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person · Reporting owner

Lewis William

Disclosed activity across 3 companies

Tapewire entity
28834
SEC CIK
0001402051

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
INSMED IncINSM · Entity 3174Director · Chair and CEOJuly 23, 2026July 24, 2026
NewAmsterdam Pharma Co N.V.NAMS · Entity 1826DirectorJanuary 07, 2026January 10, 2026
uniQure N.V.QURE · Entity 4162DirectorJanuary 27, 2017January 31, 2017

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

INSMED Inc

Report date July 23, 2026 · Filed July 24, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect259,058 Ending reported balance After 2026-07-23 transaction · row 4
4 source rows · reconciled sequence

Row 1 · 2026-07-23 · Exercise / conversion · Acquired 6,260 · Balance 265,318

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Row 2 · 2026-07-23 · Exercise / conversion · Acquired 4,440 · Balance 269,758

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Row 3 · 2026-07-23 · Sale · Disposed 4,828 · Balance 264,930

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2: This is the weighted average sales price representing 4,828 shares sold at prices ranging from $105.09 to $106.02 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Row 4 · 2026-07-23 · Sale · Disposed 5,872 · Balance 259,058

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3: This is the weighted average sales price representing 5,872 shares sold at prices ranging from $106.09 to $106.78 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $30.46 · Expires 2028-01-04Direct0 Reported balance After 2026-07-23 transaction · row 6 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 6 · 2026-07-23 · Exercise / conversion · Disposed 6,260 · Balance 0

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $17.16 · Expires 2027-05-17Direct0 Reported balance After 2026-07-23 transaction · row 7 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 7 · 2026-07-23 · Exercise / conversion · Disposed 4,440 · Balance 0

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

Common StockSEC Table I · non-derivativeIndirectBy trust233,924 Reported balance Holding disclosure · report date 2026-07-23 · row 5 Holding and transaction disclosures are not merged.
1 source row

Row 5 · Balance 233,924

Filing footnotes · ownership attribution and instrument terms

F1: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2: This is the weighted average sales price representing 4,828 shares sold at prices ranging from $105.09 to $106.02 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F3: This is the weighted average sales price representing 5,872 shares sold at prices ranging from $106.09 to $106.78 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F4: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

NewAmsterdam Pharma Co N.V.

Report date January 07, 2026 · Filed January 10, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Ordinary SharesSEC Table I · non-derivativeDirect10,360 Reported balance After 2026-01-07 transaction · row 1
1 source row

Row 1 · 2026-01-07 · Grant · Acquired 3,400 · Balance 10,360

F1: Represents restricted stock units (RSUs), each representing a contingent right to receive one ordinary share. All of the RSUs will vest on the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

F2: Each RSU was granted on January 7, 2026 for no consideration.

Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $35.45 · Expires 2036-01-07Direct15,300 Reported balance After 2026-01-07 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2026-01-07 · Grant · Acquired 15,300 · Balance 15,300

F3: All of the ordinary shares underlying the option will vest on January 2, 2027, the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

Filing footnotes · ownership attribution and instrument terms

F1: Represents restricted stock units (RSUs), each representing a contingent right to receive one ordinary share. All of the RSUs will vest on the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

F2: Each RSU was granted on January 7, 2026 for no consideration.

F3: All of the ordinary shares underlying the option will vest on January 2, 2027, the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

uniQure N.V.

Report date January 27, 2017 · Filed January 31, 2017

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $5.37 · Expires 2027-01-27Direct11,000 Reported balance After 2017-01-27 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2017-01-27 · Grant · Acquired 11,000 · Balance 11,000

F1: The Stock Option vests 100% on January 27, 2018.

Restricted Stock UnitsSEC Table II · derivative / convertible security · Conversion / exercise price $0.00Direct16,000 Reported balance After 2017-01-27 transaction · row 2 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 2 · 2017-01-27 · Grant · Acquired 11,000 · Balance 16,000

F2: The Restricted Stock Unit vests 100% on January 27, 2018.

F3: Expiration date is not applicable as the vested Restricted Stock Units shall be settled on the first business day following the date that such Restricted Stock Units vests.

Filing footnotes · ownership attribution and instrument terms

F1: The Stock Option vests 100% on January 27, 2018.

F2: The Restricted Stock Unit vests 100% on January 27, 2018.

F3: Expiration date is not applicable as the vested Restricted Stock Units shall be settled on the first business day following the date that such Restricted Stock Units vests.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 315 $174.86 $55,080.90
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 9

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 306,891

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 297 $172.36 $51,190.92
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 8

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 307,206

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F7 · price: This is the weighted average sales price representing 297 shares sold at prices ranging from $172.26 to $172.42 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 297 $171.31 $50,879.07
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 307,503

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · price: This is the weighted average sales price representing 297 shares sold at prices ranging from $171.21 to $171.52 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 160 $170.24 $27,238.40
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 307,800

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: This is the weighted average sales price representing 160 shares sold at prices ranging from $170.12 to $170.89 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 6,996 $169.57 $1,186,311.72
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 307,960

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 6,996 shares sold at prices ranging from $169.11 to $170.08 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 7,176 $168.63 $1,210,088.88
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 314,956

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 7,176 shares sold at prices ranging from $168.11 to $169.10 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 3,974 $167.73 $666,559.02
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 322,132

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 3,974 shares sold at prices ranging from $167.11 to $168.02 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 4,440 $17.16 $76,190.40
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 326,106

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
January 12, 2026 Filed Jan 13, 2026 21:04 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 6,259 $30.46 $190,649.14
Disclosure

SEC source: 0001402051-26-000007 · wk-form4_1768338242.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 321,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
January 08, 2026 Filed Jan 8, 2026 22:20 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 3,223 $174.17 $561,349.91
Disclosure

SEC source: 0001402051-26-000005 · wk-form4_1767910807.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 315,407

F1 · kind: Shares sold to satisfy tax withholding obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

Read SEC document
January 07, 2026 Filed Jan 8, 2026 22:20 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,357 $175.07 $412,639.99
Disclosure

SEC source: 0001402051-26-000005 · wk-form4_1767910807.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 318,630

F1 · kind: Shares sold to satisfy tax withholding obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

Read SEC document
January 07, 2026 Filed Jan 10, 2026 00:34 UTC NewAmsterdam Pharma Co N.V. NAMS · Entity 1826 GrantOption (right to buy) · Derivative 15,300 $0.00 Strike: $35.45 $0.00
Disclosure

SEC source: 0001193125-26-009271 · ownership.xml · derivative · entry 2

Lewis William · CIK 0001402051 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,300

Underlying: Ordinary Shares · 15,300 shares

Expires 2036-01-07

F3 · derivative.exercise_date: All of the ordinary shares underlying the option will vest on January 2, 2027, the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

Read SEC document
January 07, 2026 Filed Jan 10, 2026 00:34 UTC NewAmsterdam Pharma Co N.V. NAMS · Entity 1826 GrantOrdinary Shares 3,400 Not disclosed Not disclosed
Disclosure

SEC source: 0001193125-26-009271 · ownership.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,360

F1 · shares: Represents restricted stock units (RSUs), each representing a contingent right to receive one ordinary share. All of the RSUs will vest on the one-year anniversary of the vesting start date, subject to the Reporting Person's continued service through such date.

F2 · price: Each RSU was granted on January 7, 2026 for no consideration.

Read SEC document
January 06, 2026 Filed Jan 8, 2026 22:20 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 4,096 $173.33 $709,959.68
Disclosure

SEC source: 0001402051-26-000005 · wk-form4_1767910807.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 320,987

F1 · kind: Shares sold to satisfy tax withholding obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

Read SEC document
January 02, 2026 Filed Jan 6, 2026 21:07 UTC INSMED Inc INSM · Entity 3174 GrantStock Option (right to buy) · Derivative 110,400 $0.00 Strike: $177.12 $0.00
Disclosure

SEC source: 0001402051-26-000003 · wk-form4_1767733634.xml · derivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,400

Underlying: Common Stock · 110,400 shares

Expires 2036-01-02

F3 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter until fully vested.

Read SEC document
January 02, 2026 Filed Jan 6, 2026 21:07 UTC INSMED Inc INSM · Entity 3174 GrantCommon Stock 21,172 Not disclosed Not disclosed
Disclosure

SEC source: 0001402051-26-000003 · wk-form4_1767733634.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,083

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on January 2, 2026 for no consideration.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 6,259 $0.00 Strike: $30.46 $0.00
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · derivative · entry 16

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,627

Underlying: Common Stock · 6,259 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 4,440 $0.00 Strike: $17.16 $0.00
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · derivative · entry 15

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,160

Underlying: Common Stock · 4,440 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F12 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 51 $171.20 $8,731.20
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 12

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 303,911

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F11 · price: This is the weighted average sales price representing 51 shares sold at prices ranging from $171.09 to $171.35 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 362 $170.26 $61,634.12
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 11

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 303,962

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F10 · price: This is the weighted average sales price representing 362 shares sold at prices ranging from $170.02 to $170.91 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,938 $169.58 $328,646.04
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 10

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 304,324

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F9 · price: This is the weighted average sales price representing 1,938 shares sold at prices ranging from $169.01 to $170.00 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,175 $168.54 $366,574.50
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 9

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 306,262

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F8 · price: This is the weighted average sales price representing 2,175 shares sold at prices ranging from $168.01 to $169.00 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,431 $167.29 $239,391.99
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 8

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 308,437

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F7 · price: This is the weighted average sales price representing 1,431 shares sold at prices ranging from $167.00 to $167.95 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,783 $166.60 $297,047.80
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 309,868

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · price: This is the weighted average sales price representing 1,783 shares sold at prices ranging from $166.00 to $166.99 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 697 $165.21 $115,151.37
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 311,651

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: This is the weighted average sales price representing 697 shares sold at prices ranging from $164.83 to $165.67 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 447 $164.24 $73,415.28
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 312,348

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 447 shares sold at prices ranging from $163.75 to $164.73 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,465 $163.19 $239,073.35
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 312,795

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 1,465 shares sold at prices ranging from $162.72 to $163.62 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 350 $162.26 $56,791.00
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 314,260

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 350 shares sold at prices ranging from $161.72 to $162.69 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 6,259 $30.46 $190,649.14
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 314,610

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
December 18, 2025 Filed Dec 19, 2025 21:12 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 4,440 $17.16 $76,190.40
Disclosure

SEC source: 0001628280-25-058269 · wk-form4_1766178755.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 308,351

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 4,440 $0.00 Strike: $17.16 $0.00
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · derivative · entry 10

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,600

Underlying: Common Stock · 4,440 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 6,259 $0.00 Strike: $30.46 $0.00
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · derivative · entry 9

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 93,886

Underlying: Common Stock · 6,259 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,040 $207.42 $215,716.80
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 303,911

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: This is the weighted average sales price representing 1.040 shares sold at prices ranging from $207.20 to $207.73 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,921 $206.49 $603,157.29
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 304,951

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 2,921 shares sold at prices ranging from $206.15 to $207.13 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,222 $205.66 $456,976.52
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 307,872

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 2,222 shares sold at prices ranging from $205.11 to $206.02 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 4,516 $204.62 $924,063.92
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 310,094

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 4,516 shares sold at prices ranging from $204.01 to $204.98 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 4,440 $17.16 $76,190.40
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 314,610

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
December 04, 2025 Filed Dec 5, 2025 21:11 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 6,259 $30.46 $190,649.14
Disclosure

SEC source: 0001402051-25-000009 · wk-form4_1764969079.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 310,170

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
August 18, 2025 Filed Aug 20, 2025 20:28 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 6,865 $0.00 Strike: $10.85 $0.00
Disclosure

SEC source: 0001402051-25-000007 · wk-form4_1755721724.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 0

Underlying: Common Stock · 6,865 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
August 18, 2025 Filed Aug 20, 2025 20:28 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,416 $129.47 $183,329.52
Disclosure

SEC source: 0001402051-25-000007 · wk-form4_1755721724.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 233,924

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 1,416 shares sold at prices ranging from $129.26 to $129.95 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 18, 2025 Filed Aug 20, 2025 20:28 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,481 $128.76 $319,453.56
Disclosure

SEC source: 0001402051-25-000007 · wk-form4_1755721724.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 235,340

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 2,481 shares sold at prices ranging from $128.26 to $129.21 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 18, 2025 Filed Aug 20, 2025 20:28 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 2,968 $127.59 $378,687.12
Disclosure

SEC source: 0001402051-25-000007 · wk-form4_1755721724.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 237,821

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 2,968 shares sold at prices ranging from $127.20 to $128.16 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 18, 2025 Filed Aug 20, 2025 20:28 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 6,865 $10.85 $74,485.25
Disclosure

SEC source: 0001402051-25-000007 · wk-form4_1755721724.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 240,789

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
August 04, 2025 Filed Aug 6, 2025 20:21 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 6,830 $0.00 Strike: $10.85 $0.00
Disclosure

SEC source: 0001402051-25-000004 · wk-form4_1754511692.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 6,865

Underlying: Common Stock · 6,830 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
August 04, 2025 Filed Aug 6, 2025 20:21 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,938 $110.91 $214,943.58
Disclosure

SEC source: 0001402051-25-000004 · wk-form4_1754511692.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 233,924

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 1,938 shares sold at prices ranging from $110.26 to $111.24 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 04, 2025 Filed Aug 6, 2025 20:21 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 3,199 $109.68 $350,866.32
Disclosure

SEC source: 0001402051-25-000004 · wk-form4_1754511692.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 235,862

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 3,199 shares sold at prices ranging from $109.25 to $110.23 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 04, 2025 Filed Aug 6, 2025 20:21 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 1,693 $108.80 $184,198.40
Disclosure

SEC source: 0001402051-25-000004 · wk-form4_1754511692.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 239,061

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 1,693 shares sold at prices ranging from $108.24 to $109.23 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document
August 04, 2025 Filed Aug 6, 2025 20:21 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionCommon Stock 6,830 $10.85 $74,105.50
Disclosure

SEC source: 0001402051-25-000004 · wk-form4_1754511692.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 240,754

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

Read SEC document
July 15, 2025 Filed Jul 15, 2025 21:53 UTC INSMED Inc INSM · Entity 3174 Exercise / conversionStock Option (right to buy) · Derivative 6,830 $0.00 Strike: $10.85 $0.00
Disclosure

SEC source: 0001104506-25-000030 · wk-form4_1752616402.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 13,695

Underlying: Common Stock · 6,830 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable.

Read SEC document
July 15, 2025 Filed Jul 15, 2025 21:53 UTC INSMED Inc INSM · Entity 3174 SaleCommon Stock 170 $103.32 $17,564.40
Disclosure

SEC source: 0001104506-25-000030 · wk-form4_1752616402.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Indirect · By the Katie Procter Dynasty Trust

Disclosed balance after: 233,924

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 12, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 170 shares sold at prices ranging from $103.14 to $103.37 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.