Shenouda Maged

SEC source: 0001213900-26-098970 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,000,000

SEC source: 0001213900-26-098970 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 920,200

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F2 · price: Purchase prices range from $4.16 to $4.20 per share, inclusive.

SEC source: 0001213900-25-121973 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 800,000

SEC source: 0001213900-25-121973 · ownership.xml · derivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 828,000

Underlying: Common Stock · 828,000 shares

Expires 2035-12-12

F1 · derivative.exercise_date: The stock appreciation rights vest in 16 equal quarterly installments commencing on March 12, 2026.

SEC source: 0001213900-25-106836 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 788,335

SEC source: 0001213900-25-059869 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2035-06-26

F1 · derivative.exercise_date: The options vest in 16 equal quarterly installments commencing on September 26, 2025.

SEC source: 0001213900-25-046087 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 288,335

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F4 · price: Purchase prices range from $0.4998 to $0.5396 per share, inclusive.

SEC source: 0001213900-25-046087 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,335

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F3 · price: Purchase prices range from $0.4493 to $0.4998 per share, inclusive.

SEC source: 0001213900-25-046087 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,335

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F2 · price: Purchase prices range from $0.4229 to $0.4674 per share, inclusive.

SEC source: 0001213900-24-077792 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,335

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F4 · price: Purchase prices range from $2.79 to $3.05 per share, inclusive.

SEC source: 0001213900-24-077792 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 64,215

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F3 · price: Purchase prices range from $2.70 to $2.75 per share, inclusive.

SEC source: 0001213900-24-077792 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,097

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F2 · price: Purchase prices range from $2.49 to $2.60 per share, inclusive.

SEC source: 0001213900-24-047638 · ownership.xml · derivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,090

Underlying: Common Stock · 54,624 shares

Expires 2033-12-15

F2 · kind: On May 24, 2024, the Reporting Person voluntarily forfeited to the Issuer a portion of the December Award equal to the Additional Award Shares so that those shares can be allocated to the holders of Similar Awards who are not executive officers or directors of the Issuer.

SEC source: 0001213900-24-047638 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,714

Underlying: Common Stock · 54,624 shares

Expires 2033-12-15

F1 · kind: On May 24, 2024, under the terms of the option award granted to the Reporting Person on December 15, 2023 (the "December Award"), the Reporting Person became entitled to receive options for up to 54,624 additional shares of the Issuer's Common Stock on the same terms as the December Award (the "Additional Award Shares") out of shares that had become available under the terms of the Issuer's 2021 Equity Incentive Plan, as amended (the "Plan"), since December 15, 2023, as a result of expirations, cancelations, forfeitures and terminations of other outstanding awards under the Plan and/or tenders or withholding of shares.

SEC source: 0001213900-24-008559 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,903

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F4 · price: Purchase prices range from $3.95 to $4.18 per share, inclusive.

SEC source: 0001213900-24-008559 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,028

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F3 · price: Purchase prices range from $3.82 to $3.90 per share, inclusive.

SEC source: 0001213900-24-008559 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,028

F1 · shares: The number of securities reported represents an aggregate number of shares purchased in multiple open market transactions over a range of purchase prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares purchased by the Reporting Person at each separate price within the range.

F2 · price: Purchase prices range from $3.57 to $3.745 per share, inclusive.

SEC source: 0001213900-23-097031 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,090

Underlying: Common Stock · 82,090 shares

Expires 2033-12-15

F1 · derivative.exercise_date: The options vest in 16 equal quarterly installments commencing on March 15, 2024.

SEC source: 0001213900-23-044089 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 512,560

Underlying: Common Stock · 317,643 shares

Expires 2032-12-16

F1 · date: The option grant was approved by the Board of Directors of the Company on December 16, 2022, subject to shareholder approval of an amendment to the Company's 2021 Equity Incentive Plan, as amended (the "Plan"), increasing the number of shares of Common Stock available for the grant of awards under the Plan in an amount sufficient to cover this option grant. Shareholder approval was received for such amendment on May 25, 2023, at the 2023 Annual Meeting of the Company's shareholders.

F2 · derivative.exercise_date: 62,560 of the options immediately vested; 450,000 options vest in 16 equal quarterly installments commencing on March 16, 2023.

F2 · balance_after: 62,560 of the options immediately vested; 450,000 options vest in 16 equal quarterly installments commencing on March 16, 2023.

SEC source: 0001213900-22-081519 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 200,000 shares

Expires 2031-12-17

F1 · kind: Represents the termination of milestone-based stock options granted to the reporting person on May 25, 2022, that were eligible to vest based on achievement of certain corporate objectives by the Issuer. Upon grant, the target vesting amount was reported in Table II of Form 4. On December 16, 2022, the Board of Directors determined that such milestone objectives were not achieved by the Issuer and that all 200,000 options would be terminated.

F1 · shares: Represents the termination of milestone-based stock options granted to the reporting person on May 25, 2022, that were eligible to vest based on achievement of certain corporate objectives by the Issuer. Upon grant, the target vesting amount was reported in Table II of Form 4. On December 16, 2022, the Board of Directors determined that such milestone objectives were not achieved by the Issuer and that all 200,000 options would be terminated.

F2 · price: Not applicable.

F2 · derivative.exercise_date: Not applicable.

F3 · derivative.expiration_date: Original expiration date.

SEC source: 0001213900-22-081479 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 194,917

Underlying: Common Stock · 194,917 shares

Expires 2032-12-16

F1 · derivative.exercise_date: 62,560 of the shares are immediately vested; 132,357 shares vest in 16 equal quarterly installments commencing on March 16, 2023.

SEC source: 0001213900-22-029837 · ownership.xml · derivative · entry 2

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2031-12-17

F1 · date: The option grant was approved by the Board of Directors of the Company on December 17, 2021, subject to shareholder approval of an amendment to the Company's 2021 Equity Incentive Plan (the "Plan") increasing the number of shares of Common Stock available for the grant of awards under the Plan in an amount sufficient to cover this option grant. Shareholder approval was received for such amendment on May 25, 2022, at the 2022 Annual Meeting of the Company's shareholders.

F3 · derivative.exercise_date: 50% of the option shall vest when the Board of Directors or Compensation Committee has determined that 301, 302 and 303 Trials of dextromethadone (REL-1017) in major depressive disorder ("MDD") complete enrollment, as defined in the respective Trial's protocol, with 364 patients per Trial with the last patient in for each trial to be enrolled by December 31, 2022. The remaining 50% of the option shall vest when the Board of Directors or Compensation Committee has determined that 301, 302 and 303 Trials of REL-1017 in MDD report top-line data by December 31, 2023, and meet or exceed their primary and key secondary endpoints as defined in in the respective Trial's protocol.

SEC source: 0001213900-22-029837 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 522,729

Underlying: Common Stock · 295,211 shares

Expires 2031-12-17

F1 · date: The option grant was approved by the Board of Directors of the Company on December 17, 2021, subject to shareholder approval of an amendment to the Company's 2021 Equity Incentive Plan (the "Plan") increasing the number of shares of Common Stock available for the grant of awards under the Plan in an amount sufficient to cover this option grant. Shareholder approval was received for such amendment on May 25, 2022, at the 2022 Annual Meeting of the Company's shareholders.

F2 · derivative.exercise_date: The option vests in 16 equal quarterly installments, at 6.25% per quarter, commencing on March 17, 2022.

SEC source: 0001213900-21-066822 · ownership.xml · derivative · entry 1

Shenouda Maged · CIK 0001658369 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 227,518

Underlying: Common Stock · 227,518 shares

Expires 2031-12-17

F1 · derivative.exercise_date: The option vests in 16 equal quarterly installments commencing on March 17, 2022.

SEC source: 0001213900-21-014656 · ownership.xml · nonDerivative · entry 5

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F5 · price: Sales prices range from $35.00 to $35.37 per share, inclusive.

SEC source: 0001213900-21-014656 · ownership.xml · nonDerivative · entry 4

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,601

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F4 · price: Sales prices range from $36.02 to $36.51 per share, inclusive.

SEC source: 0001213900-21-014656 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,401

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $35.02 to $35.95 per share, inclusive.

SEC source: 0001213900-21-014656 · ownership.xml · derivative · entry 6

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,350

Underlying: Common Stock · 10,000 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · price: Not applicable

F6 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-014656 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,128

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

SEC source: 0001213900-21-014656 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,228

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-21-012169 · ownership.xml · derivative · entry 4

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,250

Underlying: Common Stock · 3,000 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · price: Not applicable

F5 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-012169 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F4 · price: Sales prices range from $34.47 to $35.03 per share, inclusive.

SEC source: 0001213900-21-012169 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,628

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $33.35 to $34.30 per share, inclusive.

SEC source: 0001213900-21-012169 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,228

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-21-009696 · ownership.xml · derivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,250

Underlying: Common Stock · 1,428 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Not applicable

F4 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-009696 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $35.12 to $35.96 per share, inclusive.

SEC source: 0001213900-21-009696 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-21-008202 · ownership.xml · nonDerivative · entry 4

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F5 · price: Sales prices range from $35.00 to $35.64 per share, inclusive

SEC source: 0001213900-21-008202 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,638

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F4 · price: Sales prices range from $35.00 to $35.82 per share, inclusive

SEC source: 0001213900-21-008202 · ownership.xml · derivative · entry 5

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,678

Underlying: Common Stock · 11,372 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · price: Not applicable

F6 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-008202 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,997

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $35.00 to $35.29 per share, inclusive.

SEC source: 0001213900-21-008202 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,600

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-21-006832 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

SEC source: 0001213900-21-006832 · ownership.xml · derivative · entry 4

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,050

Underlying: Common Stock · 3,200 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · price: Not applicable

F4 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-006832 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,328

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $35.00 to $35.21 per share, inclusive.

SEC source: 0001213900-21-006832 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,428

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001213900-21-005451 · ownership.xml · derivative · entry 4

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,250

Underlying: Common Stock · 3,000 shares

Expires 2027-10-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · price: Not applicable

F5 · derivative.exercise_date: The options vest from the date of grant in equal quarterly increments of 6.25% over a four year period.

SEC source: 0001213900-21-005451 · ownership.xml · nonDerivative · entry 3

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,228

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F4 · price: Sales prices range from $32.66 to $33.43 per share, inclusive.

SEC source: 0001213900-21-005451 · ownership.xml · nonDerivative · entry 2

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,428

F1 · kind: The sales reported on this Form 4 were effectuated pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 22, 2020.

F2 · shares: The number of securities reported represents an aggregate number of shares sold in multiple open market transactions over a range of sales prices. The price reported represents the weighted average price. The Reporting Person undertakes to provide to the staff of the SEC, the Issuer, or a stockholder of the Issuer, upon request, the number of shares sold by the Reporting Person at each separate price within the range.

F3 · price: Sales prices range from $31.59 to $32.50 per share, inclusive.

SEC source: 0001213900-21-005451 · ownership.xml · nonDerivative · entry 1

Shenouda Maged · CIK 0001658369 · CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,228

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.