Last 12 months
Inside the activity.
0 purchase rows · 5 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 3 |
| Dec 2025 | 0 | 0 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 0 |
| Mar 2026 | 0 | 0 |
| Apr 2026 | 0 | 0 |
| May 2026 | 0 | 0 |
| Jun 2026 | 0 | 2 |
| Jul 2026 | 0 | 0 |
| Aug 2026 | 0 | 0 |
| Sep 2026 | 0 | 0 |
| Oct 2026 | 0 | 0 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| October 01, 2026 Filed Oct 5, 2026 20:24 UTC |
Casale DonnDirector · President and CEO
|
GrantStock Option (right to buy) · Derivative | 1,036,923 | $0.00 Strike: $4.12 | $0.00 |
DisclosureSEC source: 0002135296-26-000009 · form4-10052026_081042.xml · derivative · entry 1 Casale Donn · CIK 0002135296 · Director · President and CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,036,923 Underlying: Common Stock · 1,036,923 shares Expires 2036-09-30 F1 · derivative.exercise_date: 25% of the shares subject to the option vest on July 7, 2027, and the remaining shares will vest monthly thereafter over three years. Read SEC document |
| September 01, 2026 Filed Sep 2, 2026 21:27 UTC |
Smith Margaret EkinsChief Commercial Officer
|
GrantStock Option (right to buy) · Derivative | 1,001,738 | $0.00 Strike: $5.77 | $0.00 |
DisclosureSEC source: 0002149973-26-000004 · form4-09022026_090920.xml · derivative · entry 1 Smith Margaret Ekins · CIK 0002149973 · Chief Commercial Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,001,738 Underlying: Common Stock · 1,001,738 shares Expires 2036-08-31 F1 · derivative.exercise_date: 25% of the shares subject to the option vest on August 17, 2027, and the remaining shares will vest monthly thereafter over three years. Read SEC document |
| July 01, 2026 Filed Jul 2, 2026 20:30 UTC |
Casale DonnPresident
|
GrantStock Option (right to buy) · Derivative | 898,456 | $0.00 Strike: $7.96 | $0.00 |
DisclosureSEC source: 0002135296-26-000007 · form4-07022026_040714.xml · derivative · entry 1 Casale Donn · CIK 0002135296 · President 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 898,456 Underlying: Common Stock · 898,456 shares Expires 2036-06-30 F1 · derivative.exercise_date: 25% of the shares subject to the option vest on June 1, 2027, and the remaining shares will vest monthly thereafter over three years. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:52 UTC |
RA CAPITAL MANAGEMENT, L.P.Director · 10% owner
RA Capital Healthcare Fund LPDirector · 10% owner
RA Capital Nexus Fund II, L.P.Director
Kolchinsky PeterDirector · 10% owner
Shah Rajeev M.Director · 10% owner
|
GrantStock Option (Right to Buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001231919-26-000704 · form4-06262026_080605.xml · derivative · entry 1 RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director Kolchinsky Peter · CIK 0001384859 · Director · 10% owner Shah Rajeev M. · CIK 0001619841 · Director · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · See Footnotes Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein. F3 · ownership.nature: Under Dr. Kolchinsky 's arrangement with the Adviser, Dr. Kolchinsky holds the option for the benefit of the Fund and the Nexus Fund II. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:19 UTC |
Dadoo RajeevDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001193125-26-285521 · ownership.xml · derivative · entry 1 Dadoo Rajeev · CIK 0001951685 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
Shah PratikDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001580787-26-000004 · form4-06262026_040614.xml · derivative · entry 1 Shah Pratik · CIK 0001580787 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
Kelly MichaelDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001952533-26-000002 · form4-06262026_040612.xml · derivative · entry 1 Kelly Michael · CIK 0001952533 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
Islam SaqibDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001575408-26-000002 · form4-06262026_040610.xml · derivative · entry 1 Islam Saqib · CIK 0001575408 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
Thompson Peter A.Director
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001357522-26-000005 · form4-06262026_040608.xml · derivative · entry 1 Thompson Peter A. · CIK 0001357522 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. F2 · ownership.direct: Pursuant to an agreement with OrbiMed Advisors LLC and OrbiMed Capital GP VI LLC, the Reporting Person is obligated to transfer any securities issued under any such stock options or other awards, or the economic benefit thereof, to OrbiMed Advisors LLC and OrbiMed Capital GP VI LLC, which will in turn ensure that such securities or economic benefits are provided to OrbiMed Private Investments VI, LP. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
SAUNDERS BRENT LDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001268854-26-000002 · form4-06262026_040607.xml · derivative · entry 1 SAUNDERS BRENT L · CIK 0001268854 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
SCHNEIDER PHILLIP MDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001230051-26-000002 · form4-06262026_040604.xml · derivative · entry 1 SCHNEIDER PHILLIP M · CIK 0001230051 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 24, 2026 Filed Jun 26, 2026 20:15 UTC |
Shawver LauraDirector
|
GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $10.54 | $0.00 |
DisclosureSEC source: 0001551891-26-000002 · form4-06262026_040601.xml · derivative · entry 1 Shawver Laura · CIK 0001551891 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2036-06-23 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 24, 2027 or the date of the Issuer's 2027 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 12, 2026 Filed Jun 13, 2026 00:06 UTC |
Karas EricChief Commercial Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 25,000 | $0.00 Strike: $1.50 | $0.00 |
DisclosureSEC source: 0001951287-26-000004 · form4-06132026_120610.xml · derivative · entry 3 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 519,588 Underlying: Common Stock · 25,000 shares Expires 2032-05-23 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: Immediately exercisable. Read SEC document |
| June 12, 2026 Filed Jun 13, 2026 00:06 UTC |
Karas EricChief Commercial Officer
|
SaleCommon Stock | 25,000 | $10.00 | $250,000.00 |
DisclosureSEC source: 0001951287-26-000004 · form4-06132026_120610.xml · nonDerivative · entry 2 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 12,176 F2 · kind: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2025. Read SEC document |
| June 12, 2026 Filed Jun 13, 2026 00:06 UTC |
Karas EricChief Commercial Officer
|
Exercise / conversionCommon Stock | 25,000 | $1.50 | $37,500.00 |
DisclosureSEC source: 0001951287-26-000004 · form4-06132026_120610.xml · nonDerivative · entry 1 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 37,176 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 1,861 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on December 31, 2025. Read SEC document |
| June 12, 2026 Filed Jun 13, 2026 00:04 UTC |
Fitzpatrick Alexander AChief Legal Officer
|
SaleCommon Stock | 3,355 | $10.00 | $33,550.00 |
DisclosureSEC source: 0001398595-26-000004 · form4-06132026_120640.xml · nonDerivative · entry 1 Fitzpatrick Alexander A · CIK 0001398595 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 90,910 F1 · kind: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 5, 2025. F2 · balance_after: Includes 2,907 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan (the "ESPP") on June 30, 2025 and 1,745 shares acquired under the ESPP on December 31, 2025. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:26 UTC |
Karas EricChief Commercial Officer
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001951287-26-000002 · form4-01052026_090126.xml · derivative · entry 1 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:27 UTC |
Scott Kathleen D.Chief Financial Officer
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001794284-26-000002 · form4-01052026_090134.xml · derivative · entry 1 Scott Kathleen D. · CIK 0001794284 · Chief Financial Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:25 UTC |
Fitzpatrick Alexander AChief Legal Officer
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001398595-26-000002 · form4-01052026_090101.xml · derivative · entry 1 Fitzpatrick Alexander A · CIK 0001398595 · Chief Legal Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:23 UTC |
Dorsey BrianChief Operating Officer
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001380762-26-000002 · form4-01052026_090119.xml · derivative · entry 1 Dorsey Brian · CIK 0001380762 · Chief Operating Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:22 UTC |
Chakma JustinChief Business Officer
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001951238-26-000003 · form4-01052026_090113.xml · derivative · entry 1 Chakma Justin · CIK 0001951238 · Chief Business Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:19 UTC |
Lowenthal Richard EDirector · PRESIDENT AND CEO · 10% owner
|
GrantStock Option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001378550-26-000003 · form4-01052026_090159.xml · derivative · entry 2 Lowenthal Richard E · CIK 0001378550 · Director · PRESIDENT AND CEO · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Spouse Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:19 UTC |
Lowenthal Richard EDirector · PRESIDENT AND CEO · 10% owner
|
GrantStock option (right to buy) · Derivative | 875,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001378550-26-000003 · form4-01052026_090159.xml · derivative · entry 1 Lowenthal Richard E · CIK 0001378550 · Director · PRESIDENT AND CEO · 10% owner 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 875,000 Underlying: Common Stock · 875,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:20 UTC |
Tanimoto SarinaCHIEF MEDICAL OFFICER · 10% owner
|
GrantStock Option (right to buy) · Derivative | 875,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001951291-26-000002 · form4-01052026_090152.xml · derivative · entry 2 Tanimoto Sarina · CIK 0001951291 · CHIEF MEDICAL OFFICER · 10% owner 10b5-1 filing: No plan indicated Ownership: Indirect · By Spouse Disclosed balance after: 875,000 Underlying: Common Stock · 875,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| January 02, 2026 Filed Jan 5, 2026 21:20 UTC |
Tanimoto SarinaCHIEF MEDICAL OFFICER · 10% owner
|
GrantStock option (right to buy) · Derivative | 240,000 | $0.00 Strike: $11.49 | $0.00 |
DisclosureSEC source: 0001951291-26-000002 · form4-01052026_090152.xml · derivative · entry 1 Tanimoto Sarina · CIK 0001951291 · CHIEF MEDICAL OFFICER · 10% owner 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 240,000 Underlying: Common Stock · 240,000 shares Expires 2036-01-01 F1 · derivative.exercise_date: The shares subject to the option shall vest in a series of 48 equal monthly installments measured from January 1, 2026. Read SEC document |
| November 13, 2025 Filed Nov 14, 2025 23:43 UTC |
Dorsey BrianChief Operating Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 21,828 | $0.00 Strike: $0.64 | $0.00 |
DisclosureSEC source: 0001380762-25-000005 · form4-11142025_111134.xml · derivative · entry 3 Dorsey Brian · CIK 0001380762 · Chief Operating Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Common Stock · 21,828 shares Expires 2028-11-28 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: Immediately exercisable. Read SEC document |
| November 13, 2025 Filed Nov 14, 2025 23:43 UTC |
Dorsey BrianChief Operating Officer
|
SaleCommon Stock | 21,828 | $8.71 | $190,049.85 |
DisclosureSEC source: 0001380762-25-000005 · form4-11142025_111134.xml · nonDerivative · entry 2 Dorsey Brian · CIK 0001380762 · Chief Operating Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 10,789 F2 · price: The weighted average sale price for the transaction report was $8.7067, and the range of prices was between $8.63 and $8.835. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided. Read SEC document |
| November 13, 2025 Filed Nov 14, 2025 23:43 UTC |
Dorsey BrianChief Operating Officer
|
Exercise / conversionCommon Stock | 21,828 | $0.64 | $13,969.92 |
DisclosureSEC source: 0001380762-25-000005 · form4-11142025_111134.xml · nonDerivative · entry 1 Dorsey Brian · CIK 0001380762 · Chief Operating Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 32,617 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 1,628 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan ("ESPP") on December 31, 2024 and 3,137 shares acquired under the ESPP on June 30, 2025. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:42 UTC |
Chakma JustinChief Business Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 30,000 | $0.00 Strike: $0.84 | $0.00 |
DisclosureSEC source: 0001951238-25-000005 · form4-11142025_111150.xml · derivative · entry 4 Chakma Justin · CIK 0001951238 · Chief Business Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 89,047 Underlying: Common Stock · 30,000 shares Expires 2029-07-04 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: Immediately exercisable. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:42 UTC |
Chakma JustinChief Business Officer
|
SaleCommon Stock | 136,380 | $8.86 | $1,208,790.49 |
DisclosureSEC source: 0001951238-25-000005 · form4-11142025_111150.xml · nonDerivative · entry 3 Chakma Justin · CIK 0001951238 · Chief Business Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 F2 · price: The weighted average sale price for the transaction reported was $8.8634, and the range of prices was between $8.62 and $9.04. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each price will be provided. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:42 UTC |
Chakma JustinChief Business Officer
|
SaleCommon Stock | 30,000 | $8.91 | $267,357.00 |
DisclosureSEC source: 0001951238-25-000005 · form4-11142025_111150.xml · nonDerivative · entry 2 Chakma Justin · CIK 0001951238 · Chief Business Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 136,380 F1 · price: The weighted average sale price for the transaction reported was $8.9119, and the range of prices was between $8.87 and $8.97. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each price will be provided. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:42 UTC |
Chakma JustinChief Business Officer
|
Exercise / conversionCommon Stock | 30,000 | $0.84 | $25,200.00 |
DisclosureSEC source: 0001951238-25-000005 · form4-11142025_111150.xml · nonDerivative · entry 1 Chakma Justin · CIK 0001951238 · Chief Business Officer 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 166,380 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:41 UTC |
Shah PratikDirector
|
GiftCommon Stock | 100,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001580787-25-000004 · form4-11142025_111147.xml · nonDerivative · entry 2 Shah Pratik · CIK 0001580787 · Director 10b5-1 filing: No plan indicated Ownership: Indirect · By The Pratik Shah Living Trust dated June 15, 2011 Disclosed balance after: 4,474,554 F3 · kind: The transaction involved the transfer of shares to a charitable fund. F2 · ownership.nature: The Reporting Person is the trustee of The Pratik Shah Living Trust dated June 15, 2011. Read SEC document |
| November 12, 2025 Filed Nov 14, 2025 23:41 UTC |
Shah PratikDirector
|
GiftCommon Stock | 250,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001580787-25-000004 · form4-11142025_111147.xml · nonDerivative · entry 1 Shah Pratik · CIK 0001580787 · Director 10b5-1 filing: No plan indicated Ownership: Indirect · By The Pratik Shah Living Trust dated June 15, 2011 Disclosed balance after: 4,574,554 F1 · kind: The transaction involved the gift of shares to a trust in which the Reporting Person is not the trustee and the Reporting Person has no pecuniary interest over shares held in the trust. F2 · ownership.nature: The Reporting Person is the trustee of The Pratik Shah Living Trust dated June 15, 2011. Read SEC document |
| August 21, 2025 Filed Aug 22, 2025 20:30 UTC |
Scott Kathleen D.Chief Financial Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 12,500 | $0.00 Strike: $1.50 | $0.00 |
DisclosureSEC source: 0001415889-25-022760 · form4-08222025_040801.xml · derivative · entry 4 Scott Kathleen D. · CIK 0001794284 · Chief Financial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 739,830 Underlying: Common Stock · 12,500 shares Expires 2032-02-29 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: Immediately exercisable. Read SEC document |
| August 21, 2025 Filed Aug 22, 2025 20:30 UTC |
Scott Kathleen D.Chief Financial Officer
|
SaleCommon Stock | 12,500 | $15.00 | $187,500.00 |
DisclosureSEC source: 0001415889-25-022760 · form4-08222025_040801.xml · nonDerivative · entry 2 Scott Kathleen D. · CIK 0001794284 · Chief Financial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 10,042 F2 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on May 22, 2025. Read SEC document |
| August 21, 2025 Filed Aug 22, 2025 20:30 UTC |
Scott Kathleen D.Chief Financial Officer
|
Exercise / conversionCommon Stock | 12,500 | $1.50 | $18,750.00 |
DisclosureSEC source: 0001415889-25-022760 · form4-08222025_040801.xml · nonDerivative · entry 1 Scott Kathleen D. · CIK 0001794284 · Chief Financial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 22,542 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 2,618 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on June 30, 2025. Read SEC document |
| August 21, 2025 Filed Aug 22, 2025 20:30 UTC |
Lowenthal Richard EDirector · PRESIDENT AND CEO · 10% owner
|
SaleCommon Stock | 50,000 | $14.49 | $724,345.00 |
DisclosureSEC source: 0001415889-25-022761 · form4-08222025_040804.xml · nonDerivative · entry 1 Lowenthal Richard E · CIK 0001378550 · Director · PRESIDENT AND CEO · 10% owner 10b5-1 filing: Plan reported Ownership: Indirect · By Richard E. Lowenthal Charitable Remainder UniTrust Dated January 7, 2020 Disclosed balance after: 1,196,494 F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on May 15, 2025. F2 · price: The weighted average sale price for the transaction reported was $14.4869 and the range of prices were between $14.31 and $14.61. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided. F3 · ownership.nature: The Reporting Person is trustee of the trust. Read SEC document |
| August 20, 2025 Filed Aug 21, 2025 21:36 UTC |
Tanimoto SarinaCHIEF MEDICAL OFFICER · 10% owner
|
SaleCommon Stock | 37,656 | $14.09 | $530,625.76 |
DisclosureSEC source: 0001415889-25-022638 · form4-08212025_090845.xml · nonDerivative · entry 2 Tanimoto Sarina · CIK 0001951291 · CHIEF MEDICAL OFFICER · 10% owner 10b5-1 filing: Plan reported Ownership: Indirect · By Sarina Tanimoto Charitable Remainder UniTrust Dated January 7, 2020 Disclosed balance after: 1,247,447 F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on May 15, 2025. F4 · price: The weighted average sale price for the transaction reported was $14.0914 and the range of prices were between $14.00 and $14.205. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided. F3 · ownership.nature: The Reporting Person is trustee of the trust. Read SEC document |
| August 19, 2025 Filed Aug 21, 2025 21:36 UTC |
Tanimoto SarinaCHIEF MEDICAL OFFICER · 10% owner
|
SaleCommon Stock | 12,344 | $14.03 | $173,129.54 |
DisclosureSEC source: 0001415889-25-022638 · form4-08212025_090845.xml · nonDerivative · entry 1 Tanimoto Sarina · CIK 0001951291 · CHIEF MEDICAL OFFICER · 10% owner 10b5-1 filing: Plan reported Ownership: Indirect · By Sarina Tanimoto Charitable Remainder UniTrust Dated January 7, 2020 Disclosed balance after: 1,285,103 F1 · shares: The shares were sold pursuant to a Rule 10b5-1 trading plan entered into on May 15, 2025. F2 · price: The weighted average sale price for the transaction reported was $14.0254 and the range of prices were between $14.00 and $14.08. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided. F3 · ownership.nature: The Reporting Person is trustee of the trust. Read SEC document |
| July 01, 2025 Filed Jul 3, 2025 20:21 UTC |
Karas EricChief Commercial Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 15,000 | $0.00 Strike: $1.50 | $0.00 |
DisclosureSEC source: 0001415889-25-019321 · form4-07032025_080720.xml · derivative · entry 3 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 544,588 Underlying: Common Stock · 15,000 shares Expires 2032-05-23 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: Immediately exercisable. Read SEC document |
| July 01, 2025 Filed Jul 3, 2025 20:21 UTC |
Karas EricChief Commercial Officer
|
SaleCommon Stock | 15,000 | $16.99 | $254,860.50 |
DisclosureSEC source: 0001415889-25-019321 · form4-07032025_080720.xml · nonDerivative · entry 2 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 10,315 F2 · kind: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 26, 2024. F3 · price: The weighted average sale price for the transaction reported was $16.9907, and the range of prices were between $16.71 and $17.31. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided. Read SEC document |
| July 01, 2025 Filed Jul 3, 2025 20:21 UTC |
Karas EricChief Commercial Officer
|
Exercise / conversionCommon Stock | 15,000 | $1.50 | $22,500.00 |
DisclosureSEC source: 0001415889-25-019321 · form4-07032025_080720.xml · nonDerivative · entry 1 Karas Eric · CIK 0001951287 · Chief Commercial Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 25,315 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 2,619 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on June 30, 2025. Read SEC document |
| June 27, 2025 Filed Jul 1, 2025 20:42 UTC |
Flynn James E10% owner
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner
Deerfield Mgmt III, L.P.10% owner
Deerfield Mgmt IV, L.P.10% owner
|
SaleClass A Common Stock | 370,074 | $18.46 | $6,831,566.04 |
DisclosureSEC source: 0001193805-25-000959 · e664668_4-arsp.xml · nonDerivative · entry 2 Flynn James E · CIK 0001352546 · 10% owner DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner Deerfield Mgmt III, L.P. · CIK 0001610540 · 10% owner Deerfield Private Design Fund III, L.P. · CIK 0001603333 · 10% owner Deerfield Mgmt IV, L.P. · CIK 0001713467 · 10% owner Deerfield Private Design Fund IV, L.P. · CIK 0001680307 · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · Through Deerfield Private Design Fund IV, L.P. Disclosed balance after: 4,887,254 F1 · price: The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.20 to $18.89, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 1. F2 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. ("Fund III"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (collectively with Fund III, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P. and Deerfield Management Company, L.P. F3 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise. Read SEC document |
| June 27, 2025 Filed Jul 1, 2025 20:42 UTC |
Flynn James E10% owner
DEERFIELD MANAGEMENT COMPANY, L.P.10% owner
Deerfield Mgmt III, L.P.10% owner
Deerfield Mgmt IV, L.P.10% owner
|
SaleClass A Common Stock | 370,075 | $18.46 | $6,831,584.50 |
DisclosureSEC source: 0001193805-25-000959 · e664668_4-arsp.xml · nonDerivative · entry 1 Flynn James E · CIK 0001352546 · 10% owner DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) · CIK 0001009258 · 10% owner Deerfield Mgmt III, L.P. · CIK 0001610540 · 10% owner Deerfield Private Design Fund III, L.P. · CIK 0001603333 · 10% owner Deerfield Mgmt IV, L.P. · CIK 0001713467 · 10% owner Deerfield Private Design Fund IV, L.P. · CIK 0001680307 · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · Through Deerfield Private Design Fund III, L.P. Disclosed balance after: 4,887,254 F1 · price: The price reported in Column 4 represents a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.20 to $18.89, inclusive. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 1. F2 · ownership.nature: This Form 4 is being filed by the undersigned as well as the entities listed on the Joint Filer Information Statement attached as an exhibit hereto (the "Reporting Persons"). Deerfield Mgmt III, L.P. is the general partner of Deerfield Private Design Fund III, L.P. ("Fund III"). Deerfield Mgmt IV, L.P. is the general partner of Deerfield Private Design Fund IV, L.P. (collectively with Fund III, the "Funds"). Deerfield Management Company, L.P. is the investment manager of the Funds. James E. Flynn is the sole member of the general partner of each of Deerfield Mgmt III, L.P., Deerfield Mgmt IV, L.P. and Deerfield Management Company, L.P. F3 · ownership.nature: In accordance with Instruction 4 (b)(iv) to Form 4, the entire amount of the Issuer's securities held by the Funds is reported herein. For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, each Reporting Person disclaims beneficial ownership of any such securities, except to the extent of his/its indirect pecuniary interest therein, if any, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of such securities for purposes of Section 16 or otherwise. Read SEC document |
| June 25, 2025 Filed Jun 27, 2025 21:21 UTC |
RA CAPITAL MANAGEMENT, L.P.Director · 10% owner
RA Capital Healthcare Fund LPDirector · 10% owner
RA Capital Nexus Fund II, L.P.Director
Kolchinsky PeterDirector · 10% owner
Shah Rajeev M.Director · 10% owner
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GrantStock Option (Right to Buy) · Derivative | 30,000 | $0.00 Strike: $17.26 | $0.00 |
DisclosureSEC source: 0001415889-25-018406 · form4-06272025_090643.xml · derivative · entry 1 RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director Kolchinsky Peter · CIK 0001384859 · Director · 10% owner Shah Rajeev M. · CIK 0001619841 · Director · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · See Footnotes Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2035-06-24 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 25, 2026 or the date of the Issuer's 2026 annual meeting of stockholders, which date has not been set by the Issuer's board of directors, subject to Dr. Peter Kolchinsky's continuous service to the Issuer through the applicable vesting date. F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund II, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein. F3 · ownership.nature: Dr. Kolchinsky is a Managing Partner of the Adviser who serves on the Issuer's board of directors. Under Dr. Kolchinsky 's arrangement with the Adviser, Dr. Kolchinsky holds the option for the benefit of the Fund and the Nexus Fund II. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock. Read SEC document |
| June 25, 2025 Filed Jun 27, 2025 20:43 UTC |
Dadoo RajeevDirector
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GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $17.26 | $0.00 |
DisclosureSEC source: 0000950170-25-090944 · ownership.xml · derivative · entry 1 Dadoo Rajeev · CIK 0001951685 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2035-06-24 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 25, 2026 or the date of the Issuer's 2026 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 25, 2025 Filed Jun 27, 2025 20:30 UTC |
Shah PratikDirector
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GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $17.26 | $0.00 |
DisclosureSEC source: 0001415889-25-018386 · form4-06272025_040610.xml · derivative · entry 1 Shah Pratik · CIK 0001580787 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2035-06-24 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 25, 2026 or the date of the Issuer's 2026 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 25, 2025 Filed Jun 27, 2025 20:30 UTC |
Kelly MichaelDirector
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GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $17.26 | $0.00 |
DisclosureSEC source: 0001415889-25-018388 · form4-06272025_040614.xml · derivative · entry 1 Kelly Michael · CIK 0001952533 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2035-06-24 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 25, 2026 or the date of the Issuer's 2026 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
| June 25, 2025 Filed Jun 27, 2025 20:30 UTC |
Islam SaqibDirector
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GrantStock Option (right to buy) · Derivative | 30,000 | $0.00 Strike: $17.26 | $0.00 |
DisclosureSEC source: 0001415889-25-018385 · form4-06272025_040608.xml · derivative · entry 1 Islam Saqib · CIK 0001575408 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 30,000 Underlying: Common Stock · 30,000 shares Expires 2035-06-24 F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 25, 2026 or the date of the Issuer's 2026 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.