Koehler Maria

SEC source: 0001415889-25-008108 · form4-03142025_040318.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 227,813

F1 · kind: Represent shares sold to satisfy the Reporting Person's tax withholding obligation in connection with the vesting and settlement of restricted stock units and does not represent a discretionary sale by the holder.

SEC source: 0000950170-24-071306 · ownership.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,520

Underlying: Common Stock · 17,520 shares

Expires 2034-06-06

F1 · derivative.exercise_date: This option shall vest in full upon the earlier of (i) June 7, 2025 or (ii) the date of the next annual meeting; provided, however, that all vesting shall cease if the director resigns from the Board or otherwise ceases to serve as a director.

SEC source: 0001415889-24-009623 · form4-04022024_010449.xml · nonDerivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 231,409

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the holder on December 22, 2023. On January 30, 2023, the holder was granted 26,450 restricted stock units ("RSUs"), as previously reported on a Form 4 filed on February 1, 2023, of which 8,817 of these RSUs vested on January 30, 2024. Amounts reported herein represent shares sold by the holder solely to satisfy the holder's tax withholding obligation due in connection with the vesting and settlement of this tranche of the RSUs and do not represent a discretionary sale by the holder.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.51 to $4.76 inclusive.

SEC source: 0001415889-24-009623 · form4-04022024_010449.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 231,709

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the holder on December 22, 2023. On January 30, 2023, the holder was granted 26,450 restricted stock units ("RSUs"), as previously reported on a Form 4 filed on February 1, 2023, of which 8,817 of these RSUs vested on January 30, 2024. Amounts reported herein represent shares sold by the holder solely to satisfy the holder's tax withholding obligation due in connection with the vesting and settlement of this tranche of the RSUs and do not represent a discretionary sale by the holder.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.40 to $4.81 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3).

SEC source: 0001415889-24-009251 · form4-03272024_100302.xml · nonDerivative · entry 3

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 232,209

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the holder on December 22, 2023. On January 30, 2023, the holder was granted 26,450 restricted stock units ("RSUs"), as previously reported on a Form 4 filed on February 1, 2023, of which 8,817 of these RSUs vested on January 30, 2024. Amounts reported herein represent shares sold by the holder solely to satisfy the holder's tax withholding obligation due in connection with the vesting and settlement of this tranche of the RSUs and do not represent a discretionary sale by the holder.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.53 to $4.74 inclusive.

SEC source: 0001415889-24-009251 · form4-03272024_100302.xml · nonDerivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 232,709

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the holder on December 22, 2023. On January 30, 2023, the holder was granted 26,450 restricted stock units ("RSUs"), as previously reported on a Form 4 filed on February 1, 2023, of which 8,817 of these RSUs vested on January 30, 2024. Amounts reported herein represent shares sold by the holder solely to satisfy the holder's tax withholding obligation due in connection with the vesting and settlement of this tranche of the RSUs and do not represent a discretionary sale by the holder.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.52 to $4.76 inclusive.

SEC source: 0001415889-24-009251 · form4-03272024_100302.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 233,209

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the holder on December 22, 2023. On January 30, 2023, the holder was granted 26,450 restricted stock units ("RSUs"), as previously reported on a Form 4 filed on February 1, 2023, of which 8,817 of these RSUs vested on January 30, 2024. Amounts reported herein represent shares sold by the holder solely to satisfy the holder's tax withholding obligation due in connection with the vesting and settlement of this tranche of the RSUs and do not represent a discretionary sale by the holder.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.72 to $4.91 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

SEC source: 0001415889-24-006462 · form4-03052024_020328.xml · derivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Shares · 85,000 shares

Expires 2034-02-28

F2 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest on March 1, 2025, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001415889-24-006462 · form4-03052024_020328.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 233,709

F1 · shares: Represents a restricted stock unit ("RSU") award. Thirty-three and one third percent (33 1/3%) of the RSUs shall vest on each of March 1, 2025, March 1, 2026 and March 1, 2027, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-23-058272 · doc4.xml · derivative · entry 4

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,691

Underlying: Common Shares · 23,556 shares

Expires 2029-12-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option vested on December 16, 2020, and one thirty-ninth (1/39th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-23-058272 · doc4.xml · derivative · entry 3

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,229

Underlying: Common Shares · 20,190 shares

Expires 2029-05-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested and exercisable.

SEC source: 0001209191-23-058272 · doc4.xml · nonDerivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,709

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-058272 · doc4.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,153

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-23-015450 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,520

Underlying: Common Stock · 17,520 shares

Expires 2033-06-09

F1 · derivative.exercise_date: This option shall vest in full upon the earlier of (i) June 9, 2024 or (ii) the date of the next annual meeting, all vesting shall cease if the director resigns from the Board or otherwise ceases to service as a director.

SEC source: 0001209191-23-006063 · doc4.xml · derivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,250

Underlying: Common Shares · 119,250 shares

Expires 2033-01-29

F2 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest on January 30, 2024, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-23-006063 · doc4.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,963

F1 · shares: Represents a restricted stock unit ("RSU") award. Thirty-three and one third percent (33 1/3%) of the RSUs shall vest on each of January 30, 2024, January 30, 2025 and January 30, 2026, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-22-062253 · doc4.xml · derivative · entry 4

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,247

Underlying: Common Shares · 51 shares

Expires 2029-12-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option vested on December 16, 2020, and one thirty-ninth (1/39th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-22-062253 · doc4.xml · derivative · entry 3

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,419

Underlying: Common Shares · 48,456 shares

Expires 2029-05-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option vested on May 1, 2020, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-22-062253 · doc4.xml · nonDerivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,513

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-062253 · doc4.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,462

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-036475 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 10, 2023 or the date of the Issuer's 2023 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0000899243-22-022232 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,419

Underlying: Common Stock · 13,419 shares

Expires 2032-06-09

F1 · derivative.exercise_date: This option shall vest in full upon the earlier of (i) June 9, 2023 or (ii) the date of the next annual meeting, all vesting shall cease if the director resigns from the Board or otherwise ceases to service as a director.

SEC source: 0001209191-22-004047 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Shares · 115,000 shares

Expires 2032-01-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest on January 18, 2023, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0000899243-21-049696 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,419

Underlying: Common Stock · 13,419 shares

Expires 2031-12-21

F1 · derivative.exercise_date: This option shall vest (1) 25% on December 21, 2022, and the remaining shall vest in equal monthly installments over the next 36 months.

SEC source: 0001209191-21-069076 · doc4.xml · derivative · entry 4

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,298

Underlying: Common Shares · 51 shares

Expires 2029-12-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option vested on December 16, 2020, and one thirty-ninth (1/39th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-21-069076 · doc4.xml · derivative · entry 3

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,875

Underlying: Common Shares · 48,460 shares

Expires 2029-05-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option vested on May 1, 2020, and one thirty-sixth (1/36th) of the remaining shares subject to the option vested or shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-21-069076 · doc4.xml · nonDerivative · entry 2

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,006

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-069076 · doc4.xml · nonDerivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,955

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-21-016001 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,838

Underlying: Common Stock · 26,838 shares

Expires 2031-04-15

F1 · derivative.exercise_date: This option shall vest and become exercisable in 36 equal monthly installments beginning on April 15, 2021.

SEC source: 0000899243-21-017841 · doc4a.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,838

Underlying: Common Stock · 26,838 shares

Expires 2031-04-15

F1 · derivative.exercise_date: This option will vest in equal installments on the first, second, and third anniversaries of the grant date.

SEC source: 0001209191-21-020742 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2031-03-11

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over the 36 months following March 12, 2021.

SEC source: 0001209191-21-009489 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2031-02-08

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest on February 5, 2022, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-20-037780 · doc4.xml · derivative · entry 1

Koehler Maria · CIK 0001815378 · EVP, Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,240

Underlying: Common Stock · 41,240 shares

Expires 2030-06-18

F1 · derivative.exercise_date: Twenty-five percent (25%) of the shares subject to the option shall vest on June 18, 2021, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to Reporting Person continuing to provide service through each such date.