ENRIGHT PATRICK G

SEC source: 0000899243-21-016024 · doc4.xml · nonDerivative · entry 2

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,012

F4 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LCP4 to its members.

F5 · ownership.nature: These shares are held by a limited partnership (the "Partnership") of which the general partner is a trust (the "Trust"). Mr. Enright is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Partnership. Each of the Trust and Mr. Enright disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Mr. Enright, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-21-016024 · doc4.xml · nonDerivative · entry 1

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,918,691

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners IV, L.P. ("LVP4") to its general and limited partners, pursuant to a Rule 10b5-1 trading plan.

F2 · ownership.direct: These shares are held directly by LVP4. Longitude Capital Partners IV, LLC ("LCP4") is the general partner of LVP4 and may be deemed to have voting, investment and dispositive power over the shares held by LVP4. Juliet Tammenoms Bakker, a member of the Issuer's board of directors, and Patrick G. Enright are managing members of LCP4 (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to the shares held by LVP4. Each of LCP4 and the Managers disclaims beneficial ownership of the shares held by LVP4 and this report shall not be deemed an admission that any of them is the beneficial owner of such shares for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

F3 · ownership.direct: (Continued from footnote 2) Juliet Tammenoms Bakker, a managing member of LCP4, currently serves on the Issuer's Board of Directors and files separate reports under Section 16(a) of the Securities Exchange Act of 1934 to report transactions in securities of the Issuer.

SEC source: 0001415889-21-000087 · form4-01052021_040102.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,149

Underlying: Common Stock · 8,149 shares

Expires 2030-12-30

F1 · shares: The option award was issued to the Reporting Person, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant.

F2 · derivative.exercise_date: This option is fully vested at time of grant.

SEC source: 0000899243-20-031489 · doc4.xml · nonDerivative · entry 4

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 891

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F6 · ownership.nature: These shares are held directly by Ms. Bakker.

SEC source: 0000899243-20-031489 · doc4.xml · nonDerivative · entry 3

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,080

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F5 · ownership.nature: These shares are held by a trust. Ms. Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Ms. Bakker, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-20-031489 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,973

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F4 · ownership.nature: These shares are held by a limited partnership (the "Partnership") of which the general partner is a trust (the "Trust"). Mr. Enright is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Partnership. Each of the Trust and Mr. Enright disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Mr. Enright, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-20-031489 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,750,877

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners III, L.P. ("Longitude Venture III") to its general and limited partners.

F2 · ownership.nature: These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III and may be deemed to have voting, investment and dispositive power with respect to these securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of Longitude Capital III (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to these securities. Each of Longitude Capital III and the Managers disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001765581-20-000120 · edgardoc.xml · nonDerivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,368

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.56 to $147.66, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001765581-20-000120 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,991

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $146.559 to $147.55, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001765581-20-000120 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,074

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $145.36 to $146.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001765581-20-000103 · edgardoc.xml · derivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 9,929 shares

Expires 2020-11-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On November 2, 2020, the Reporting Person's 9,929 phantom stock rights under the Issuer's Amended and Restated Directors Deferred Compensation Plan were settled for an equal number of the Issuer's ordinary shares.

F1 · price: On November 2, 2020, the Reporting Person's 9,929 phantom stock rights under the Issuer's Amended and Restated Directors Deferred Compensation Plan were settled for an equal number of the Issuer's ordinary shares.

SEC source: 0001765581-20-000103 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,297

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On November 2, 2020, the Reporting Person's 9,929 phantom stock rights under the Issuer's Amended and Restated Directors Deferred Compensation Plan were settled for an equal number of the Issuer's ordinary shares.

SEC source: 0000899243-20-029109 · doc4.xml · derivative · entry 3

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,685,358 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series E Preferred Stock automatically converted into shares of Common Stock on a 1:1 basis immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.

F1 · derivative.exercise_date: The Series E Preferred Stock automatically converted into shares of Common Stock on a 1:1 basis immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.

F1 · derivative.expiration_date: The Series E Preferred Stock automatically converted into shares of Common Stock on a 1:1 basis immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.

F2 · ownership.direct: These shares are are held directly by the Reporting Person. Longitude Capital Partners IV, LLC ("LCP4") is the general partner of the Reporting Person and may be deemed to have voting, investment and dispositive power over the shares held by the Reporting Person. Juliet Tammenoms Bakker, a member of the Issuer's board of directors, and Patrick G. Enright are managing members of LCP4 (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to the shares held by the Reporting Person. Each of LCP4 and the Managers disclaims beneficial ownership of the shares held by the Reporting Person and this report shall not be deemed an admission that any of them is the beneficial owner of such shares for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein..

SEC source: 0000899243-20-029109 · doc4.xml · nonDerivative · entry 2

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,918,691

F2 · ownership.direct: These shares are are held directly by the Reporting Person. Longitude Capital Partners IV, LLC ("LCP4") is the general partner of the Reporting Person and may be deemed to have voting, investment and dispositive power over the shares held by the Reporting Person. Juliet Tammenoms Bakker, a member of the Issuer's board of directors, and Patrick G. Enright are managing members of LCP4 (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to the shares held by the Reporting Person. Each of LCP4 and the Managers disclaims beneficial ownership of the shares held by the Reporting Person and this report shall not be deemed an admission that any of them is the beneficial owner of such shares for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein..

SEC source: 0000899243-20-029109 · doc4.xml · nonDerivative · entry 1

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,685,358

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series E Preferred Stock automatically converted into shares of Common Stock on a 1:1 basis immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.

F2 · ownership.direct: These shares are are held directly by the Reporting Person. Longitude Capital Partners IV, LLC ("LCP4") is the general partner of the Reporting Person and may be deemed to have voting, investment and dispositive power over the shares held by the Reporting Person. Juliet Tammenoms Bakker, a member of the Issuer's board of directors, and Patrick G. Enright are managing members of LCP4 (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to the shares held by the Reporting Person. Each of LCP4 and the Managers disclaims beneficial ownership of the shares held by the Reporting Person and this report shall not be deemed an admission that any of them is the beneficial owner of such shares for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein..

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 10

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,398 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 9

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,432 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 8

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 7

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,500 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 6

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,755 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 5

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 52,421 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · derivative · entry 4

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 65,849 shares

Expires not disclosed

F4 · derivative.exercise_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

F4 · derivative.expiration_date: Pursuant to the Merger Agreement, at the Effective Time, each stock option outstanding and unexercised immediately prior to the Effective Time vested in full, terminated and was converted into the right to receive a cash payment equal to the product of (i) the number of shares of common stock that were subject to such stock option immediately prior to the Effective Time and (ii) the excess, if any, of the Offer Price over the per share exercise price of such stock option.

SEC source: 0000899243-20-028173 · doc4.xml · nonDerivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F2 · shares: Disposed of to SPN MergerSub, Inc. ("Merger Sub"), which, pursuant to the Agreement and Plan of Merger, dated August 29, 2020, by and between the Issuer, Societes des Produits Nestle S.A., ("Nestle"), and Merger Sub (the "Merger Agreement"), commenced a tender offer to acquire any and all of the outstanding shares of the Issuer's common stock (other than those shares owned by Nestle and its affiliates) at a purchase price of $34.50 per share (the "Offer Price").

F3 · shares: Pursuant to the Merger Agreement, each Issuer restricted stock unit ("RSU") that was outstanding immediately prior to the date and time at which the Merger became effective (the "Effective Time") vested in full, terminated, and was converted into the right to receive a cash payment equal to (i) the Offer Price multiplied by (ii) the number of shares of common stock subject to the RSU.

SEC source: 0000899243-20-028173 · doc4.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By: LCP2

Disclosed balance after: 0

F1 · ownership.nature: Reflects shares held by Longitude Capital Partners II, LLC ("LCP2"). The Reporting Person is a managing member of LCP2 and in his capacity as such may be deemed to share voting and investment power over the shares held by LCP2. The Reporting Person disclaims beneficial ownership over these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028173 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001415889-20-002398 · form4-10022020_031001.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,379

Underlying: Common Stock · 8,379 shares

Expires 2030-09-29

F1 · shares: The option award was issued to the Reporting Person, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant.

F2 · derivative.exercise_date: This option is fully vested at time of grant.

SEC source: 0000899243-20-026210 · doc4.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By: LCP2

Disclosed balance after: 91,697

F3 · kind: Represents a change in the form of ownership of LCP2 by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by LVP2.

F4 · ownership.nature: Reflects shares held by LCP2. The Reporting Person is a managing member of LCP2 and in his capacity as such may be deemed to share voting and investment power over the shares held by LCP2. The Reporting Person disclaims beneficial ownership over these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.

SEC source: 0000899243-20-026210 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By: LVP2

Disclosed balance after: 0

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners II, L.P. ("LVP2") to its general and limited partners.

F2 · ownership.nature: Reflects shares that were held by LVP2. Longitude Capital Partners II, LLC ("LCP2") is the general partner of LVP2 and may be deemed to share voting and investment power over the shares of the Issuer held by LVP2. The Reporting Person is a managing member of LCP2 and in his capacity as such may be deemed to share voting and investment power over the shares held by LVP2. Each of LCP2 and the Reporting Person disclaim beneficial ownership over these securities and this report shall not be deemed an admission that either of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-023790 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.63 to $10.88, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F3 · ownership.nature: These shares were held by a trust. Ms. Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Ms. Bakker, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-20-023790 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.63 to $10.88, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: These shares were held directly by Juliet Tammenoms Bakker ("Ms. Bakker").

SEC source: 0001765581-20-000069 · edgardoc.xml · derivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,765

Underlying: Ordinary Shares · 6,765 shares

Expires 2030-08-05

F2 · derivative.exercise_date: These options are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Subject to the Reporting Person's continuous service and certain additional conditions, these options will vest in full on July 30, 2021.

SEC source: 0001765581-20-000069 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,368

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 30, 2021.

SEC source: 0000899243-20-020572 · doc4.xml · derivative · entry 5

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 187,154 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: On July 28, 2020, the Series A-2 Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F3 · derivative.exercise_date: On July 28, 2020, the Series A-2 Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F3 · derivative.expiration_date: On July 28, 2020, the Series A-2 Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-020572 · doc4.xml · derivative · entry 4

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 2,007,225 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On July 28, 2020, the Series A Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F1 · derivative.exercise_date: On July 28, 2020, the Series A Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F1 · derivative.expiration_date: On July 28, 2020, the Series A Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-020572 · doc4.xml · nonDerivative · entry 3

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 2,819,379

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-020572 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 2,194,379

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: On July 28, 2020, the Series A-2 Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-020572 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 2,007,225

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On July 28, 2020, the Series A Convertible Preferred Stock automatically converted into Common Stock on a 7.4730-for-1 basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-20-019123 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,600,877

F1 · shares: On July 10, 2020, Longitude Venture Partners III, L.P. ("Longitude Venture III") purchased 109,090 shares of the Issuer's common stock at a price of $27.50 per share in the Issuer's follow-on public offering.

F2 · ownership.nature: These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III and may be deemed to have voting, investment and dispositive power with respect to these securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of Longitude Capital III (each a "Manager" and collectively, the "Managers") and may each be deemed to share voting, investment and dispositive power with respect to these securities. Each of Longitude Capital III and the Managers disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-20-001795 · form4-07022020_040733.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,436

Underlying: Common Stock · 5,436 shares

Expires 2030-06-29

F1 · shares: The option award was issued to the Reporting Person, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant.

F2 · derivative.exercise_date: This option is fully vested at time of grant.

SEC source: 0000899243-20-014612 · doc4.xml · derivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,398

Underlying: Common Stock · 15,398 shares

Expires 2030-05-26

F3 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2021 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0000899243-20-014612 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,401

F1 · shares: These shares represent restricted stock units ("RSUs") and will be settled in common stock upon vesting. The RSUs vest on the earlier of (i) the first anniversary of the grant date or (ii) the date of the 2021 Annual Meeting of the Issuer's stockholders, assuming continuous service as a director until such vesting date.

SEC source: 0000899243-20-014482 · doc4.xml · nonDerivative · entry 4

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,049

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F6 · ownership.nature: These shares are held by a trust. Ms. Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Ms. Bakker, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-20-014482 · doc4.xml · nonDerivative · entry 3

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,447

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F5 · ownership.nature: These shares are held directly by Ms. Bakker.

SEC source: 0000899243-20-014482 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 3,495

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Capital III to its members.

F4 · ownership.nature: These shares are held by a limited partnership (the "Partnership") of which the general partner is a trust (the "Trust"). Mr. Enright is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Partnership. Each of the Trust and Mr. Enright disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein. Each of the Reporting Persons disclaims the existence of a "group" and, other than Mr. Enright, disclaims beneficial ownership of these securities, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-20-014482 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 3,199,035

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners III, L.P. ("Longitude Venture III") to its general and limited partners.

F2 · ownership.nature: These shares are held by Longitude Venture III. This report is filed jointly by Longitude Capital Partners III, LLC ("Longitude Capital III"), Longitude Venture III, Patrick G. Enright ("Mr. Enright"), and Juliet Tammenoms Bakker ("Ms. Bakker"). Longitude Capital III is the general partner of Longitude Venture III and may be deemed to have voting, investment and dispositive power over the shares held by Longitude Venture III. Mr. Enright and Ms. Bakker are the managing members of Longitude Capital III and may be deemed to share voting, investment and dispositive power over the shares held by Longitude Venture III. Each of Longitude Capital III, Mr. Enright and Ms. Bakker disclaims beneficial ownership of such shares except to the extent of its, his or her pecuniary interest therein.

SEC source: 0001104659-20-065359 · a4.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-05-19

F1 · derivative.exercise_date: This option vests in ratable monthly installments over one year from the date of grant.

SEC source: 0001567619-20-007434 · doc1.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,573

Underlying: Common Stock · 8,573 shares

Expires 2030-03-30

F1 · shares: The option award was issued to the Reporting Person, who elected to take equity awards in lieu of cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation plan. The number of options granted was determined by dividing the cash compensation otherwise payable with respect to the quarter by the Black-Scholes value of a single option calculated as of the date of the grant.

F2 · derivative.exercise_date: This option is fully vested at time of grant.

SEC source: 0000899243-20-009016 · doc4.xml · nonDerivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,561

F3 · price: The price reported in Column 4 is a weighted price. These Shares were purchased in multiple transactions at prices ranging from $10.66 to $11.50 inclusive. Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0000899243-20-009016 · doc4.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,348

SEC source: 0000899243-20-009016 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By: LVP2

Disclosed balance after: 6,113,134

F1 · price: The price reported in Column 4 is a weighted price. These Shares were purchased in multiple transactions at prices ranging from $11.35 to $11.50 inclusive. Upon request, the Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Longitude Capital Partners II, LLC ("LCP II") is the general partner of Longitude Venture Partners II, L.P. ("LVP II") and may be deemed to have voting, investment and dispositive power with respect to such securities. The Reporting Person (a member of the Issuer's board of directors) and Juliet Tammenoms Bakker are the managing members of LCP II. Each of LCP II, Ms. Tammenoms Bakker and the Reporting Person disclaim beneficial ownership over such securities except to the extent of their respective pecuniary interest therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.