ENRIGHT PATRICK G

SEC source: 0001209191-23-054904 · doc4.xml · derivative · entry 5

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Longitude Venture Partners IV, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 319,126 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Upon the closing of the Issuer's initial public offering, each share of Series B convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-9.106601 basis, which reflects an anti-dilution adjustment to the conversion ratio pursuant to a provision of the Series B convertible preferred stock based on the pricing of the initial public offering (as described in the Reporting Person's Form 3). The shares had no expiration date.

F3 · price: Upon the closing of the Issuer's initial public offering, each share of Series B convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-9.106601 basis, which reflects an anti-dilution adjustment to the conversion ratio pursuant to a provision of the Series B convertible preferred stock based on the pricing of the initial public offering (as described in the Reporting Person's Form 3). The shares had no expiration date.

F3 · derivative.exercise_date: Upon the closing of the Issuer's initial public offering, each share of Series B convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-9.106601 basis, which reflects an anti-dilution adjustment to the conversion ratio pursuant to a provision of the Series B convertible preferred stock based on the pricing of the initial public offering (as described in the Reporting Person's Form 3). The shares had no expiration date.

F3 · derivative.expiration_date: Upon the closing of the Issuer's initial public offering, each share of Series B convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-9.106601 basis, which reflects an anti-dilution adjustment to the conversion ratio pursuant to a provision of the Series B convertible preferred stock based on the pricing of the initial public offering (as described in the Reporting Person's Form 3). The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Mr. Enright and Ms. Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-23-054904 · doc4.xml · derivative · entry 4

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Longitude Venture Partners IV, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 1,793,429 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Upon the closing of the Issuer's initial public offering, each share of Series A convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-10.594230 basis. The shares had no expiration date.

F1 · price: Upon the closing of the Issuer's initial public offering, each share of Series A convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-10.594230 basis. The shares had no expiration date.

F1 · derivative.exercise_date: Upon the closing of the Issuer's initial public offering, each share of Series A convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-10.594230 basis. The shares had no expiration date.

F1 · derivative.expiration_date: Upon the closing of the Issuer's initial public offering, each share of Series A convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-10.594230 basis. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Mr. Enright and Ms. Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-23-054904 · doc4.xml · nonDerivative · entry 3

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Longitude Venture Partners IV, L.P.

Disclosed balance after: 2,567,100

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Mr. Enright and Ms. Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-23-054904 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Longitude Venture Partners IV, L.P.

Disclosed balance after: 2,112,555

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Upon the closing of the Issuer's initial public offering, each share of Series B convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-9.106601 basis, which reflects an anti-dilution adjustment to the conversion ratio pursuant to a provision of the Series B convertible preferred stock based on the pricing of the initial public offering (as described in the Reporting Person's Form 3). The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Mr. Enright and Ms. Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-23-054904 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners IV, LLC · CIK 0001829169 · 10% owner

Longitude Venture Partners IV, L.P. · CIK 0001787456 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Longitude Venture Partners IV, L.P.

Disclosed balance after: 1,793,429

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Upon the closing of the Issuer's initial public offering, each share of Series A convertible preferred stock automatically converted into shares of the Issuer's common stock on a one-for-10.594230 basis. The shares had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Mr. Enright and Ms. Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001765581-23-000078 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,946

F2 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $137.78 to $138.16. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-23-000078 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,187

F1 · kind: Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on August 3, 2024.

SEC source: 0001209191-23-029014 · doc4.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Class A Common Stock · 20,000 shares

Expires 2033-05-09

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2024 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0000899243-23-004345 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,714,285

F1 · ownership.nature: These shares are held by Longitude Prime Fund, L.P. ("LPF"). Longitude Prime Partners, LLC ("LPP") is the general partner of LPF and may be deemed to have voting and investment power over the securities held by LPF. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LPP and may be deemed to share voting and dispositive power over the shares held by LPF. Each of LPP, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001765581-22-000126 · edgardoc.xml · nonDerivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 0

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $152.84 to $152.91. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

F4 · balance_after: These shares were held by a trust (the "Trust"). Reporting person is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Trust. Reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein and this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.

SEC source: 0001765581-22-000126 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,112

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $149.76 to $150.06. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000126 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,181

F1 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $148.51 to $149.34. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001765581-22-000084 · edgardoc.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,086

F2 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

SEC source: 0001765581-22-000084 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,175

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 28, 2023.

SEC source: 0001415889-22-005905 · form4-05312022_040514.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-05-25

F1 · derivative.exercise_date: This option vests in ratable monthly installments over one year from the date of grant.

SEC source: 0001209191-22-032181 · doc4.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,925

Underlying: Class A Common Stock · 9,925 shares

Expires 2032-05-23

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of the first anniversary of the grant date or the date of the Company's 2023 annual stockholder meeting, subject to the Reporting Person's continuous service through such vesting date. Notwithstanding the foregoing, the shares will vest in full upon a change in control, subject to the Reporting Person's continuous service through the date of such change in control.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 8

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 8,015

F9 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LPP to its members

F8 · ownership.nature: These shares are held directly by Patrick G. Enright.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 7

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,404

F9 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LPP to its members

F7 · ownership.nature: These shares are held by a trust. Juliet Tammenoms Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Tammenoms Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 6

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,611

F9 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LPP to its members

F6 · ownership.nature: These shares are held directly by Juliet Tammenoms Bakker.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 5

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 7,175

F5 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LCP III to its members.

F8 · ownership.nature: These shares are held directly by Patrick G. Enright.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 4

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,152

F5 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LCP III to its members.

F7 · ownership.nature: These shares are held by a trust. Juliet Tammenoms Bakker is the Investment Trustee of such trust and may be deemed to share voting and dispositive power with regard to the reported shares. Ms. Tammenoms Bakker disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 3

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 5,023

F5 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by LCP III to its members.

F6 · ownership.nature: These shares are held directly by Juliet Tammenoms Bakker.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F3 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Venture Partners III, L.P. ("LVP III") to its general and limited partners.

F4 · ownership.nature: These securities are held directly by LVP III. Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting, investment and dispositive power with respect to such securities. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP III and may be deemed to share voting, investment and dispositive power over such securities. Each of LCP III, Mr. Enright, and Ms. Tammenoms Bakker disclaim beneficial ownership over such securities except to the extent of their respective pecuniary interest therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-22-016052 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · kind: Represents a pro rata distribution, and not a purchase or sale, without additional consideration by Longitude Prime Fund, L.P. ("LPF") to its general and limited partners.

F2 · ownership.nature: The securities are held directly by LPF. Longitude Prime Partners, LLC ("LPP"), the general partner of LPF, may be deemed to have voting and investment power with respect to the shares held by LPF. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LPP and may be deemed to share voting, investment and dispositive power over such securities. Each of LPP, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-22-015325 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 4,174,379

F1 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P. ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and dispositive power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and dispositive power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-22-013596 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,429,927

F1 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-22-004271 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 175,000

F1 · ownership.nature: The securities are held directly by Longitude Prime Fund, L.P. ("LPF"). Longitude Prime Partners, LLC ("LPP"), the general partner of LPF, may be deemed to have voting and investment power with respect to the shares held by LPF. Patrick G. Enright, Juliet Tammenoms Bakker and Joshua Richardson, a member of the Issuer's board of directors, are each members of LPF and may be deemed to share voting, investment and dispositive power over such securities. Mr. Enright and Ms. Tammenoms Bakker are the managing members of LPP. Each of Mr. Enright, Ms. Tammenoms Bakker and Dr. Richardson disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-22-003502 · doc4.xml · derivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 487,451 shares

Expires 2022-04-10

F2 · shares: Consists of 1,477,125 Series B Warrants held by LVP III which are exercisable for an aggregate of 487,451 shares of Common Stock.

F1 · ownership.nature: These securities are held directly by Longitude Venture Partners III, L.P. ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting, investment and dispositive power with respect to such securities. Patrick G. Enright, Juliet Tammenoms Bakker and Joshua Richardson, a member of the Issuer's board of directors, are each members of LCP III and may be deemed to share voting, investment and dispositive power over such securities. Mr. Enright and Ms. Tammenoms Bakker are the managing members of LCP III. Each of LCP III, Mr. Enright, Ms. Tammenoms Bakker and Joshua Richardson disclaim beneficial ownership over such securities except to the extent of their respective pecuniary interest therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0000899243-22-003502 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,964,771

F1 · ownership.nature: These securities are held directly by Longitude Venture Partners III, L.P. ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting, investment and dispositive power with respect to such securities. Patrick G. Enright, Juliet Tammenoms Bakker and Joshua Richardson, a member of the Issuer's board of directors, are each members of LCP III and may be deemed to share voting, investment and dispositive power over such securities. Mr. Enright and Ms. Tammenoms Bakker are the managing members of LCP III. Each of LCP III, Mr. Enright, Ms. Tammenoms Bakker and Joshua Richardson disclaim beneficial ownership over such securities except to the extent of their respective pecuniary interest therein, and the inclusion of such securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 or for any other purpose.

SEC source: 0001765581-21-000114 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 2,000

F1 · balance_after: These shares are held by a trust (the "Trust"). Reporting person is the Trustee of the Trust and may be deemed to share voting, investment and dispositive power over the shares held by the Trust. Reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein and this report shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.

SEC source: 0001765581-21-000069 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,614

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 29, 2022.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 9

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 129,032

Underlying: Class A Common Stock · 129,032 shares

Expires 2028-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Immediately exercisable.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 8

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 0

Underlying: Series B1 Preferred Stock · 645,160 shares

Expires 2028-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · kind: The Issuer's Preferred Stock warrants automatically converted into warrants to purchase Common Stock immediately prior to the closing of the Issuer's initial public offering without payment or further consideration. The transaction is listed solely for the purpose of reporting the change in the shares underlying the warrants.

F4 · derivative.exercise_date: The Issuer's Preferred Stock warrants automatically converted into warrants to purchase Common Stock immediately prior to the closing of the Issuer's initial public offering without payment or further consideration. The transaction is listed solely for the purpose of reporting the change in the shares underlying the warrants.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 7

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 500,000

Underlying: Class A Common Stock · 500,000 shares

Expires 2027-07-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Immediately exercisable.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 6

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 0

Underlying: Series A1 Preferred Stock · 2,500,000 shares

Expires 2027-07-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · kind: The Issuer's Preferred Stock warrants automatically converted into warrants to purchase Common Stock immediately prior to the closing of the Issuer's initial public offering without payment or further consideration. The transaction is listed solely for the purpose of reporting the change in the shares underlying the warrants.

F4 · derivative.exercise_date: The Issuer's Preferred Stock warrants automatically converted into warrants to purchase Common Stock immediately prior to the closing of the Issuer's initial public offering without payment or further consideration. The transaction is listed solely for the purpose of reporting the change in the shares underlying the warrants.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 5

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 0

Underlying: Class A Common Stock · 458,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.exercise_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.expiration_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 4

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 0

Underlying: Class A Common Stock · 1,130,904 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.exercise_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.expiration_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · derivative · entry 3

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 0

Underlying: Class A Common Stock · 1,754,801 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.exercise_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F3 · derivative.expiration_date: The Series A1 Preferred Stock, Series B1 Preferred Stock and Series C1 Preferred Stock (collectively, the "Preferred Stock") are convertible at any time, at the holder's election and have no expiration date. Each share of Preferred Stock automatically converted into 0.20 shares of the Issuer's Class A Common Stock upon the closing of the Issuer's initial public offering.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0000899243-21-029105 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Prime Fund, L.P.

Disclosed balance after: 150,000

F2 · ownership.nature: The securities are held directly by Longitude Prime Fund, L.P. ("LPF"). Longitude Prime Partners, LLC ("LPP"), the general partner of LPF, may be deemed to have voting and investment power with respect to the shares held by LPF. Mr. Enright and Ms. Tammenoms Bakker are the managing members of LPP and may be deemed to have voting, investment and dispositive power over the shares held by LPF. LPP and each of Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-029105 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners II, LLC · CIK 0001647491 · 10% owner

Longitude Venture Partners II, L.P. · CIK 0001527510 · 10% owner

Longitude Prime Partners, LLC · CIK 0001865779 · 10% owner

Longitude Prime Fund, L.P. · CIK 0001865844 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Longitude Venture Partners II, L.P.

Disclosed balance after: 3,407,952

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: The securities are held directly by Longitude Venture Partners II, L.P. ("LVP II"). Longitude Capital Partners II, LLC, ("LCP II"), the general partner of LVP II, may be deemed to have voting and investment power with respect to the shares held by LVP II. Patrick G. Enright and Juliet Tammenoms Bakker are the managing members of LCP II and may be deemed to share voting and investment power over the shares held by LVP II. Each of LCP II, Mr. Enright and Ms. Tammenoms Bakker disclaim beneficial ownership of such securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interest therein.

SEC source: 0001415889-21-002734 · form4-06012021_010612.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-05-26

F1 · derivative.exercise_date: This option vests in ratable monthly installments over one year from the date of grant.

SEC source: 0001209191-21-033809 · doc4.xml · derivative · entry 3

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Class A Common Stock · 2,187,504 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series C Preferred Stock automatically converted into Class A Common Stock on a 11.5869:1 basis (on an adjusted basis, after giving effect to the reverse stock split of the Class A Common Stock effected by the Issuer on May 7, 2021) and had no expiration date.

F1 · derivative.exercise_date: The Series C Preferred Stock automatically converted into Class A Common Stock on a 11.5869:1 basis (on an adjusted basis, after giving effect to the reverse stock split of the Class A Common Stock effected by the Issuer on May 7, 2021) and had no expiration date.

F1 · derivative.expiration_date: The Series C Preferred Stock automatically converted into Class A Common Stock on a 11.5869:1 basis (on an adjusted basis, after giving effect to the reverse stock split of the Class A Common Stock effected by the Issuer on May 7, 2021) and had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-21-033809 · doc4.xml · nonDerivative · entry 2

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,096,594

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-21-033809 · doc4.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,187,504

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series C Preferred Stock automatically converted into Class A Common Stock on a 11.5869:1 basis (on an adjusted basis, after giving effect to the reverse stock split of the Class A Common Stock effected by the Issuer on May 7, 2021) and had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners IV, L.P ("LVP IV"). Longitude Capital Partners IV, LLC ("LCP IV") is the general partner of LVP IV and may be deemed to have voting and dispositive power over the shares held by LVP IV. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP IV and may be deemed to share voting and dispositive power with respect to the shares held by LVP IV. Each of LCP IV, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-21-033340 · doc4.xml · derivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,925

Underlying: Class A Common Stock · 9,925 shares

Expires 2031-05-12

F1 · derivative.exercise_date: The shares subject to the option will vest on the earlier of May 13, 2022 or the 2022 annual meeting of stockholders.

SEC source: 0000899243-21-019166 · doc4.xml · derivative · entry 5

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 406,338 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and investment power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and investment power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-019166 · doc4.xml · derivative · entry 4

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 1,271,027 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and investment power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and investment power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-019166 · doc4.xml · derivative · entry 3

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 1,308,410 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and investment power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and investment power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-019166 · doc4.xml · nonDerivative · entry 2

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 3,220,775

F3 · price: On May 11, 2021, LVP III purchased 235,000 shares of Common Stock of the Issuer at a price of $17.00 per share pursuant to an underwritten public offering.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and investment power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and investment power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-019166 · doc4.xml · nonDerivative · entry 1

Longitude Capital Partners III, LLC · CIK 0001713663 · 10% owner

Longitude Venture Partners III, L.P. · CIK 0001674099 · 10% owner

ENRIGHT PATRICK G · CIK 0001253886 · 10% owner

Tammenoms Bakker Juliet · CIK 0001431159 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Longitude Venture Partners III, L.P.

Disclosed balance after: 2,985,775

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series A-1 Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. Each share of Series B Preferred Stock converted into common stock on a 1-for-5.35 basis automatically upon the closing of the Issuer's initial public offering. The Series A Preferred Stock, Series A-1 Preferred Stock and Series B Preferred Stock had no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners III, L.P ("LVP III"). Longitude Capital Partners III, LLC ("LCP III") is the general partner of LVP III and may be deemed to have voting and investment power over the shares held by LVP III. Patrick G. Enright and Juliet Tammenoms Bakker are managing members of LCP III and may be deemed to share voting and investment power with respect to the shares held by LVP III. Each of LCP III, Mr. Enright and Ms. Tammenoms Bakker disclaims beneficial ownership of such shares and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.