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person · Reporting owner

OYLER JOHN

Disclosed activity across 1 company

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24276
SEC CIK
0001042047

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
BeOne Medicines Ltd.ONC · Entity 2168Director · Chief Executive OfficerAugust 10, 2026August 12, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

BeOne Medicines Ltd.

Report date August 10, 2026 · Filed August 12, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
American Depositary SharesSEC Table I · non-derivativeDirect0 Last balance in matching sequence After 2026-08-12 transaction · row 30 Source-order balances reconcile. Account continuity and personal attribution are not independently verified.
24 source rows

Row 7 · 2026-08-10 · Sale · Disposed 67 · Balance 240,743

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Row 8 · 2026-08-10 · Sale · Disposed 2,813 · Balance 237,930

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.01 to $351.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 9 · 2026-08-10 · Sale · Disposed 3,673 · Balance 234,257

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.00 to $353.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 10 · 2026-08-10 · Sale · Disposed 6,717 · Balance 227,540

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.03 to $355.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 11 · 2026-08-10 · Sale · Disposed 3,476 · Balance 224,064

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.08 to $356.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 12 · 2026-08-10 · Sale · Disposed 12,418 · Balance 211,646

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.08 to $357.06, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 13 · 2026-08-10 · Sale · Disposed 15,869 · Balance 195,777

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.08 to $358.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 14 · 2026-08-10 · Sale · Disposed 45,044 · Balance 150,733

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F14: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.08 to $359.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 15 · 2026-08-10 · Sale · Disposed 21,254 · Balance 129,479

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.08 to $360.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 16 · 2026-08-10 · Sale · Disposed 3,680 · Balance 125,799

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.25 to $361.14, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 17 · 2026-08-11 · Sale · Disposed 13,695 · Balance 112,104

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F17: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.90 to $359.89, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 18 · 2026-08-11 · Sale · Disposed 8,081 · Balance 104,023

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F18: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.92 to $360.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 19 · 2026-08-11 · Sale · Disposed 14,569 · Balance 89,454

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F19: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.92 to $361.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 20 · 2026-08-11 · Sale · Disposed 11,568 · Balance 77,886

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F20: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $361.94 to $362.74, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 21 · 2026-08-11 · Sale · Disposed 13,403 · Balance 64,483

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F21: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.95 to $363.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 22 · 2026-08-11 · Sale · Disposed 5,211 · Balance 59,272

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F22: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $363.95 to $364.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 23 · 2026-08-11 · Sale · Disposed 3,176 · Balance 56,096

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F23: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $365.00 to $365.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 24 · 2026-08-11 · Sale · Disposed 1,200 · Balance 54,896

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F24: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $366.00 to $366.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 25 · 2026-08-11 · Sale · Disposed 4 · Balance 54,892

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Row 26 · 2026-08-12 · Sale · Disposed 1,980 · Balance 52,912

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F25: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.35 to $355.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 27 · 2026-08-12 · Sale · Disposed 2,515 · Balance 50,397

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F26: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.92 to $356.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 28 · 2026-08-12 · Sale · Disposed 15,396 · Balance 35,001

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F27: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.95 to $357.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 29 · 2026-08-12 · Sale · Disposed 20,899 · Balance 14,102

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F28: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.95 to $358.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Row 30 · 2026-08-12 · Sale · Disposed 14,102 · Balance 0

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F29: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.95 to $359.68, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Ordinary SharesSEC Table I · non-derivativeDirect1,330,988 Reported balance Holding disclosure · report date 2026-08-10 · row 1 Holding and transaction disclosures are not merged.
1 source row

Row 1 · Balance 1,330,988

Ordinary SharesSEC Table I · non-derivativeIndirectSee Footnote481,533 Reported balance Holding disclosure · report date 2026-08-10 · row 2 Holding and transaction disclosures are not merged.
1 source row

Row 2 · Balance 481,533

F1: These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

Ordinary SharesSEC Table I · non-derivativeIndirectSee Footnote7,699,158 Reported balance Holding disclosure · report date 2026-08-10 · row 3 Holding and transaction disclosures are not merged.
1 source row

Row 3 · Balance 7,699,158

F2: These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Ordinary SharesSEC Table I · non-derivativeIndirectSee Footnote28,204,115 Reported balance Holding disclosure · report date 2026-08-10 · row 4 Holding and transaction disclosures are not merged.
1 source row

Row 4 · Balance 28,204,115

F3: These securities are held by Oyler Investment LLC, of which 99% of the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

Ordinary SharesSEC Table I · non-derivativeIndirectSee Footnote9,545,000 Reported balance Holding disclosure · report date 2026-08-10 · row 5 Holding and transaction disclosures are not merged.
1 source row

Row 5 · Balance 9,545,000

F4: These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

Ordinary SharesSEC Table I · non-derivativeIndirectSee Footnote102,188 Reported balance Holding disclosure · report date 2026-08-10 · row 6 Holding and transaction disclosures are not merged.
1 source row

Row 6 · Balance 102,188

F5: These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.

Filing footnotes · ownership attribution and instrument terms

F1: These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

F2: These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F3: These securities are held by Oyler Investment LLC, of which 99% of the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

F4: These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

F5: These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.

F6: Each American Depositary Share represents 13 Ordinary Shares.

F7: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.01 to $351.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F9: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.00 to $353.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F10: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.03 to $355.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F11: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.08 to $356.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F12: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.08 to $357.06, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F13: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.08 to $358.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F14: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.08 to $359.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F15: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.08 to $360.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F16: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.25 to $361.14, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F17: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.90 to $359.89, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F18: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.92 to $360.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F19: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.92 to $361.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F20: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $361.94 to $362.74, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F21: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.95 to $363.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F22: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $363.95 to $364.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F23: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $365.00 to $365.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F24: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $366.00 to $366.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F25: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.35 to $355.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F26: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.92 to $356.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F27: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.95 to $357.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F28: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.95 to $358.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F29: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.95 to $359.68, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
August 12, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 14,102 $359.12 $5,064,252.42
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 30

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F29 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.95 to $359.68, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 12, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 20,899 $358.41 $7,490,448.21
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 29

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,102

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F28 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.95 to $358.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 12, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 15,396 $357.63 $5,506,146.92
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 28

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,001

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F27 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.95 to $357.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 12, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 2,515 $356.43 $896,425.98
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 27

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,397

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F26 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.92 to $356.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 12, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 1,980 $354.71 $702,320.26
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 26

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,912

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F25 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.35 to $355.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 4 $367.00 $1,468.00
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 25

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,892

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 1,200 $366.31 $439,574.40
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 24

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,896

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F24 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $366.00 to $366.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 3,176 $365.26 $1,160,079.10
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 23

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,096

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F23 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $365.00 to $365.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 5,211 $364.31 $1,898,442.34
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 22

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 59,272

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F22 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $363.95 to $364.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 13,403 $363.45 $4,871,344.48
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 21

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,483

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F21 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.95 to $363.94, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 11,568 $362.34 $4,191,547.96
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 20

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,886

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F20 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $361.94 to $362.74, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 14,569 $361.47 $5,266,268.09
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 19

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,454

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F19 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.92 to $361.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 8,081 $360.33 $2,911,849.36
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 18

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 104,023

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F18 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.92 to $360.91, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 11, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 13,695 $359.32 $4,920,843.58
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,104

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F17 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.90 to $359.89, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 3,680 $360.63 $1,327,130.18
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,799

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.25 to $361.14, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 21,254 $359.50 $7,640,825.75
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 129,479

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $359.08 to $360.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 45,044 $358.70 $16,157,075.60
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 150,733

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $358.08 to $359.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 15,869 $357.67 $5,675,863.64
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 195,777

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.08 to $358.07, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 12,418 $356.62 $4,428,482.32
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 211,646

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.08 to $357.06, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 3,476 $355.66 $1,236,261.30
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 224,064

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.08 to $356.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 6,717 $354.78 $2,383,028.38
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 227,540

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.03 to $355.01, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 3,673 $353.32 $1,297,741.05
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 234,257

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.00 to $353.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 2,813 $351.80 $989,602.71
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 237,930

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.01 to $351.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
August 10, 2026 Filed Aug 12, 2026 21:53 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 67 $350.00 $23,450.00
Disclosure

SEC source: 0001042047-26-000019 · wk-form4_1786571605.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 240,743

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Read SEC document
July 21, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 2,340 $320.06 $748,936.42
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 21

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F20 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $319.82 to $320.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 21, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 15,807 $319.29 $5,047,018.61
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 20

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,340

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F19 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $318.79 to $319.78, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 21, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 7,842 $318.41 $2,496,997.10
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 19

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,147

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F18 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $317.72 to $318.685, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 21, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 20,029 $316.91 $6,347,340.32
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 18

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,989

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F17 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $316.67 to $317.62, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 21, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 15,379 $316.26 $4,863,765.62
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,018

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.67 to $316.66, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 Exercise / conversionShare Option (Right to Buy) · Derivative 441,870 $0.00 Strike: $9.23 $0.00
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · derivative · entry 22

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 441,870 shares

Expires 2029-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F21 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F22 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 5, 2020, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

Read SEC document
July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 280 $318.30 $89,124.00
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

Read SEC document
July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 523 $316.14 $165,339.28
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 280

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.91 to $316.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 1,512 $315.26 $476,677.66
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 803

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $314.74 to $315.60, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 1,850 $313.91 $580,731.65
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,315

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.47 to $314.36, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 14,326 $312.96 $4,483,433.44
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,165

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $312.46 to $313.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 15,499 $312.29 $4,840,114.51
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,491

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.98 to $312.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 Exercise / conversionAmerican Depositary Shares 33,990 $119.96 $4,077,440.40
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,990

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 2,907 $311.80 $906,388.65
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.46 to $311.98, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 6,273 $310.75 $1,949,310.29
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,907

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $310.39 to $311.36, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 20, 2026 Filed Jul 22, 2026 21:03 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 5,146 $310.08 $1,595,677.86
Disclosure

SEC source: 0001042047-26-000017 · wk-form4_1784754189.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,180

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $309.39 to $310.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 Exercise / conversionShare Option (Right to Buy) · Derivative 840,164 $0.00 Strike: $9.23 $0.00
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · derivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 441,870

Underlying: Ordinary Shares · 840,164 shares

Expires 2029-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F17 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F18 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 5, 2020, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 51 $315.06 $16,068.18
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $314.88 to $315.18, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 740 $314.32 $232,596.65
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.83 to $314.67, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 14,915 $313.19 $4,671,197.53
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 791

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $312.78 to $313.76, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 35,829 $312.17 $11,184,910.91
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,706

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.78 to $312.77, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 5,543 $311.42 $1,726,217.69
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,535

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $310.78 to $311.77, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 4,833 $310.37 $1,500,015.31
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,078

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $309.78 to $310.76, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 680 $309.05 $210,156.79
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,911

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $308.77 to $309.37, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 597 $306.96 $183,257.63
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,591

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.61 to $307.59, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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July 17, 2026 Filed Jul 17, 2026 21:36 UTC BeOne Medicines Ltd. ONC · Entity 2168 SaleAmerican Depositary Shares 1,440 $305.20 $439,485.84
Disclosure

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,188

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.96 to $305.605, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.