LANGER DENNIS

SEC source: 0001104659-26-103376 · tm2624320-2_4seq1.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,243

F1 · security: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

F2 · kind: On August 27, 2026, the Issuer and the Reporting Person, entered into an exchange agreement, pursuant to which $177,849 of accrued interest outstanding ("Outstanding Debt") owed in connection with a note previously purchased by the Reporting Person was exchanged for 34,534 ADSs. The exchange agreement and the exchange of the Outstanding Debt for the ADSs was approved in advance by the Issuer's audit committee and board of directors.

SEC source: 0001104659-26-011613 · tm265448-3_4seq1.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,709

Underlying: ADS · 21,709 shares

Expires 2036-02-04

F1 · derivative.exercise_price: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F2 · derivative.exercise_date: The option vests in four annual installments with 20% vesting on each of February 4, 2027, 2028 and 2029 and 40% vesting on February 4, 2030.

F1 · derivative.underlying_shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · balance_after: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

SEC source: 0001104659-25-099782 · tm2528832-1_4seq1.xml · derivative · entry 5

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,152

Underlying: ADS · 15,152 shares

Expires not disclosed

F2 · kind: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F2 · price: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F3 · derivative.exercise_date: The Warrants were exercisable immediately upon issuance, subject to a beneficial ownership cap.

F7 · derivative.expiration_date: The Series K Warrants will expire on the earlier of (i) five (5) years from the Closing Date or (ii) 30 days after the public announcement of the Company's sale of a Priority Review Voucher (PRV).

F1 · derivative.underlying: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

SEC source: 0001104659-25-099782 · tm2528832-1_4seq1.xml · derivative · entry 4

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,152

Underlying: ADS · 15,152 shares

Expires not disclosed

F2 · kind: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F2 · price: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F3 · derivative.exercise_date: The Warrants were exercisable immediately upon issuance, subject to a beneficial ownership cap.

F6 · derivative.expiration_date: The Series J Warrants will expire on the earlier of (i) five (5) years from the Closing Date or (ii) 30 days after the public announcement of the receipt of either accelerated or traditional approval by the FDA of QRX003 for the treatment of Netherton Syndrome.

F1 · derivative.underlying: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

SEC source: 0001104659-25-099782 · tm2528832-1_4seq1.xml · derivative · entry 3

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,152

Underlying: ADS · 15,152 shares

Expires not disclosed

F2 · kind: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F2 · price: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F3 · derivative.exercise_date: The Warrants were exercisable immediately upon issuance, subject to a beneficial ownership cap.

F5 · derivative.expiration_date: The Series I Warrants will expire as follows: (i) 50% of the Series I Warrants will expire on the earlier of (A) five (5) years from the Closing Date or (B) 30 days after the Company's public announcement that the primary endpoint has been met in the monotherapy pivotal trial of QRX003 for the treatment of Netherton Syndrome, and (ii) 50% of the Series I Warrants will expire on the earlier of (A) five (5) years from the Closing Date or (B) 30 days after the Company's public announcement that the primary endpoint has been met in the adjuvant pivotal trial of QRX003 for the treatment of Netherton Syndrome.

F1 · derivative.underlying: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

SEC source: 0001104659-25-099782 · tm2528832-1_4seq1.xml · derivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,152

Underlying: ADS · 15,152 shares

Expires not disclosed

F2 · kind: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F2 · price: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

F3 · derivative.exercise_date: The Warrants were exercisable immediately upon issuance, subject to a beneficial ownership cap.

F4 · derivative.expiration_date: The Series H Warrants will expire on the earlier of (i) five (5) years from the Closing Date or (ii) 30 days after the Company's public announcement that the Company has received Type C meeting minutes from the FDA indicating openness to baseline-controlled pivotal studies for QRX003 for the treatment of Netherton Syndrome.

F1 · derivative.underlying: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

SEC source: 0001104659-25-099782 · tm2528832-1_4seq1.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,153

F1 · security: Ordinary Shares are represented by American Depositary Shares ("ADSs"). Each ADS represents thirty-five (35) ordinary shares of the Issuer.

F2 · kind: Each ADS purchased together with a Series H Warrant, a Series I Warrant, a Series J Warrant and a Series K Warrant to purchase one ADS in the Issuer's private placement which closed on October 14, 2025, at a combined price of $8.49. The Series H Warrants, Series I Warrants, Series J Warrants and Series K Warrants are collectively referred to as the "Warrants."

SEC source: 0001104659-25-082511 · tm2524172-1_4seq1.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,682

Underlying: ADS · 13,682 shares

Expires 2035-05-28

F1 · derivative.exercise_price: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F2 · date: The option grant was approved by the Compensation Committee and the Board on May 29, 2025, subject to shareholder approval. The Company's shareholder's approved this option grant on August 21, 2025.

F1 · shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F3 · derivative.exercise_date: The option vests in four annual installments with 20% vesting on each of May 29, 2026, 2027 and 2028 and 40% vesting on May 29, 2029.

F1 · derivative.underlying: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · derivative.underlying_shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · balance_after: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

SEC source: 0001104659-25-055629 · tm2516320-3_4seq1.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,760

Underlying: ADS · 7,760 shares

Expires 2035-05-29

F1 · derivative.exercise_price: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F2 · derivative.exercise_date: The option vests in four annual installments with 20% vesting on each of May 29, 2026, 2027 and 2028 and 40% vesting on May 29, 2029.

F1 · derivative.underlying: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · derivative.underlying_shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

F1 · balance_after: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents thirty-five ordinary shares of the Issuer.

SEC source: 0001104659-24-127230 · tm2430519-1_4seq1.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,714

Underlying: ADS · 50,714 shares

Expires 2034-12-09

F1 · derivative.exercise_price: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

F1 · shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

F2 · derivative.exercise_date: The option vests in four annual installments with 20% vesting on each of December 9, 2025, 2026 and 2027 and 40% vesting on December 9, 2028.

F1 · derivative.underlying: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

F1 · derivative.underlying_shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

F1 · balance_after: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

SEC source: 0001104659-24-070017 · tm2416851-1_4seq1.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53

F1 · shares: Reported securities are represented by American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

F1 · balance_after: Reported securities are represented by American Depositary Shares ("ADSs"). Each ADS represents one ordinary share of the Issuer.

SEC source: 0001104659-23-112558 · tm2329341-5_4seq1.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,652

Underlying: American Depositary Share · 7,652 shares

Expires 2033-10-26

F1 · derivative.exercise_price: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"), with sixty thousand (60,000) ordinary shares of the Issuer represented by one (1) ADS.

F1 · shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"), with sixty thousand (60,000) ordinary shares of the Issuer represented by one (1) ADS.

F2 · derivative.exercise_date: The option vests in four annual installments with 20% vesting on each of October 26, 2024, 2025 and 2026 and 40% vesting on October 26, 2027.

F1 · derivative.underlying: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"), with sixty thousand (60,000) ordinary shares of the Issuer represented by one (1) ADS.

F1 · derivative.underlying_shares: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"), with sixty thousand (60,000) ordinary shares of the Issuer represented by one (1) ADS.

F1 · balance_after: The number of securities underlying the option and the exercise price are listed in terms of American Depositary Shares ("ADSs"), with sixty thousand (60,000) ordinary shares of the Issuer represented by one (1) ADS.

SEC source: 0001628280-22-016225 · wf-form4_165429170294984.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,802

F1 · kind: Consists of restricted stock units granted pursuant to Myriad Genetics, Inc.'s 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of common stock and vests upon the earlier of (a) the first anniversary of the Date of Grant and (b) the date of the next annual meeting of stockholders following such grant.

SEC source: 0001140361-21-041284 · form4.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,000

Underlying: Common Stock · 67,000 shares

Expires 2031-12-07

F1 · derivative.exercise_date: A total of 22,336 of the shares subject to the option vest and become exercisable as of 12:01 a.m. Eastern time on the date of the issuer's 2022 Annual Meeting of Stockholders and the remaining 44,664 shares vest and become exercisable in equal monthly installments over the following 24 months, subject to continued service through each vesting date.

SEC source: 0001274225-21-000004 · edgardoc.xml · derivative · entry 3

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 30,000 shares

Expires 2021-12-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

F2 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0001274225-21-000004 · edgardoc.xml · nonDerivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,527

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001274225-21-000004 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,527

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001274225-21-000002 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,527

F1 · kind: Consists of restricted stock units granted pursuant to Myriad Genetics, Inc.'s 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of common stock and vests on the anniversary of the date of grant.

SEC source: 0001274225-20-000002 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,679

F1 · kind: Consists of restricted stock units granted pursuant to the Company's 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of the Company's common stock and vests on the anniversary of the date of grant.

SEC source: 0001274225-19-000002 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,790

F1 · kind: Consists of restricted stock units granted pursuant to the Company's 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of the Company's common stock and vests on the anniversary of the date of grant.

SEC source: 0000899243-19-017862 · doc4.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2029-06-20

F1 · derivative.exercise_date: This option vests monthly over 12 months from June 20, 2019 ("Grant Date") in substantially equal monthly installments, provided that the option will vest in full on the Issuer's next regularly scheduled annual meeting of stockholders that occurs following the Grant Date, subject to the Reporting Person's continued service to the Issuer through each such date or, if earlier, such annual meeting.

SEC source: 0001274225-18-000013 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,103

F1 · kind: Consists of restricted stock units granted pursuant to the Company's 2017 Employee, Director and Consultant Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one share of the Company's common stock and vests on the anniversary of the date of grant.

SEC source: 0000905148-18-000728 · form4.xml · nonDerivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,064

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 21, 2018.

SEC source: 0000905148-18-000728 · form4.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Langer Family Holdings, LLLP

Disclosed balance after: 47,978

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 21, 2018.

F2 · ownership.nature: The reporting person disclaims beneficial ownership of the shares owned by Langer Family Holdings, LLLP.

SEC source: 0000899243-18-018021 · doc4.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-06-21

F1 · derivative.exercise_date: This option vests monthly over 12 months from June 21, 2018 ("Grant Date") in substantially equal monthly installments, provided that the option will vest in full on the Issuer's next regularly scheduled annual meeting of stockholders that occurs following the Grant Date, subject to the Reporting Person's continued service to the Issuer through each such date or, if earlier, such annual meeting.

SEC source: 0001274225-18-000011 · edgardoc.xml · derivative · entry 9

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,664 shares

Expires 2021-12-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 6

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 5

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,407

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000011 · edgardoc.xml · derivative · entry 8

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,664

Underlying: Common Stock · 3,096 shares

Expires 2021-12-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 4

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 3

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,839

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000011 · edgardoc.xml · derivative · entry 7

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,760

Underlying: Common Stock · 3,609 shares

Expires 2021-12-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000011 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · derivative · entry 10

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,369

Underlying: Common Stock · 1,227 shares

Expires 2021-12-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 8

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 7

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,970

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · derivative · entry 11

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2018-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001274225-18-000009 · edgardoc.xml · derivative · entry 9

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,596

Underlying: Common Stock · 8,404 shares

Expires 2021-12-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 6

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 5

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,147

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 4

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 3

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,743

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · derivative · entry 12

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 30,000 shares

Expires 2019-11-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000009 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,743

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001274225-18-000007 · edgardoc.xml · derivative · entry 3

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2018-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0001274225-18-000007 · edgardoc.xml · nonDerivative · entry 2

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,743

SEC source: 0001274225-18-000007 · edgardoc.xml · nonDerivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,743

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001136261-18-000141 · primary_doc.xml · derivative · entry 1

LANGER DENNIS · CIK 0001274225 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2018-05-21

F1 · derivative.exercise_date: The stock option vests in four equal annual installments of 6,250 shares over a four-year period, with the first installment vesting on May 22, 2019, which is the one-year anniversary of the grant date.