Heino Mary Anne

SEC source: 0002064832-26-000218 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · Executive Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 321,897

SEC source: 0002064832-26-000110 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · Executive Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 323,124

SEC source: 0002064832-26-000110 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · Executive Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 365,040

F1 · kind: The transaction reported in this Form 4 reflects additional shares of common stock issued by Lantheus Holdings, Inc. to the reporting person upon the vesting of relative Total Shareholder Return performance-based restricted stock units ("PSUs") that were previously granted and included in the Form 4 filed on March 6, 2023. The number of shares reported in the Form 4 reflected 100% of the target number of shares underlying the PSUs. The number of shares that actually vested under the PSUs equaled 162.8% of the target number of shares. Accordingly, the number of shares reported in this Form 4 reflects the difference between the number of shares that actually vested under the PSUs and the target number of shares originally included in the Form 4.

SEC source: 0002064832-25-000020 · form4.xml · derivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director · Executive Chair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,325

Underlying: Common Stock · 26,325 shares

Expires 2035-11-17

F2 · derivative.exercise_date: The option vests in full on November 17, 2026.

SEC source: 0002064832-25-000020 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · Executive Chair

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 332,935

F1 · kind: Consists of 14,285 restricted stock units that will vest in full on November 17, 2026.

SEC source: 0001062993-25-011002 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 318,650

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 3, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $76.64 to $77.59, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0001062993-25-011002 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 341,576

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 3, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.40 to $75.35, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH"), any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0001062993-25-010490 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By The Heino 2024 Family Trust

Disclosed balance after: 179,300

SEC source: 0001062993-25-010490 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By The Mary Anne Fennell Heino Revocable Trust - 2018

Disclosed balance after: 40,434

F1 · balance_after: Balance reflects 50,000 shares transferred from the Reporting Person to The Mary Anne Fennell Heino Revocable Trust - 2018 on May 22, 2025. This transfer is exempt from Section 16 pursuant to Rule 16a-13.

SEC source: 0001062993-25-009690 · form4.xml · derivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,543

Underlying: Common Stock · 4,543 shares

Expires 2035-05-14

SEC source: 0001062993-25-009690 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 394,716

F1 · balance_after: Balance reflects 48,220 shares transferred from the Reporting Person to The Mary Anne Fennell Heino Revocable Trust - 2018 on May 13, 2025. This transfer is exempt from Section 16 pursuant to Rule 16a-13.

SEC source: 0001062993-25-005651 · form4.xml · nonDerivative · entry 4

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Heino Irrevocable Trust

Disclosed balance after: 8,618

SEC source: 0001062993-25-005651 · form4.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Grantor Retained Annuity Trust

Disclosed balance after: 0

SEC source: 0001062993-25-005651 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Grantor Retained Annuity Trust

Disclosed balance after: 8,618

F1 · balance_after: Balance reflects 121,514 shares transferred from a Grantor Retained Annuity Trust ("GRAT") to the The Mary Anne Fennell Heino Revocable Trust - 2018 on March 13, 2025. This transfer is exempt from Section 16 pursuant to Rule 16a-13.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 6

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 440,399

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024, in connection with sell-to-cover transactions to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.79 to $96.09, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (7) to this Form 4.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 445,370

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024, in connection with sell-to-cover transactions to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.79 to $95.77, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 4

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 463,064

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024, in connection with sell-to-cover transactions to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.79 to $94.78, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 478,081

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024, in connection with sell-to-cover transactions to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.79 to $93.755, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 487,241

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024, in connection with sell-to-cover transactions to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $91.76 to $92.725, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0001062993-25-004620 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 493,506

F1 · kind: The transaction reported in this Form 4 reflects additional shares of common stock issued by Lantheus Holdings, Inc. ("LNTH") to the reporting person upon the vesting of relative Total Shareholder Return performance-based restricted stock units ("PSUs") that were previously granted and included in the Form 4 filed on March 7, 2022. The number of shares reported in the Form 4 reflected 100% of the target number of shares underlying the PSUs. The number of shares that actually vested under the PSUs equaled 200% of the target number of shares. Accordingly, the number of shares reported in this Form 4 reflects the difference between the number of shares that actually vested under the PSUs and the target number of shares originally included in the Form 4.

SEC source: 0001062993-24-018931 · form4.xml · nonDerivative · entry 4

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 443,436

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $89.38 to $89.86, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

SEC source: 0001062993-24-018931 · form4.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 444,136

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $88.30 to $89.10, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0001062993-24-018931 · form4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 447,036

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $86.85 to $87.04, inclusive. The reporting person undertakes to provide to LNTH, any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0001062993-24-018931 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 447,436

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.84 to $86.75, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH"), any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0000950170-24-091891 · ownership.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 454,923

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

SEC source: 0000950170-24-091891 · ownership.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 455,019

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.675 to $96.49, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0000950170-24-091891 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 458,680

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.665 to $95.66, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

F3 · balance_after: Balance reflects 41,260 shares transferred from a Grantor Retained Annuity Trust (GRAT) to the Grantor on June 7, 2024. These transfers are exempt from Section 16 pursuant to Rule 16a-13.

SEC source: 0001062993-25-005651 · form4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Grantor Retained Annuity Trust

Disclosed balance after: 37,719

SEC source: 0000950170-24-058804 · ownership.xml · derivative · entry 4

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,853

Underlying: Common Stock · 4,853 shares

Expires 2034-05-09

SEC source: 0000950170-24-058804 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 424,144

F1 · balance_after: Balance reflects 169,866 shares transferred from a Grantor Retained Annuity Trust (GRAT) to the Grantor on March 13, 2024. These transfers are exempt from Section 16 pursuant to Rule 16a-13.

SEC source: 0000950170-24-026682 · ownership.xml · nonDerivative · entry 4

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 251,643

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

SEC source: 0000950170-24-026682 · ownership.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 251,743

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.14 to $66.10, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0000950170-24-026682 · ownership.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 310,994

F2 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.14 to $65.13, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0000950170-24-026682 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 345,506

F1 · kind: The transaction reported in this Form 4 reflects additional shares of common stock issued by Lantheus Holdings, Inc. ("LNTH") to the reporting person upon the vesting of relative Total Shareholder Return PSUs that were previously granted and included in the Form 4 filed on March 8, 2021. The number of shares reported in the Form 4 reflected 100% of the target number of shares underlying the PSUs. The number of shares that actually vested under the PSUs equaled 200% of the target number of shares. Accordingly, the number of shares reported in this Form 4 reflects the difference between the number of shares that actually vested under the PSUs and the target number of shares originally included in the Form 4.

SEC source: 0000950170-23-070777 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 264,337

F1 · balance_after: The reporting person transferred 53,350 shares of Lantheus Holdings, Inc. common stock to the Seamus C. Fennell Foundation, a charitable foundation of which the reporting person is a trustee.

SEC source: 0000950170-23-064209 · ownership.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 317,687

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.85 to $64.40, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0000950170-23-064209 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 323,555

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.85 to $63.815, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0000950170-23-042888 · ownership.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 329,467

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.59 to $69.14, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0000950170-23-042888 · ownership.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 335,989

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 9, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.585 to $68.58, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

F3 · balance_after: On June 5, 2023, the reporting person transferred 78,980 shares of LNTH common stock to a Grantor Retained Annuity Trust of which the reporting person's spouse is a trustee. The reporting person and members of her immediate family are the sole beneficiaries of the trust.

SEC source: 0000899243-23-010004 · doc4a.xml · derivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 44,484 shares

Expires 2023-04-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F6 · derivative.exercise_date: 100% of the shares subject to the option are fully vested and exercisable.

SEC source: 0000899243-23-010004 · doc4a.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 419,397

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.89 to $81.838, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

F3 · ownership.direct: The Form 4 originally filed on March 29, 2023 inadvertently identified shares as Indirect Ownership due to an administrative error.

SEC source: 0000899243-23-010004 · doc4a.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 435,219

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.89 to $80.88, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

F3 · ownership.direct: The Form 4 originally filed on March 29, 2023 inadvertently identified shares as Indirect Ownership due to an administrative error.

SEC source: 0000899243-23-010004 · doc4a.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 463,881

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F2 · balance_after: On March 10, 2023, the reporting person transferred 300,000 shares of LNTH common stock to a Grantor Retained Annuity Trust of which the reporting person's spouse is a trustee. The reporting person and members of her immediate family are the sole beneficiaries of the trust.

F3 · ownership.direct: The Form 4 originally filed on March 29, 2023 inadvertently identified shares as Indirect Ownership due to an administrative error.

SEC source: 0000899243-23-009990 · doc4.xml · derivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 44,484 shares

Expires 2023-04-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F5 · derivative.exercise_date: 100% of the shares subject to the option are fully vested and exercisable.

SEC source: 0000899243-23-009990 · doc4.xml · nonDerivative · entry 3

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Common Stock

Disclosed balance after: 419,397

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.89 to $81.838, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0000899243-23-009990 · doc4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Common Stock

Disclosed balance after: 435,219

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.89 to $80.88, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0000899243-23-009990 · doc4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · Common Stock

Disclosed balance after: 463,881

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 24, 2023.

F2 · balance_after: On March 10, 2023, the reporting person transferred 300,000 shares of LNTH common stock to a Grantor Retained Annuity Trust of which the reporting person's spouse is a trustee. The reporting person and members of her immediate family are the sole beneficiaries of the trust.

SEC source: 0000899243-23-008147 · doc4.xml · nonDerivative · entry 2

Heino Mary Anne · CIK 0001610676 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 719,397

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 11, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $74.82 to $75.69, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0000899243-23-008147 · doc4.xml · nonDerivative · entry 1

Heino Mary Anne · CIK 0001610676 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 724,141

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 11, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $73.75 to $74.69, inclusive. The reporting person undertakes to provide to Lantheus Holdings, Inc. ("LNTH") any security holder of LNTH or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0000899243-23-007259 · doc4.xml · nonDerivative · entry 5

Heino Mary Anne · CIK 0001610676 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 729,461

F3 · kind: The Company requires certain senior executives to cover tax liabilities resulting from the vesting of their equity awards pursuant to sell-to-cover transactions in compliance with Rule 10b5-1. The transaction reported in this Form 4 was effected in compliance with Rule 10b5-1 to satisfy withholding tax liabilities of the Reporting Person associated with the vesting of restricted stock previously granted and reported on a previously filed Form 4.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.69 to $72.6, inclusive. The reporting person undertakes to provide to LNTH any security holder of LNTH or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.