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person · Reporting owner

Lee Jennifer Kayden

Disclosed activity across 2 companies

Tapewire entity
23364
SEC CIK
0001801372

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Krystal Biotech, Inc.KRYS · Entity 3500Chief Commercial OfficerJanuary 31, 2020February 04, 2020
RHYTHM PHARMACEUTICALS, INC.RYTM · Entity 3693EVP, Head of North AmericaAugust 13, 2026August 14, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Krystal Biotech, Inc.

Report date January 31, 2020 · Filed February 04, 2020

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $52.26 · Expires 2030-01-30Direct125,000 Reported balance After 2020-01-31 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2020-01-31 · Grant · Acquired 125,000 · Balance 125,000

F1: The options vest ratably over a four-year period beginning on January 20, 2020.

Filing footnotes · ownership attribution and instrument terms

F1: The options vest ratably over a four-year period beginning on January 20, 2020.

RHYTHM PHARMACEUTICALS, INC.

Report date August 13, 2026 · Filed August 14, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect0 Ending reported balance After 2026-08-13 transaction · row 3
3 source rows · reconciled sequence

Row 1 · 2026-08-13 · Exercise / conversion · Acquired 35,000 · Balance 54,233

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

Row 2 · 2026-08-13 · Exercise / conversion · Acquired 21,601 · Balance 75,834

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

Row 3 · 2026-08-13 · Sale · Disposed 75,834 · Balance 0

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

Stock Options (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $24.29 · Expires 2030-11-09Direct36,283 Reported balance After 2026-08-13 transaction · row 4 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 4 · 2026-08-13 · Exercise / conversion · Disposed 35,000 · Balance 36,283

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

F2: The stock options were granted on November 9, 2020. 25% of the shares subject to the option vested and become exercisable on November 9, 2021 and the remaining 75% of the shares subject to the option vested and become exercisable in 12 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer thereafter.

Stock Options (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $6.80 · Expires 2032-02-08Direct0 Reported balance After 2026-08-13 transaction · row 5 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 5 · 2026-08-13 · Exercise / conversion · Disposed 21,601 · Balance 0

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

F3: The stock options were granted on February 9, 2022. The options vested and became exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Filing footnotes · ownership attribution and instrument terms

F1: The exercises and sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2026.

F2: The stock options were granted on November 9, 2020. 25% of the shares subject to the option vested and become exercisable on November 9, 2021 and the remaining 75% of the shares subject to the option vested and become exercisable in 12 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer thereafter.

F3: The stock options were granted on February 9, 2022. The options vested and became exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
March 19, 2024 Filed Mar 20, 2024 00:52 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 15,515 $39.22 $608,498.30
Disclosure

SEC source: 0001104659-24-036312 · tm249308-2_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,087

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $39.07 to $39.22. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 16, 2024 Filed Feb 22, 2024 00:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Option (Right to Buy) · Derivative 67,000 $0.00 Strike: $49.23 $0.00
Disclosure

SEC source: 0001104659-24-026154 · tm246920-1_4seq1.xml · derivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Stock · 67,000 shares

Expires 2034-02-15

F4 · derivative.exercise_date: The stock options were granted on February 16, 2024. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
February 16, 2024 Filed Feb 22, 2024 00:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 22,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-026154 · tm246920-1_4seq1.xml · derivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

Read SEC document
February 16, 2024 Filed Feb 22, 2024 00:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantCommon Stock 33,750 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-026154 · tm246920-1_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,602

F1 · shares: The Issuer previously granted the Reporting Person an award of restricted stock units that vest based on the Issuer's satisfaction of certain performance objectives. On February 16, 2024, the Board determined that the performance condition had been satisfied.

Read SEC document
February 13, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 615 $49.83 $30,645.45
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · nonDerivative · entry 4

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,852

F2 · kind: The sales reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
February 12, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,023 $51.38 $52,561.74
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · nonDerivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,467

F2 · kind: The sales reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
February 11, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,031 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · derivative · entry 6

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,031

Underlying: Common Stock · 2,031 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F4 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

F4 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

Read SEC document
February 11, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,031 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,490

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 09, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,438 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · derivative · entry 5

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,874

Underlying: Common Stock · 3,438 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

Read SEC document
February 09, 2024 Filed Feb 14, 2024 01:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,438 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-24-022538 · tm246165-3_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,459

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 01, 2024 Filed Feb 5, 2024 23:55 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 4,513 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-010800 · tm245251-5_4seq1.xml · derivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,537

Underlying: Common Stock · 4,513 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

Read SEC document
February 01, 2024 Filed Feb 5, 2024 23:55 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,492 $45.06 $67,229.52
Disclosure

SEC source: 0001104659-24-010800 · tm245251-5_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,021

F2 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
February 01, 2024 Filed Feb 5, 2024 23:55 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 4,513 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-24-010800 · tm245251-5_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,513

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
November 14, 2023 Filed Nov 16, 2023 21:05 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 12,030 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-119095 · tm2330902-2_4seq1.xml · derivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,412

Underlying: Common Stock · 12,030 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 14, 2023 Filed Nov 16, 2023 21:05 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 13,677 $32.01 $437,818.55
Disclosure

SEC source: 0001104659-23-119095 · tm2330902-2_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $32.00 to $32.125. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
November 14, 2023 Filed Nov 16, 2023 21:05 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 12,030 $6.80 $81,804.00
Disclosure

SEC source: 0001104659-23-119095 · tm2330902-2_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,677

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 09, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 3,438 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · derivative · entry 8

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,442

Underlying: Common Stock · 3,438 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 09, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,719 $28.00 $48,132.00
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 6

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,647

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

Read SEC document
November 09, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,719 $27.37 $47,051.09
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 5

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,366

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $26.86 to $27.51. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
November 09, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,438 $6.80 $23,378.40
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 4

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,085

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 08, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 5,712 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · derivative · entry 7

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,880

Underlying: Common Stock · 5,712 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 08, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 2,233 $29.31 $65,455.71
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,647

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $29.04 to $29.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
November 08, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,479 $28.64 $99,648.65
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,880

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at per share prices ranging from $28.04 to $29.01. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
November 08, 2023 Filed Nov 13, 2023 22:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 5,712 $6.80 $38,841.60
Disclosure

SEC source: 0001104659-23-117365 · tm2330582-1_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,359

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 03, 2023 Filed Nov 7, 2023 23:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 80 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-115368 · tm2330154-1_4seq1.xml · derivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,592

Underlying: Common Stock · 80 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
November 03, 2023 Filed Nov 7, 2023 23:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 80 $28.00 $2,240.00
Disclosure

SEC source: 0001104659-23-115368 · tm2330154-1_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,647

F1 · kind: The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

Read SEC document
November 03, 2023 Filed Nov 7, 2023 23:17 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 80 $6.80 $544.00
Disclosure

SEC source: 0001104659-23-115368 · tm2330154-1_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,727

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
September 05, 2023 Filed Sep 7, 2023 21:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 4,519 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-099017 · tm2325695-1_4seq1.xml · derivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,672

Underlying: Common Stock · 4,519 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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September 05, 2023 Filed Sep 7, 2023 21:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 6,166 $28.05 $172,957.53
Disclosure

SEC source: 0001104659-23-099017 · tm2325695-1_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,647

F1 · kind: The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

F2 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $28.00 to $28.25. The Reporting Person undertakes to provide upon request the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

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September 05, 2023 Filed Sep 7, 2023 21:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 4,519 $6.80 $30,729.20
Disclosure

SEC source: 0001104659-23-099017 · tm2325695-1_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,813

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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August 09, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 1,718 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · derivative · entry 6

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,191

Underlying: Common Stock · 1,718 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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August 09, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,718 $24.66 $42,365.88
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · nonDerivative · entry 4

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,294

F2 · kind: The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

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August 09, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 1,718 $6.80 $11,682.40
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · nonDerivative · entry 3

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,012

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 07, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Option (Right to Buy) · Derivative 8,591 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · derivative · entry 5

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,909

Underlying: Common Stock · 8,591 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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August 07, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 11,223 $24.18 $271,347.45
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · nonDerivative · entry 2

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,294

F2 · kind: The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 8, 2023.

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August 07, 2023 Filed Aug 9, 2023 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 8,591 $6.80 $58,418.80
Disclosure

SEC source: 0001104659-23-089331 · tm2323302-1_4seq1.xml · nonDerivative · entry 1

Lee Jennifer Kayden · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,517

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 986 shares acquired under Issuer's Employee Stock Purchase Plan on February 28, 2023.

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February 14, 2023 Filed Feb 15, 2023 01:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 635 $26.87 $17,062.45
Disclosure

SEC source: 0001104659-23-022113 · tm236871-9_4seq1.xml · nonDerivative · entry 2

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,940

F2 · kind: The sales reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 11, 2023 Filed Feb 15, 2023 01:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,031 $0.00 $0.00
Disclosure

SEC source: 0001104659-23-022113 · tm236871-9_4seq1.xml · derivative · entry 3

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,062

Underlying: Common Stock · 2,031 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

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February 11, 2023 Filed Feb 15, 2023 01:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,031 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-23-022113 · tm236871-9_4seq1.xml · nonDerivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,575

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 09, 2023 Filed Feb 13, 2023 22:04 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,438 $0.00 $0.00
Disclosure

SEC source: 0001104659-23-019835 · tm236605-6_4seq1.xml · derivative · entry 3

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,312

Underlying: Common Stock · 3,438 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

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February 09, 2023 Filed Feb 13, 2023 22:04 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,192 $27.66 $32,970.72
Disclosure

SEC source: 0001104659-23-019835 · tm236605-6_4seq1.xml · nonDerivative · entry 2

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,556

F2 · kind: The sales reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 09, 2023 Filed Feb 13, 2023 22:04 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,438 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-23-019835 · tm236605-6_4seq1.xml · nonDerivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,748

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 09, 2023 Filed Feb 15, 2023 00:19 UTC Amendment RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,204 $27.51 $33,122.04
Disclosure

SEC source: 0001104659-23-022065 · tm236871-2_4aseq1.xml · nonDerivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,544

F1 · kind: The sales reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 01, 2023 Filed Feb 3, 2023 21:06 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Option (Right to Buy) · Derivative 46,900 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-23-010483 · tm235340-1_4seq1.xml · derivative · entry 2

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,900

Underlying: Common Stock · 46,900 shares

Expires 2033-01-31

F3 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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February 01, 2023 Filed Feb 3, 2023 21:06 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 18,050 $0.00 $0.00
Disclosure

SEC source: 0001104659-23-010483 · tm235340-1_4seq1.xml · derivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,050

Underlying: Common Stock · 18,050 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

F2 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

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February 15, 2022 Filed Feb 16, 2022 00:28 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 722 $6.10 $4,404.20
Disclosure

SEC source: 0001104659-22-023948 · tm226880-1_4seq1.xml · nonDerivative · entry 2

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,310

F2 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported Restricted Share Units.

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February 11, 2022 Filed Feb 16, 2022 00:28 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,032 $0.00 $0.00
Disclosure

SEC source: 0001104659-22-023948 · tm226880-1_4seq1.xml · derivative · entry 3

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,093

Underlying: Common Stock · 2,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

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February 11, 2022 Filed Feb 16, 2022 00:28 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,032 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-22-023948 · tm226880-1_4seq1.xml · nonDerivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,032

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 09, 2022 Filed Feb 12, 2022 02:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Option (Right to Buy) · Derivative 82,500 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-22-020887 · tm226394-1_4seq1.xml · derivative · entry 2

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,500

Underlying: Common Stock · 82,500 shares

Expires 2032-02-08

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
February 09, 2022 Filed Feb 12, 2022 02:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 13,750 $0.00 $0.00
Disclosure

SEC source: 0001104659-22-020887 · tm226394-1_4seq1.xml · derivative · entry 1

Chien Jennifer · CIK 0001801372 · EVP, Head of North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,750

Underlying: Common Stock · 13,750 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

F2 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 9, 2026. The restricted stock units have no expiration date.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.