009.xml · derivative · entry 2

McElhaugh Michael J. · CIK 0001635326 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 334,700

Underlying: Common Shares · 334,700 shares

Expires 2033-02-01

F2 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000011 · wf-form4_167545871089009.xml · nonDerivative · entry 1

McElhaugh Michael J. · CIK 0001635326 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,391,157

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-23-000010 · wf-form4_167545866810752.xml · derivative · entry 3

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 328,700

Underlying: Common Shares · 328,700 shares

Expires 2033-02-01

F3 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000010 · wf-form4_167545866810752.xml · nonDerivative · entry 1

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,385,603

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-23-000009 · wf-form4_167545863617086.xml · derivative · entry 2

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 316,000

Underlying: Common Shares · 316,000 shares

Expires 2033-02-01

F2 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000009 · wf-form4_167545863617086.xml · nonDerivative · entry 1

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,000

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-23-000008 · wf-form4_167545861445606.xml · derivative · entry 2

Collier William H. · CIK 0001780495 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 866,000

Underlying: Common Shares · 866,000 shares

Expires 2033-02-01

F2 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0001447028-23-000008 · wf-form4_167545861445606.xml · nonDerivative · entry 1

Collier William H. · CIK 0001780495 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 216,500

F1 · shares: Represents the grant of restricted stock units ("RSUs"), which represent a contingent right to receive one common share for each RSU. The RSUs vest in three equal annual installments beginning one year from the grant date, subject to the Reporting Person's continuous service as of each vesting date. Unless otherwise provided, on each vesting date, common shares will automatically be sold to satisfy the Reporting Person's tax withholding obligations in a non-discretionary transaction.

SEC source: 0001447028-22-000038 · wf-form4_165359633960254.xml · derivative · entry 1

HENRIQUES RICHARD C JR · CIK 0001181178 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000036 · wf-form4_165359615932033.xml · derivative · entry 1

Meyers James R · CIK 0001387521 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000037 · wf-form4_165359625754672.xml · derivative · entry 1

BURGESS DANIEL D · CIK 0001239650 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000035 · wf-form4_165359607419806.xml · derivative · entry 1

Torti Frank · CIK 0001647805 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000034 · wf-form4_165359597719078.xml · derivative · entry 1

Tran Tram · CIK 0001892918 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000033 · wf-form4_165359582944568.xml · derivative · entry 1

MANCHESTER KEITH S · CIK 0001244828 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,000

Underlying: Common Shares · 41,000 shares

Expires 2032-05-25

F1 · derivative.exercise_price: Reflects the closing price of the Company's common shares on the Nasdaq Stock Market on May 25, 2022, the date of the grant.

F2 · derivative.exercise_date: The option is fully vested and exercisable as of the date of the grant.

SEC source: 0001447028-22-000010 · wf-form4_164271927133471.xml · derivative · entry 1

Howard Elizabeth · CIK 0001669530 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,500

Underlying: Common Shares · 237,500 shares

Expires 2032-01-20

F1 · derivative.exercise_date: These stock options will vest and become exercisable 1/48th each month over the four year period.

SEC source: 0001447028-22-000012 · wf-form4_164271931496383.xml · derivative · entry 1

Collier William H. · CIK 0001780495 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 787,550

Underlying: Common Shares · 787,550 shares

Expires 2032-01-20

F1 · derivative.exercise_date: These stock options will vest and become exercisable 1/48th each month over the four year period.

SEC source: 0001447028-22-000011 · wf-form4_164271929611191.xml · derivative · entry 1

HASTINGS DAVID C · CIK 0001237401 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 285,000

Underlying: Common Shares · 285,000 shares

Expires 2032-01-20

F1 · derivative.exercise_date: These stock options will vest and become exercisable 1/48th each month over the four year period.

SEC source: 0001447028-22-000009 · wf-form4_164271925075900.xml · derivative · entry 1

Sofia Michael J. · CIK 0001635324 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 285,000

Underlying: Common Shares · 285,000 shares

Expires 2032-01-20

F1 · derivative.exercise_date: These stock options will vest and become exercisable 1/48th each month over the four year period.