DENYES NANCY

SEC source: 0001193125-26-037996 · ownership.xml · nonDerivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,124

F3 · kind: Sale made by the Reporting Person to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on February 3, 2022.

SEC source: 0001193125-26-037996 · ownership.xml · derivative · entry 3

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,687 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

F4 · derivative.expiration_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

SEC source: 0001193125-26-037996 · ownership.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,242

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on February 3, 2022.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001193125-26-009152 · ownership.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 412,500

Underlying: Common Stock · 412,500 shares

Expires 2036-01-09

F2 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 36 equal monthly installments beginning February 9, 2026, such that this option will be fully exercisable on January 9, 2029. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0000950170-25-013878 · ownership.xml · nonDerivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,555

F4 · kind: Sale made by the Reporting Person to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on February 3, 2022.

SEC source: 0000950170-25-013878 · ownership.xml · derivative · entry 3

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,687

Underlying: Common Stock · 2,687 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F5 · derivative.exercise_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

F5 · derivative.expiration_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

SEC source: 0000950170-25-013878 · ownership.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,454

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on February 3, 2022.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · balance_after: Includes 2,500 shares acquired on November 15, 2024 under the Company's 2015 Employee Purchase Plan.

SEC source: 0000950170-25-004131 · ownership.xml · derivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,000

Underlying: Common Stock · 275,000 shares

Expires 2035-01-08

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning February 8, 2025, such that this option will be fully exercisable on January 8, 2029. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0000950170-24-069680 · ownership.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,267

F1 · price: Represents weighted average price for the shares. The shares were purchased at prices ranging from $1.835 to $1.87 per share. The reporting person will provide to the Securities and Exchange Commission staff, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares purchased at each separate price.

F2 · balance_after: Includes 2,500 shares acquired on May 15, 2024 under the Company's 2015 Employee Purchase Plan.

SEC source: 0001209191-24-002945 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,374

Underlying: Common Stock · 2,688 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

F3 · derivative.expiration_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

SEC source: 0001209191-24-002945 · doc4.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,767

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on February 3, 2022.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001209191-24-001297 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2034-01-05

F2 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning February 5, 2024, such that this option will be fully exercisable on January 5, 2028. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-23-011248 · doc4.xml · derivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 84,023

Underlying: Common Stock · 84,023 shares

Expires 2033-02-16

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 16, 2023, such that this option will be fully exercisable on February 16, 2027. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-23-007367 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,062

Underlying: Common Stock · 2,688 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

F4 · derivative.expiration_date: The RSUs vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. The RSUs are subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

SEC source: 0001209191-23-007367 · doc4.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,079

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on February 3, 2022.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

F3 · balance_after: Includes 944 shares acquired under that Company's 2015 Employee Stock Purchase Plan on November 15, 2022.

SEC source: 0001209191-22-032216 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,097

Underlying: Common Stock · 88,097 shares

Expires 2032-05-24

F2 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 24, 2022, such that this option will be fully exercisable on May 24, 2026. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-22-007494 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,750

Underlying: Common Stock · 10,750 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit (RSU) represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The RSUs are scheduled to vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. This grant is subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

F3 · derivative.expiration_date: The RSUs are scheduled to vest in four equal annual installments beginning on February 3, 2023, such that the RSUs will fully vest on February 3, 2026. This grant is subject to accelerated vesting upon termination without cause upon a change of control of the Issuer.

SEC source: 0001209191-22-007494 · doc4.xml · derivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2032-02-03

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 3, 2022, such that this option will be fully exercisable on February 3, 2026. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-21-035837 · doc4.xml · derivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,000

Underlying: Common Stock · 59,000 shares

Expires 2025-05-21

F2 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 21, 2021, such that this option will be fully exercisable on May 21, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-21-008631 · doc4.xml · derivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2031-02-04

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 4, 2021, such that this option will be fully exercisable on February 4, 2025. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-20-032794 · doc4.xml · derivative · entry 3

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-05-26

F4 · derivative.exercise_date: 50% of the shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning June 26, 2020, such that these shares will be fully exercisable on May 26, 2024; 25% of the shares subject to this option will vest on May 26, 2021 if and only if a clinical development milestone is achieved by September 30, 2020; and the remaining 25% of the shares will vest on May 26, 2021 if and only if an additional clinical development milestone is achieved by September 30, 2020.

SEC source: 0001209191-20-032794 · doc4.xml · nonDerivative · entry 2

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,735

F3 · kind: Sale made by the Reporting Person in compliance with the provisions of Rule 10b5-1 to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on May 16, 2018.

F3 · shares: Sale made by the Reporting Person in compliance with the provisions of Rule 10b5-1 to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on May 16, 2018.

SEC source: 0001209191-20-032794 · doc4.xml · derivative · entry 4

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 892 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units (RSU) convert into common stock on a one-for-one basis.

F5 · derivative.exercise_date: The RSU grant vests as to one-half (1/2) of the total number of units on each one year anniversary of the grant commencing on May 16, 2019.

F5 · derivative.expiration_date: The RSU grant vests as to one-half (1/2) of the total number of units on each one year anniversary of the grant commencing on May 16, 2019.

SEC source: 0001209191-20-032794 · doc4.xml · nonDerivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,057

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units (RSU) convert into common stock on a one-for-one basis.

F2 · balance_after: Includes 178 shares acquired under the Company's 2015 Employee Stock Purchase Plan (ESPP) on May 15, 2020.

SEC source: 0001209191-20-007716 · doc4.xml · derivative · entry 1

DENYES NANCY · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,778

Underlying: Common Stock · 13,778 shares

Expires 2030-02-05

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 5, 2020, such that this option will be fully exercisable on February 5, 2024. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.

SEC source: 0001209191-19-031424 · doc4.xml · nonDerivative · entry 2

Krueger Nancy · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,348

F3 · kind: Sale made by the Reporting Person in compliance with the provisions of Rule 10b5-1 to satisfy tax withholding obligations in connection with the partial vesting of RSUs granted on May 16, 2018.

SEC source: 0001209191-19-031424 · doc4.xml · derivative · entry 3

Krueger Nancy · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on May 16, 2018.

F4 · derivative.exercise_date: The RSU grant vests as to one-half (1/2) of the total number of units on each one year anniversary of the grant commencing on May 16, 2019.

F4 · derivative.expiration_date: The RSU grant vests as to one-half (1/2) of the total number of units on each one year anniversary of the grant commencing on May 16, 2019.

SEC source: 0001209191-19-031424 · doc4.xml · nonDerivative · entry 1

Krueger Nancy · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,999

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents shares acquired upon the vesting of restricted stock units (RSUs) granted to the Reporting Person on May 16, 2018.

F2 · balance_after: Includes 2,500 shares acquired under the Company's 2015 Employee Stock Purchase Plan (ESPP) on May 15, 2019.

SEC source: 0001209191-19-008781 · doc4.xml · derivative · entry 1

Krueger Nancy · CIK 0001640869 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2029-02-06

F1 · derivative.exercise_date: The shares subject to this option shall vest and become exercisable in 48 equal monthly installments beginning March 6, 2019, such that this option will be fully exercisable on February 6, 2023. This option is subject to accelerated vesting upon termination without cause upon change of control of the issuer.